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| 1 | Gastrointestinal stromal tumor of the stomach with axillary lymph node metastasis: A case report显示文摘Gastrointestinal stromal tumors (GISTs) are the most common type of gastrointestinal mesenchymal tumors, although metastasis to the perigastric lymph nodes is relatively rare, compared with liver or peritoneal metastasis. In this report, we describe a case of stomach GIST with a solitary simultaneous metastasis in the left axillary lymph node. A 68-year-old man was diagnosed with a large upper-stomach GIST, and computed tomography and positron emission tomography revealed masses in the left axilla and right mediastinum. We did not detect evidence of metastases to the liver, or other sites including the perigastric lymph nodes, although findings from the surgically resected axillary lymph nodes were compatible with GIST metastasis. Treatment using imatinib markedly reduced the gastric and mediastinal lesions, and this response persisted for 3 years. The patient subsequently experienced rapid growth of the gastric lesion without mediastinal or axilla recurrence, which required palliative surgery. Despite continuing medical treatment(sunitinib and regorafenib), the patient died of liver metastases 23 mo after the surgery. Based on our findings, it appears that the axillary lymph nodes can be a potential metastatic site for GIST metastasis. | Naoki Kubo Nobumichi Takeuchi | 2017 | World Journal of Gastroenterology2017，23，9： | 5 |
| 2 | How Group Heuristics Promotes Cooperative Behavior in Social Dilemma SituationmExploration of Group Heuristics Effects on the Basis of Computer Simulation显示文摘 | Atsuo Murata Saki Kubo Naoki Hata | 2012 | Computer Technology and Application2012，3，10： | 2 |
| 3 | Deletion detection for diagnosis of Duchenne muscular dystrophy in the Japanese population—Comparisom between the polymerase chain reaction and the Southern blot analysis显示文摘 | Susumu Katayama Naoki Takeshita Tomone Yano Tsuneyuki Ubagai Xiao Jin Qiu Yukiko Katagiri Harumi Kubo Shun Hirakawa | 1993 | The Japanese Journal of Human Genetics1993，，2： | 1 |
| 4 | Agrobacterium tumefaciens-mediated transformation for random insertional mutagenesis in Colletotrichum lagenarium显示文摘 | Gento Tsuji Satoshi Fujii Naoki Fujihara Chika Hirose Seiji Tsuge Tomonori Shiraishi Yasuyuki Kubo | 2003 | Journal of General Plant Pathology2003，，4： | 1 |
| 5 | Biomarkers of skin toxicity induced by anti-epidermal growthfactor receptor antibody treatment in colorectal cancer显示文摘Skin toxicity is a common symptom of anti-epidermal rowth factor receptor(EGFR) antibody treatment and is also a predictive marker of its efficacy in colorectal cancer patients. However, severe skin disorders induced by such antibodies negatively impact on the quality of life of patients and decreases drug compliance during treatment. If we can predict the high-risk group susceptible to severe skin toxicity before treatment, we can undertake the early management of any arising skin disorders and formulate a more accurate prognosis for anti-EGFR antibody treatment. Previous studies have identified molecular markers of skin toxicity induced by anti-EGFR antibody, such as EGFR polymorphisms, the expression of inflammatory chemokines and serum levels of EGFR ligands. A clinical trial was undertaken involving the escalation of cetuximab doses, guided by the grade of skin toxicity observed, such as no or low-grade, in metastatic colorectal cancer(the EVEREST study). The dose escalation of cetuximab was confirmed by a safety profile and had the tendency to achieve a higher response rate in KRAS wild-type patients. A large, prospective randomized trial is now ongoing(EVEREST 2) and the results of this trial may contribute to personalized medicine in KRAS wild-type colorectal cancer patients. | Akiko Kubo Hironobu Hashimoto Naoki Takahashi Yasuhide Yamada | 2016 | World Journal of Gastroenterology2016，22，2： | 1 |
| 6 | Regulating Assisted Reproductive Technologies in Japan显示文摘 | Naoki Takeshita Kanako Hanaoka Yukihiro Shibui Hikoyoshi Jinnai Yuji Abe Harumi Kubo | | Journal of Assisted Reproduction and Genetics0，，： | 1 |
| 7 | Changes in cognitive function during the 1-year period following endarterectomy and stenting of patients with high-grade carotid artery stenosis显示文摘 | Akiko Takaiwa Nakamasa Hayashi Naoya Kuwayama Naoki Akioka Michiya Kubo Shunro Endo | 2009 | Acta Neurochirurgica2009，，12： | 1 |
| 8 | Cellular behavior on TiO 2 nanonodular structures in a micro-to-nanoscale hierarchy model显示文摘 | Katsutoshi Kubo Naoki Tsukimura Fuminori Iwasa Takeshi Ueno Lei Saruwatari Hideki Aita Wen-An Chiou Takahiro Ogawa | 2009 | Biomaterials2009，，29： | 1 |
| 9 | Agrobacterium tumefaciens-mediated transformation for random insertional mutagenesis in Colletotrichum lagenarium显示文摘 | Gento Tsuji Satoshi Fujii Naoki Fujihara Chika Hirose Seiji Tsuge Tomonori Shiraishi Yasuyuki Kubo | 2003 | Journal of General Plant Pathology2003，，4： | 1 |
| 10 | Agrobacterium tumefaciens-mediated transformation for random insertional mutagenesis in Colletotrichum lagenarium显示文摘 | Gento Tsuji Satoshi Fujii Naoki Fujihara Chika Hirose Seiji Tsuge Tomonori Shiraishi Yasuyuki Kubo | 2003 | Journal of General Plant Pathology2003，，4： | 1 |
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