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| 1 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 2 | Rapid and sensitive identification of pathogenic and apathogenic Bacillus anthraeis by real time PCR 显示文摘 | Ellerbrok H Nattermann H Ozel M | 2002 | FEMS Microbiol Lett2002，214，1： | 1 |
| 3 | Rapid and sensitive identification of pathogenic and apathogenic Bacillus anthracis by real-time PCR 显示文摘 | Ellerbrok H Nattermann H Ozel M | 2002 | FEMS Microbiol Lett2002，214，1： | 1 |
| 4 | Binding of HCV E2 to CD81 induces RANTES secretion and internalization of CC chemokine receptor 5 显示文摘 | Nattermann J Nischalke H D Feldmann G | 2004 | J Viral Hepatitis2004，11，： | 1 |
| 5 | Hepatitis C virus E2 and CD81 interaction may be associated with altered trafficking of dendritic cells in chronic hepatitis C 显示文摘 | Nattermann J Zimmermann H Iwan A | 2006 | Hepatology2006，44，4： | 1 |
| 6 | Rapid and sensitive identification of pathogenic and apathogenic Bacilus anthracis by real-time PCR显示文摘 | Heinz E H Nattermann M O Lothar B | 2002 | FEMS Microbiology Letters2002，214，： | 1 |
| 7 | The HLA-A2 restricted T cell epitope HCV core 35-44 stabilizes HLA-E expression and inhibits cytolysis mediated by natural killer cells显示文摘 | Nattermann J Nischalke H Hofmeister V | 2005 | Am J Pathol2005，166，2： | 1 |
| 8 | Laboratory and field testing of a programmable plot-size rainfall simulator erosion and sediment transport measurement proceedings of the florence symposium显示文摘 | Neibling W H Foster G R Nattermann J D | 1981 | IAHS Publ1981，133，： | 1 |
| 9 | MALDI- TOF mass spectrometry compatible inactivation method for highly pathogenic microbial cells and spores显示文摘 | Lasch P Nattermann H Erhard M | 2008 | Analytical Chemistry2008，80，6： | 1 |
| 10 | Hepatitis C virus E2 and CD81 interaction may be associated with altered trafficking of dendritic ceils in chronic hepatitis C 显示文摘 | Nattermann J Zimmermann H | 2006 | Hepatology2006，44，： | 1 |
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