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| 1 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 2 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 3 | Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial显示文摘 | Kris V Kowdley Eric Lawitz Israel Crespo Tarek Hassanein Mitchell N Davis Michael DeMicco David E Bernstein Nezam Afdhal John M Vierling Stuart C Gordon Jane K Anderson Robert H Hyland Hadas Dvory-Sobol Di An Robert G Hindes Efsevia Albanis William T Symo | 2013 | The Lancet2013，，9883： | 3 |
| 4 | Label-retaining liver cancer cells are relatively resistant to sorafenib显示文摘 | Hong-Wu Xin Chenwi M Ambe Danielle M Hari Gordon W Wiegand Tyler C Miller Jin-Qiu Chen Andrew J Anderson Satyajit Ray John E Mullinax Tomotake Koizumi Russell C Langan Douglas Burka Michelle A Herrmann Paul K Goldsmith Alexander Stojadinovic Udo Rudloff S | 2013 | Gut2013，，12： | 2 |
| 5 | A new three dimensional model for flow in fractured rock 显示文摘 | Dershowitz W S Gordon M Kafritsas J C | 1985 | Int Assoc Hydrogeol1985，17，： | 1 |
| 6 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 7 | Issues over high speed non invasive monitoring of railway trackbed显示文摘 | Clark M Gordon M Forde M C | 2004 | NDT and E International2004，37，2： | 1 |
| 8 | Volatile organic compounds as breath biomarkers for active and passive smoking 显示文摘 | Gordon S M Wallace L A Brinkman M C | 2002 | Environ Health Perspect2002，110，7： | 1 |
| 9 | New development in catalysis using ionic liquids显示文摘 | GORDON C M | 2001 | Appl Catal A2001，222，2： | 1 |
| 10 | Humanoid Muhimodal Tactile-Sensing Modules 显示文摘 | PHILIPP M GORDON C | 2011 | IEEE Transactions on Robotics2011，27，3： | 1 |
| 11 | Dehn surgery on knots显示文摘 | CULLER M GORDON C LUECKE J | 1987 | Annals of Math1987，125，： | 1 |
| 12 | Peginter- feron alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial 显示文摘 | Manns M P McHutchison J G Gordon S C | 2001 | Lancet2001，358，9286： | 1 |
| 13 | The effect of radial head excision and arthroplasty on elbow kinematics and stability显示文摘 | BEINGESSNER D M DUNNING C E GORDON K D | 2004 | J Bone Joint Surg Am2004，86，8： | 1 |
| 14 | An experimental study of the variation of wettability of SMDs using the micro-global wetting method 显示文摘 | Sargent P M Tang A C T Gordon F H | 1991 | IEEE/CHMT''91 IEMT Syrups1991，，： | 1 |
| 15 | lnteraction of DNAbinding proteins with a milk protein gene promoter in vitro: identification of a mammary gland-specific factor 显示文摘 | Watson C J Gordon K E Robertson M | 1991 | Nucleotide Acids Res1991，19，23： | 1 |
| 16 | Lyapunov control of vehicle handling dy- namics显示文摘 | Gordon T J Best M C | 1999 | JSAE Review1999，20，4： | 1 |
| 17 | Extension of postharvest life of ' Mission' figs by CO2-enriched at- mospheres显示文摘 | Giancarlo C F Gordon M Adel A | 1991 | Hort Science1991，26，9： | 1 |
| 18 | A new three dimensional model for flow in fractured rock显示文摘 | Dershowitz W S Gordon B M Kafritsas J C | 1985 | Int Assoc Hydrogeol1985，25，17： | 1 |
| 19 | The HITRAN 2008 molecular spectroscopic database 显示文摘 | Rothman L S Gordon I E Barbe A ChrisBenner D Bernath P F Birk M Boudon V Brown L R Campargue A Champi-on J P Chance K Coudert L H Dana V Devi V M Fally S Flaud J M Gamache R R Goldman A Jacquemart D Klein er I Lacome N Lafferty W J Mandin J Y Massie S T Mikhailenko S N Miller C E Moazzen A N Naumenko 0 VNikitin A V Orphal J Perevalov V I Perrin A Predoi C A Rinsland C P Rotger M ime kovd M Smith M A H Sung K Tashkun S A Tennyson J Toth R A Vandaele A C Vander A J | 2009 | Journal of Quantitative Spectroscopy Radiative Transfer2009，110，： | 1 |
| 20 | Predictive and diagnostic aspects of a universal thermodynamic model for chillers显示文摘 | Gordon J M Ng K C | 1995 | International Journal of Heat and Mass Transfer1995，38，5： | 1 |
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