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| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 3 | Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials显示文摘 | Naveed Sattar David Preiss Heather M Murray Paul Welsh Brendan M Buckley Anton JM de Craen Sreenivasa Rao Kondapally Seshasai John J McMurray Dilys J Freeman J Wouter Jukema Peter W Macfarlane Chris J Packard David J Stott Rudi G Westendorp James Shepherd | 2010 | The Lancet2010，，9716： | 2 |
| 4 | Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials显示文摘 | Naveed Sattar David Preiss Heather M Murray Paul Welsh Brendan M Buckley Anton JM de Craen Sreenivasa Rao Kondapally Seshasai John J McMurray Dilys J Freeman J Wouter Jukema Peter W Macfarlane Chris J Packard David J Stott Rudi G Westendorp James Shepherd | 2010 | The Lancet2010，，9716： | 2 |
| 5 | Granulocyte colony-stimulating factor mobilizes functional endothelial progenitor cells in patients with coronary artery disease 显示文摘 | Powell TM Paul JD Hill JM | 2005 | Arterioscler Thromb Vasc Biol2005，25，2： | 1 |
| 6 | Fatigue and its impact on patients with myasthenia gravis显示文摘 | Paul RH Cohen RA Gilehrist JM | 2000 | Muscle Nerves2000，23，： | 1 |
| 7 | Largely typical patterns of resting-state functional connectivity in high-functioning adults with autism显示文摘 | Yyszka JM Kennedy DP Paul LK | 2014 | Cereb Cortex2014，24，7： | 1 |
| 8 | Cognitive dysfunction in individuals with myasthenia gravis显示文摘 | Paul RH Cohen RA Gilchrist JM | 2000 | J Neurol Sci2000，179，12： | 1 |
| 9 | Ratings of subjective mental fatigue relate to cognitive performance in patients with myasthenia gravis显示文摘 | Paul RH Cohen RA Gilchrist JM | 2002 | J Clin Neurosci2002，9，3： | 1 |
| 10 | Granulocyte colony-stimulating factor mobilizes functional endothelial progenitor cells in patients with coronary artery disease显示文摘 | Powell TM Paul JD Hill JM | 2005 | Arterioscler Thromb Vasc Biol2005，25，2： | 1 |
| 11 | Regulation of intestinal blood flow 显示文摘 | Paul JM Mark AW Neal RG | 2000 | J Surg Res2000，93，1： | 1 |
| 12 | Safety of topical calcineurin inhibitors for the treatment of atopie dermatitis 显示文摘 | Paul JM Jenny JM | 2007 | Pharmacother2007，27，7： | 1 |
| 13 | Treatment of complete obstruction of the nasolacrimal system by temporary placement of nasolacrimal polyurethane stents:preliminary results显示文摘 | Pinto I Vicente JM | 2003 | Clin Radiol2003，58，： | 1 |
| 14 | Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety显示文摘 | Gatt JM Nemeroff CB Dobson-Stone C Paul RH Bryant RA Schofield PR | 2009 | Mol Psychiatry2009，14，7： | 1 |
| 15 | Granulocyte colony - stimulating factor mobilizes functional endothelial progenitor cells in patients with coronary artery disease 显示文摘 | Powell TM Paul JD Hill JM | 2005 | Arterioseler Thromb Vasc Biol2005，25，2： | 1 |
| 16 | Close physical linkage of human troponin genes organization, sequence, and expression of the locus encoding cardiac troponin I and slow skeletal troponin T显示文摘 | Anthony JM Paul JB | 1999 | Genomics1999，57，1： | 1 |
| 17 | Development of novel treatments for hepatitis C显示文摘 | Daniel P Webster Paul Klenerman Jane Collier Katie JM Jeffery | 2009 | The Lancet Infectious Diseases2009，，2： | 1 |
| 18 | Cogniti,te dysfunction in individuals with myasthenia gravis 显示文摘 | Paul RH Cohen RA Gilchrist JM | 2000 | J Neurol Sci2000，179，： | 1 |
| 19 | Risk factors for falls among older a- dults :a review of the literature显示文摘 | Ambrose AF Paul G Hausdorff JM | 2013 | Maturitas2013，75，1： | 1 |
| 20 | Internal fixation of unstable pelvic ring injuries显示文摘 | Matta JM Paul Tornetta | 1996 | Clin Orthop1996，329，8： | 1 |
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