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| 1 | Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease显示文摘BackgroundKlotho 蛋白质(α - 并且 β) 是基于膜的传播调整细胞新陈代谢的蛋白质,以及成纤维细胞生长因素(FGF ) 的 lifespan modulating 活动。最近的数据证明了更高的血浆传播 Klotho 层次减少心血管的风险,建议 Klotho 有在心血管的疾病的一个保护的角色。然而,尽管到目前为止它在各种各样的机关被识别了,它是未知的是否,并且高心血管的风险是否能影响 Klotho 的心脏的表示 cardiomyocytes 快车 Klotho 和 FGF , FGF 和另外的 molecules.MethodsWe 与心血管的疾病和 10 匹配年龄的控制使遭到,估计的10年的低风险经历的一名估计的10年的高动脉粥样硬化患者选择了 20 个病人为除冠的动脉以外的原因的心脏的外科绕过。在心肌的活体检视,我们由免疫组织化学评估了 Klotho 和 FGF 是否在 cardiomyocytes 被表示,并且更高心血管的风险是否影响涉及 endoplasmic 蜂窝胃应力的另外的分子的表示,氧化应力,发炎并且 fibrosis.ResultsOnly ,有更高心血管的风险的病人的 cardiomyocytes 显示出 Klotho 的更低的表示,但是 FGF 的更高的表情。而且,更高心血管的风险与增加的表示被联系氧化并且网状的应力,发炎和 fibrosis.ConclusionsThis 学习的 endoplasmic 第一次证明 Klotho 蛋白质在人的 cardiomyocytes 被表示, Klotho 的那心脏的表情在更高心血管的风险病人是下面调整的,当压力相关的分子的表示显著地被增加时。 | Giovanni Corsetti Evasio Pasini Tiziano M Scarabelli Claudia Romano Pratik R Agrawal Carol Chen-Scarabelli Richard Knight Louis Saravolatz Jagat Narula Mario Ferrari-Vivaldi Vincenzo Flati Deodato Assanelli Francesco S Dioguardi | 2016 | Journal of Geriatric Cardiology2016，13，8： | 7 |
| 2 | Resected specimen evaluation,anorectal manometry,endoanal ultrasonography and clinical follow-up after STARR procedures显示文摘AIM:To investigate stapled transanal rectal resection (STARR) procedures as surgical techniques for obstructed defecation syndrome (ODS) by analyzing specimen evaluation,anorectal manometry,endoanal ultrasonography and clinical follow-up.METHODS:From January to December 2007,we have treated 30 patients.Fifteen treated with double PPH-01 staplers and 15 treated using new CCS 30 contour.Resected specimen were measured with respect to average surface and volume.All patients have been evaluated at 24 mo with clinical examination,anorectal manometry and endoanal ultrasonography.RESULTS:Average surface in the CCS 30 group was 54.5 cm2 statistically different when compared to the STARR group (36.92 cm2).The average volume in the CCS 30 group was 29.8 cc,while in the PPH-01 it was23.8 cc and difference was statistically significant.The mean hospital stay in the CCS 30 group was 3.1 d,while in the PPH-01 group the median hospital stay was 3.4 d.As regards the long-term follow-up,an overall satisfactory rate of 83.3% (25/30) was achieved.Endoanal ultrasonography performed 1 year following surgery was considered normal in both of the studied groups.Mean resting pressure was higher than the preoperative value (67.2 mmHg in the STARR group and 65.7 mmHg in the CCS30 group vs 54.7 mmHg and 55.3 mmHg,respectively).Resting and squeezing pressures were lower in those patients not satisfied,but data are not statistically significant.CONCLUSION:The STARR procedure with two PPH-01 is a safe surgical procedure to correct ODS.The new Contour CCS 30 could help to increase the amount of the resected tissue without differences in early complications,post-operative pain and in hospital stay compared to the STARR with two PPH-01 technique. | Gabriele Naldini Guido Cerullo Claudia Menconi Jacopo Martellucci Simone Orlandi Nicola Romano Mauro Rossi | 2011 | World Journal of Gastroenterology2011，17，19： | 6 |
| 3 | Surgical Treatment of Metastatic Tumors to the Pancreas: A Single Center Experience and Review of the Literature显示文摘 | Stefano Crippa MD Carlo Angelini MD Chiara Mussi Claudia Bonardi MD Fabrizio Romano MD Paola Sartori MD Franco Uggeri MD Giorgio Bovo MD | 2006 | World Journal of Surgery2006，，8： | 2 |
| 4 | Psychopharmacological Treatment and Psychological Interventions in Irritable Bowel Syndrome显示文摘 | Emanuele Sinagra Claudia Romano Mario Cottone Giovanni Barbara | 2012 | Gastroenterology Research and Practice2012，，： | 1 |
| 5 | Surgical Treatment of Metastatic Tumors to the Pancreas: A Single Center Experience and Review of the Literature显示文摘 | Stefano Crippa Carlo Angelini Chiara Mussi Claudia Bonardi Fabrizio Romano Paola Sartori Franco Uggeri Giorgio Bovo | 2006 | World Journal of Surgery2006，，： | 1 |
| 6 | The Role of Portal Vein Thrombosis in the Clinical Course of Inflammatory Bowel Diseases: Report on Three Cases and Review of the Literature显示文摘 | Emanuele Sinagra Emma Aragona Claudia Romano Simonetta Maisano Ambrogio Orlando Roberto Virdone Lorenzo Tesè Irene Modesto Valeria Criscuoli Mario Cottone Paolo Gionchetti | 2012 | <journal-title>Gastroenterology Research and Practice2012，，： | 1 |
| 7 | P wave dispersion and short-term vs. late atrial fibrillation recurrences after cardioversion显示文摘 | Giuseppe Boriani Igor Diemberger Mauro Biffi Claudia Camanini Cinzia Valzania Ivan Corazza Cristian Martignani Romano Zannoli Angelo Branzi | 2004 | International Journal of Cardiology2004，，3： | 1 |
| 8 | Clinical implications of mucosal healing in the management of patients with inflammatory bowel disease显示文摘 | Ambrogio Orlando Francesco William Guglielmi Mario Cottone Emanuele Orlando Claudia Romano Emanuele Sinagra | 2013 | Digestive and Liver Disease2013，，12： | 1 |
| 9 | Psychopharmacological Treatment and Psychological Interventions in Irritable Bowel Syndrome显示文摘 | Emanuele Sinagra Claudia Romano Mario Cottone Giovanni Barbara | 2012 | Gastroenterology Research and Practice2012，，： | 1 |
| 10 | Surgical Treatment of Metastatic Tumors to the Pancreas: A Single Center Experience and Review of the Literature显示文摘 | Stefano Crippa MD Carlo Angelini MD Chiara Mussi Claudia Bonardi MD Fabrizio Romano MD Paola Sartori MD Franco Uggeri MD Giorgio Bovo MD | 2006 | World Journal of Surgery2006，，8： | 1 |
| 11 | Comparison of partners-heart failure algorithm vs care alert in remote heart failure management显示文摘AIM: To compare the utility of the partners-heart failure(HF) algorithm with the care alert strategy for remote monitoring,in guiding clinical actions oriented to treat impending HF.METHODS: Consecutive cardiac resynchronizationdefibrillator recipients were followed with biweekly automatic transmissions. After every transmission,patients received a phone contact in order to check their health status,eventually followed by clinical actions,classified as 'no-action','non-active' and 'active'. Active clinical actions were oriented to treat impending HF. The sensitivity,specificity,positive and negative predictive values and diagnostic accuracy of the partners-HF algorithm vs care alert in determining active clinical actions oriented to treat pre-HF status and to prevent an acute decompensation,were also calculated.RESULTS: The study population included 70 patients with moderate to advanced systolic HF and QRS duration longer than 120 ms. During a mean follow-up of 8 ± 2 mo,665 transmissions were collected. No deaths or HF hospitalizations occurred. The sensitivity and specificity of the partners-HF algorithm for active clinical actions oriented to treat impending HF were 96.9%(95%CI: 0.96-0.98) and 92.5%(95%CI: 0.90-0.94) respectively. The positive and negative predictive values were 84.6%(95%CI: 0.82-0.87) and 98.6%(95%CI: 0.98-0.99) respectively. The partners-HF algorithm had an accuracy of 93.8%(95%CI: 0.92-0.96) in determining active clinical actions. With regard to active clinical actions,care alert had a sensitivity and specificity of 11.05%(95%CI: 0.09-0.13) and 93.6% respectively(95%CI: 0.92-0.95). The positive predictive value was 42.3%(95%CI: 0.38-0.46); the negative predictive value was 71.1%(95%CI: 0.68-0.74). Care alert had an accuracy of 68.9%(95%CI: 0.65-0.72) in determining active clinical actions.CONCLUSION: The partners-HF algorithm proved higher accuracy and sensitivity than care alert in determining active clinical actions oriented to treat impending HF. Future studies in larger populations should evaluate partners-HF ability to improve HF-related clinical outcomes. | Leonardo Calo’ Annamaria Martino Claudia Tota Alessandro Fagagnini Renzo Iulianella Marco Rebecchi Luigi Sciarra Giuseppe Giunta Maria Grazia Romano Roberto Colaceci Antonio Ciccaglioni Fabrizio Ammirati Ermenegildo de Ruvo | 2015 | World Journal of Cardiology2015，7，12： | 0 |
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