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| 1 | Multidrug resistance 1 gene in inflammatory bowel disease: A meta-analysis显示文摘MDR1 基因是为煽动性的肠疾病(IBD ) 并且也许的致病的吸引人的候选人基因对治疗的反应,与在功能、基因的层次的证据。它的产品, P-glycoprotein (P-gp ) 作为因此影响许多药的布置和反应的 transmembrane 流出泵工作,一些(即 glucocorticoids ) 对 IBD 中央治疗。另外, P-gp 高度在许多上皮的表面被表示,包括的胃肠道(官方补给) 与在减少的一个通常认为的角色吸收内长或外毒素,并且也许主人细菌相互作用。MDR1 基因的许多基因变化被描述了,在为不同 P-gp 表示的一些例子证据,也,药新陈代谢被提供了。然而,数据经常由于采用的基因异质和不同方法论正在冲突。也许,在官方补给的道的 P-gp 的生理的重要性的证据的最大的片来自对老鼠建模的 mdr1 大美人的描述,它在特定的没有病原体的环境开发自发的大肠炎。学习调查到 IBD 的基因多型性和倾向也显示出冲突结果的 MDR1,由于在复杂疾病的已知的困难,特别当建议基因贡献是弱的时。在这研究,我们承担了在 IBD 与二 SNP 多型性(C3435T 和 G2677T/A ) 获得的可得到的调查结果的元分析;3435T 等位基因和 3435TT 遗传型的一个重要协会与 UC 被发现了(或 = 1.17, P = 0.003 并且或 = 1.36, P = 0.017,分别地) 。在对比,有 CD 和 G2677T/A 多型性的协会都不能被表明。 | V Annese MR Valvano O Palmieri A Latiano F Bossa A Andriulli | 2006 | World Journal of Gastroenterology2006，12，23： | 14 |
| 2 | Role of CARD15,DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases显示文摘AIM: To investigate the contribution of variants of CARD15, OCTN1/2 and DLG5 genes in disease predispo- sition and phenotypes in a large Italian cohort of pediatric patients with inflammatory bowel diseases (IBD). METHODS: Two hundred patients with Crohn’s disease (CD), 186 ulcerative colitis (UC) patients, 434 par- ents (217 trios), and 347 healthy controls (HC) were studied. Polymorphisms of the three major variants of CARD15, 1672C/T and -207G/C SNPs for OCTN genes, IGR2096a_1 and IGR2198a_1 SNPs for the IBD5 locus, and 113G/A variant of the DLG5 gene were evaluated. Potential correlations with clinical sub-phenotypes were investigated. RESULTS: Polymorphisms of CARD15 were significantly associated with CD, and at least one variant was found in 38% of patients (15% in HC, OR = 2.7, P < 0.001). Homozygosis for both OCTN1/2 variants was more com- mon in CD patients (1672TT 24%, -207CC 29%) than in HC (16% and 21%, respectively; P = 0.03), with an in- creased frequency of the TC haplotype (44.8% vs 38.3% in HC, P = 0.04). No association with the DLG5 variant was found. CD carriers of OCTN1/2 and DLG5 variants more frequently had penetrating disease (P = 0.04 and P = 0.01), while carriers of CARD15 more frequently had ileal localization (P = 0.03). No gene-gene interaction was found. In UC patients, the TC haplotype was morefrequent (45.4%, P = 0.03), but no genotype/phenotype correlation was observed. CONCLUSION: Polymorphisms of CARD15 and OCTN genes, but not DLG5 are associated with pediatric on- set of CD. Polymorphisms of CARD15, OCTN, and DLG5 genes exert a weak influence on CD phenotype. | S Cucchiara A Latiano O Palmieri AM Staiano R D'Incà G Guariso G Vieni V Rutigliano O Borrelli MR Valvano V Annese | 2007 | World Journal of Gastroenterology2007，13，8： | 9 |
| 3 | Long-term outcome afterantiviral therapy of patients with hepatitis C virusinfection and de-compensated cirrhosis显示文摘 | Iacobellis A Perri F Valvano MR | 2011 | Clin Gastroenterol Hepatol2011，9，： | 1 |
| 4 | Long-term outcome after antiviral therapy of patients with hepatitis C virus infection and decornpensated cirrhosis显示文摘 | Iacobellis A Perri F Valvano MR | 2011 | Clin Gastroenterol Hepatol2011，9，3： | 1 |
| 5 | The association of MYO9B gene in Italian patients with inflammatory bowel diseases显示文摘 | Latiano A Palmieri O Valvano MR | 2008 | Aliment Pharmacol Ther2008，27，3： | 1 |
| 6 | Clock gene expression levels and relationship with clinical and pathological features in colorectal cancer patients 显示文摘 | Mazzoccoli G Panza A Valvano MR | 2011 | Chronobiol Int2011，28，10： | 1 |
| 7 | Long-tel~ outcomeafter antiviral therapy of patients with hepatitis C virus infection and decompensated cirrhosis显示文摘 | Iacobellis A Perri F Valvano MR | 2011 | Clini Gastroenterol Hepatol2011，9，3： | 1 |
| 8 | Clock gene expression levels and relationship with clinical and pathological features in color- ectal cancer patients显示文摘 | Mazzoccoli G Panza A Valvano MR | 2011 | Chronobiol Int2011，28，10： | 1 |
| 9 | The association of MYOgB gene in Italian patients with inflammatory bowel diseases 显示文摘 | Latiano A Palmieri O Valvano MR | 2008 | Aliment Pharmacol Ther2008，27，3： | 1 |
| 10 | Clock gene expression levels and relationship with clinical and pathological features in color- ectal cancer patients显示文摘 | Mazzoccoli G Panza A Valvano MR | 2011 | Chronobiol Int2011，28，10： | 1 |
| 11 | Erythroeytes-mediated delivery of dexarnethasone 21-phosphate in steroid-dependent ulcerative colitis: a randomized, double-blind Sham-controlled study 显示文摘 | Bossa F Annese V Valvano MR | 2013 | Inflamm Bowel Dis2013，19，9： | 1 |
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