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| 1 | The versatile functions of Sox9 in development,stem cells,and human diseases显示文摘The transcription factor Sox9 was first discovered in patients with campomelic dysplasia,a haploinsufficiency disorder with skeletal deformities caused by dysregulation of Sox9 expression during chondrogenesis.Since then,its role as a cell fate determiner during embryonic development has been well characterized;Sox9 expression differentiates cells derived from all three germ layers into a large variety of specialized tissues and organs.However,recent data has shown that ectoderm-and endoderm-derived tissues continue to express Sox9 in mature organs and stem cell pools,suggesting its role in cell maintenance and specification during adult life.The versatility of Sox9 may be explained by a combination of posttranscriptional modifications,binding partners,and the tissue type in which it is expressed.Considering its importance during both development and adult life,it follows that dysregulation of Sox9 has been implicated in various congenital and acquired diseases,including fibrosis and cancer.This review provides a summary of the various roles of Sox9 in cell fate specification,stem cell biology,and related human diseases.Ultimately,understanding the mechanisms that regulate Sox9 will be crucial for developing effective therapies to treat disease caused by stem cell dysregulation or even reverse organ damage. | Alice Jo Sahitya Denduluri Bosi Zhang Zhongliang Wang Liangjun Yin Zhengjian Yan Richard Kang Lewis L.Shi James Mok Michael J.Lee Rex C.Haydon | 2014 | Genes & Diseases2014，1，2： | 16 |
| 2 | Personalizing therapies for gastric cancer: Molecular mechanisms and novel targeted therapies显示文摘Globally,gastric cancer is the 4thmost frequently diagnosed cancer and the 2ndleading cause of death from cancer,with an estimated 990000 new cases and738000 deaths registered in 2008.In the advanced setting,standard chemotherapies protocols acquired an important role since last decades in prolong survival.Moreover,recent advances in molecular therapies provided a new interesting weapon to treat advanced gastric cancer through anti-human epidermal growth factor receptor 2(HER2)therapies.Trastuzumab,an anti-HER2 monoclonal antibody,was the first target drug in the metastatic setting that showed benefit in overall survival when in association with platinum-5-fluorouracil based chemotherapy.Further,HER2 overexpression analysis acquired a main role in predict response for trastuzumab in this field.Thus,we conducted a review that will discuss the main points concerning trastuzumab and HER2 in gastric cancer,providing a comprehensive overview of molecular mechanisms and novel trials involved. | Michael Luis Ana Tavares Liliana S Carvalho Lúcio Lara-Santos António Araújo Ramon Andrade de Mello | 2013 | World Journal of Gastroenterology2013，19，38： | 6 |
| 3 | Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g显示文摘 | Junius Salendo Melanie Spitzner Frank Kramer Xin Zhang Peter Jo Hendrik A. Wolff Julia Kitz Silke Kaulfu? Tim Bei?barth Matthias Dobbelstein Michael Ghadimi Marian Grade Jochen Gaedcke | 2013 | Radiotherapy and Oncology2013，，： | 2 |
| 4 | Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g<!-- MicroRNA chemoradiosensitivity signature -->显示文摘 | Junius Salendo Melanie Spitzner Frank Kramer Xin Zhang Peter Jo Hendrik A. Wolff Julia Kitz Silke Kaulfu? Tim Bei?barth Matthias Dobbelstein Michael Ghadimi Marian Grade Jochen Gaedcke | 2013 | Radiotherapy and Oncology2013，，： | 2 |
| 5 | Discovery of 1- (4-methoxyphenyl) -7-oxo-6- (4- (2-oxopiperidin- 1 - yl) phenyl) -4,5,6,7-tetrahydro-1H-pyrazolo t3,4-c] pyridine- 3-carboxamide (Apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa 显示文摘 | Donald J Michael JO Stephanie K | 2007 | JMed Chem2007，50，22： | 1 |
| 6 | Clonal analysis of xpression of epithelial antigens in cultures of normal human breast 显示文摘 | Paul AW Isobel MB Michael JO | 1986 | J Cell Sci1986，80，： | 1 |
| 7 | Usefulness of Fragmented QRS on a 12-Lead Electrocardiogram in Acute Coronary Syndrome for Predicting Mortality显示文摘 | Mithilesh K. Das Mark A. Michael Hussam Suradi Jonathan Peng Anjan Sinha Changyu Shen Jo Mahenthiran Richard J. Kovacs | 2009 | The American Journal of Cardiology2009，，12： | 1 |
| 8 | Narrowing the phase window width in prospectively ECG-gaated single heart beat 320-detector row coronary CT angiography显示文摘 | Michael LS Hansel JO Cai TX | 2009 | Int J Cardiovasc Imaging2009，25，： | 1 |
| 9 | The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments显示文摘 | Bustin Stephen A Benes Vladimir Garson Jeremy A Hellemans Jan Huggett Jim Kubista Mikael Mueller Reinhold Nolan Tania Pfaffl Michael W Shipley Gregory L Vandesompele Jo Wittwer Carl T | 2009 | Clinical Chemistry2009，，： | 1 |
| 10 | Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch显示文摘 | Paul Cohen Julia D. Levy Yingying Zhang Andrea Frontini Dmitriy P. Kolodin Katrin J. Svensson James C. Lo Xing Zeng Li Ye Melin J. Khandekar Jun Wu Subhadra C. Gunawardana Alexander S. Banks Jo?o Paulo G. Camporez Michael J. Jurczak Shingo Kajimura David | 2013 | Cell2013，，： | 1 |
| 11 | The MFMU Cesarean Registry: Factors affecting the success of trial of labor after previous cesarean delivery显示文摘 | Mark B. Landon Sharon Leindecker Catherine Y. Spong John C. Hauth Steven Bloom Michael W. Varner Atef H. Moawad Steve N. Caritis Margaret Harper Ronald J. Wapner Yoram Sorokin Menachem Miodovnik Marshall Carpenter Alan M. Peaceman Mary Jo O’Sullivan Baha | 2005 | American Journal of Obstetrics and Gynecology2005，，3： | 1 |
| 12 | Human resources for health: overcoming the crisis显示文摘 | Lincoln Chen Timothy Evans Sudhir Anand Jo Ivey Boufford Hilary Brown Mushtaque Chowdhury Marcos Cueto Lola Dare Gilles Dussault Gijs Elzinga Elizabeth Fee Demissie Habte Piya Hanvoravongchai Marian Jacobs Christoph Kurowski Sarah Michael Ariel Pablos-Men | 2004 | The Lancet . 2004 (9449)2004，，： | 1 |
| 13 | The ubiquitin-specific protease USP28 is required for MYC stability 显示文摘 | NIKITA POPOV MICHAEL WANZEL MANDY MADIRED- JO | 2007 | Nature Cell Biology2007，9，： | 1 |
| 14 | Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin- 1-yl) phenyl)-4,5,6,7-tetrahydro- 1H-pyrazolopyridine-3- carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa显示文摘 | Donald JP Michael JO Stephanie K | 2007 | J Med Chem2007，50，22： | 1 |
| 15 | The association between gestational diabetesmellitus and recreational physical activity 显示文摘 | Redden Stephanie L LaMonte Michael J Freudenheim Jo L Rudra Carole B | 2010 | Maternal andchild health journal2010，25，2： | 1 |
| 16 | Absolute Bioavailability and Pharmacokinetics of Treprostinil Sodium Administered by Acute Subcutaneous Infusion显示文摘 | Michael Wade F. Jo Baker Robert Roscigno Wayne DellaMaestra Thomas L. Hunt Allen A. Lai | 2004 | The Journal of Clinical Pharmacology2004，，： | 1 |
| 17 | Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice显示文摘 | Chabory Eléonore Damon Christelle Lenoir Alain Kauselmann Gary Kern Hedrun Zevnik Branko Garrel Catherine Saez Fabrice Cadet Rémi Henry-Berger Joelle Schoor Michael Gottwald Ulrich Habenicht Ursula Drevet Jo?l R Vernet Patrick | 2009 | Journal of Clinical Investigation2009，，7： | 1 |
| 18 | Use of endoscopy in diarrheal illnesses显示文摘 | Glenn M. Eisen Jason A. Dominitz Douglas O. Faigel Jay A. Goldstein Anthony N. Kalloo Bret T. Petersen Hareth M. Raddawi Michael E. Ryan John J. Vargo Harvey S. Young Robert D. Fanelli Neil H. Hyman Jo Wheeler-Harbaugh | 2001 | Gastrointestinal Endoscopy2001，，6： | 1 |
| 19 | Is the diagnostic yield of upper GI endoscopy improved by the use of explicit panel-based appropriateness criteria?显示文摘 | Florian Froehlich Claude Repond Beat Müllhaupt John-Paul Vader Bernard Burnand Catherine Schneider Isabelle Pache Jo?l Thorens Jean-Pierre Rey Vanessa DeBosset Vincent Wietlisbach Michael Fried Robert W DuBois Robert H Brook Jean-Jacques Gonvers | 2000 | Gastrointestinal Endoscopy2000，，3： | 1 |
| 20 | The association between gestational diabetes mellitus and recreational physical activity显示文摘 | Redden Stephanie L LaMonte Michael J9Freudenheim Jo L Rudra Carole B | 2013 | Maternal and child health journal2013，11，3： | 1 |
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