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| 1 | Three-point bending of honeycomb sandwich beams with facesheet perforations显示文摘A novel square honeycomb-cored sandwich beam with perforated bottom facesheet is investigated under threepoint bending,both analytically and numerically.Perforated square holes in the bottom facesheet are characterized by the area ratio of the hole to intact facesheet(perforation ratio).While for large-scale engineering applications like the decks of cargo vehicles and transportation ships,the perforations are needed to facilitate the fabrication process(e.g.,laser welding)as well as service maintenance,it is demonstrated that these perforations,when properly designed,can also enhance the resistance of the sandwich to bending.For illustration,fair comparisons among competing sandwich designs having different perforation ratios but equal mass is achieved by systematically thickening the core webs.Further,the perforated sandwich beam is designed with a relatively thick facesheet to avoid local indention failure so that it mainly fails in two competing modes:(1)bending failure,i.e.,yielding of beam cross-section and buckling of top facesheet caused by bending moment;(2)shear failure,i.e.,yielding and buckling of core webs due to shear forcing.The sensitivity of the failure loads to the ratio of core height to beam span is also discussed for varying perforation ratios.As the perfo-ration ratio is increased,the load of shear failure increases due to thickening core webs,while that of bending failure decreases due to the weakening bottom facesheet.Design of a sandwich beam with optimal perforation ratio is realized when the two failure loads are equal,leading to significantly enhanced failure load(up to 60%increase)relative to that of a non-perforated sandwich beam with equal mass. | Pengbo Su Bin Han Zhongnan Zhao Qiancheng Zhang Tian Jian Lu | 2018 | Acta Mechanica Sinica2018，34，4： | 3 |
| 2 | Molecular Characterisation of the Faecal Microbiota in Patients with Type II Diabetes显示文摘 | Xiaokang Wu Chaofeng Ma Lei Han Muhammad Nawaz Fei Gao Xuyan Zhang Pengbo Yu Chang’an Zhao Lianchuan Li Aiping Zhou Juan Wang John E. Moore B. Cherie Millar Jiru Xu | 2010 | Current Microbiology2010，，1： | 2 |
| 3 | NAD^(+) salvage governs the immunosuppressive capacity of mesenchymal stem cells显示文摘Mesenchymal stem/stromal cells(MSCs)possess robust immunoregulatory functions and are promising therapeutics for inflammatory disorders.This capacity is not innate but is activated or‘licensed’by inflammatory cytokines.The licensing mechanism remains unclear.Here,we examined whether inflammatory cytokines metabolically reprogrammed MSCs to confer this immunoregulatory capacity.In response to stimulation by inflammatory cytokines,MSCs exhibited a dramatic increase in the consumption of glucose,which was accompanied by an enhanced use of nicotinamide adenine dinucleotide(NAD^(+))and increased expression of nicotinamide phosphoribosyltransferase(NAMPT),a central enzyme in the salvage pathway for NAD^(+) production.When NAD^(+) synthesis was blocked by inhibiting or depleting NAMPT,the immunosuppressive function of MSCs induced by inflammatory cytokines was greatly attenuated.Consequently,when NAD^(+) metabolism in MSCs was perturbed,their therapeutic benefit was decreased in mice suffering from inflammatory bowel disease and acute liver injury.Further analysis revealed that NAMPT-driven production of NAD^(+) was critical for the inflammatory cytokine-induced increase in glycolysis in MSCs.Furthermore,the increase in glycolysis led to succinate accumulation in the tricarboxylic acid cycle,which led to hypoxia-inducible factor 1α(HIF-1α)stabilization and subsequently increased the transcription of key glycolytic genes,thereby persistently maintaining glycolytic flux.This study demonstrated that unlike its proinflammatory role in immune cells,NAD^(+) metabolism governs the anti-inflammatory function of MSCs during inflammation. | Jiankai Fang Pengbo Hou Shisong Liu Muqiu Zuo Zhanhong Liu Wangwang Chen Yuyi Han Yanan Li Tingting Wang Chao Feng Peishan Li Changshun Shao Yufang Shi | 2023 | Cellular & Molecular Immunology2023，20，10： | 1 |
| 4 | Nested PCR-denaturing gradient gel electrophoresis analysis of human skin microbial diversity with age显示文摘 | Wei Li Lei Han Pengbo Yu Chaofeng Ma Xiaokang Wu Jiru Xu | 2014 | Microbiological Research2014，，： | 1 |
| 5 | Two Supporting Factors Greatly Improve the Efficiency of Human iPSC Generation显示文摘 | Yang Zhao Xiaolei Yin Han Qin Fangfang Zhu Haisong Liu Weifeng Yang Qiang Zhang Chengang Xiang Pingping Hou Zhihua Song Yanxia Liu Jun Yong Pengbo Zhang Jun Cai Meng Liu Honggang Li Yanqin Li Xiuxia Qu Kai Cui Weiqi Zhang Tingting Xiang Yetao Wu Yiding Zh | 2008 | Cell Stem Cell2008，，5： | 1 |
| 6 | Outbreak of acute respiratory disease caused by human adenovirus type 7 in a military training camp in Shaanxi, China显示文摘 | Pengbo Yu Chaofeng Ma Muhammad Nawaz Lei Han Jianfang Zhang Quanli Du Lixia Zhang Qunling Feng Jingjun Wang Jiru Xu | 2013 | Microbiol Immunol2013，，8： | 1 |
| 7 | Structural Controls of Tetraphenylbenzene-based AIEgens for Non-doped Deep Blue Organic Light-emitting Diodes显示文摘Aggregation-induced emission(AIE)has emerged as a new concept,giving highly efficient solid-state photoluminescence.Particularly,AIE luminogens(AIEgens)with deep blue emission(400–450 nm)have displayed salient advantages for non-doped organic light-emitting diodes(OLEDs).However,deep blue emitters with Commission Internationale de L’Eclairage(CIE)coordinates less than 0.08 are still rare.In this review,we outline the latest achievements in the molecular guidelines based on the AIE core of tetraphenylbenzene(TPB)for developing efficient deep blue AIEgens.We provide insights into the construction of deep blue emitters with high horizontal orientation by regulating the length of the linear molecule.We also discuss the luminescence mechanisms of these AIEgens-based OLEDs by using the magnetic field effects measurements.Finally,a summary of the challenges and perspectives of deep blue AIEgens for non-doped OLEDs is also presented. | HAN Pengbo QIN Anjun | 2021 | Chemical Research in Chinese Universities2021，37，1： | 0 |
| 8 | Highly Emissive Luminogens in Both Solution and Aggregate States显示文摘Organic light-emitting materials have attracted considerable attention because of their promising applications in diverse areas.Most fluorophores emit brightly in either dilute solutions or aggregate states;the former generally suffer from aggregation-caused quenching problem,and the latter encounter intensity loss at low concentrations.Herein,we propose a new strategy to overcome these dilemmas by balancing the planar and distorted structures of terphenyl-based luminogens and obtain three luminogens,2PB-AC,2Me2PB-AC,and 2T2PB-AC,with bright emission in both solution and aggregate states.Among them,2PB-AC shows absolute photoluminescence quantum yields(ФPL)higher than 90%in both tetrahydrofuran solution(90.2%)and aggregate states(92.7%for powder and 95.3%for crystal).Thus,2PB-AC could be an efficient probe to realize dual-channel explosive detection in both solution and aggregate states.Moreover,it could be used to image live-cell lipid droplets at a wide range of concentrations.In addition,benefiting from its thermodynamically favorable intersystem crossing process,2Me2PB-AC could be doped in polymethyl methacrylate matrix to provide efficient room-temperature phosphorescence.Thus,this work provides a feasible strategy for the design of luminogens with highly efficient emission in both solution and aggregate states,greatly facilitating and broadening their practical applications. | Pengbo Han Guiquan Zhang Jia Wang Yejun Yao Yanping Qiu He Xu Anjun Qin Ben Zhong Tang | 2023 | CCS Chemistry2023，5，7： | 0 |
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