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| 1 | What is the quantitative risk of gastric cancer in the first-degree relatives of patients? A meta-analysis显示文摘AIM To quantify the risk of gastric cancer in first-degree relatives of patients with the cancer. METHODS A comprehensive literature search was performed. Case-control trials comparing the frequency of a positive family history of gastric cancer in patients with gastric cancer, vs non-gastric cancer controls were retrieved. Studies with missed or non-extractable data, studies in children, abstracts, and duplicate publications were excluded. A meta-analysis of pooled odd ratios was performed using Review Manager 5.0.25. We performed subgroup analysis on Asian studies and a sensitivity analysis based on the quality of the studies, type of the outcome, sample size, and whether studies considered only first-degree relatives. RESULTS Thirty-two relevant studies out of 612 potential abstracts(n = 80690 individuals) were included. 19.0% of the patients and 10.9% of the controls had at least one relative with gastric cancer(P < 0.00001). The pooled relative risk for the development of gastric cancer in association with a positive family history was 2.35(95%CI: 1.96-2.81). The Cochran Q test for heterogeneity was positive(P < 0.00001, I 2 = 92%). After excluding the three outlier studies with the highest relative risks, heterogeneity remained significant(P < 0.00001, I 2 = 90%). The result was not different among Asian studies as compared to others and remained robust in several sensitivity analyses. In the 26 studies which exclusively analysed the history of gastric cancer in first-degree relatives, the relative risk was 2.71(95%CI: 2.08-3.53; P < 0.00001). CONCLUSION Individuals with a first-degree relative affected with gastric cancer have a risk of about 2.5-fold for the development of gastric cancer. This could be due to genetic or environmental factors. Screening and preventive strategies should be developed for this highrisk population. | Mohammad Yaghoobi Julia McNabb-Baltar Raheleh Bijarchi Richard H Hunt | 2017 | World Journal of Gastroenterology2017，23，13： | 13 |
| 2 | Quantitative risk of positive family history in developing colorectal cancer: A meta-analysis显示文摘BACKGROUND Positive family history is a risk factor for development of colorectal cancer.Despite numerous studies on the topic,the absolute risk in patients with a positive family history remains unclear and therefore studies are lacking to validate non-invasive screening methods in individuals with positive family history.AIM To quantify the risk of colorectal cancer in individuals with a positive family history.METHODS A comprehensive electronic literature search was performed using PubMed from January 1955 until November 2017,EMBASE from 1947 until 2018,and Cochrane Library without date restrictions.Two independent reviewers conducted study selection,data extraction and quality assessment.A meta-analysis of Mantel-Haenzel relative risks was performed using the random effects model.Newcastle-Ottawa scale was used to score the quality of selected papers.Funnel plot and Egger’s regression test was performed to detect publication bias.Subgroup analysis was performed comparing Asian and non-Asian studies.Sensitivity analyses were performed to rule out the effect of the timing of the study,overall quality,the main outcome and the effect of each individual study in overall result.RESULTS Forty-six out of 3390 studies,including 906981 patients were included in the final analysis.41 of the included studies were case-control and 5 were cohort.A positive family history of colorectal cancer in first-degree relatives was associated with significantly increased risk of colorectal cancer with a relative risk of 1.87(95%CI:1.68-2.09;P<0.00001).Cochrane Q test was significant(P<0.00001,I2=90%).Egger’s regression test showed asymmetry in the funnel plot and therefore the Trim and Fill method was used which confirmed the validity of the results.There was no difference between Asian versus non-Asian studies.Results remained robust in sensitivity analyses.CONCLUSION Individuals with a positive family history of colorectal cancer are 1.87 times more likely to develop colorectal cancer.Screening guidelines should pay specific attention to individuals with positive family history and further studies need to be done on validating current screening methods or developing new modalities in this high-risk population. | Parsa Mehraban Far Abdulaziz Alshahrani Mohammad Yaghoobi | 2019 | World Journal of Gastroenterology2019，25，30： | 4 |
| 3 | Survey of tick species parasiting domestic ruminants in Ghaemshahr county,Mazandaran province,Iran显示文摘Objective:To determine the tick species parasitizing domestic ruminants in Ghaemshahr county in Mazandaran,a Caspian province in the north of Iran.Methods:About 361 sheep, 54 goats and 10 cattle of 18 herds in several villages in Ghaemshahr were inspected for tick infestation.Separated ticks were preserved in 70% alcohol and identified.Results:About 323 ticks(207 female,116 male) were collected,the occurrence of ticks on sheep,goats and cattle were 28.3% .22.2% and 20.0% respectively.The mean number of ticks on each animal was low (3-5 ticks per animal).Rhipicephalus sanguineus,Rhipicephalus bursa.Ixodes ricinus,Boophilus annulalus,Haemaphysalis punctata and Haemaphysalis numidiana were the tick species we found.Rhipicephalus sanguineus were the most abundant species in the study area.The largest number of ticks were generally present from April to July,mostly in animal ears and tails. Ixodes,Boophilus and Haemaphysalis occurred in mountainous areas of Ghaemshahr.whereas Rhipicephalus were present in both mountains and plains of the study area.Conclusions:The result of this study is a survey of tick species from domestic animals in Iran and implication of possible prevention measures for diseases transmitted by ticks. | Hosseini Vasoukolaei Nasibeh Telmadarraiy Zakkyeh Vatandoost Hassan Yaghoobi Ershadi Mohammad Reza Hosseini Vasoukolaei Morteza Oshaghi Mohammad Ali | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，10： | 2 |
| 4 | First molecular detection of Theileria ovis in Rhipicephalus sanguineus tick in Iran显示文摘Objective:To determine tick infestation of domestic ruminants and their infection to ovine theileriosis in northern Iran.Methods:About 425 domestic ruminants in Ghaemshahr city in northern Iran were inspected for tick infestations.Twenty tick specimens(13 females and 7 males) of Rhipicephalus sanguineus(R.sanguineus).the most common lick in the study area, were tested by PCR amplification against 18s rRNA genome of Theileria spp using specie specific primers and then the PCR products were sequenced for species identification In comparison with data base available in GenBank.Results:About 323 ticks were collected from 102 animals(88 sheep,12 goats and 2 cattle).The prevalence of ticks infesting animals was R.sanguineus(82.35%), Rhipieeplialus bursa(R.bursa)(0.3%),Ixodes ricinus(I.ricinus)(15.2%),Boophilus annulatus (B.annulalus)(1.2%).Haemaphxsalis punctata(H.punctata)(0.3%) and Haemaphysalis numidiana(H.numidianu)(0.6%).Eleven(55%) tick specimens were PCR positive against genome of Theileria ovis(T.avis).Sequence analysis of the PCR products confirmed presence of T. oris in one R.sanguinus.Conclusions:This is the first report of tick infection to T.oris in Iran. Due to dominant prevalence of R.sanguineus as well as its infection to T.oris,it is postulated this tick is the main vector of ovine theileriosis in northern Iran. | Telmadarraiy Zakkyeh Oshaghi Mohammad Ali Hosseini Vasoukolaei Nasibeh Yaghoobi Ershadi Mohammad Reza Babamahmoudi Farhang Mohtarami Fatemeh | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，1： | 2 |
| 5 | 内镜在炎症性肠病中的作用显示文摘克罗恩病(CD)和溃疡性结肠炎(UC)是炎症性肠病(IBD)两种最常见的类型。回结肠镜加活检被认为是IBD诊断的金标准。CD与UC的鉴别诊断是非常重要的,因为它们的治疗策略及预后是有所不同的。然而,约有15%的IBD患者由于未能明确诊断为CD或UC而错误地归入了不定型肠炎。内镜在IBD中的作用受到了越来越多的关注。例如,一些新的影像技术有助于CD与UC的内镜下鉴别诊断。内镜球囊扩张和内镜下支架放置已经CD狭窄治疗的重要组成部分。在CD患者的肛瘘检查中,内镜超声也被认为较磁共振更加准确。此外,色素内镜较普通白光肠镜能更早期发现不典型增生。因此,内镜已经成为IBD诊断、治疗以及并发症处理的基石。近年来,内镜在IBD中的作用不断提升,从小肠成像到内镜球囊扩张以及色素内镜对不典型增生的监测。本文我们讨论了内镜用于IBD诊断、治疗和并发症处理的最新证据。 | Shishira Bharadwaj Neeraj Narula Parul Tandon Mohammad Yaghoobi | 2018 | Gastroenterology Report2018，6，2： | 1 |
| 6 | Correlation between clinical severity score and the lower esophageal sphincter relaxation pressure in idiopathic achalasia显示文摘 | Mohammad Yaghoobi Javad Mikaeli Ghodratollah Montazeri Negin Nouri Masoud R Sohrabi Reza Malekzadeh | 2003 | The American Journal of Gastroenterology2003，，2： | 1 |
| 7 | Laparoscopic Heller’s Myotomy Versus Pneumatic Dilation In The Treatment of Idiopathic Achalasia: A Meta-Analysis of Randomized Controlled Trials显示文摘 | Mohammad Yaghoobi Serge Mayrand Myriam Martel Ira Roshan-Afshar Raheleh Bijarchi Alan Barkun | 2013 | Gastrointestinal Endoscopy2013，，： | 1 |
| 8 | A Population-Based Assessment of the Burden of Acute Pancreatitis in the United States显示文摘 | Julia McNabb-Baltar Praful Ravi Ghislaine Annie Isabwe Shadeah Laila Suleiman Mohammad Yaghoobi Quoc-Dien Trinh Peter A. Banks | 2014 | Pancreas2014，，5： | 1 |
| 9 | Human dental pulp stem cells express many pluripotency regulators and differentiate into neuronal cells显示文摘Stem cells were isolated from human dental pulp using an optimized method, in which pulp pieces were digested by enzymes and immobilized to enhance cell outgrowth. Stem cell marker expression was detected by reverse transcription-PCR (RT-PCR), and differentiation markers were detected by real-time quantitative RT-PCR and immunocytochemistry. Results showed that dental pulp stem cells actively expressed nanog, oct4, nucleostemin slain-1, jmjd1a, jmjd2c, and cyclin D1. When stem cells were induced to differentiate into neurons, nucleostemin, nanog, and cyclin D1 expres-sion significantly decreased, whereas expression of neuronal markers, such as microtubule asso-ciated protein-2 and neurofilament-heavy, significantly increased. These results suggested that stem cells exited a pluripotent state and entered a neuronal differentiation pathway. In addition, results demonstrated that human dental pulp serves as a reservoir of stem cells that express defined stem cell markers; these cells were easily isolated and were induced to differentiate towards a desired cell lineage. | Behnam Ebrahimi Mohammad Mehdi Yaghoobi Ali Mohammadi Kamal-abadi Maryam Raoofn | 2011 | Neural Regeneration Research2011，6，34： | 0 |
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