| 2 | Synaptic plasticity effects on FeCl_2-induced post-traumatic epilepsy onset in the rat显示文摘Studies have confirmed that iron induces epilepsy onset,and iron ion-induced epilepsy in animal models closely resembles the clinical situation.Models of post-traumatic epilepsy (PTE) were established by intracortical injection of FeCl2 using stereotactic techniques.Electron microscopy revealed neuronal degeneration,with shrinkage of the neuronal soma,hyperplasia of rough endoplasmic reticulum,ribosomal detachment from the endoplasmic reticulum,and vacuolar degeneration of glial cells in the right frontal lobe of FeCl2-induced PTE rats.With prolonged time,injuries became more severe and neuronal apoptosis was observed.Synapses in the hippocampal neuropil significantly increased (primarily type I/excitatory synapses) at day 14 following injury.Type II synapses (inhibitory synapse) were observed in the rat hippocampus at day 30.Cortical neuronal degeneration,apoptosis,glial cell proliferation,and ultrastructural hippocampal changes,in particular changes in type of neuronal synapse,play an important role in PTE onset. | Yuanxiang Lin Feng Wang Ruxiang Xu Xiaodan Jiang Dezhi Kang Yiquan Ke Mouxuan Du Lishuang Xu | 2010 | Neural Regeneration Research2010，5，18： | 0 |
| 3 | Transient axonal glycoprotein-1 induces apoptosisrelated gene expression without triggering apoptosis in U251 glioma cells显示文摘Previous studies show that transient axonal glycoprotein-1, a ligand of amyloid precursor protein, increases the secretion of amyloid precursor protein intracellular domain and is involved in apoptosis in Alzheimer's disease. In this study, we examined the effects of transient axonal glycoprotein-1 on U251 glioma cells. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay showed that transient axonal glycoprotein-1 did not inhibit the proliferation of U251 cells, but promoted cell viability. The terminal deoxynucleotidyl transferase dUTP nick end labeling assay showed that transient axonal glycoprotein-1 did not induce U251 cell apoptosis. Real-time PCR revealed that transient axonal glycoprotein-1 substantially upregulated levels of amyloid precursor protein intracellular C-terminal domain, and p53 and epidermal growth factor receptor mRNA expression. Thus, transient axonal glycoprotein-1 increased apoptosis-related gene expression in U251 cells without inducing apoptosis. Instead, transient axonal glycoprotein-1 promoted the proliferation of these glioma cells. | Haigang Chang Shanshan Song Zhongcan Chen Yaxiao Wang Lujun Yang Mouxuan Du Yiquan Ke Ruxiang Xu Baozhe Jin Xiaodan Jiang | 2014 | Neural Regeneration Research2014，9，5： | 0 |
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