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| 1 | Circular RNA F-circEA produced from EML4-ALK fusion gene as a novel liquid biopsy biomarker for non-small cell lung cancer显示文摘 | Shuanqyan Tan Qiheng Gou Wenchen Pu Chenglin Guo Yun Yang Ke Wu Yaxin Liu Lunxu Liu Yu-Quan Wei Yong Peng | 2018 | Cell Research2018，28，6： | 24 |
| 2 | Enrichment of putative human epidermal stem cells based on cell size and collagen type IV adhesiveness显示文摘人的表皮的干细胞(EpSCs ) 的丰富和鉴定具有为基本研究和临床的申请的首要的重要性。尽管为 EpSCs 的丰富的几条途径被建立了,充实可行 EpSCs 的一张纯人口仍然是一项挑战性的任务。一条改进途径值得发展提高 EpSCs 的纯净和生存能力。这里,我们报导那种房间尺寸与骨胶原类型 IV 粘着性结合了能在一条改进途径被使用充实纯、可行的人的 EpSCs。我们分开了很快支持者 keratinocytes 进从 5-7 microm (人口 A )在尺寸 的三张人口到 7-9 microm (人口 B ),到>或在直径的 =9 microm (人口 C ),并且发现人的通常认为的 EpSCs 能进一步与最小的尺寸在人口 A 被充实。在三张人口之中,人口 A 显示了 beta1-integrin 受体的最高的密度,在 G0/G1 阶段包含了房间的最高的百分比,显示出最高的原子核到细胞质比率,并且拥有了最高的殖民地形成效率(CFE ) 。当注入了鼠科的胚囊时,这些房间参予了多织物形成。与根据 beta1-integrin 抗体染色排序通常认为的 EpSCs 的一条以前的途径相比,更显著地, EpSCs 的生存能力由改进途径充实显著地被提高。我们的结果为人的 EpSCs 的丰富提供通常认为的策略,并且在干细胞生物学鼓励进一步的学习进房间尺寸的角色。 | Juxue Li Chenglin Miao Welxiang Guo Liwei Jia Jiaxi Zhou Baohua Ma Sha Peng Shuang Liu Yujing Cao Enkui Duan | 2008 | Cell Research2008，18，3： | 8 |
| 3 | Multiple Dolomitization and Fluid Flow Events in the Precambrian Dengying Formation of Sichuan Basin, Southwestern China显示文摘The Precambrian Dengying Formation is a set of large-scale, extensively dolomitized, carbonate reservoirs occurring within the Sichuan Basin. Petrographic and geochemical studies reveal dolomitization was a direct result of precipitation by chemically distinct fluids occurring at different times and at different intensities. Based on this evidence, dolomitization and multiple fluid flow events are analyzed, and three types of fluid evolution models are proposed. Results of analysis show that Precambrian Dengying Formation carbonates were deposited in a restricted peritidal environment(630–542 Ma). A high temperature and high Mg^(2+) concentration seawater was a direct result of dolomitization for the micrite matrix, and for fibrous aragonite in primary pores. Geochemical evidence shows low δ^(18)O values of micritic dolomite varying from-1.29‰ to-4.52‰ PDB, abundant light rare earth elements(REEs), and low dolomite order degrees. Microbes and meteoric water significantly altered dolomite original chemical signatures, resulting in algal micritic dolomite and the fine-grained, granular, dolosparite dolomite having very negative δ^(18)O values. Finely crystalline cement dolomite(536.3–280 Ma) and coarsely crystalline cement dolomite have a higher crystallization degree and higher order degree. The diagenetic sequence and fluid inclusion evidence imply a linear correlation between their burial depth and homogenization temperatures, which closely resemble the temperature of generated hydrocarbon. Compared with finely crystalline dolomite, precipitation of coarsely crystalline dolomite was more affected by restricted basinal fluids. In addition, there is a trend toward a more negative δ^(18)O value, higher salinity, higher Fe and Mn concentrations, REE-rich. Two periods of hydrothermal fluids are identified, as the exceptionally high temperatures as opposed to the temperatures of burial history, in addition to the presence of high salinity fluid inclusions. The early hydrothermal fluid flow event was characterized by hot magnesium-and silicon-rich fluids, as demonstrated by the recrystallized matrix dolomite that is intimately associated with flint, opal, and microcrystalline quartz in intergranular or intercrystalline pores. This event was likely the result of a seafloor hydrothermal chimney eruption during Episode I of the Tongwan Movement(536.3±5.5 Ma). In contrast, later hydrothermal fluids, which caused precipitation of saddle dolomite, were characterized by high salinity(15–16.05 wt% NaCl equivalent) and homogenization temperatures(250 to 265°C), δ^(18)O values that were more enriched, and REE signatures. Geochemical data and the paragenetic sequence indicate that this hydrothermal fluid was related to extensive Permian large igneous province activity(360–280 Ma). This study demonstrates the presence of complicated dolomitization processes occurring during various paleoclimates, tectonic cycles, and basinal fluids flow; results are a useful reference for these dolomitized Precambrian carbonates reservoirs. | PENG Bo LI Zongxing LI Guorong LIU Chenglin ZHU Shifa ZHANG Wang ZUO Yinhui GUO Yingchun WEI Xiaojie | 2018 | Acta Geologica Sinica(English Edition)2018，92，1： | 5 |
| 4 | Artemisinin ameliorated proteinuria in rats with adriamycin-induced nephropathy through regulating nephrin and podocin expressions显示文摘OBJECTIVE:To investigate the effects of artemisinin against proteinuria and glomerular filtration barrier damage in rats with adriamycin-induced nephropathy,and the potential mechanism underpinned the action.METHODS:Forty adriamycin rats were randomly divided into two groups with the ratio of 1︰3;the small-number group served as control group(n=10),and the rats in the large-number group were treated with adriamycin to induce nephropathy;then they were further randomly assigned into 3subgroups:benazepril group(n=10),artemisiningroup(n=10),and adriamycin group(n=10).The benazepril group and artemisinin group were treated with benazepril suspl(5.0 mg/kg daily)and artemisinin suspl(150 mg/kg daily)respectively after being modeled;those in the control group and adriamycin group were intragastrically administered an equivalent volume of distilled water every day.The treatment after model establishment lasted for a total of 4 weeks.The 24 h uric protein,blood biochemicals,renal pathological changes,renal ultrastrutural changes,Nephrin and Podocin proteins and gene expressions were measured by Coomassie brilliant blue assay,completely automatic biochemical analyzer,light microscope,electron microscopy,Western blot and reverse transcription polymerase chain reaction,respectively.RESULTS:The rats in adriamycin group showed a significant increase in 24 h uric protein excretion,serum total cholesterol(TC),triglyceride(TG),blood urea nitrogen(BUN),serum creatinine(Scr)and decrease in albumin(Alb)(P<0.05 or P<0.01).Compared with adriamycin group,artemisinin could reduce uric protein excretion,decrease the serum TC,TG elevation,increase the serum Alb level,up-regulate the expressions of Nephrin and Podocin(P<0.05 or P<0.01),but no statistical significance effects on the levels of BUN,Scr in artemisinin group(P>0.05).The renal pathological and ultrastrutural observation indicate that artemisinin could attenuate the severity of foot process effacement and fusion in the nephropathic rats.CONCLUSION:Artemisinin might have an effect on the nephropathy in rats caused by adriamycin,which may be at least partly correlated with attenu-ation of the severity of foot process effacement and fusion,up-regulation of the expressions of Nephrin and Podocin in the glomeruli in the rats. | Xili Wu Peng An Bingyu Ye Xingmin Shi Huimin Dang Rongguo Fu Chenglin Qiao | 2014 | Journal of Traditional Chinese Medicine2014，34，1： | 5 |
| 5 | Broadband mid-infrared molecular spectroscopy based on passive coherent optical–optical modulated frequency combs显示文摘Mid-infrared dual-comb spectroscopy is of great interest owing to the strong spectroscopic features of trace gases,biological molecules,and solid matter with higher resolution,accuracy,and acquisition speed. However,the prerequisite of achieving high coherence of optical sources with the use of bulk sophisticated control systems prevents their widespread use in field applications. Here we generate a highly mutually coherent dual midinfrared comb spectrometer based on the optical–optical modulation of a continuous-wave (CW) interband or quantum cascade laser. Mutual coherence was passively achieved without post-data processes or active carrier envelope phase-locking processes. The center wavelength of the generated mid-infrared frequency combs can be flexibly tuned by adjusting the wavelength of the CW seeds. The parallel detection of multiple molecular species,including C_(2)H_(2),CH_(4),H_(2)CO,H_(2)S,COS,and H_(2)O,was achieved. This technique provides a stable and robust dual-comb spectrometer that will find nonlaboratory applications including open-path atmospheric gas sensing,industrial process monitoring,and combustion. | ZHONG ZUO CHENGLIN GU DAOWANG PENG XING ZOU YUANFENG DI LIAN ZHOU DAPING LUO YANG LIU WENXUE LI | 2021 | Photonics Research2021，9，7： | 3 |
| 6 | NUMB maintains bone mass by promoting degradation of PTEN and GLI1 via ubiquitination in osteoblasts显示文摘The adaptor protein NUMB is involved in asymmetric division and cell fate determination and recognized as an antagonist of Notch.Previous studies have proved that Notch activation in osteoblasts contributes to a high bone mass. In this study, however, an osteopenic phenotype was found in 9-week-old mice using osteoblastic specific Col1a1–2.3-Cre to ablate both Numb and its homologue Numbl. The trabecular bone mass decreased dramatically while the cortical bone mass was unaffected. Here, the Notch signal was not activated,while the tensin homologue deleted on human chromosome 10(PTEN), which dephosphorylates phosphatidylinositide 3-kinases, was elevated, attenuating protein kinase B(Akt). The ubiquitination assay revealed that NUMB may physiologically promote PTEN ubiquitination in the presence of neural precursor cell-expressed developmentally downregulated protein 4–1. In addition, the deficiency of Numb/Numbl also activated the Hedgehog pathway through GLI1. This process was found to improve the ratio of the receptor activator of nuclear factor-k B ligand to osteoprotegerin, which enhanced the differentiation of osteoclasts and bone resorption. In conclusion, this study provides an insight into new functons of NUMB and NUMBL on bone homeostasis. | Ling Ye Feng Lou Fanyuan Yu Demao Zhang Chenglin Wang Fanzi Wu Xin Li Yilin Ping Xiao Yang Jing Yang Dian Chen Bo Gao Dingming Huang Peng Liu | 2018 | Bone Research2018，6，4： | 3 |
| 7 | Doppler velocimeter based on dual-comb absorption spectroscopy显示文摘The determination of airflow parameters is essential to the research of critical information on environment monitoring,chemical kinetics,and aerodynamic and propulsion applications.During the past few decades,tunable diode laser absorption spectroscopy has become a common and efficient tool for the flow velocity measurement based on the Doppler shift of the absorption line.Dual-comb absorption spectroscopy(DCAS),as a state-of-theart Fourier-transform broadband spectroscopic technique,not only can detect multiple trace molecules in parallel but also can extract Doppler shifts to derive the flow velocity through the analysis of dozens of molecular absorption lines simultaneously with high precision.Here,we report a proof-of-principle demonstration of the velocity measurements of acetylene at various flow velocities by means of a high-resolution and broadband DCAS.Mode-resolved Doppler-shifted rotational-vibrational lines in the P branch of acetylene molecules are obtained.A model for multiline Doppler frequency determination is investigated and experimentally verified.The flow velocity measurements with a measuring uncertainty down to the submeter per second over the range from 8.7 m/s to 44.8 m/s at an effective time resolution of 1 s and a measuring uncertainty of 1.97 m/s at 0.1 s are demonstrated.With broadband mid-infrared frequency combs covering atmospheric transmission windows,the open-path measurement for monitoring diffusion of the weak pollutant source would be realized. | CHENGLIN GU XING ZOU ZHONG ZUO DAOWANG PENG YUANFENG DI YANG LIU DAPING LUO WENXUE LI | 2020 | Photonics Research2020，8，12： | 2 |
| 8 | Origin of Taiwan Canyon and its effects on deepwater sediment显示文摘The continental slope of the Taiwan Shoal, which has cultivated numerous submarine canyons, is located in a passive continental margin environment. However, the trend of the Taiwan Canyon, with its 45° intersection angle, is obviously different from that of the erosion valley downward along the continental slope. A distinct break is present in the lower segment of the Taiwan Canyon, which then extends from west to east parallel to the continental slope until finally joining the Manila Trench. By utilizing multiple-beam water depth data, high-resolution seismic data, and sediment cores, this study describes the topographic characteristics of the Taiwan Canyon and provides a preliminary discussion on the origin of the Taiwan Canyon and its effect on deepwater sediment. The terrain, landform, and sediment of the Taiwan Canyon exhibit segmentation characteristics. The upper segment is characterized primarily by erosion, downward cutting with a V shape, and wide development of sliding, slumping, and other gravity flow types. The middle segment is characterized mostly by U-shaped erosion-sedimentation transition and development of an inner levee. The lower segment is characterized primarily by sedimentation and development of a sediment wave. The bottom current has a significant reworking effect on the interior sediments of the canyon and forms reworked sands. The formation and evolution of the Taiwan Canyon is closely related to sediment supply, gravity sliding(slumping), faulting activities, and submarine impaling. Given the sufficient terrigenous clastic supply, the sediments along the continental shelf edge continuously proceed seaward; gliding and slumping in the front edge provide driving forces for the formation of the canyon. Faulting activities result in stratum crushing, and the gravity flow takes priority in eroding the relatively fragile stratum. Thus, the direction of the extension of the canyon crosses the surrounding erosion valley obliquely. Seamounts are formed through submarine impaling. Owing to seamount blocking, the lower segment of the canyon is turned toward the east–west direction. Large amounts of sediments overflow at the turning, forming sediment waves. | XU Shang WANG YingMin PENG XueChao ZOU HuaYao QIU Yan GONG ChengLin ZHUO HaiTeng | 2014 | Science China Earth Sciences2014，57，11： | 2 |
| 9 | Discovery of Palaeozoic Karsts in the Qaidam Basin and Their Oil and Gas Prospects显示文摘Objective Complex geological factors have been constraining the oil and gas exploration in the Paleozoic strata of the Qaidam Basin,although there are high-quality hydrocarbon source rocks.One of the most important reasons may be reservoir densification due to the multiple stages of destructive cementation,which has hindered our understanding of the Paleozoic petroleum enrichment rules in the Qaidam basin.In recent years,the | PENG Bo LIU Chenglin LI Zongxing MA Yinsheng CAO Jun WANG Bing ZHANG Xu | 2016 | Acta Geologica Sinica(English Edition)2016，90，5： | 2 |
| 10 | Development of a gaseous and solid-state hybrid system for stationary hydrogen energy storage显示文摘Hydrogen can serve as a carrier to store renewable energy in large scale.However,hydrogen storage still remains a challenge in the current stage.It is difficult to meet the technical requirements applying the conventional storage of compressed gaseous hydrogen in high-pressure tanks or the solid-state storage of hydrogen in suitable materials.In the present work,a gaseous and solid-state(G-S)hybrid hydrogen storage system with a low working pressure below 5 MPa for a 10 kW hydrogen energy storage experiment platform is developed and validated.A Ti-Mn type hydrogen storage alloy with an effective hydrogen capacity of 1.7 wt%was prepared for the G-S hybrid hydrogen storage system.The G-S hybrid hydrogen storage tank has a high volumetric hydrogen storage density of 40.07 kg H_(2)m^(-3) and stores hydrogen under pressure below5 MPa.It can readily release enough hydrogen at a temperature as low as-15C when the FC system is not fully activated and hot water is not available.The energy storage efficiency of this G-S hybrid hydrogen storage system is calculated to be 86.4%-95.9%when it is combined with an FC system.This work provides a method on how to design a G-S hydrogen storage system based on practical demands and demonstrates that the G-S hybrid hydrogen storage is a promising method for stationary hydrogen storage application. | Haizhen Liu Li Xu Yu Han Xin Chen Peng Sheng Shumao Wang Xiantun Huang Xinhua Wang Chenglin Lu Hui Luo Shixuan He Zhiqiang Lan Jin Guo | 2021 | Green Energy & Environment2021，6，4： | 2 |
| 11 | Sedi- ment waves on the South China Sea Slope off southwestern Taiwan Implications {or the intrusion of the Northern Pacific Deep Water into the South China Sea 显示文摘 | Gong Chenglin Wang Yingmin Peng Xuechao | 2012 | Marine and Petro- leum Geology2012，32，： | 1 |
| 12 | Thermal History since the Paleozoic in the Eastern Qaidam Basin,Northwest China显示文摘The Qaidam Basin is the one of the three major petroliferous basins in northeastern Tibetan Plateau, which has experienced multiphase superimposition and transformation. The study of thermal history not only plays an important role on revealing the tectonic origin of the Qaidam Basin and the forming mechanism and uplift history of the Tibetan Plateau,but also can provide scientific evidence for the assessment of oil and gas resources. This work used balanced cross-section technique and apatite fission track ages with modeling of fission track length distribution to infer that the eastern Qaidam Basin has experienced significant tectonic movement in the Early Jurassic movement(~200 Ma), which caused the carboniferous uplift and denudation, the geological movement in the Late Cretaceous, characterized by early stretching and late northeast-southwest extrusion; the Himalayan movement in multi-stage development in eastern Qaidam Basin, which can be divided into the early Himalayan movement(41.1–33.6 Ma) and the late Himalayan movement(9.6–7.1 Ma, 2.9–1.8 Ma), and large-scale orogeny caused pre-existing faults reactivated in late Himalayan movement. On the basis of burial history reconstruction, the thermal history of eastern Qaidam Basin was restored. The result shows that the thermal history in eastern Qaidam Basin shows slow cooling characteristics; the paleo-geothermal gradient of eastern Qaidam Basin was 38–41.5℃/km, with an average value of 39.0℃/km in the Late Paleozoic, 29–35.2℃/km, with an average value of 33.0℃/km in the Early Paleogene; the geothermal gradient of the Qaidam Basin increased in the Late Paleogene, which was similar to the present geothermal gradient in the Late Neogene. The characteristics of the tectono-thermal evolution since Paleozoic in the eastern Qaidam Basin are mainly controlled by magmatic thermal events in the study area. | WANG Li LI Zongxing LIU Chenglin PENG Bo FANGXinxin YUAN Guide | 2019 | Acta Geologica Sinica(English Edition)2019，93，2： | 1 |
| 13 | Advanced numerical simulations of pulsed magnets with a finite element method显示文摘 | Peng Tao Gu Chenglin Rosseel K | 2005 | Meas Sci Technol2005，16，2： | 1 |
| 14 | Sediment waves on the South China Sea Slope off southwestern Taiwan:Implications for the intrusion of the Northern Pacific Deep Water into the South China Sea显示文摘 | Chenglin Gong Yingmin Wang Xuechao Peng | 2012 | Marine and Petroleum Geology2012，32，： | 1 |
| 15 | Sediment waves on the South China Sea Slope off southwestern Taiwan:Implications for the intrusion of the Northern Pacific Deep Water into the South China Sea显示文摘 | Chenglin Gong Yingmin Wang Xuechao Peng | 2012 | Marine and Petroleum Geology2012，32，： | 1 |
| 16 | Fuzzy approxima- tion relations on fuzzy n-cell number space and their applications in classification 显示文摘 | WANG Guixiang SHI Peng WEN Chenglin | 2011 | Information Science2011，181，18： | 1 |
| 17 | Advanced numerical simulations of pulsed magnets with a finite element method 显示文摘 | PENG Tao Gu Chenglin Rosseel K | 2005 | Measurement Science and Technology2005，16，2： | 1 |
| 18 | Advanced numerical simulation of pulsed magnets with a finite element method显示文摘 | Peng Tao Gu Chenglin Vanacken J | 2005 | Meas Sci Technol2005，16，： | 1 |
| 19 | Development of a vector and host system and characterization of replication of plasmid pSQIO in moderately halophilic Nocardiopsis显示文摘Nocardiopsis 的类是抗菌素,化学药品,和酶的新来源。这里,我们报导了向量和主人系统的发展在中等经由一种调停 oriT 的变化形式的 halophilic Nocardiopsis。由屏蔽大约 80 个 Nocardiopsis 种类,他们中的 6 个怀有 8 plasmids (1880 kb ) 。pSQ10 的完全的核苷酸顺序由 18,219 bp 组成了,与 71.9%G + C 内容,编码 17 个开的读物框架,他们中的 5 个 Streptomyces plasmids 类似于那些。一个 rep 地点(在基因以内的 iteron ) 在 Nocardiopsis sp 为复制被识别。YIM 90083,和 rep 蛋白质跳了到它的 iteron 顺序。这个系统可能为基因在 Nocardiopsis 克隆和表示是有用的。 | Ana Zeng Tao. Wang Haiyang Xia Shiyuan Peng Weihua Chen Chenglin Jiang Lihua Xu Li Zhong Meijuan Shen Zhongjun Qin | 2011 | Acta Biochimica et Biophysica Sinica2011，43，9： | 1 |
| 20 | Blind source separation with time series variational Bayes expectation maximization algorithm 显示文摘 | Sun Shijun Peng Chenglin Hou Wensheng | 2012 | Digital Signal Processing2012，22，1： | 1 |
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