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| 1 | Emergence of immunotherapy as a novel way to treat hepatocellular carcinoma显示文摘Tumor immunity proceeds through multiple processes, which consist of antigen presentation by antigen presenting cells(APCs) to educate effector cells and destruction by the effector cytotoxic cells. However, tumor immunity is frequently repressed at tumor sites. Malignantly transformed cells rarely survive the attack by the immune system, but cells that do survive change their phenotypes to reduce their immunogenicity. The resultant cells evade the attack by the immune system and form clinically discernible tumors. Tumor microenvironments simultaneously contain a wide variety of immune suppressive molecules and cells to dampen tumor immunity. Moreover, the liver microenvironment exhibits immune tolerance to reduce aberrant immune responses to massively-exposed antigens via the portal vein, and immune dysfunction is frequently associated with liver cirrhosis, which is widespread in hepatocellular carcinoma(HCC) patients. Immune therapy aims to reduce tumor burden, but it is also expected to prevent non-cancerous liver lesions from progressing to HCC, because HCC develops or recurs from noncancerous liver lesions with chronic inflammatory states and/or cirrhosis and these lesions cannot be cured and/or eradicated by local and/or systemic therapies. Nevertheless, cancer immune therapy should augment specific tumor immunity by using two distinct measures: enhancing the effector cell functions such as antigen presentation capacity of APCs and tumor cell killing capacity of cytotoxic cells, and reactivating the immune system in immune-suppressive tumor microenvironments. Here, we will summarize the current status and discuss the future perspective on immune therapy for HCC. | Naofumi Mukaida Yasunari Nakamoto | 2018 | World Journal of Gastroenterology2018，24，17： | 13 |
| 2 | Pathophysiological roles of Pim-3 kinase in pancreatic cancer development and progression显示文摘Pim-3 is a member of the provirus integration site for Moloney murine leukemia virus(Pim)family proteins that exhibit serine/threonine kinase activity.Similar to the other Pim kinases(Pim-1 and Pim-2),Pim-3 is involved in many cellular processes,including cell proliferation,survival,and protein synthesis.Although Pim-3is expressed in normal vital organs,it is overexpressed particularly in tumor tissues of endoderm-derived organs,including the liver,pancreas,and colon.Silencing of Pim-3 expression can retard in vitro cell proliferation of hepatocellular,pancreatic,and colon carcinoma cell lines by promoting cell apoptosis.Pim-3 lacks the regulatory domains similarly as Pim-1 and Pim-2 lack,and therefore,Pim-3 can exhibit its kinase activity once it is expressed.Pim-3 expression is regulated at transcriptional and post-transcriptional levels by transcription factors(e.g.,Ets-1)and post-translational modifiers(e.g.,translationally-controlled tumor protein),respectively.Pim-3 could promote growth and angiogenesis of human pancreatic cancer cells in vivo in an orthotopic nude mouse model.Furthermore,a Pim-3 kinase inhibitor inhibited cell proliferation when human pancreatic cancer cells were injected into nude mice,without inducing any major adverse effects.Thus,Pim-3 kinase may serve as a novel molecular target for developing targeting drugs against pancreatic and other types of cancer. | Ying-Yi Li Naofumi Mukaida | 2014 | World Journal of Gastroenterology2014，20，28： | 6 |
| 3 | CCR5 gene expression in fulminant hepatitis and DTH in mice显示文摘CCR5geneexpressioninfulminanthepatitisandDTHinmiceGUOBaoYu1,ZHANGSuYing2,NaofumiMukaida3,AkihisaHarada3,KoujiKuno3,WANGJian... | GUO Bao-Yu ZHANG Su-Ying Naofumi Mukaida Akihisa Harada Kouji Kuno WANG Jian-Bin SUN Shu-Han Kouji Matsushima | 1998 | World Journal of Gastroenterology1998，4，1： | 5 |
| 4 | Fibroblasts, an inconspicuous but essential player in colon cancer development and progression显示文摘Tumor microenvironments have a crucial role in cancer initiation and progression, and share many molecular and pathological features with wound healing process. Unless treated, tumors, however, do not heal in contrast to wounds that heal within a limited time framework. Wounds heal in coordination of a myriad of types of cells, particularly endothelial cells, leukocytes, and fibroblasts. Similar sets of cells also contribute to cancer initiation and progression, and as a consequence, anti-cancer treatment strategies have been proposed and tested by targeting endothelial cells and/or leukocytes. Compared with endothelial cells and leukocytes, less attention has been paid to the roles of cancer-associated fibroblasts(CAFs), fibroblasts present in tumor tissues, because their heterogeneity hinders the elucidation on them at cellular and molecular levels. Here, we will discuss the origin of CAFs and their crucial roles in cancer initiation and progression, and the possibility to develop a novel type of anti-cancer treatment by manipulating the migration and functions of CAFs. | Naofumi Mukaida Soichiro Sasaki | 2016 | World Journal of Gastroenterology2016，22，23： | 4 |
| 5 | Inhibition of Immature eryrthroid progenitor cell proliferation by macrophage inflammatory protein-1 alpha by interacting mainly with a C-C chemokine receptor, CCR1显示文摘 | Su S Mukaida N Wand J | 1997 | Blood1997，90，2： | 2 |
| 6 | Prevention of endotoxemia-induced acute respiratory distress syndrome-like lung injury in rabbits by a monoclonal antibody to IL-8显示文摘 | Yokoi K Mukaida N Harada A | 1997 | Lab Invest1997，76，3： | 2 |
| 7 | Blocking TNF-[alpha] in mice reduces colorectal carcinogenesis associated with chronic colitis显示文摘 | Popivanova Boryana K Kitamura Kazuya Wu Yu Kondo Toshikazu Kagaya Takashi Kaneko Shiuchi Oshima Masanobu Fujii Chifumi Mukaida Naofumi | 2008 | Journal of Clinical Investigation2008，，2： | 2 |
| 8 | Chemokines in tumor development and progression显示文摘 | Naofumi Mukaida Tomohisa Baba | 2011 | Experimental Cell Research2011，，2： | 2 |
| 9 | Pivotal role of interleukin-8 in the acute respiratory distress syndrome and cerebral reperfusion injury 显示文摘 | Yokoi K Mukaida N Harada A Yamashita J Watanabe Y Matsushima K | 1997 | J Leukoc Biol1997，62，5： | 1 |
| 10 | Vitrification of human embryos based on the assessment of suitable conditions for 8 cell mouse embryos显示文摘 | Mukaida T Wada S Takahashi K | 1998 | Hum Reprod1998，13，10： | 1 |
| 11 | Successful birth after transfer of vitrified human blastocysts with use of a cryoloop eontainerless technique 显示文摘 | Mukaida T Nakamura S Tomiyama T | 2001 | Fertil Steril2001，76，： | 1 |
| 12 | Clinicd significance of the expression of epidermal growth factor and its receptor in esophage-aleancer 显示文摘 | Mukaida H Toi M Hirai T | 1991 | Cancer1991，68，1： | 1 |
| 13 | The Frequency of Type 2 CD8+ T Cells Is Increased in Peripheral Blood from Patients with Psoriasis Vulgaris显示文摘 | Makoto Inaoki Shinichi Sato Fumiaki Shirasaki Naofumi Mukaida Kazuhiko Takehara | 2003 | Journal of Clinical Immunology2003，，4： | 1 |
| 14 | Aleviation of lipopolysaccharide-induced acute liver injury in propionivacterium acnes-primed IFN-γ-dificient mice by a concomitant reduction of TNF-α, IL-12 p40/p70 and IL-18 production显示文摘 | Mukaida N Harada A | 1999 | J Immunol1999，162，： | 1 |
| 15 | Interleukin -8 (IL -8 ) and monocyte chemotactic and activating factor (MCAF/MCP - 1 ), ehemokines essentially involved in inflammatory and immune reactions显示文摘 | Mukaida N Harada A Matsushima K | 1998 | Cytokine Growth Factor Rev1998，9，1： | 1 |
| 16 | Alleviation of lipopolysaceharideinduced acute liver injury in propionibactefium acheS-primed IFN-gamma-defieient mice by a concomitant reduction of TNF-alpha, IL-12,and IL-18 production显示文摘 | Tsuji H Mukaida N Harada A | 1999 | J Immunol1999，162，2： | 1 |
| 17 | Vitrification of oocytes, embryos and blastocysts显示文摘 | Mukaida T Oka C | 2012 | Best Pract Res Clin Obstet Gynaecol2012，26，6： | 1 |
| 18 | Effects of fluridone and norflurazon on conditioning and germination of Striga asiatics seeds 显示文摘 | Kusumoto D Chae S H Mukaida K etal | 2006 | Plant Growth Regulat2006，48，： | 1 |
| 19 | Comparison of density of states of transition metal disilicides and their related compounds systematically calculated by a first-principle pseudopotential method using plane-wave basis显示文摘 | Imai Y Mukaida M Tsunoda T | 2000 | Intermetallics2000，8，： | 1 |
| 20 | Successful birth after transfer of vitrified human blastocysts with use of a cryoloop containerless technique显示文摘 | Mukaida T Nakamura T Tomiuyama T | 2001 | Fertil Steril2001，76，3： | 1 |
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