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| 1 | Systematic review of laparoscopic vs open surgery for colorectal cancer in elderly patients显示文摘AIM: To verify the safety and validity of laparoscopic surgery for the treatment of colorectal cancer in elderly patients.METHODS: A meta-analysis was performed of a systematic search of studies on an electronic database. Studies that compared laparoscopic colectomy(LAC) in elderly colorectal cancer patients with open colectomy(OC) were retrieved, and their short and long-term outcomes compared. Elderly people were defined as 65 years old or more. Inclusion criteria were set at: Resection of colorectal cancer, comparison between laparoscopic and OC and no significant difference in backgrounds between groups.RESULTS: Fifteen studies were identified for analysis. LAC was performed on 1436 patients, and OC performed on 1810 patients. In analyses of short-term outcomes, operation time for LAC was longer than for OC(mean difference = 34.4162, 95%CI: 17.8473-50.9851, P < 0.0001). The following clinical parameters were lower in LAC than in OC: Amount of estimated blood loss(mean difference =-93.3738, 95%CI:-132.3437 to-54.4039, P < 0.0001), overall morbidity(OR = 0.5427, 95%CI: 0.4425-0.6655, P < 0.0001), incisional surgical site infection(OR = 0.6262, 95%CI: 0.4310-0.9097, P = 0.0140), bowel obstruction and ileus(OR = 0.6248, 95%CI: 0.4519-0.8638, P = 0.0044) and cardiovascular complications(OR = 0.4767, 95%CI: 0.2805-0.8101, P = 0.0062). In analyses of long-term outcomes(median follow-up period: 36.4 mo in LAC, 34.3 mo in OC), there was no significant difference in overall survival(mean difference = 0.8321, 95%CI: 0.5331-1.2990, P = 0.4187) and disease specific survival(mean difference = 1.0254, 95%CI: 0.6707-1.5675, P = 0.9209). There was also no significant difference in the number of dissected lymph nodes(mean difference =-0.1360, 95%CI:-4.0553-3.7833, P = 0.9458).CONCLUSION: LAC in elderly colorectal cancer patients had benefits in short-term outcomes compared with OC except operation time. The long-term outcomes and oncological clearance of LAC were similar to that of OC. These results support the assertion that LAC is an effective procedure for elderly patients with colorectal cancer. | Shoichi Fujii Mitsuo Tsukamoto Yoshihisa Fukushima Ryu Shimada Koichi Okamoto Takeshi Tsuchiya Keijiro Nozawa Keiji Matsuda Yojiro Hashiguchi | 2016 | World Journal of Gastrointestinal Oncology2016，8，7： | 10 |
| 2 | Treatment with dimethyl fumarate ameliorates liver ischemia/reperfusion injury显示文摘AIM To investigate the hypothesis that treatment with dimethyl fumarate(D MF) mayame liorate liver ischemia/reperfusion injury(I/RI).METHODS Rats were divided into 3 groups: sham, control(CTL), and DMF. DMF(25 mg/kg, twice/d) was orally administered for 2 d before the procedure. The CTL and DMF rats were subjected to ischemia for 1 h and reperfusion for 2 h. The serum alanine aminotransferase(ALT) and malondialdehyde(MDA) levels, adenosine triphosphate(ATP), NO × metabolites, anti-oxidant enzyme expression level, antiinflammatory effect, and anti-apoptotic effect were determined.RESULTS Histological tissue damage was significantly reduced in the DMF group(Suzuki scores: sham: 0 ± 0; CTL: 9.3± 0.5; DMF: 2.5 ± 1.2; sham vs CTL, P < 0.0001; CTL vs DMF, P < 0.0001). This effect was associated with significantly lower serum ALT(DMF 5026 ± 2305 U/L vs CTL 10592 ± 1152 U/L, P = 0.04) and MDA(DMF 18.2 ± 1.4 μmol/L vs CTL 26.0 ± 1.0 μmol/L, P = 0.0009). DMF effectively improved the ATP content(DMF 20.3 ± 0.4 nmol/mg vs CTL 18.3 ± 0.6 nmol/mg, P = 0.02), myeloperoxidase activity(DMF 7.8 ± 0.4 m U/m L vs CTL 6.0 ± 0.5 m U/m L, P = 0.01) and level of endothelial nitric oxide synthase expression(DMF 0.38 ± 0.05-fold vs 0.17 ± 0.06-fold, P = 0.02). The higher expression levels of anti-oxidant enzymes(catalase and glutamatecysteine ligase modifier subunit and lower levels of key inflammatory mediators(nuclear factor-kappa B and cyclooxygenase-2 were confirmed in the DMF group.CONCLUSION DMF improved the liver function and the anti-oxidant and inflammation status following I/RI. Treatment with DMF could be a promising strategy in patients with liver I/RI. | Chie Takasu Nosratola D Vaziri Shiri Li Lourdes Robles Kelly Vo Mizuki Takasu Christine Pham Seyed H Farzaneh Mitsuo Shimada Michael J Stamos Hirohito Ichii | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 3 | Hepatocyte growth factor and transforming growth factor β1 contribute to regeneration of small-for-size liver graft immediately after transplantation显示文摘 | Mizuki Ninomiya Noboru Harada Satoko Shiotani Shoji Hiroshige Ryosuke Minagawa Yuji Soejima Taketoshi Suehiro Takashi Nishizaki Mitsuo Shimada Keizo Sugimachi | 2003 | Transplant International2003，，11： | 2 |
| 4 | Extended Indication for Living Donor Liver Transplantation in Patients With Hepatocellular Carcinoma显示文摘 | Yuji Soejima Akinobu Taketomi Tomoharu Yoshizumi Hideaki Uchiyama Shinich Aishima Takahiro Terashi Mitsuo Shimada Yoshihiko Maehara | 2007 | Transplantation2007，，7： | 2 |
| 5 | A Pancreaticoduodenectomy Risk Model Derived From 8575 Cases From a National Single-Race Population (Japanese) Using a Web-Based Data Entry System: The 30-Day and In-hospital Mortality Rates for Pancreaticoduodenectomy显示文摘 | Wataru Kimura Hiroaki Miyata Mitsukazu Gotoh Ichiro Hirai Akira Kenjo Yuko Kitagawa Mitsuo Shimada Hideo Baba Naohiro Tomita Tohru Nakagoe Kenichi Sugihara Masaki Mori | 2014 | Annals of Surgery2014，，4： | 2 |
| 6 | Isolation and characterization of the somatic embryogenesis receptor-like kinase gene homologue (CitSERK1) from Citrus unshiu Marc.显示文摘 | Takehiko Shimada Toshiro Hirabayashi Tomoko Endo Hiroshi Fujii Masayuki Kita Mitsuo Omura | 2004 | Scientia Horticulturae2004，，2： | 2 |
| 7 | Designing a proposal review process to facilitate interdisciplinary research 显示文摘 | Shimada K Mitsuo A Kazamaki T | 2007 | Research Evaluation2007，16，1： | 1 |
| 8 | Donor Risk in Adult-to-Adult Living Donor Liver Transplantation: Impact of Left Lobe Graft显示文摘 | Akinobu Taketomi Hiroto Kayashima Yuji Soejima Tomoharu Yoshizumi Hideaki Uchiyama Toru Ikegami Yoichi Yamashita Noboru Harada Mitsuo Shimada Yoshihiko Maehara | 2009 | Transplantation2009，，3： | 1 |
| 9 | The effects of the Kampo medicine (Japanese herbal medicine) “Daikenchuto” on the surgical inflammatory response following laparoscopic colorectal resection显示文摘 | Kozo Yoshikawa Mitsuo Shimada Masanori Nishioka Nobuhiro Kurita Takashi Iwata Shinya Morimoto Tomohiko Miyatani Masato Komatsu Hideya Kashihara Chie Mikami | 2012 | Surgery Today2012，，7： | 1 |
| 10 | Current concept of small-for-size grafts in living donor liver transplantation显示文摘 | Toru Ikegami Mitsuo Shimada Satoru Imura Yusuke Arakawa Akira Nii Yuji Morine Hirofumi Kanemura | 2008 | Surgery Today2008，，11： | 1 |
| 11 | Kampo Medicine “Dai-Kenchu-To” Prevents Bacterial Translocation in Rats显示文摘 | Kozo Yoshikawa Nobuhiro Kurita Jun Higashijima Tomohiko Miyatani Hidenori Miyamoto Masanori Nishioka Mitsuo Shimada | 2008 | Digestive Diseases and Sciences2008，，7： | 1 |
| 12 | Total Gastrectomy Risk Model: Data From 20,011 Japanese Patients in a Nationwide Internet-Based Database显示文摘 | Masayuki Watanabe Hiroaki Miyata Mitsukazu Gotoh Hideo Baba Wataru Kimura Naohiro Tomita Tohru Nakagoe Mitsuo Shimada Yuko Kitagawa Kenichi Sugihara Masaki Mori | 2014 | Annals of Surgery2014，，6： | 1 |
| 13 | Significance of Hyaluronic Acid for Evaluation of Hepatic Endothelial Cell Damage after Cold Preservation/Reperfusion显示文摘 | Hidetoshi Itasaka Taketoshi Suehiro Shigeki Wakiyama Katsuhiko Yanaga Mitsuo Shimada Keizo Sugimachi | 1995 | Journal of Surgical Research1995，，5： | 1 |
| 14 | Rare occurrence of colorectal cancer metastasis in livers infected with Hepatitis B or C virus显示文摘 | Tohru Utsunomiya Hideki Saitsu Motonori Saku Kohji Yoshida Takashi Matsumata Mitsuo Shimada Keizo Sugimachi | 1999 | The American Journal of Surgery1999，，4： | 1 |
| 15 | Cytokine Characteristics of Jaundice in Mouse Liver 显示文摘 | Yuh Fujiwara Mitsuo Shimada Yoichi Yamashita | 2001 | CYTOKINE2001，13，3： | 1 |
| 16 | Strategies for improving the outcomes of small-for-size grafts in adult-to-adult living-donor liver transplantation显示文摘 | Satoru Imura Mitsuo Shimada Toru Ikegami Yuji Morine Hirofumi Kanemura | 2008 | Journal of Hepato - Biliary - Pancreatic Surgery2008，，2： | 1 |
| 17 | microRNA expression is able to predict response to chemoradiotherapyin rectal cancer显示文摘 | Masanori Hotchi Mitsuo Shimada Nobuhiro Kurita Takashi Iwata Hirohiko Sato Shinya Morimoto Kozo Yoshikawa Jun Higashijima Tomohiko Miyatani | 2013 | Molecular and Clinical Oncology2013，，： | 1 |
| 18 | Decreased expression of an ATP-binding cassette transporter, MRP2, in human livers with hepatitis C virus infection显示文摘 | Eiji Hinoshita Ken-ichi Taguchi Akihiko Inokuchi Takeshi Uchiumi Naoko Kinukawa Mitsuo Shimada Masazumi Tsuneyoshi Keizo Sugimachi Michihiko Kuwano | 2001 | Journal of Hepatology2001，，6： | 1 |
| 19 | Ectopic Expression of an FT Homolog from Citrus Confers an Early Flowering Phenotype on Trifoliate Orange (Poncirus trifoliata L. Raf.)显示文摘 | Tomoko Endo Takehiko Shimada Hiroshi Fujii Yasushi Kobayashi Takashi Araki Mitsuo Omura | 2005 | Transgenic Research2005，，5： | 1 |
| 20 | Real-time elastography for noninvasive diagnosis of liver fibrosis显示文摘 | Mami Kanamoto Mitsuo Shimada Toru Ikegami | 2009 | Hepatobiliary Panereat Surg2009，16，4： | 1 |
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