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| 1 | Role of CARD15,DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases显示文摘AIM: To investigate the contribution of variants of CARD15, OCTN1/2 and DLG5 genes in disease predispo- sition and phenotypes in a large Italian cohort of pediatric patients with inflammatory bowel diseases (IBD). METHODS: Two hundred patients with Crohn’s disease (CD), 186 ulcerative colitis (UC) patients, 434 par- ents (217 trios), and 347 healthy controls (HC) were studied. Polymorphisms of the three major variants of CARD15, 1672C/T and -207G/C SNPs for OCTN genes, IGR2096a_1 and IGR2198a_1 SNPs for the IBD5 locus, and 113G/A variant of the DLG5 gene were evaluated. Potential correlations with clinical sub-phenotypes were investigated. RESULTS: Polymorphisms of CARD15 were significantly associated with CD, and at least one variant was found in 38% of patients (15% in HC, OR = 2.7, P < 0.001). Homozygosis for both OCTN1/2 variants was more com- mon in CD patients (1672TT 24%, -207CC 29%) than in HC (16% and 21%, respectively; P = 0.03), with an in- creased frequency of the TC haplotype (44.8% vs 38.3% in HC, P = 0.04). No association with the DLG5 variant was found. CD carriers of OCTN1/2 and DLG5 variants more frequently had penetrating disease (P = 0.04 and P = 0.01), while carriers of CARD15 more frequently had ileal localization (P = 0.03). No gene-gene interaction was found. In UC patients, the TC haplotype was morefrequent (45.4%, P = 0.03), but no genotype/phenotype correlation was observed. CONCLUSION: Polymorphisms of CARD15 and OCTN genes, but not DLG5 are associated with pediatric on- set of CD. Polymorphisms of CARD15, OCTN, and DLG5 genes exert a weak influence on CD phenotype. | S Cucchiara A Latiano O Palmieri AM Staiano R D'Incà G Guariso G Vieni V Rutigliano O Borrelli MR Valvano V Annese | 2007 | World Journal of Gastroenterology2007，13，8： | 9 |
| 2 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 3 | Peliosis hepatis: Personal experience and literature review显示文摘Peliosis hepatis(PH) is a disease characterized by multiple and small,blood-filled cysts within the parenchymatous organs. PH is a very rare disease,more common in adults,and when it affects the liver,it comes to the surgeon's attention only in an extremely urgent situation after the lesion's rupture with the resulting hemoperitoneum. This report describes the case of a 29-year-old woman affected by recurring abdominal pain. Computed tomography scans showed a hepatic lesion formed by multiple hypodense areas,which showed an early acquisition of the contrast during the arterial phase. Furthermore,it remained isodense with the remaining parenchyma during the late venous phase. We decided on performing a liver resection of segment Ⅶ while avoiding a biopsy for safety reasons. The histopathologic examination confirmed the diagnosis of focal PH. PH should always be considered in the differential diagnosis of hepatic lesions. Clinicians should discuss the possible causes and issues related to the differential diagnosis in addition to the appropriate therapeutic approach. The fortuitous finding of a lesion,potentially compatible with PH,requires elective surgery with diagnostic and therapeutic intents. The main aim is to prevent the risk of a sudden bleeding that,in absence of properly equipped structures,may have a fatal outcome. | Daniele Crocetti Andrea Palmieri Giuseppe Pedullà Vittorio Pasta Valerio D'Orazi Gian Luca Grazi | 2015 | World Journal of Gastroenterology2015，21，46： | 7 |
| 4 | Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult-and pediatric-onset inflammatory bowel disease in Italy显示文摘AIM: To investigate gene variants in a large Italian inflammatory bowel disease (IBD) cohort, and to analyze the correlation of sub-phenotypes (including age at diagnosis) and epistatic interaction with other IBD genes. METHODS: Total of 763 patients with Crohn's disease (CD, 189 diagnosed at age < 19 years), 843 with ulcerative colitis (UC, 179 diagnosed <19 years), 749 healthy controls, and 546 healthy parents (273 trios) were included in the study. The rs2241880 [autophagy-related 16-like 1 (ATG16L1)], rs11209026 and rs7517847 [interleukin 23 receptor (IL23R)], rs2066844, rs2066845, rs2066847 (CARD15), rs1050152 (OCTN1), and rs2631367 (OCTN2) gene variants were genotyped. RESULTS: The frequency of G allele of ATG16L1 SNP (Ala197Thr) was increased in patients with CD compared with controls (59% vs 54% respectively) (OR = 1.25, CI = 1.08-1.45, P = 0.003), but not in UC (55%). The frequency of A and G (minor) alleles of Arg381Gln, rs11209026 and rs7517847 variants of IL23R were reduced significantly in CD (4%, OR = 0.62, CI = 0.45-0.87, P = 0.005; 28%, OR = 0.64, CI = 0.55-0.75, P < 0.01), compared with controls (6% and 38%, respectively). The A allele (but not G) was also reduced signifi cantly in UC (4%, OR = 0.69, CI = 0.5-0.94, P = 0.019). No association was demonstrated with sub-phenotypes and interaction with CARD15 , and OCTN1/2 genes, although both gene variants were associated with pediatric-onset disease. CONCLUSION: The present study confirms the association of IL23R polymorphisms with IBD, and ATG16L1 with CD, in both adult- and pediatric-onset subsets in our study population. | Anna Latiano Orazio Palmieri Maria Rosa Valvano Renata D'Incà Salvatore Cucchiara Gabriele Riegler Anna Maria Staiano Sandro Ardizzone Salvatore Accomando Gian Luigi de Angelis Giuseppe Corritore Fabrizio Bossa Vito Annese | 2008 | World Journal of Gastroenterology2008，14，29： | 3 |
| 5 | Molecular characterization of pig muscle phosphoglucose isomerase 显示文摘 | Gww D M Hathaway G M Palmieri R H | 1980 | J Mol Biol1980，142，1： | 1 |
| 6 | Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer显示文摘 | Piovan C Palmieri D Di Leva G | 2012 | Mole Oncol2012，6，4： | 1 |
| 7 | Megestrolacetate elevation of Nm23-H1 metastasis suppressor expression in hormone receptor-negative colorectal cancer显示文摘 | Palmieri D Halverson DO Ouatas T | 2005 | J Natl Cancer Inst2005，97，9： | 1 |
| 8 | Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis显示文摘 | Palmieri D Fitzgerald D Shreeve SM | 2009 | Mol Cancer Res2009，7，9： | 1 |
| 9 | Identification of the yeast ACR1 gene product as a succinate-fumarate transporter essential for growth on ethanol or acetate显示文摘 | PALMIERI L LASORSA F M PALMA A D | 1997 | FEBS Lett1997，417，： | 1 |
| 10 | Identification and quantification of flavonol glycosides in cultivated blueberry coltivars显示文摘 | VRHOVSEK U MASUERO D PALMIERI L | 2012 | Journal of Food Composition and Analysis2012，25，1： | 1 |
| 11 | Effect of type 2 diabetes mellitus on left ventricular geometry and systolic function in hypertensive subjects 显示文摘 | Palmieri V Bella J N Arnett D K | 2001 | Circulation2001，103，1： | 1 |
| 12 | Lapatinib prevents the metastatic colonization of EGFR and Her-2 breast cancer cells in the brain 显示文摘 | Palmieri D Gril BM Herring J | 2007 | Breast Cancer Res Treat2007，106，301： | 1 |
| 13 | Basic and translational advances in cancermetastasis: Nm23 显示文摘 | Ouatas T SalemoM Palmieri D | 2003 | J Bioenerg Biomembr2003，35，1： | 1 |
| 14 | Whipple Shied Ballistic at Impact Velocity Higher than 7km/s显示文摘 | Palmieri D Faraud M Destefanis R | 2001 | Int J Impact Eng2001，26，： | 1 |
| 15 | Modification of electrical properties and performance of EVA and PP insulation through nanostructure by organophilic silicates显示文摘 | Montanari G C Fabiani D Palmieri F | | 0，，05： | 1 |
| 16 | Metabolic fate ofpartially depolimerized chondroitin sulfate administered to the rat显示文摘 | CONTE A PALMIERI L SEGNINI D | 1991 | Drugs Exp Clin Res1991，17，1： | 1 |
| 17 | Reactive glia are recruited by highly proliferative brain metastases of breast cancer andpromote tumor cell colonization显示文摘 | Fitzgerald DP Palmieri D Hua E | 2008 | Clin Exp Metastasis2008，25，7： | 1 |
| 18 | Numerical Simulation of Non-Perforation Impacts on Shielded Gas-Filled Pressure Vessels显示文摘 | Palmieri D Schafer F Hiermaier S | 2001 | Int J Impact Eng2001，26，： | 1 |
| 19 | Age-related expression of PEDF/EPC-1 in human endometrial stromal fibroblasts∶ implications for interactive senescence显示文摘 | Watson JM Rinehart CA | 1999 | Exp Cell Res1999，247，1： | 1 |
| 20 | Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro显示文摘 | Tassone P Tagliaferri P Viscomi C Palmieri C Caraglia M D' Alessandro A | 2003 | Br J Cancer2003，88，： | 1 |
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