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4篇 您的检索式：作者名="Michael Peabody"

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		题名	作者	年代	出处	被引量
	1	Bone Morphogenetic Protein (BMP) signaling in development and human diseases显示文摘Bone Morphogenetic Proteins(BMPs)are a group of signaling molecules that belongs to the Transforming Growth Factor-b(TGF-b)superfamily of proteins.Initially discovered for their ability to induce bone formation,BMPs are now known to play crucial roles in all organ systems.BMPs are important in embryogenesis and development,and also in maintenance of adult tissue homeostasis.Mouse knockout models of various components of the BMP signaling pathway result in embryonic lethality or marked defects,highlighting the essential functions of BMPs.In this review,we first outline the basic aspects of BMP signaling and then focus on genetically manipulated mouse knockout models that have helped elucidate the role of BMPs in development.A significant portion of this review is devoted to the prominent human pathologies associated with dysregulated BMP signaling.	Richard N.Wang Jordan Green Zhongliang Wang Youlin Deng Min Qiao Michael Peabody Qian Zhang Jixing Ye Zhengjian Yan Sahitya Denduluri Olumuyiwa Idowu Melissa Li Christine Shen Alan Hu Rex C.Haydon Richard Kang James Mok Michael J.Lee Hue L.Luu Lewis L.Shi	2014	Genes & Diseases2014，1，1：	47
	2	Vattikuti Institute Prostatectomy: Contemporary Technique and Analysis of Results显示文摘	Mani Menon Alok Shrivastava Sanjeev Kaul Ketan K. Badani Michael Fumo Mahendra Bhandari James O. Peabody	2006	European Urology2006，，3：	2
	3	CRISPR clear? Dimeric Cas9-Fok1 nucleases improve genome-editing specificity显示文摘Bacteria and archaea have been known for decades having evolved adaptive immunedefenses called clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPRassociated(Cas)systems to degrade foreign nucleic acids.Recently,these RNA-guided Cas9 nucleases derived from CRISPR/Cas systems have shown promise in transforming our ability to edit mammalian genomes.1 While zinc-finger nucleases(ZFNs)and transcription activator-like effector nucleases(TALENs)have shown similar promise,the ease of producing targeting RNAs over the generation of unique sequence-directed nucleases to guide site-specific modifications makes the CRISPR/Cas9 system an appealing method forgenome editing.A short guideRNA(sgRNA)can direct Cas9 to a specific genomic sequence where it induces doublestrand breaks that,when imperfectly repaired,yield mutations.1 Cas9 can also catalyze gene replacement through homologous recombination.	Hongmei Zhang Zhengjian Yan Melissa Li Michael Peabody Tong-Chuan He	2014	Genes & Diseases2014，1，1：	1
	4	Marital status: a gender‐independent risk factor for poorer survival after radical cystectomy显示文摘	Jesse D. Sammon Monica Morgan Orchidee Djahangirian Quoc‐Dien Trinh Maxine Sun Khurshid R. Ghani Wooju Jeong Jay Jhaveri Michael Ehlert Jan Schmitges Marco Bianchi Shahrokh F. Shariat Paul Perrotte Craig G. Rogers James O. Peabody Mani Menon Pierre I. Kar	2012	BJU International2012，，：	1

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