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| 1 | Immune signature profiling identified prognostic factors for gastric cancer显示文摘Objective: Tumor microenvironment, especially the host immune system, plays a pivotal role in tumor initiation and progression. Profiling of immune signature within tumor might uncover biomarkers for targeted therapies and clinical outcomes. However, systematic analysis of immune-related genes in gastric cancer(GC) has not been reported.Methods: Expressions of a total of 718 immune-related genes were generated in 372 stomach adenocarcinoma(STAD) patients from The Cancer Genome Atlas(TCGA) database using RNA-sequencing data. Integrated bioinformatics analyses were performed to identify prognostic factors as well.Results: Survival analyses revealed 73 genes, which were significantly associated with patient’s overall survival(OS). Taken together with clinicopathological parameters, we established a predictive model, containing 10 immune-related genes, which were NRP1, C6, CXCR4, LBP, PNMA1, TLR5, ITGA6, MICB, PBK and TNFRSF18,with powerful efficiency in distinguishing satisfactory or poor survival of STAD patients. Moreover, the top 3 ranked prognostic genes, NRP1, TGFβ2 and MFGE8, were also significantly associated with patient’s OS by an independent validation achieved from Kaplan-Meier plotter database.Conclusions: We profiled prognostic immune signature and established prognostic predictive model for GC,which could reflect immune disorders within tumor microenvironment, and also may provide novel predictive and therapeutic targets for GC patients in the near future. | Wenhui Yang Zhiyong Lai Yuan Li Jianbing Mu Mudan Yang Jun Xie Jun Xu | 2019 | Chinese Journal of Cancer Research2019，31，3： | 5 |
| 2 | Geoscience Frontiers 2016 Annual Convention显示文摘The 2016 Geoscience Frontiers Annual Convention was held in Beijing,China on October 14,2015 hosted by China University of Geosciences,Beijing(Fig.1).This convention assembled earth scientists from six countries,including Australia(Dr.Christopher Spencer),Italy(Prof.Emilio Saccani),India(Prof.G.Parthasarathy and Prof.M.Jayananda),Japan(Prof.Masaki Yoshida),UK(Dr.Nick Roberts),China,and also representative from Elsevier(Beijing). | Fei Gao Lily Wang Yongqiang Yang Mudan Yin | 2017 | Geoscience Frontiers2017，8，2： | 0 |
| 3 | Geoscience Frontiers 2015 Annual Convention显示文摘The 2015 Geoscience Frontiers Annual Convention was held in Beijing,China during October 29,2015 hosted by China University of Geosciences,Beijing(Fig.1).This convention assembled earth scientists from 5 countries,including Australia(Prof.Franco Pirajno),China(several delegates),Germany(Prof.Daniel Harlov),Italy(Prof.Carlo Doglioni),Norway(Dr.Mathew Domeier),South Korea(Prof.S.Kwon)and United States(Prof. | Fei Gao Lily Wang Yongqiang Yang Mudan Yin | 2016 | Geoscience Frontiers2016，7，2： | 0 |
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