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| 1 | Recombinant streptokinase vs hydrocortisone suppositories in acute hemorrhoids:A randomized controlled trial显示文摘AIM: To compare the efficacy and safety of recombinant streptokinase(rSK) vs hydrocortisone acetate-based suppositories in acute hemorrhoidal disease.METHODS: A multicenter(11 sites), randomized(1:1:1), open, controlled trial with parallel groups was performed. All participating patients gave their written,informed consent. After inclusion, patients with acute symptoms of hemorrhoids were centrally randomized to receive, as outpatients, by the rectal route, suppositories of rSK 200000 IU of one unit every 8 h(first 3 units)and afterwards every 12 h until 8 administrations were completed(schedule A), one unit every 8 h until 6 units were completed(schedule B), or 25 mg hydrocortisone acetate once every 8 h up to a maximum of 24 administrations. Evaluations were performed at 3, 5,and 10 d post-inclusion. The main end-point was the 5thday response(disappearance of pain and bleeding, and≥ 70% reduction of the lesion size). Time to response and need for thrombectomy were secondary efficacy variables. Adverse events were also evaluated.RESULTS: Groups were homogeneous with regards to demographic and baseline characteristics. Fifth day complete response rates were 156/170(91.8%; 95%CI:87.3-96.2), 155/170(91.2%; 95%CI: 86.6%-95.7%),and 46/170(27.1%; 95%CI: 20.1%-34.0%) with rSK(schedule A and B) and hydrocortisone acetate suppositories, respectively. These 64.6% and 63.9%differences(95%CI: 56.7%-72.2% and 55.7%-72.0%)were highly significant(P < 0.001). This advantage was detected since the early 3rd day evaluation(68.8% and64.1% vs 7.1% for the rSK and active control groups,respectively; P < 0.001) and was maintained even at the late 10 th day assessment(97.1% and 93.5% vs67.1% for rSK and hydrocortisone acetate, respectively;P < 0.001). Time to response was 3 d(95%CI: 2.9-3.1)for both rSK groups and 10 d(95%CI: 9.3-10.7) in the hydrocortisone acetate group. This difference was highly significant(P < 0.001). All subgroup stratified analyses(with or without thrombosis and hemorrhoid classification) showed a statistically significant advantage for the rSK groups. Thrombectomy was necessary in4/251 and 14/133 patients with baseline thrombosis in the rSK and hydrocortisone acetate groups, respectively(P < 0.001). There were no adverse events attributable to the experimental treatment.CONCLUSION: rSK suppositories showed a significant advantage over a widely-used over-the-counter hydrocortisone acetate preparation for the treatment of acute hemorrhoidal illness, as well as having an adequate safety profile. | Francisco Hernández-Bernal Georgina Castellanos-Sierra Carmen M Valenzuela-Silva Karem M Catasús-Alvarez Osmany Martínez-Serrano Odalys C Lazo-Diago Cimara H Bermúdez-Badell José R Causa-García Juan E Domínguez-Suárez Pedro A López-Saura 无 | 2015 | World Journal of Gastroenterology2015，21，23： | 2 |
| 2 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 3 | INSPM: An interactive evolutionary multi-objective algorithm with preference model显示文摘 | Pedro L R Takahashi R H | 2014 | Information Sciences2014，268，1： | 1 |
| 4 | Endoglin modulates cellular responses to TGF-β1显示文摘 | Pedro L Ainhoa L Zhang H W | 1996 | Cell Biol1996，133，： | 1 |
| 5 | Influence of calcium nitrite inhibitor and crack width on corrosion of steel in high performance concrete subjected to a simulated marine environment显示文摘 | PEDRO M THEODERO W B DEREK H L | 2004 | Cement and Concrete Composites2004，26，3： | 1 |
| 6 | Ozone treatment for mercury determination in white wines显示文摘 | CAPELO J L PEDRO H A MOTA A M | 2003 | Talanta2003，61，4： | 1 |
| 7 | Pd-Pt bi- metallienanodendrites with high activity for oxygen re- duction显示文摘 | Byungkwon L Majiong J Pedro H C | 2009 | Science2009，，324： | 1 |
| 8 | RFID system: a survey on security threats and proposed solutions显示文摘 | PEDRO P L JUL10 C H C JUAN M | 2006 | Lecture Notes in Computer Science2006，42，17： | 1 |
| 9 | Multi-objective lot-sizing and scheduling dealing with perishability issues 显示文摘 | PEDRO A CARLOS H A BERNARDO A L | 2011 | Ind & Eng Chem Res2011，50，6： | 1 |
| 10 | Design of an Immobilized Enzyme System for Naringin Hydrolysis at High-Pressure 显示文摘 | Pedro H A L Alfaia A J Marques J | 2007 | Enzyme Microb Tech2007，40，3： | 1 |
| 11 | Free-product plume distribution and recovery modeling prediction in a diesel-contaminated volcanic aquifer显示文摘 | ANTONIO H E PEDRO M S EMILIO S L | | 0，，02： | 1 |
| 12 | Optimized heat transfer correlations for pure and blended refrigerants显示文摘 | PORTO M P PEDRO H T C MACHADO L | 2015 | International Journal of Heat and Mass Transfer2015，85，： | 1 |
| 13 | Pancreatic-specific inactivation of IGF-Ⅰ gene causes enlarged pancreatic islets and significant resistance to diabetes显示文摘 | YARONG L PEDRO L H YUBIN G | 2004 | Diabetes2004，53，： | 1 |
| 14 | Multi-objective lot-sizing and scheduling dealing with perishability issues 显示文摘 | PEDRO A CARLOS H A BERNARDO A L | 2011 | Industrial and Engineering Chemistry Research2011，50，6： | 1 |
| 15 | Assessment of the spectrophotometric method for determination of angiotensin-converting-enzyme activity:influence of the inhibition type显示文摘 | Blanca H L Pedro J M I Encarnacion P | 2003 | J Agr Food Chem2003，51，： | 1 |
| 16 | Optimized heat transfer correlations for pure and blended refrigerants显示文摘 | Porto M P Pedro H T C Machado L | 2015 | International Journal of Heat and Mass Transfer2015，85，： | 1 |
| 17 | Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study显示文摘 | Karen L Kotloff James P Nataro William C Blackwelder Dilruba Nasrin Tamer H Farag Sandra Panchalingam Yukun Wu Samba O Sow Dipika Sur Robert F Breiman Abu SG Faruque Anita KM Zaidi Debasish Saha Pedro L Alonso Boubou Tamboura Doh Sanogo Uma Onwuchekwa Byo | 2013 | The Lancet2013，，9888： | 1 |
| 18 | Anal Sphincter Preservation in Locally Advanced Low Rectal Adenocarcinoma After Preoperative Chemoradiation Therapy and Coloanal Anastomosis显示文摘 | Pedro LP San L R Freddl H N | 2003 | Journal of Surgical Oncology2003，82，1： | 1 |
| 19 | The Carbohydrate-active enzymes database (CAZy): an expert resource for glycogenomics 显示文摘 | Brandi LC Pedro MC Corinne R Thomas B Vincent L Bernard H | 2009 | Nucleic Acids Res2009，37，： | 1 |
| 20 | Isolation of rabies virus in Molossus ater in (Chiroptera:Molossidae) in Sao Paulo State,Brazil显示文摘 | Silva L H Cunha E M Pedro W A | 1999 | Rev Saude Publica1999，33，6： | 1 |
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