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| 1 | Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease显示文摘BackgroundKlotho 蛋白质(α - 并且 β) 是基于膜的传播调整细胞新陈代谢的蛋白质,以及成纤维细胞生长因素(FGF ) 的 lifespan modulating 活动。最近的数据证明了更高的血浆传播 Klotho 层次减少心血管的风险,建议 Klotho 有在心血管的疾病的一个保护的角色。然而,尽管到目前为止它在各种各样的机关被识别了,它是未知的是否,并且高心血管的风险是否能影响 Klotho 的心脏的表示 cardiomyocytes 快车 Klotho 和 FGF , FGF 和另外的 molecules.MethodsWe 与心血管的疾病和 10 匹配年龄的控制使遭到,估计的10年的低风险经历的一名估计的10年的高动脉粥样硬化患者选择了 20 个病人为除冠的动脉以外的原因的心脏的外科绕过。在心肌的活体检视,我们由免疫组织化学评估了 Klotho 和 FGF 是否在 cardiomyocytes 被表示,并且更高心血管的风险是否影响涉及 endoplasmic 蜂窝胃应力的另外的分子的表示,氧化应力,发炎并且 fibrosis.ResultsOnly ,有更高心血管的风险的病人的 cardiomyocytes 显示出 Klotho 的更低的表示,但是 FGF 的更高的表情。而且,更高心血管的风险与增加的表示被联系氧化并且网状的应力,发炎和 fibrosis.ConclusionsThis 学习的 endoplasmic 第一次证明 Klotho 蛋白质在人的 cardiomyocytes 被表示, Klotho 的那心脏的表情在更高心血管的风险病人是下面调整的,当压力相关的分子的表示显著地被增加时。 | Giovanni Corsetti Evasio Pasini Tiziano M Scarabelli Claudia Romano Pratik R Agrawal Carol Chen-Scarabelli Richard Knight Louis Saravolatz Jagat Narula Mario Ferrari-Vivaldi Vincenzo Flati Deodato Assanelli Francesco S Dioguardi | 2016 | Journal of Geriatric Cardiology2016，13，8： | 7 |
| 2 | Concept of vulnerable/unstable plaque显示文摘 | Finn AV Nakano M Narula J | 2010 | Arterioscler Thromb Vase Biol2010，30，7： | 1 |
| 3 | Concept of vulnerable/ unstable plaque显示文摘 | Finn AV Nakano M Narula J | 2010 | Arterioscler Thromb Vasc Biol2010，30，7： | 1 |
| 4 | Enhancement in biomass and berberine concentration by neem cake and nitrogen(urea) and sul- phur nutrients in Tinospora cordifolia Miers 显示文摘 | Kumar S Narula A Abdin M Z | 2004 | Physiology and Molecular Biology of Plants2004，10，： | 1 |
| 5 | Histopathologic characteristics of atherosclerotic coronary disease and implications of the findings for the invasive and noninvasive detection of vulnerable plaques显示文摘 | Narula J Nakano M Virmani R | 2013 | Journal of the American College of Cardiology2013，61，10： | 1 |
| 6 | Three-dimensional solution structure of Callinectes sapidus metallothionein-Ⅰ determined by homonuclear and heteronuclear magnetic resonance spectroscopy 显示文摘 | Narula S S Brouwer M Hua Y | 1995 | Biochemistry1995，34，： | 1 |
| 7 | Echocardiography in heart failure: applications, utility, and new horizons 显示文摘 | Kirkpatrick J N Vannan M A Narula J | 2007 | J Am Coll Cardiol2007，50，5： | 1 |
| 8 | A Method for the Ra diohalogenation of Proteins Resulting in Decreased Thyroid Uptake of Radioiodine显示文摘 | Zalusky M R Narula A S | 1987 | Appl Radiat Isot1987，38，： | 1 |
| 9 | Radiohalogenation of a Monoclonal Antibody Using a N-Succinimidyl-3-(Tri-n-Butystannyl) Benzoate Intermediate显示文摘 | Zalusky M R Narula A S | 1988 | Cancer Res1988，48，： | 1 |
| 10 | Histopathologic characteristics of atherosclerotic coronary disease and implications of the findings for the invasive and noninvasive detection of vulnerable plaques显示文摘 | Narula J Nakano M Virrnani R | 2013 | J Am Coil Cardiol2013，61，10： | 1 |
| 11 | Exploring liquid metal plasma facing component (PFC) concepts liquid metal film flow behavior under fusion relevant magnetic fields 显示文摘 | Narula M Abdou M A Ying A | 2006 | Fusion Engineering and Design2006，81，： | 1 |
| 12 | IgG-related sclerosing disease:a novel mimic of inflammatory bowel disease显示文摘 | Narula N Vasudev M Marshall JK | 2010 | Dig Dis Sci2010，55，11： | 1 |
| 13 | Enhancement in biomass and berberine concentration by neem cake and nitrogen (urea) and su|phur nutrients in Tinospora cordifolia Miers显示文摘 | Kumar S Narula A Abdin M Z | 2004 | Physiol Mol Biol Plants2004，10，： | 1 |
| 14 | Histopathologic character- istics of atheresclerotic coronary disease and implications of the findings for the invasive and noninvasive detection of vulnerable plaques显示文摘 | Narula J Nakano M Virmani R | 2013 | J Am Coll Cardiol2013，61，10： | 1 |
| 15 | Robot-assisted radical prostatectomy: current evaluation of surgical margins in clinically low-, intermediate-, and high-risk prostate cancer显示文摘 | Yee D S Narula N Amin M B | 2009 | J Endourol2009，23，9： | 1 |
| 16 | Histopathologic characteris- tics of atherosclerotic coronary disease and implications of the find- ings for the invasive and noninvasive detection of vulnerable plaques 显示文摘 | Narula J Nakano M Virmani R | 2013 | JAm Coil Cardiol2013，61，10： | 1 |
| 17 | Robot-as-sisted radical prostatectomy; current evaluation of sur-gical margins in clinically low - , intermediate-,andhigh-risk prostate cancer 显示文摘 | YEE D S NARULA N AMIN M B | 2009 | J Endourol2009，23，： | 1 |
| 18 | Complications of third trimester amniocentesis using continuous ultrasound guidance 显示文摘 | Gordon M C Narula K O shanghnessy R | 2002 | Obstet Gynecol2002，99，2： | 1 |
| 19 | Efficient Use of Side Information in Multiple-Antenna Transmission over Fading Channels显示文摘 | NARULA A LOPEZ M J TROTT M D | 1998 | IEEE J Select Areas Commun1998，16，8： | 1 |
| 20 | Efficient use of side information in multiple-antenna data transmission over fading channels 显示文摘 | A Narula M J Lopez M D Trott G W Womell | 1998 | IEEE Journal on Selected Areas in Communications1998，16，8： | 1 |
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