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| 1 | Statistical design and evaluation of a propranolol HCl gastric floating tablet显示文摘The purpose of this research was to apply statistical design for the preparation of a gastric floating tablet(GFT)of propranolol HCl and to investigate the effect of formulation variables on drug release and the buoyancy properties of the delivery system.The contents of polyethylene oxide(PEO)WSR coagulant and sodium bicarbonate were used as independent variables in central composite design of the best formulation.Main effects and interaction terms of the formulation variables were evaluated quantitatively using a mathematical model approach showing that both independent variables have significant effects on floating lag time,%drug release at 1 h(D_(1h))and time required to release 90%of the drug(t_(90)).The desired function was used to optimize the response variables,each with a different target,and the observed responses were in good agreement with the experimental values.FTIR and DSC studies of the statistically optimized formulation revealed there was no chemical interaction between drug and polymer.The statistically optimized formulation released drug according to first order kinetics with a non-Fickian diffusion mechanism.Evaluation of the optimized formulation in vivo in human volunteers showed that the GFT was buoyant in gastric fluid and that its gastric residence time was enhanced in the fed but not the fasted state. | Meka Venkata Srikanth Nali Sreenivasa Rao Songa Ambedkar Sunil Battu Janaki Ram Venkata Ramana Murthy Kolapalli | 2012 | Acta Pharmaceutica Sinica B2012，2，1： | 6 |
| 2 | Life style modification improves insulin resistance and liver histology in patients with non-alcoholic fatty liver disease显示文摘AIM: To study the effect of regular aerobic exercise on insulin resistance, serum aminotransferase and liver histology in nonalcoholic fatty liver disease (NAFLD) patients. METHODS: Sixty (mean age 40.0 ± 8.5 years, 75% male) NAFLD patients were included in the study. After baseline anthropometric measurement i.e., body mass index (BMI), waist circumference (WC); all patients were advised regular aerobic exercise for 30 min/d, for at least 5 d/wk and trained to achieve around 70% of his maximal heart rate. In addition, moderately energy restricted diet was advised to patients with high BMI (> 25 kg/m 2 ). Monthly follow up was done by measuring BMI, WC, aspartate aminotransferase, and alanine aminotransferase (ALT). Insulin resistance was calculated using homeostasis model assessment (HOMA) of insulin resistance (HOMA-IR) model, at baseline and after 6mo. Insulin resistance was arbitrarily considered altered when it was ≥ 2. Liver biopsy was done in a section of patients at baseline and after 6 mo. RESULTS: Seventy percent (42/60) patients were overweight or obese; 95% (57/60) had central obesity (WC > 90 cm in men, > 80 cm in women). In the 45 exercise compliant patients insulin resistance decreased from 6.4 ± 6.1 to 1.3 ± 1.0, BMI from 26.7 ± 3.3 kg/m 2 to 25.0 ± 3.3 kg/m 2 , WC from 95.7 ± 8.9 cm to 90.8 ± 7.3 cm and ALT from 84.8 ± 43.5 U/L to 41.3 ± 18.2 U/L (P < 0.01). In 15 exercise noncompliant patient's insulin resistance, BMI, WC and ALT did not show significant change at 6 mo follow up. Six of 8 patients in compliant group on repeat liver biopsy showed significant change in steatosis and necroinflammation. Nonalcoholic steatohepatitis scores improved form 5.3 ± 1.5 to 3.35 ± 1.5. The decline in insulin resistance correlated with decline in ALT (P = 0.01, r s = 0.90) and liver histology (P = 0.03, r s = 0.73). CONCLUSION: Life style modification improves insulin resistance resulting in improvement in ALT and liver histology in NAFLD patients. | Ganesh Bhat Chalamalasetty Sreenivasa Baba Amaresh Pandey Neeraj Kumari Gourdas Choudhuri | 2012 | World Journal of Hepatology2012，4，7： | 5 |
| 3 | Review on electromagnetic welding of dissimilar materials显示文摘Electromagnetic welding (EMW) is a high-speed joining technique that is used to join similar ordissimilar metals, as well as metals to non-metals. Thistechnique uses electromagnetic force to mainly joinconductive materials. Unlike conventional joining pro-cesses, the weld interface does not melt, thus keeping thematerial properties intact. Extremely high velocity andstrain rate involved in the process facilitate extending theEMW technique for joining several materials. In this paper,the research and progress in electromagnetic welding arereviewed from various perspectives to provide a basis forfurther research. | K. SHANTHALA T. N. SREENIVASA | 2016 | Frontiers of Mechanical Engineering2016，11，4： | 4 |
| 4 | Physical and degradation properties of PLGA scaffolds fabricated by salt fusion technique显示文摘Tissue engineering scaffolds require a controlled pore size and interconnected pore structures to support the host tissue growth. In the present study, three dimensional (3D) hybrid scaffolds of poly lactic acid (PLA) and poly glycolic acid (PGA) were fabricated using solvent casting/particulate leaching. In this case, partially fused NaCl particles were used as porogen (200-300μ) to improve the overall porosity (≥90%) and internal texture of scaffolds. Differential scanning calorimeter (DSC) analysis of these porous scaffolds revealed a gradual reduction in glass transition temperature (Tg) (from 48°C to 42.5°C) with increase in hydrophilic PGA content. The potential applications of these scaffolds as implants were further tested for their biocompatibility and biodegradability in four simulated body fluid (SBF) types in vitro. Whereas, simulated body fluid (SBF) Type1 with the optimal amount of HCO 3 ions was found to be more appropriate and sensible for testing the bioactivity of scaffolds. Among three combinations of polymer scaffolds, sample B with a ratio of 75:25 of PLA: PGA showed greater stability in body fluids (pH 7.2) with an optimum degradation rate (9% to 12% approx). X-ray diffractogram also confirmed a thin layer of hydroxyapatite deposition over sample B with all SBF types in vitro. | Naveen Kumar Mekala Rama Raju Baadhe Sreenivasa Rao Parcha Prameela Devi Yalavarthy | 2013 | The Journal of Biomedical Research2013，27，4： | 3 |
| 5 | Effect of Commiphora mukul gum resin on hepatic marker enzymes,lipid peroxidation and antioxidants status in pancreas and heart of streptozotocin induced diabetic rats显示文摘Objective:To study the antioxidant efficacy of Commiphora mukul(C.mukul) gum resin ethanolic extract in streptozotocin(STZ) induced diabetic rats.Methods:The male Wistar albino rats were randomly divided into four groups of eight animals each:Control group(C),CM-treated control group(C_+CMEE),Diabetic control group(D),CM- treated diabetic group(D_+CMEE).Diabetes was induced by intraperitoneal injection of STZ(55 mg/kg/ bwt).After being confirmed the diabetic rats were treated with C.mukul gum resin ethanolic extract(CMEE) for 60 days.The biochemical estimations like antioxidant,oxidative stress marker enzymes and hepatic marker enzymes of tissues were performed.Results:The diabetic rats showed increased level of enzymatic activities aspartate aminotransaminase(AST),alanine aminotransaminase(ALT) in liver and kidney and oxidative markers like lipid peroxidation(LPO) and protein oxidation(PO) in pancreas and heart. Antioxidant enzyme activities were significantly decreased in the pancreas and heart compared to control group.Administration of CMEE(200 mg/kg bw) to diabetic rats for 60 days significantly reversed the above parameters towards normalcy.Conclusions:In conclusion,our data indicate the preventive role of C.mukul against STZ-induced diabetic oxidative stress;hence this plant could be used as an adjuvant therapy for the prevention and/or management of diabetes and aggravated antioxidant status. | Ramesh B Karuna R Sreenivasa Reddy S Haritha K Sai Mangala D Sasi Bhusana Rao B Saralakumari D | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，11： | 3 |
| 6 | Primary and overall success rates for clinical outcomes after laparoscopic, endoscopic, and open pancreatic cystgastrostomy for pancreatic pseudocysts显示文摘 | Lora Melman Riad Azar Kathleen Beddow L. Michael Brunt Valerie J. Halpin J. Christopher Eagon Margaret M. Frisella Steven Edmundowicz Sreenivasa Jonnalagadda Brent D. Matthews | 2009 | Surgical Endoscopy2009，，2： | 3 |
| 7 | The cellular and molecular basis of hyperthermia显示文摘 | Bert Hildebrandt Peter Wust Olaf Ahlers Annette Dieing Geetha Sreenivasa Thoralf Kerner Roland Felix Hanno Riess | 2002 | Critical Reviews in Oncology and Hematology2002，，： | 3 |
| 8 | Hyperthermia in combined treatment of cancer显示文摘 | P Wust B Hildebrandt G Sreenivasa B Rau J Gellermann H Riess R Felix PM Schlag | 2002 | Lancet Oncology2002，，8： | 2 |
| 9 | Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials显示文摘 | Naveed Sattar David Preiss Heather M Murray Paul Welsh Brendan M Buckley Anton JM de Craen Sreenivasa Rao Kondapally Seshasai John J McMurray Dilys J Freeman J Wouter Jukema Peter W Macfarlane Chris J Packard David J Stott Rudi G Westendorp James Shepherd | 2010 | The Lancet2010，，9716： | 2 |
| 10 | Incidence of Sedation-Related Complications With Propofol Use During Advanced Endoscopic Procedures显示文摘 | Gregory A. Coté Robert M. Hovis Michael A. Ansstas Lawrence Waldbaum Riad R. Azar Dayna S. Early Steven A. Edmundowicz Daniel K. Mullady Sreenivasa S. Jonnalagadda | 2010 | Clinical Gastroenterology and Hepatology2010，，2： | 2 |
| 11 | ASGE Bariatric Endoscopy Task Force systematic review and meta-analysis assessing the ASGE PIVI thresholds for adopting endoscopic bariatric therapies显示文摘 | Barham K. Abu Dayyeh Nitin Kumar Steven A. Edmundowicz Sreenivasa Jonnalagadda Michael Larsen Shelby Sullivan Christopher C. Thompson Subhas Banerjee | 2015 | Gastrointestinal Endoscopy2015，，3： | 2 |
| 12 | Endoscopic bariatric therapies显示文摘 | Barham K. Abu Dayyeh Steven A. Edmundowicz Sreenivasa Jonnalagadda Nitin Kumar Michael Larsen Shelby Sullivan Christopher C. Thompson Subhas Banerjee | 2015 | Gastrointestinal Endoscopy2015，，5： | 2 |
| 13 | Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials显示文摘 | Naveed Sattar David Preiss Heather M Murray Paul Welsh Brendan M Buckley Anton JM de Craen Sreenivasa Rao Kondapally Seshasai John J McMurray Dilys J Freeman J Wouter Jukema Peter W Macfarlane Chris J Packard David J Stott Rudi G Westendorp James Shepherd | 2010 | The Lancet2010，，9716： | 2 |
| 14 | Hyperthermiain combined treatment of cancer显示文摘 | Wust P Hildebrandt B Sreenivasa G | 2002 | Lancet Oncol2002，3，8： | 1 |
| 15 | Hyperthermia in com- bined treatment of cancer显示文摘 | Wust P Hildebrandt B Sreenivasa G | 2002 | Lancet Oncol2002，3，8： | 1 |
| 16 | The M and Ngenes-based simplex and multiplex PCRs are better than the F or H gene-based simplex PCR for Pestedes-petits-ruminantsvirus显示文摘 | George A Dhar P Sreenivasa B P | 2005 | Actavirologica2005，50，4： | 1 |
| 17 | Clinical use of the hyperthermia treatment planning system HyperPlan to predict effectiveness and toxicity 显示文摘 | Sreenivasa G Gellermann J Rau B | 2003 | Int J Radiat Oncol Biol Phys2003，55，2： | 1 |
| 18 | Recent epidemiology of peste des petits ruminants virus (PPRV)显示文摘 | Dhar P Sreenivasa B P Barrett T | 2002 | Vet Microbiol2002，88，2： | 1 |
| 19 | Recent epidemiology of peste des petits ruminants virus (PPRV)显示文摘 | Dhar P Sreenivasa B P Barrett T | 2002 | Vet Microbiol2002，88，2： | 1 |
| 20 | Porous thiiranyl polymers:Newer supports for immobilization of penicillin G acylase 显示文摘 | SKARIA S SREENIVASA E R PONRATHNAM S | 1997 | J Eur Polym1997，33，9： | 1 |
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