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| 1 | 腹膜透析和血液透析对尿毒症合并高尿酸血症患者微炎症及痛风发作的影响显示文摘目的研究腹膜透析和血液透析对尿毒症合并高尿酸血症患者微炎症及痛风发作的影响。方法选取湖北医药学院附属随州医院收治的尿毒症合并高尿酸血症患者98例,其中接受血液透析51例(HD组),接受腹膜透析47例(PD组),随访6个月,根据患者是否有痛风性关节炎急性发作分为发作组(A组)和未发作组(NA组),按照其发生次数分为0次、1或2次、3或4次、≥5次4个等级,分别比较HD组与PD组、A组与NA组微炎症因子水平,并比较HD组和PD组患者急性痛风性关节炎急性发作例数的差异。结果PD组体内微炎症因子水平低于HD组患者体内微炎症水平(P<0.05);A组患者体内微炎症因子平均水平较NA组患者高(P<0.05);PD组痛风性关节炎急性发作例数低于HD组(P<0.05)。结论腹膜透析相较血液透析可降低尿毒症合并高尿酸血症患者痛风急性发作的风险,其可能机制为腹膜透析患者体内微炎症水平远低于血液透析患者。 | 邱紫菡 蒋欣辰 Deepak Bhandari 吴屹哲 华杜鹃 高武 黄金平 | 2020 | 中国现代医学杂志2020，30，5： | 19 |
| 2 | Intra-abdominal pressure:Time ripe to revise managementguidelines of acute pancreatitis?显示文摘AIM: To systematically review evidence on pathophysiology of intra-abdominal pressure(IAP) in acute pancreatitis(AP) with its clinical correlates. METHODS: Systematic review of available evidence in English literature with relevant medical subject heading terms on Pub Med, Medline and Scopus with further search from open access sources on internet as suggested by articles retrieved. RESULTS: Intra-abdominal hypertension(IAH) is increasingly gaining recognition as a point of specific intervention with potential to alter disease outcome and improve mortality in AP. IAH can be expected in at least 17% of patients presenting with diagnosis of AP to a typical tertiary care hospital(prevalence increasing to 50% in those with severe disease). Abdominal compartment syndrome can be expected in at least 15% patients with severe disease. Recent guidelines on management of AP do not acknowledge utility of surveillance for IAP other than those by Japanese Society of Hepato-BiliaryPancreatic Surgery. We further outline pathophysiologic mechanisms of IAH; understanding of which advances our knowledge and helps to coherently align common observed variations in management related conundrums(such as fluid therapy, nutrition and antibiotic prophylaxis) with potential to further individualize treatment in AP. CONCLUSION: We suggest that IAP be given its due place in future practice guidelines and that recommendations be formed with help of a broader panel with inclusion of clinicians experienced in management of IAH. | jiten jaipuria vimal bhandari avneet singh chawla mohit singh | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 14 |
| 3 | 全膝关节置换后感染的随访分析显示文摘背景:人工关节置换后感染是人工关节置换最严重的并发症之一,但有关感染发生相关危险因素的研究报道较少。目的:分析影响全膝关节置换后感染的危险因素。方法:对122例全膝关节置换后感染发生情况进行分析。其中男25例,女97例,平均年龄63.1岁(27~82岁),平均随访3.6年。采用Logistic多因素回归分析方法对性别、年龄、肥胖程度、关节原发病(是否为免疫相关性疾病)、糖尿病/高血压、肿瘤、关节内注射类固醇类消炎药史、假体类型、术中失血量、手术持续时间、术后伤口引流量、术后发热(>38℃)持续时间、术后1d血色素13项临床因素与全膝关节置换后感染的相关性进行分析。结果与结论:置换后发生感染9例,发生率为7.4%。Logistic多因素回归分析表明,与感染相关的因素中手术持续时间长、术后伤口引流量多及术后发热持续状态长者,置换后发生感染的风险分别增加到5.823,10.561,7.757倍(P<0.05)。提示手术持续时间、术后伤口引流量及术后发热持续状态是预测全膝关节置换后感染发生的危险因素。 | 许杰 马若凡 丁悦 Prakash-Raj Bhandari 李卫平 杨睿 | 2011 | 中国组织工程研究与临床康复2011，15，13： | 14 |
| 4 | 移位跟骨骨折——不良结果的预后因素显示文摘关于移位跟骨骨折的治疗方法的争论使许多文献问世,在争论中,少数的研究报告了患者及创伤的类型与治疗结果间的关系。那些报告中的与治疗结果不良的有关因素包括工伤赔偿情况、Bhler角小于0°的骨折、男性患者、重体力劳动职业、双侧跟骨骨折及SandersⅣ型骨折。 | Beate P.Hanson Mohit Bhandari 陈滨 姜小惟 | 2005 | 中华创伤骨科杂志2005，7，11： | 12 |
| 5 | Antagonism of Transcription Factor MYC2 by EDS1/PAD4 Complexes Bolsters Salicylic Acid Defense in Arabidopsis Effector-Triggered Immunity显示文摘在植物免疫,激活病原体的细胞内部的核苷酸绑定 / 白氨酸富人重复(NLR ) 受体动员疾病抵抗小径,但是下游的发信号机制仍然保持阴暗。(EDS1 ) 提高的疾病危险性 1 在 Toll-Interleukin1-Receptor 触发的抵抗控制 transcriptional reprogramming 域(TIR ) 家庭 NLR (TNL ) 。水杨酸酸(SA ) 的 Transcriptional 正式就职荷尔蒙防卫部门对 biotrophic 病原体提供一个关键障碍。这里,我们现在的基因、分子的证据在 Arabidopsis ? 有它的搭挡 PAD4 的 EDS1 建筑群 ? 禁止 MYC2,反对 SA jasmonic 酸(JA ) 的一个主人管理者荷尔蒙小径。在 TNL 有免疫力的反应,有 MYC2 的 EDS1/PAD4 干扰独立于导致 EDS1 的 SA 合成增加 SA 防卫部门,有效地从而堵住一个有势力的行动细菌的 JA 模仿, coronatine (英国管) 。我们证明在英国管在 nucle 剔 ? 畦据楴湯椠 ? 牁 'L 摩灯楳? 晡敦瑣 ? 桴 ? 硥牰獥楳湯漠 ? 内被察觉到以后, MYC2 的那对抗发生 ? 楬業整 ? ?獢瑥漠 ? 敧敮 ? 潣瑮潲汬摥戠 ? 剐至 ? 佐奌佃 ? 删偅 ? 卓噉? 佃偍 ???? 湩汣摵湩 ? 桴 ? 汦睯牥湩 ? 楴敭爠来汵瑡牯吗?? | Haitao Cui Jingde Qiu Yue Zhou Deepak D. Bhandari Chunhui Zhao Jaqueline Bautor Jane E. Parker | 2018 | Molecular Plant2018，11，8： | 10 |
| 6 | 英国胃肠病学会关于胃癌风险患者的诊断和管理指南显示文摘胃癌预后较差,部分原因在于诊断较晚。胃癌的危险因素包括幽门螺杆菌(H.pylori,HP)感染和胃癌家族史,尤其是遗传性弥漫性胃癌和恶性贫血。胃癌发展的阶段包括慢性胃炎、胃黏膜萎缩(GA)、胃黏膜肠化生(GIM)和异型增生。胃癌早期发现和提高生存率的关键是在内镜检查前以非侵入性方式识别高危人群。然而,尽管生物标志物可能有助于检测慢性萎缩性胃炎,但尚无足够的证据支持其用于人群筛查。高质量内镜检查是胃癌早期发现的重要组成部分,图像增强内镜结合组织病理学活检是GA和GIM最佳的诊断方法,并能准确进行风险分层。按照悉尼标准从胃窦、角切迹、小弯和大弯进行活检,既能明确诊断,也能对胃癌进行风险分层。理想状态应当是在高质量内镜检查中对GA或GIM区域活检。英国属于低危地区,可根据需要接受常规诊断性胃镜检查,但没有足够证据支持筛查,对于广泛GA或GIM的患者,每3年检查内镜。对于胃异型增生和早期癌,只要满足标准,内镜下黏膜切除术或内镜黏膜下剥离术的治疗有效,成功率高,复发率低。 | Matthew Banks David Graham Marnix Jansen TakujiGotoda Sergio Coda Massimiliano di Pietro NoriyaUedo Pradeep Bhandari D Mark Pritchard Ernst J Kuipers Manuel Rodriguez-Justo Marco R Novelli KrishRagunath Neil Shepherd Mario Dinis-Ribeiro 乌雅罕(译) 张冬雪(译) 牛占岳(校) 刘鑫(校) 丁士刚(译/校) | 2020 | 中华胃肠内镜电子杂志2020，7，2： | 10 |
| 7 | Acrosome reaction: relevance of zona pellucida glycoproteins显示文摘在哺乳动物的使肥沃期间,包围卵母细胞的带 pellucida (ZP ) 矩阵在 ZP 固定的精子为到 acrosome 反应(AR ) 的卵母细胞和正式就职的精子的绑定负责。AR 为由精子的 ZP 矩阵的穿入是关键的。在老鼠的 ZP 矩阵由三 glycoproteins 组成,在人指明了 ZP1, ZP2 和 ZP3,它由四组成(ZP1, ZP2, ZP3 和 ZP4 ) 。ZP3 充当通常认为的主要精子受体并且,在人为在老鼠感应的 AR 负责(除了 ZP3 ) , ZP1 和 ZP4 也导致 AR。ZP3 的能力居住在它的 C 终端碎片导致 AR。连接 O 的 glycans 为鼠科的调停 ZP3 的 AR 是批评的。然而,人的 ZP1, ZP3 和 ZP4 的连接 N 的 glycans 在 AR 的正式就职有重要角色。有药理学禁止者的研究证明导致 ZP3 的 AR 包含官方补给夫妇的受体小径的激活,而调停 ZP1 、调停 ZP4 的艺术独立于这条小径。导致 ZP3 的 AR 包含 T 类型操作电压的钙隧道(VOCC ) 的激活,而导致 ZP1 、导致 ZP4 的艺术包含 T 类型和 L 类型 VOCC。断定在鼠标,, ZP3 为到 ZP 矩阵和 AR 的正式就职的使能够的精子的绑定主要负责在人(除了 ZP3 ) , ZP1 和 ZP4 也参予使肥沃的这些阶段。 | Satish K Gupta Beena Bhandari | 2011 | Asian Journal of Andrology2011，13，1： | 9 |
| 8 | 基于ABAQUS的带帽桩复合地基初始地应力平衡方法浅析显示文摘为探究ABAQUS中何种地应力平衡方法在模拟带帽桩复合地基承载性状中的平衡效果更为理想及其适用性。本研究以带帽管桩复合地基模型为例,利用ABAQUS数值建模进行初始地应力平衡效果精准度问题研究,详细阐述了ABAQUS中5种初始地应力平衡方法的应用,并针对自动平衡方法、关键字定义初始地应力法和ODB导入法的平衡效果进行对比分析,得出自动平衡法的平衡效果最佳,为此模型首选地应力平衡方法;关键字定义初始地应力法的平衡效果较理想,但需满足一定的条件方可适用;ODB导入法平衡效果不是很理想,需要反复导入,才可以达到满意结果。该3种方法模拟地应力平衡效果研究为其他类似模型提供了积极的指导作用和参考价值。 | 杨金尤 雷金波 邹永强 李壮状 万梦华 乐腾胜 Pratik Kumar Bhandari | 2017 | 南昌航空大学学报(自然科学版)2017，31，4： | 7 |
| 9 | 如何设计高质量针刺临床研究:基于证据的专家共识显示文摘本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究小组联合制订。该共识将有助于临床试验资助者、注册者以及期刊编辑等评估针刺RCT方案及研究结果的相关性、重要性和质量。 | 张誉清 焦睿珉 Claudia M Witt 劳力行 刘建平 Lehana Thabane Karen J Sherman Mike Cummings Dawn P Richards Eun-Kyung Anna Kim Tae-Hun Kim Myeong Soo Lee Michael E Wechsler Benno Brinkhaus Jun J Mao Caroline A Smith 岗卫娟 刘保延 刘志顺 刘岩 郑晖 吴佳霓 AloBSO Carrasco-Labra Mohit Bhandari Philip J Devereaux 景向红 Gordon Guyatt | 2022 | 英国医学杂志中文版2022，25，6： | 7 |
| 10 | A study of local amplification effect of soil layers on ground motion in the Kathmandu Valley using microtremor analysis显示文摘Past researchers have anticipated the occurrence of a great earthquake in the central Himalayas in the near future.This may cause serious damage in the Kathmandu Valley,which sits on an ancient lake bed zone,with lacustrine sediments of more than 500 m depth.In this study,the predominant frequency of ground motion is evaluated using the Horizontal-to-Vertical(H/V) spectral ratio technique and recordings of ambient noise.The results of the H/V ratio show two peaks in about 20 percent of the locations,which are distributed mainly in and around the center and northern part of the Kathmandu Valley.The predominant frequencies vary from 0.5 Hz to 8.9 Hz in the study area,whereas the second resonance frequency varies from 4 Hz to 6 Hz in the center and northern part of the valley.This indicates that the center and northern part of the valley have a wide range of resonance frequency due to two levels of impedance contrast one may be from the surface layer and the other may be from the layer underneath.These two levels of resonance indicate the importance of considering the effects of surface and lower layers during the planning and designing of infrastructures in the Kathmandu Valley. | Paudyal Y.R. Yatabe R. Bhandary N.P. Dahal R.K. | 2012 | Earthquake Engineering and Engineering Vibration2012，11，2： | 7 |
| 11 | Radiofrequency ablation for early oesophageal squamous neoplasia:Outcomes form United Kingdom registry显示文摘AIM:To report outcomes on patients undergoing radiofrequency ablation(RFA)for early oesophageal squamous neoplasia from a National Registry.METHODS:A Prospective cohort study from 8 tertiary referral centres in the United Kingdom.Patients with squamous high grade dysplasia(HGD)and early squamous cell carcinoma(ESCC)confined to the mucosa were treated.Visible lesions were removed by endoscopic mucosal resection(EMR)before RFA.Following initial RFA treatment,patients were followed up 3monthly.Residual flat dysplasia was treated with RFA until complete reversal dysplasia(CR-D)was achieved or progression to invasive Squamous cell cancer defined as infiltration into the submucosa layer or beyond.The main outcome measures were CR-D at 12 mo from start of treatment,long term durability,progression to cancer and adverse events.RESULTS:Twenty patients with squamous HGD/ESCC completed treatment protocol.Five patients(25%)had EMR before starting RFA treatment.CR-D was 50%at12 mo with a median of 1 RFA treatment,mean 1.5(range 1-3).Two further patients achieved CR-D with repeat RFA after this time.Eighty per cent with CR-D remain dysplasia free at latest biopsy,with median follow up 24 mo(IQR 17-54).Six of 20 patients(30%)progressed to invasive cancer at 1 year.Four patients(20%)required endoscopic dilatations for symptomatic structuring after treatment.Two of these patients have required serial dilatations thereafter for symptomatic dysphagia with a median of 4 dilatations per patient.The other 2 patients required only a single dilatation to achieve an adequate symptomatic response.One patient developed cancer during follow up after end of treatment protocol.CONCLUSION:The role of RFA in these patients re-mains unclear.In our series 50%patients responded at12 mo.These figures are lower than limited published data. | Rehan J Haidry Mohammed A Butt Jason Dunn Matthew Banks Abhinav Gupta Howard Smart Pradeep Bhandari Lesley Ann Smith Robert Willert Grant Fullarton Morris John Massimo Di Pietro Ian Penman Marco Novelli Laurence B Lovat | 2013 | World Journal of Gastroenterology2013，19，36： | 7 |
| 12 | 髋关节置换后双下肢不等长对功能影响的Meta分析显示文摘背景:髋关节置换后肢体不等长对功能的影响仍存在不同观点,近年已有一些学者进行了置换后肢体不等长对功能影响的随机对照研究,对这些随机对照研究进行系统评价能更客观地反映情况,为临床工作所借鉴。目的:系统评价全髋关节置换后肢体不等长对功能的影响。方法:计算机检索Cochrane图书馆、Cochrane协作网专业试验数据库、MEDLINE(1950/2010-09),EMBASE(1979/2010-09)、中国生物医学文献数据库(1978/2010-09),手工检索中文文献(截至2010-09),收集所有髋关节置换后双下肢不等长对功能影响的所有随机对照试验或临床对照试验,对其逐个进行方法学质量评价并采用RevMan5软件进行系统评价。结果与结论:共纳入6篇临床对照试验,包括1304例患者。其中4篇数据完善,可满足就置换后肢体等长组与非等长组关节功能差异进行Meta分析。结果提示,置换后肢体不等长可影响关节的功能,平衡双下长度,对于减轻跛行步态,提高关节功能有一定临床意义。随时间推移,肢体不等长者的功能障碍有所改善,但与等长者仍存差异。置换后肢体不等长与并发症的发生,诸如脱位、神经损伤、磨损、松动等,由于纳入研究及病例数太少,尚需更多设计严格的研究以增加证据的强度。 | 许杰 梁国彦 Prakash-Raj Bhandari 马若凡 | 2011 | 中国组织工程研究与临床康复2011，15，9： | 6 |
| 13 | 髋部骨折——经皮加压钢板固定与髋螺钉固定的探讨显示文摘研究表明,经皮加压钢板固定(PCCP)和髋螺钉固定(HS)在治疗髋部骨折相比较的结果各式各样。研究结果推荐PCCP,因为它需求的平均输血量较低,术后疼痛较轻。PCCP和HS两种治疗方法的置入失败率都很低。然而,置入失败和二次手术在PCCP组可能更为常见。额外的随机对照实验可以被用来检验这些结果。 | Beate P.Hanson Mohit Bhandari 陈滨(译校) 姜小惟(译校) | 2005 | 中华创伤骨科杂志2005，7，10： | 6 |
| 14 | GIS-based Frequency Ratio and Logistic Regression Modelling for Landslide Susceptibility Mapping of Debre Sina Area in Central Ethiopia显示文摘Ethiopia has a mountainous landscape which can be divided into the Northwestern and Southeastern plateaus by the Main Ethiopian Rift and Afar Depression. Debre Sina area is located in Central Ethiopia along the escarpment where landslide problem is frequent due to steep slope, complex geology, rift tectonics, heavy rainfall and seismicity. In order to tackle this problem, preparing a landslide susceptibility map is very important. For this, GISbased frequency ratio(FR) and logistic regression(LR) models have been applied using landslide inventory and the nine landslide factors(i.e. lithology, land use, distance from river & fault, slope, aspect, elevation, curvature and annual rainfall). Database construction, weighting each factor classes or factors, preparing susceptibility map and validation were the major steps to be undertaken. Both models require a rasterized landslide inventory and landslide factor maps. The former was classified into training and validation landslides. Using FR model, weights for each factor classes were calculated and assigned so that all the weighted factor maps can be added to produce a landslide susceptibility map. In the case of LR model, the entire study area is firstly divided into landslide and non-landslide areas using the training landslides. Then, these areas are changed into landslide and non-landslide points so as to extract the FR maps of the nine landslide factors. Then a linear relationship is established between training landslides and landslide factors in SPSS. Based on this relationship, the final landslide susceptibility map is prepared using LR equation. The success-rate and prediction-rate of FR model were 74.8% and 73.5%, while in case of LR model these were 75.7% and 74.5% respectively. A close similarity in the prediction and validation rates showed that the model is acceptable. Accuracy of LR model is slightly better in predicting the landslide susceptibility of the area compared to FR model. | Matebie METEN Netra Prakash BHANDARY Ryuichi YATABE | 2015 | Journal of Mountain Science2015，12，6： | 6 |
| 15 | 不同类型多囊卵巢综合征患者行体外受精-胚胎移植的妊娠结局分析显示文摘目的:对不同类型多囊卵巢综合征(PCOS)患者行体外受精-胚胎移植(IVF-ET)的妊娠结局进行分析,以了解其相互关系,并对PCOS不孕患者进行IVF-ET前的治疗提供参考和依据。方法:对2000年1月至2009年2月在中山大学附属第一医院生殖医学中心进行首个IVF-ET周期的无排卵或稀发排卵PCOS患者共576例进行回顾性分析。按患者进入周期前的临床特征分为4个组别。高雄激素组(高T组):高T的临床和(或)生化表现+双侧卵巢PCO样+稀发或无排卵,共85例;高黄体生成激素组(高LH组):LH/FSH>2+双侧卵巢PCO样+稀发或无排卵,共105例;高T+高LH组:高T的临床和(或)生化表现+LH/FSH>2+双侧卵巢PCO样+稀发或无排卵,共70例;对照组:仅符合双侧卵巢PCO样+稀发或无排卵,共316例。对4组患者的基本资料、IVF-ET周期的卵子和胚胎情况及妊娠结局进行回顾性比较。结果:4组患者的年龄、体重指数、不孕年限比较,差异无统计学意义(P>0.05);IVF周期中的获卵数、受精率、卵裂胚胎数和种植率比较,差异也无统计学意义(P>0.05);临床妊娠率对照组高于其他3组(P<0.05);早期流产率在4组中比较,差异无统计学意义(P>0.05);继续妊娠率对照组高于高T组和高T+高LH组(P<0.05),而高LH组与其他各组比较,差异无统计学意义(P>0.05)。结论:在接受IVF-ET的不同类型无排卵或稀发排卵的PCOS患者中,不合并高T和(或)高LH的患者妊娠结局最佳,高LH血症和高T均对妊娠结局产生不利影响。对PCOS不孕患者行IVF-ET前内分泌紊乱的正确评估及积极纠正可能有利于改善其妊娠结局。 | 罗璐 刘娟 李洁明 郑清泉 Sunita Bhandari 王琼 | 2010 | 实用妇产科杂志2010，26，10： | 6 |
| 16 | Operative vs non-operative management of displaced proximal humeral fractures in the elderly: A systematic review and meta-analysis of randomized controlled trials显示文摘AIM: To perform a systematic review and meta-analysis comparing operative vs non-operative treatment of displaced proximal humerus fractures in elderly patients.METHODS: A systematic literature search was performed using EMBASE and MEDLINE through the OVID interface,CINAHL,the Cochrane Central Register of Controlled Trials(CENTRAL),Proquest,Web of Science,SAE digital library,and Transportation Research Board's TRID database.Searches of conference proceedings were also conducted.All available randomized controlled trials comparing operative vs non-operative management of displaced three- and four-part proximal humerus fractures in elderly patients were included.The primary outcomes measures included physical function,pain,health related quality of life,mortality,and the re-operation rate.RESULTS: Six randomized controlled trials(n = 287) were included.There was no statistically significant difference in function(MD = 1.72,95%CI:-2.90-6.34,P = 0.47),as measured by the Constant score,between the operative and the non-operative treatment groups.There was no statistically significance difference insecondary outcomes of health related quality of life(standardized MD = 0.27,95%CI:-0.05-0.59,P = 0.09),and mortality(relative risk 1.29,95%CI: 0.50-3.35,P = 0.60).Operative treatment had a statistically significant higher re-operation rate(relative risk 4.09,95%CI: 1.50-11.15,P = 0.006),and statistically significant decreased pain(MD = 1.26,95%CI: 0.02-2.49,P = 0.05).CONCLUSION: There is moderate quality evidence to suggest that there is no difference in functional outcomes between the two treatments.Further high quality randomized controlled trials are required to determine if certain subgroup populations benefit from surgical management. | Santa Rabi Nathan Evaniew Sheila A Sprague Mohit Bhandari Gerard P Slobogean | 2015 | World Journal of Orthopedics2015，6，10： | 5 |
| 17 | A Local Contrast Fusion Based 3D Otsu Algorithm for Multilevel Image Segmentation显示文摘To overcome the shortcomings of 1 D and 2 D Otsu’s thresholding techniques, the 3 D Otsu method has been developed.Among all Otsu’s methods, 3 D Otsu technique provides the best threshold values for the multi-level thresholding processes. In this paper, to improve the quality of segmented images, a simple and effective multilevel thresholding method is introduced. The proposed approach focuses on preserving edge detail by computing the 3 D Otsu along the fusion phenomena. The advantages of the presented scheme include higher quality outcomes, better preservation of tiny details and boundaries and reduced execution time with rising threshold levels. The fusion approach depends upon the differences between pixel intensity values within a small local space of an image;it aims to improve localized information after the thresholding process. The fusion of images based on local contrast can improve image segmentation performance by minimizing the loss of local contrast, loss of details and gray-level distributions. Results show that the proposed method yields more promising segmentation results when compared to conventional1 D Otsu, 2 D Otsu and 3 D Otsu methods, as evident from the objective and subjective evaluations. | Ashish Kumar Bhandari Arunangshu Ghosh Immadisetty Vinod Kumar | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，1： | 5 |
| 18 | 山茱萸黄酮微胶囊制备工艺及性质显示文摘为提高山茱萸黄酮的稳定性和生物活性,应用喷雾干燥法,以乳清分离蛋白和阿拉伯胶作为壁材制备山茱萸黄酮微胶囊,以山茱萸黄酮包埋率为评价指标优化包埋工艺,并对微胶囊颗粒理化特性、热力学行为、微观形态、结构进行综合分析。优化得到的山茱萸黄酮微胶囊包埋工艺为:壁材质量分数9.34%、壁材添加物比例[m(WPI)∶m(GA)]1.07∶1、芯壁体积比1∶10、进料温度170℃、pH 3。在此条件下制备的山茱萸黄酮微胶囊呈现球形,表面光滑且结构完整,其包埋率可达到90.34%,平均粒径为23μm。差示扫描量热仪测示结果显示,微胶囊粉末具有良好热性能,可在室温贮藏。微胶囊红外、荧光以及紫外光谱分析表明,山茱萸黄酮完整地封装在胶囊内,保证其生物活性,同时具有良好感官价值和稳定性。 | 赵梦月 段续 任广跃 曹伟伟 李琳琳 徐一铭 楚倩倩 BHESH Bhandari | 2023 | 食品与发酵工业2023，49，7： | 4 |
| 19 | Phospholipase C Delta 3 inhibits apoptosis and promotes proliferation,migration,and invasion of thyroid cancer cells via Hippo pathway显示文摘In recent decades,the incidence of thyroid cancer(TC)has rapidly increased,leading us to explore the complex underlying mechanisms.We identified the gene Phospholipase C Delta 3(PLCD3)as a potential oncogene in TC by conducting the whole transcriptome sequencing.Our study is to understand the oncogenic role of PLCD3 in TC.We verified the overexpression of PLCD3 in TC from The Cancer Genome Atlas,Gene Expression Omnibus databases,and a locally validated cohort.Clinical correlation analysis showed that PLCD3 expression was related to histological type,T stage,lymph node metastasis(LNM),and disease stage.The high expression of PLCD3 could be a distinguishing factor for TC and its LNM.The biological function was examined using small interfering RNA-transfected TC cell lines.Silenced PLCD3 could inhibit colony formation,migration,and invasion ability and promote apoptosis of TC cell lines.PLCD3 silencing reversed the epithelial-mesenchymal transition but induced the apoptotic progress.Further exploration revealed that PLCD3 might be associated with critical genes of the Hippo pathway.The expressions of RHOA,YAP1/TAZ,and their downstream targets were decreased significantly when PLCD3 was down-regulated.YAP1 overexpression rescued the tumor-suppressive effect caused by PLCD3 silencing.This study demonstrates that PLCD3 is an oncogene that supports tumorigenesis and progression in TC,and PLCD3 may be a potential target gene for TC treatment. | Lizhi Lin Jialiang Wen Bangyi Lin Hao Chen Adheesh Bhandari Yufeng Qi Danni Zheng Ouchen Wang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，4： | 4 |
| 20 | 肱骨干骨折——髓内钉与钢板固定的比较显示文摘总体而言,这些报道提示:采用髓内钉治疗肱骨干骨折较采用钢板带来更多的并发症,尤其是采用顺行入路。同时,这些报道没有提供确切的证据证明何种方法在骨折愈合、减少感染或上肢总体功能上优于另一种。 | Mohid Bhandari Joseph R Beate P.Hanson Dan C. Norvell 陈国奋 顾立强 | 2004 | 中华创伤骨科杂志2004，6，6： | 4 |
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