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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, protects pancreas against acute cerulein-induced pancreatitis显示文摘ABM: To determine the effect of pioglitazone, a specific peroxisome proliferator-activated receptor-γ(PPARγ) ligand, on the development of acute pancreatitis (AP) and on the expression of heat shock protein 70 (HSP70) in the pancreas. METHODS: AP was induced in rats by subcutaneous infusion of cerulein for 5 h. Pancreatic blood flow was measured by laser Doppler flowmetry. Plasma lipase activity, interleukin-1β (IL-1β) and IL-10 were determined, Pancreatic weight and histology were evaluated and pancreatic DNA synthesis and blood flow as well as pancreatic mRNA for IL-1β and HSP70 were assessed in rats treated with pioglitazone alone or in combination with cerulein. RESULTS: Pioglitazone administered (10-100 mg/kg i.g.) 30 min before cerulein, attenuated dose-dependently the pancreatic tissue damage in cerulein-induced pancreatitis (CIP) as demonstrated by the improvement of pancreatic histology, reduction in plasma lipase activity, plasma concentration of pro-inflammatory IL-1β and its gene expression in the pancreas and attenuation of the pancreatitis-evoked fall in pancreatic blood flow. CIP increased pancreatic HSP70 mRNA and protein expression in the pancreas and this effect was enhanced by pioglitazone treatment. CONCLUSION: Pioglitazone attenuates CIP and the beneficial effect of this pioglitazone is multifactorial probably due to its anti-inflammatory activities, to the suppression of IL-1β and to the over-expression of HSP70. PPARγ ligands could represent a new therapeutic option in the treatment of AP. | Peter C Konturek Artur Dembinski Zygmunt Warzecha Grzegorz Burnat Piotr Ceranowicz Eckhart G Hahn Marcin Dembinski Romana Tomaszewska Stanislaw J Konturek | 2005 | World Journal of Gastroenterology2005，11，40： | 7 |
| 3 | Requirement for cyclin D3 in germinal center formation and function显示文摘第二等的淋巴的纸巾的幼芽的中心(GC ) 对装高亲密关系的体液的有免疫力的回答批评。当多样化他们的抗体基因时,在 GC 以内的 B 房间经历快速的同种细胞的扩大和选择。尽管 GC B 房间采用一个唯一的 proliferative 程序提供这些进程,这通常被相信,很少联系 GC 的房间周期怎么被安排被知道。D 类型 cyclins 组成使房间能对生理的变化作出回应的房间周期引擎的一个重要部件。房间类型 -- 并且 D 类型 cyclins 的发展阶段特定的角色被描述了,但是 cyclin D 要求没在 GC 反应期间被探讨。在这研究,我们报导 cyclin D3 为切换的增长和 Ig 班大部分是非必需的在 vitro 激活的 B 房间。相反,在 Ccnd3 的 GC 开发 ?/ ?老鼠显著地被损害,作为是 T 房间依赖者抗体反应。在 GC 以内,尽管切换, unswitched B 房间被 cyclin D3 inactivation 影响, IgM?水池更严重地被减少。有趣地尽管有 cyclin D2 表示的补偿增加, Ccnd3 的一个重要数字 ?/ ?GC B 房间处于静止 G0 状态积累。最后,尽管 cyclin D3 inactivation 没在 GC B 房间破坏 BCL6 表示,支持 BCL6 overexpression 的效果完全堵住了 GC,建议 cyclin D3 调整 GC 形成的 BCL6 下游地行动。这是 cyclin D3 玩的第一示范在 B 房间开发的 GC 阶段的一个重要、唯一的角色。 | Jonathan U Peled J Jessica Yu Jeganathan Venkatesh Enguang Bi B Belinda Ding Melissa Krupski-Downs Rita Shaknovich Piotr Sicinski Betty Diamond Matthew D Scharff B Hilda Ye | 2010 | Cell Research2010，20，6： | 3 |
| 4 | Ischemic preconditioning inhibits development of edematous cerulein-induced pancreatitis: Involvement of cyclooxygenases and heat shock protein 70显示文摘AIM: To determine whether ischemic preconditioning (IP)affects the development of edematous cerulein-induced pancreatitis and to assess the role of cyclooxygenase-1 (COX-1), COX-2, and heat shock protein 70 (HSP 70) in this process.METHODS: In male Wistar rats, IP was performed by damping of celiac artery (twice for 5 min at 5-min intervals).Thirty minutes after IP or sham operation, acute pancreatitis was induced by cerulein. Activity of COX-1 or COX-2 was inhibited by resveratrol or rofecoxib, respectively (10 mg/kg).RESULTS: IP significantly reduced pancreatic damage in cerulein-induced pancreatitis as demonstrated by the improvement of pancreas histology, reduction in serum lipase and poly-C ribonuclease activity, and serum concentration of pro-inflammatory interleukin (IL)-1β.Also, IP attenuated the pancreatitis-evoked fall in pancreatic blood flow and pancreatic DNA synthesis.Serum level of anti-inflammatory IL-10 was not affected by IP. Cerulein-induced pancreatitis and IP increased the content of HSP 70 in the pancreas. Maximal increase in HSP 70 was observed when IP was combined with cerulein-induced pancreatitis. Inhibition of COXs, especially COX-2, reduced the protective effect of IP in edematous pancreatitis.CONCLUSION: Our results indicate that IP reduces pancreatic damage in cerulein-induced pancreatitis and this effect, at least in part, depends on the activity of COXs and pancreatic production of HSP 70. | Zygmunt Warzecha Artur Dembinski Piotr Ceranowicz Stanislaw J Konturek Marcin Dembinski Wieslaw W Pawlik Romana Tomaszewska Jerzy Stachura Beata Kusnierz-Cabala Jerzy W Naskalski Peter C Konturek | 2005 | World Journal of Gastroenterology2005，11，38： | 2 |
| 5 | Minimum spanning tree based one-class classifier显示文摘 | Piotr J Tax D M J Elzbieta P | 2009 | Neurocomputing2009，72，79： | 1 |
| 6 | The benefits & potentialhealth hazards posed by the prebiotic inulin-a review显示文摘 | Piotr H Barbara J L Iwona W | 2010 | Polish Journal of Food and Nutrition Sciences2010，60，3： | 1 |
| 7 | Discharge of rapeseeds from a model silo: Physical testing and discrete element method simulations显示文摘 | Piotr Parafiniuk Marek Molenda Józef Horabik | 2013 | Computers and Electronics in Agriculture2013，，： | 1 |
| 8 | Transcervical embryo tranfer as a risk for ectopic pregnancy 显示文摘 | Piotr L Stephen R Robinsin J | 1999 | Fertil Steril1999，72，2： | 1 |
| 9 | A method for dead reckoning parameter correction in pedestrian navigation system显示文摘 | ROMMANEE J PIOTR P VANJA G | 2003 | IEEE Transactions on Instrumentation and Measurement2003，52，1： | 1 |
| 10 | Flexible multiagent decision - making under time pressure, IEEE Transactions on Systems显示文摘 | NOH Sanguk GMYTRASIEWICZ Piotr J | 2005 | Man Cybernetics - Part A: Systems and Humans2005，35，5： | 1 |
| 11 | A thermodynamic analysis of refrigerants: Performance limits of the vapor compression cycle显示文摘 | Piotr A Domanskia J Steven Brown | 2014 | International Journal of Refrigeration2014，38，： | 1 |
| 12 | The effects of aseorbate on root regeneration in seedling cuttings of tomato显示文摘 | JAROSLAW T PIOTR J ANDRZEJ T | 2006 | Plant Grozz th Regulation2006，48，2： | 1 |
| 13 | Multi Residue Confirmatory Method for the Determination of Twelve Coccidiostats in Chicken Liver using Liquid Chromatography Tandem Mass Spectrometry 显示文摘 | Magorzata O Teresa S Piotr J | 2009 | Journal of Chromatography A2009，1216，： | 1 |
| 14 | Formationof Droplets and Bubbles in a Microfluidic T-Junction-Scaling and Mechanism of Break-up显示文摘 | Piotr G Michael J F Howard A S | 2006 | Lab on a Chip2006，6，： | 1 |
| 15 | Low-Carbon,Mn-Si Cast Steel Structure Modification by Fluidized Bed Heat Treatment显示文摘The effect of fluidized bed heat treatment (FBHT) on low-carbon Mn-Si cast steel strength properties improvement,strictly ductility is shown in this paper.Fluidized bed heat treatment variants are chosen in order to eliminate the structure defaults after a crystallization process.FBHT parameters are set considering an initial state material chemical composition,structure morphology and application criterion after heat treatment.The results are verified according with the standard BS 3100:1991 recommendations.Fluidized bed heat treatment variants are chosen mainly in order to the Widmanst tten ferrite structures elimination,carbides morphology modification and matrix optimum performance properties achievement.The ZG35SiMn (EN:L30GS) FBHT processes results are verified by the metallographic researches,hardness/microhardness measurements and tensile strength examination. | Jasiński Józef Podsiad Piotr Jasiński Jaroslaw Bul Arnold Kaczmarczyk Andrzej | 2011 | Journal of Iron and Steel Research(International)2011，18，S1： | 1 |
| 16 | Near infrared and acoustic chemometrics monitoring of volatile fatty acids and dry matter during codigestion of manure and maize silage 显示文摘 | Carina J Lomborg Jens Bo Holm- Nielsen Piotr Oleskowicz -Popiel | 2009 | Binresource Technology2009，100，5： | 1 |
| 17 | A thermodynamic analysis of refrig- erants: Performance limits of the vapor compression cycle 显示文摘 | Piotr A D Steven J B | 2014 | International Journal of Refrigeration2014，，38： | 1 |
| 18 | Fluorine content of two submerged plant species in four warta river oxbow lake reservoirs near Poznan, Poland显示文摘 | Piotr P Maria J M Hanna G | 2006 | Fluoride2006，39，4： | 1 |
| 19 | Integrating geographical information systems and multi ple criteria decision-making methods显示文摘 | PIOTR J | 1995 | International Journal of Geographical Information Science1995，9，3： | 1 |
| 20 | Comparison of spectral irradiance standards used to calibrate shortwave radiometers and spectral radiometers 显示文摘 | PIOTR W K JOSEPH J M JERRY L B | 1999 | Applied Optics1999，38，12： | 1 |
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