4篇
您的检索式：作者名="Wenchen Pu"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Circular RNA F-circEA produced from EML4-ALK fusion gene as a novel liquid biopsy biomarker for non-small cell lung cancer显示文摘 | Shuanqyan Tan Qiheng Gou Wenchen Pu Chenglin Guo Yun Yang Ke Wu Yaxin Liu Lunxu Liu Yu-Quan Wei Yong Peng | 2018 | Cell Research2018，28，6： | 24 |
| 2 | The Role of Exportin-5 in MicroRNA Biogenesis and Cancer显示文摘Micro RNAs(mi RNAs) are conserved small non-coding RNAs that play an important role in the regulation of gene expression and participate in a variety of biological processes. The biogenesis of mi RNAs is tightly controlled at multiple steps, such as transcription of mi RNA genes,processing by Drosha and Dicer, and transportation of precursor mi RNAs(pre-mi RNAs) from the nucleus to the cytoplasm by exportin-5(XPO5). Given the critical role of nuclear export of premi RNAs in mi RNA biogenesis, any alterations of XPO5, resulting from either genetic mutation,epigenetic change, abnormal expression level or posttranslational modification, could affect mi RNA expression and thus have profound effects on tumorigenesis. Importantly, XPO5 phosphorylation by ERK kinase and its cis/trans isomerization by the prolyl isomerase Pin1 impair XPO50 s nucleo-to-cytoplasmic transport ability of pre-mi RNAs, leading to downregulation of mature mi RNAs in hepatocellular carcinoma. In this review, we focus on how XPO5 transports pre-mi RNAs in the cells and summarize the dysregulation of XPO5 in human tumors. | Ke Wu Juan He Wenchen Pu Yong Peng | 2018 | Genomics, Proteomics & Bioinformatics2018，16，2： | 8 |
| 3 | Exosomes rewire the cartilage microenvironment in osteoarthritis:from intercellular communication to therapeutic strategies显示文摘Osteoarthritis(OA)is a prevalent degenerative joint disease characterized by cartilage loss and accounts for a major source of pain and disability worldwide.However,effective strategies for cartilage repair are lacking,and patients with advanced OA usually need joint replacement.Better comprehending OA pathogenesis may lead to transformative therapeutics.Recently studies have reported that exosomes act as a new means of cell-to-cell communication by delivering multiple bioactive molecules to create a particular microenvironment that tunes cartilage behavior.Specifically,exosome cargos,such as noncoding RNAs(ncRNAs)and proteins,play a crucial role in OA progression by regulating the proliferation,apoptosis,autophagy,and inflammatory response of joint cells,rendering them promising candidates for OA monitoring and treatment.This review systematically summarizes the current insight regarding the biogenesis and function of exosomes and their potential as therapeutic tools targeting cell-to-cell communication in OA,suggesting new realms to improve OA management. | Yuangang Wu Jiao Li Yi Zeng Wenchen Pu Xiaoyu Mu Kaibo Sun Yong Peng Bin Shen | 2022 | International Journal of Oral Science2022，14，3： | 4 |
| 4 | Cysteine-113 covalency inspires the development of Pin1 inhibitor显示文摘Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1(Pin1)controls the functional switch of phosphoproteins and plays an oncogenic role in human cancer,but the discovery of effective Pin1 inhibitors remains challenging.A recent study by Pinch et al.developed a novel Pin1 inhibitor by endowing molecule with covalent reactivity toward Pin1 cysteine-113,1 providing new insights into the design of anticancer Pin1 inhibitors. | Wenchen Pu Jiao Li Yong Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员