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| 1 | Effect of early preoperative 5-fluorouracil on the integrity of colonic anastomoses in rats显示文摘AIM:To determine the effect of chemotherapy on wound healing by giving early preoperative 5-fluorouracil (5-FU)to rats with colonic anastomoses. METHODS:Sixty Albino-Wistar male rats(median weight,235 g)were used in this study.The rats were fed with standard laboratory food and given tap water ad libitum.The animals were divided into three groups: Group 1:Control group(chemotherapy was not administered),Group 2:Intraperitoneally(IP)administered 5-FU group(chemotherapy was administered IP to animals at a dose of 20 mg/kg daily during the 5 d preceeding surgery),Group 3:Intravenously(IV)administered 5-FU group.Chemotherapy was administered via the penil vein,using the same dosing scheme and duration as the second group.After a 3-d rest to minimize the side effects of chemotherapy,both groups underwent surgery.One centimeter of colon was resected 2 cm proximally from the peritoneal reflection,thensutured intermittently and subsequently end-to-end anastomosed.In each group,half the animals were given anaesthesia on the 3rd postoperative(PO)day and the other half on the 7th PO day,for in vivo analytic procedures.The abdominal incisions in the rats were dissected,all the new and old anastomotic segments were clearly seen and bursting pressures of each anastomotic segment,tissue hydroxyproline levels and DNA content were determined to assess the histologic tissue repair process. RESULTS:When the IV group was compared with the IP group,bursting pressures of the anastomotic segments on the 3rd and 7th PO days,were found to be significantly decreased,hydroxyproline levels at the anastomotic segment on the 7th PO day were significantly decreased(P<0.01). CONCLUSION:In this study,we conclude that early preoperative 5-FU,administered IV,negatively affects wound healing.However,IP administered 5-FU does not negatively affect wound healing. | Leyla Ozel M Sefa Ozel Ahmet Burak Toros Melih Kara Kemal Sirri Ozkan Gurkan Tellioglu Osman Krand Meral Koyuturk Ibrahim Berber | 2009 | World Journal of Gastroenterology2009，15，33： | 7 |
| 2 | Wound complications and clinical results of electrocautery versus a scalpel to create a cutaneous flap in thyroidectomy:a prospective randomized trial显示文摘 | Uludag M Yetkin G Ozel A | 2011 | Surg Today2011，41，8： | 1 |
| 3 | Sonographic imaging of theperipheral nerves in a patient with neurofibromatosis type 1显示文摘 | Kara M Yilmaz A Ozel S | | 0，，06： | 1 |
| 4 | Rapid and sensitive identification of pathogenic and apathogenic Bacillus anthraeis by real time PCR 显示文摘 | Ellerbrok H Nattermann H Ozel M | 2002 | FEMS Microbiol Lett2002，214，1： | 1 |
| 5 | Two year follow up of fractured anterior teeth restored with direct composite resin:report of three cases显示文摘 | Ozel E Kazandag MK Soyman M | 2008 | Dent Traumatol2008，24，5： | 1 |
| 6 | Antimycoplasma properties and applications in cell culture of surfactin,a lipopeptide antibiotic from Bacillus subtilis显示文摘 | Vollenbroich D Pauli G Ozel M | 1997 | Appl Environ Microbiol1997，63，1： | 1 |
| 7 | 2003, Istanbul earthquake rapid response and the early warning system显示文摘 | Erdik M Fahian Y Ozel O Aleik H Mert A Gul M | 2003 | Bull Earthq Eng2003，1，1： | 1 |
| 8 | Mechanism of inactivation of enveloped viruses,by the biosurfactant surfactin from Bacillus subtilis显示文摘 | Vollenbroich D Ozel M Vater J | 1997 | Biologicals1997，25，3： | 1 |
| 9 | Granulomatous mastitis:is it an autoimmune disease? Diagnostic and therapeutic dilemmas 显示文摘 | Ozel L Unal E Kara M | 2011 | Surg Today2011，10，： | 1 |
| 10 | Antiviral and hemolytic activities of surfactin isoforms and their methyl ester derivatives显示文摘 | Kracht M Rokos H Ozel M | 1999 | J Antibiot1999，52，7： | 1 |
| 11 | Mechanism of inactivation of enveloped viruses by the biosurfactant surfactin from Bacillus subtilis显示文摘 | Vollenbroich D Ozel M Vater J | 1997 | Biologicals1997，25，3： | 1 |
| 12 | Istanbul earthquake rapid response and the early warning system显示文摘 | Erdik M Fahjan Y Ozel O | 2003 | Bull Earthquake Eng2003，1，： | 1 |
| 13 | Istanbul earthquake rapid response and early warning system显示文摘 | Erdik M YFahjan O Ozel | 2003 | Bulletin of Earthquake Engineering2003，1，： | 1 |
| 14 | Induction and assessment methods used in experimental adhesion studies显示文摘 | OZEL H AVSAR F M TOPALOGLU S | 2005 | Wound Repair Regen2005，13，4： | 1 |
| 15 | Antimycoplasma properties and application in cell culture of surfactin,a lipopeptide antibiotic from Bacillus subtilis显示文摘 | Vollenbroich D Pauli G Ozel M | 1997 | Applied and Environmental Microbiology1997，63，1： | 1 |
| 16 | Rapid and sensitive identification of pathogenic and apathogenic Bacillus anthracis by real-time PCR 显示文摘 | Ellerbrok H Nattermann H Ozel M | 2002 | FEMS Microbiol Lett2002，214，1： | 1 |
| 17 | Effect of the residual stresses on the fatigue crack growth behavior at fastener holes 显示文摘 | Toparli M Ozel A Aksoy T | 1997 | Jour- nal of Material1997，22，5： | 1 |
| 18 | 109 expression of genes related to endometrial receptivity in equine endometrium during the estrous cycle and early pregnancy 显示文摘 | Hitit M Guzeloglu A Ozel C | 2014 | Reprod Fertil Dev2014，27，1： | 1 |
| 19 | Mechanism of inactivation of enveloped viruses by the biosurfactant surfactin from Bacillus subtilis 显示文摘 | Vollenbroich D Ozel M Vater J | 1997 | Biologicals1997，25，： | 1 |
| 20 | Effect of fiber nets, application techniques and flowable composites on microleakage and the effect of fiber nets on polymerization shrinkage in class II MOD cav- ities 显示文摘 | Ozel E Soyman M | 2009 | Oper Dent2009，34，2： | 1 |
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