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| 1 | Gastric cancer: Current status of lymph node dissection显示文摘D2 procedure has been accepted in Far East as the standard treatment for both early(EGC) and advanced gastric cancer(AGC) for many decades. Recently EGC has been successfully treated with endoscopy by endoscopic mucosal resection or endoscopic submucosal dissection, when restricted or extended Gotoda's criteria can be applied and D1+ surgery is offered only to patients not fitted for less invasive treatment. Furthermore, two randomised controlled trials(RCTs) have been demonstrating the non inferiority of minimally invasive technique as compared to standard open surgery for the treatment of early cases and recently the feasibility of adequate D1+ dissection has been demonstrated also for the robot assisted technique. In case of AGC the debate on the extent of nodal dissection has been open for many decades. While D2 gastrectomy was performed as the standard procedure in eastern countries, mostly based on observational and retrospective studies, in the west the Medical Research Council(MRC), Dutch and Italian RCTs have been conducted to show a survival benefit of D2 over D1 with evidence based medicine. Unfortunately both the MRC and the Dutch trials failed to show a survival benefit after the D2 procedure, mostly due to the significant increase of postoperative morbidity and mortality, which was referred to splenopancreatectomy. Only 15 years after the conclusion of its accrual, the Dutch trial could report a significant decrease of recur-rence after D2 procedure. Recently the long term survival analysis of the Italian RCT could demonstrate a benefit for patients with positive nodes treated with D2 gastrectomy without splenopancreatectomy. As nowadays also in western countries D2 procedure can be done safely with pancreas preserving technique and without preventive splenectomy, it has been suggested in several national guidelines as the recommended procedure for patients with AGC. | Maurizio Degiuli Giovanni De Manzoni Alberto Di Leo Domenico D'Ugo Erica Galasso Daniele Marrelli Roberto Petrioli Karol Polom Franco Roviello Francesco Santullo Mario Morino | 2016 | World Journal of Gastroenterology2016，22，10： | 29 |
| 2 | Spontaneous regression of hepatic inflammatory pseudotumor with primary biliary cirrhosis:Case report and literature review显示文摘肝的煽动性的假肿瘤(IPT ) 是煽动性的房间渗入的增殖的纤维组织描绘的稀罕良性的非肿瘤的损害。IPT 的准确病原学仍然保持不清楚。尽管有全身的煽动性的混乱的 IPT 的协会很好被建立了,有胆管炎的一种特殊关系是显然稀罕的。我们与主要胆汁性肝硬变(PBC ) 报导肝的 IPT 的自发的回归的一个案例。迄今为止,仅仅有 PBC 的 IPT 的二个案例被报导了。在我们的情况中,然而, IPT 在有效治疗导致的 PBC 的胆管炎的改进的功课期间发展了,不同于二个以前报导的案例。我们的案例显示 IPT 的发展也不联系到胆管炎或亢奋的 gamma-globulinemia 的活动,自从我们的案例被证实当胆汁的酶和免疫球蛋白比承认上的相应价值高得多时,没有 IPT 的放射线学的联盟者。我们有二个以前报导的案例的案例的比较建议与 PBC 发生的 IPT 不代表一样的疾病实体或是为 PBC 的一个旁观者。 | Hiroshi Koide Ken Sato Toshio Fukusato Kenji Kashiwabara Noriaki Sunaga Takafumi Tsuchiya Saeko Morino Naondo Sohara Satoru Kakizaki Hitoshi Takagi Masatomo Mori | 2006 | World Journal of Gastroenterology2006，12，10： | 12 |
| 3 | Conversion of laparoscopic colorectal resection for cancer: What is the impact on short-term outcomes and survival?显示文摘Laparoscopic resection for colon and rectal cancer is associated with quicker return of bowel function, reduced postoperative morbidity rates and shorter length of hospital stay compared to open surgery, with no differences in long-term survival. Conversion to open surgery is reported in up to 30% of patients enrolled in randomized control trials comparing open and laparoscopic colorectal resection for cancer. In this review, reasons for conversion are anatomical-related factors, disease-related-factors and surgeon-related factors. Body mass index, local tumour extension and co-morbidities are independent predictors of conversion. The current evidence has shown that patients with converted resection for colon cancer have similar outcomes compared to patients undergoing a laparoscopic completed or open resection. The few studies that have assessed the outcomes after conversion of laparoscopic rectal resection reported significantly higher rates of complications and longer length of hospital stay in converted patients compared to laparoscopically treated patients. No definitive conclusions can be drawn when converted and open rectal resections are compared. Early and pre-emptive conversion appears to have more favourable outcomes than reactive conversion; however, further large studies are needed to better define the optimal timing of conversion. With regard to long-term oncologic outcome, overall and disease-free survival in the case of conversion in laparoscopic colorectal cancer surgery seems to be worse than those achieved in patients in whom resection was successfully completed by laparoscopy. Although a worse long-term oncologic outcome has been suggested, it remains difficult to draw a proper conclusion due to the heterogeneity of the long-term outcomes as well as the inclusion of both colon and rectal cancer patients in most of the studies. Therefore, we discuss the currently available evidence of the impact of conversion in laparoscopic resection for colon and rectal cancer on both short-term outcomes and long-term survival. | Marco E Allaix Edgar JB Furnée Massimiliano Mistrangelo Alberto Arezzo Mario Morino | 2016 | World Journal of Gastroenterology2016，22，37： | 11 |
| 4 | Randomized clinical trial comparing survival after D1 or D2 gastrectomy for gastric cancer显示文摘 | M. Degiuli M. Sasako A. Ponti A. Vendrame M. Tomatis C. Mazza A. Borasi L. Capussotti G. Fronda M. Morino | 2014 | Br J Surg2014，，2： | 5 |
| 5 | Laparoscopy for rectal cancer reduces short-term mortality and morbidity: results of a systematic review and meta-analysis显示文摘 | Alberto Arezzo Roberto Passera Gitana Scozzari Mauro Verra Mario Morino | 2013 | Surgical Endoscopy2013，，5： | 4 |
| 6 | Gastroesophageal reflux disease and morbid obesity: To sleeve or not to sleeve?显示文摘Laparoscopic sleeve gastrectomy(LSG) has reached wide popularity during the last 15 years, due to the limited morbidity and mortality rates, and the very good weight loss results and effects on comorbid conditions. However, there are concerns regarding the effects of LSG on gastroesophageal reflux disease(GERD). The interpretation of the current evidence is challenged by the fact that the LSG technique is not standardized, and most studies investigate the presence of GERD by assessing symptoms and the use of acid reducing medications only. A few studies objectively investigated gastroesophageal function and the reflux profile by esophageal manometry and 24-h p H monitoring, reporting postoperative normalization of esophageal acid exposure in up to 85% of patients with preoperative GERD, and occurrence of de novo GERD in about 5% of cases. There is increasing evidence showing the key role of the surgical technique on the incidence of postoperative GERD. Main technical issues are a relative narrowing of the mid portion of the gastric sleeve, a redundant upper part of the sleeve(both depending on the angle under which the sleeve is stapled), and the presence of a hiatal hernia. Concomitant hiatal hernia repair is recommended. To date, either medical therapy with proton pump inhibitors or conversion of LSG to laparoscopic Rouxen-Y gastric bypass are the available options for the management of GERD after LSG. Recently, new minimally invasive approaches have been proposed in patients with GERD and hypotensive LES: the LINX? Reflux Management System procedure and the Stretta? procedure. Large studies are needed to assess the safety and long-term efficacy of these new approaches. In conclusion, the recent publication of p H monitoring data and the new insights in the association between sleeve morphology and GERD control have led to a wider acceptance of LSG as bariatric procedure also in obese patients with GERD, as recently stated in the 5^(th) International Consensus Conference on sleeve gastrectomy. | Fabrizio Rebecchi Marco E Allaix Marco G Patti Francisco Schlottmann Mario Morino | 2017 | World Journal of Gastroenterology2017，23，13： | 4 |
| 7 | Effect of chlorine dioxide on avian influenza A(H7N9)virus显示文摘Avian influenza remains a threat to human wellbeing.Hypochlorite derivatives are commonly used as disinfectants to prevent the spread of the disease.The World Health Organization(WHO)has listed chlorine dioxide(ClO_(2))as an A1‐level,safe,and efficient disinfectant.In this study,we tested the efficacy of ClO_(2),in aqueous solution and gas forms,against avian influenza A(H7N9)virus.The virus suspension was mixed with ClO_(2) aqueous solutions of various concentrations and for various time intervals.Aliquots of the mixture were then serially diluted,and the 50%tissue culture infective dose(TCID50)was measured with a hemagglutination test on MDCK cells.ClO_(2) gas produced from generators was introduced in a chamber containing the virus suspension in a Petri dish.The infective activity of the surviving virus was measured by the hemagglutination test.An aqueous solution of ClO_(2) at 126μg/mL for 15 s was effective given that no surviving virus was detected with the hemagglutination test.ClO_(2) gas at>5μL/L sustained for 1 h inactivated the virus effectively,while at 2.5μL/L for 1 h,it only partially inactivated the virus.ClO_(2) as gas or aqueous solution at a certain concentration is effective in inactivating the H7N9 virus,and can be applied for the decontamination and disinfection of environments. | Zhiping Sun Yun Qian Norio Ogata Xia Cai Wendong Han Youhua Xie Hirofumi Morino Koushirou Sogawa Takashi Shibata Di Qu | 2022 | Biosafety and Health2022，4，1： | 2 |
| 8 | Laparoscopic liver resection of benign liver tumors显示文摘 | B. Descottes D. Glineur F. Lachachi D. Valleix J. Paineau A. Hamy M. Morino H. Bismuth D. Castaing E. Savier P. Honore O. Detry M. Legrand J.S. Azagra M. Goergen M. Ceuterick J. Marescaux D. Mutter B. Hemptinne R. Troisi J. Weerts B. Dallemagne C. Jehaes | 2003 | Surgical Endoscopy2003，，4： | 2 |
| 9 | Efficacy of the over-the-scope clip (OTSC) for treatment of colorectal postsurgical leaks and fistulas显示文摘 | Alberto Arezzo Mauro Verra Rossella Reddavid Francesca Cravero Marco Augusto Bonino Mario Morino | 2012 | Surgical Endoscopy2012，，11： | 2 |
| 10 | Laparoscopic total mesorectal excision the Turin experience 显示文摘 | Morino M Giraudo G | 2005 | Recent Results Cancer Res2005，165，16： | 1 |
| 11 | Mechanical properties of steel fiber-reinforced,high-strength,lightweight concrete显示文摘 | Wei Sun Keiji Morino | 1997 | Cement and Concrete Composites1997，19，4： | 1 |
| 12 | Laparoscopic total mesorectal excision :a consecutive series of 100 patients显示文摘 | Morino M Parini U Giraudo G | 2003 | Ann Surg2003，237，3： | 1 |
| 13 | Hammerhead ribozyme specifically inhibits vascular endothelial growth factor gene expression in a human hepatocellular carcinoma cell line显示文摘 | Tokunage T Tsucheda T | 2000 | Int J Oncol2000，17，3： | 1 |
| 14 | Immunochemieal approach to characterize advanced glycation end products of the Mailand reaction: evidence for the presence of a common strueure显示文摘 | Horiuchi S Araki N Morino Y | 1991 | J Biol Chem1991，266，12： | 1 |
| 15 | Behavior of centrally loaded concrete-filled steel-tube short columns 显示文摘 | Sakino K Nakahara H Morino S Nishiyama I | 2004 | Journal of Structural Engineering2004，130，2： | 1 |
| 16 | Impact of final stent dimensions on long-term results following sirolimus-eluting stent implantation:serial intravascular ulteasond analysis from the SIRUS trial显示文摘 | Sonoda S Morino Y Ako J | 2004 | J Am Coll Cardiol2004，43，11： | 1 |
| 17 | Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents 显示文摘 | Morino K Petersen KF Dufour S | 2005 | J Clin Invest2005，115，： | 1 |
| 18 | Laparoscopic vs open hepatic resection: a comparative study显示文摘 | Morino M Morra I Rosso E | 2003 | Surg Endosc2003，17，12： | 1 |
| 19 | A novel thermoelectric cooling device using Peltier modules for inducing local hypothermia of the spinal cord:The effect of local electrically controlled cooling for the treatment of spinal cord injuries in conscious rats显示文摘 | Morizane K Ogate T Morino T | | 0，，3： | 1 |
| 20 | E.A.E.S. multicenter prospective randomized trial comparing two-stage vs single-stage management of patients with gallstone disease and ductal calculi显示文摘 | A. Cuschieri E. Lezoche M. Morino E. Croce A. Lacy J. Toouli A. Faggioni V. M. Ribeiro J. Jakimowicz J. Visa G. B. Hanna | 1999 | Surgical Endoscopy1999，，10： | 1 |
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