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| 1 | Personalizing therapies for gastric cancer: Molecular mechanisms and novel targeted therapies显示文摘Globally,gastric cancer is the 4thmost frequently diagnosed cancer and the 2ndleading cause of death from cancer,with an estimated 990000 new cases and738000 deaths registered in 2008.In the advanced setting,standard chemotherapies protocols acquired an important role since last decades in prolong survival.Moreover,recent advances in molecular therapies provided a new interesting weapon to treat advanced gastric cancer through anti-human epidermal growth factor receptor 2(HER2)therapies.Trastuzumab,an anti-HER2 monoclonal antibody,was the first target drug in the metastatic setting that showed benefit in overall survival when in association with platinum-5-fluorouracil based chemotherapy.Further,HER2 overexpression analysis acquired a main role in predict response for trastuzumab in this field.Thus,we conducted a review that will discuss the main points concerning trastuzumab and HER2 in gastric cancer,providing a comprehensive overview of molecular mechanisms and novel trials involved. | Michael Luis Ana Tavares Liliana S Carvalho Lúcio Lara-Santos António Araújo Ramon Andrade de Mello | 2013 | World Journal of Gastroenterology2013，19，38： | 6 |
| 2 | Autoimmune hepatitis in childhood: The role of genetic and immune factors显示文摘Autoimmune hepatitis (AIH) is a rare chronic inflammatory disease of the liver, which affects a group of patients who lost their immunological tolerance to antigens of the liver. It is clinically characterized by hypergammaglobulinemia, elevated liver enzymes, presence of autoantibodies and histological changes. Although being rare in children, it represents a serious cause of chronic hepatic disease that can lead to cirrhosis and hepatic failure. Clinical findings, exclusion of more common liver disorders and the detection of antibodies antinuclear antibodies, smooth muscle antibodies and anti-LKM1 are usually enough for diagnosis on clinical practice. The pathogenic mechanisms that lead to AIH remain obscure, but some research findings suggest the participation of immunologic and genetic factors. It is not yet knew the triggering factor or factors that stimulate inflammatory response. Several mechanisms proposed partially explain the immunologic findings of AIH. The knowledge of immune factors evolved might result in better markers of prognosis and response to treatment. In this review, we aim to evaluate the findings of research about genetic and immune markers and their perspectives of application in clinical practice especially in pediatric population. | Priscila Menezes Ferri Liu Débora Marques de Miranda Eleonora Druve Tavares Fagundes Alexandre Rodrigues Ferreira Ana Cristina Simoes e Silva | 2013 | World Journal of Gastroenterology2013，19，28： | 3 |
| 3 | Survey of infectious and parasitic diseases in stray cats at the Lisbon Metropolitan Area, Portugal显示文摘 | Ana Duarte Isabel Castro Isabel M. Pereira da Fonseca Virgilio Almeida Luis M. Madeira de Carvalho José Meireles Maria I. Fazendeiro Luis Tavares Yolanda Vaz | 2009 | Journal of Feline Medicine and Surgery2009，，6： | 1 |
| 4 | Phosphorus as an early marker of morbidity and mortality in type 2 chronic kidney disease diabetic patients显示文摘 | Ana Paula Silva André Fragoso Ana Pinho Nelson Tavares Ana Camacho Marília Faísca Pedro Le?o Neves | 2013 | Journal of Diabetes and Its Complications2013，，4： | 1 |
| 5 | Sleep and Academic Performance in Undergraduates: A Multi-measure, Multi-predictor Approach显示文摘 | Ana Allen Gomes José Tavares Maria Helena P. de Azevedo | 2011 | Chronobiology International2011，，9： | 1 |
| 6 | A novel approach for the oxidative catalysis employing polyoxometalate-laccase system:application to the oxygen bleaching of Kraft pulp显示文摘 | Ana P M Tavares Jose A F Gamelas Armindo R Gaspar | 2004 | Catalysis Communications2004，，5： | 1 |
| 7 | Polymer blends based On polyolefin elastomer and polypropylene 显示文摘 | Ana Lcia N Da Silva Maria Ines B Tavares Daniel P Politano | 1997 | J Appl polym Sei1997，66，： | 1 |
| 8 | Electro-Acupuncture Efficacyon Pain Control after Mandibular Third Molar Surgery显示文摘 | MARCONI GONZAGA TAVARES ANA PAULA MACHADO BRENO GUTIERREZ MOTTA | 2007 | BRAZ Dent2007，18，2： | 1 |
| 9 | Addressing soil protection concerns in forest ecosystem management under climate change显示文摘Background: Climate change may strongly influence soil erosion risk, namely through variations in the precipitation pattern. Forests may contribute to mitigate the impacts of climate change on soil erosion and forest managers are thus challenged by the need to define strategies that may protect the soil while addressing the demand for other ecosystem services. Our emphasis is on the development of an approach to assess the impact of silvicultural practices and forest management models on soil erosion risks under climate change. Specifically, we consider the annual variation of the cover-management factor(C) in the Revised Universal Soil Loss Equation over a range of alternative forest management models to estimate the corresponding annual soil losses, under both current and changing climate conditions. We report and discuss results of an application of this approach to a forest area in Northwestern Portugal where erosion control is the most relevant water-related ecosystem service.Results: Local climate change scenarios will contribute to water erosion processes, mostly by rainfall erosivity increase.Different forest management models provide varying levels of soil protection by trees, resulting in distinct soil loss potential.Conclusions: Results confirm the suitability of the proposed approach to address soil erosion concerns in forest management planning. This approach may help foresters assess management models and the corresponding silvicultural practices according to the water-related services they provide. | Ana Raquel Rodrigues Brigite Botequim Catarina Tavares Patrícia Pécurto JoséGBorges | 2020 | Forest Ecosystems2020，7，3： | 1 |
| 10 | A novel approach for the oxidative catalysis employing polyoxometalate-laccase system: application to the oxygen bleaching of kraft pulp显示文摘 | Ana P M Tavares Jose A F Gamelas Armindo R Gaspar | 2004 | Catalysis Communications2004，5，9： | 1 |
| 11 | Oxygen bleaching of kraft pulp with polyoxometalates and laccase applying a novel multi-stage process显示文摘 | Jose A F Gamelas Ana P M Tavares Dmitry V Evtuguin | 2005 | Journal of Molecular Catalysis B: Enzyme2005，33，36： | 1 |
| 12 | Undernutrition and associated factors among hospitalized patients显示文摘 | Teresa F. Amaral Luís C. Matos Maria A. Teixeira Maria M. Tavares Luísa álvares Ana Antunes | 2010 | Clinical Nutrition2010，，5： | 1 |
| 13 | Astrovirus infection in children living in the central west region of Brazil显示文摘 | Rodrigo Alessandro Togo Santos Ana Maria Tavares Borges Paulo Sergio Sucasas da Costa | 2007 | Mem Inst Oswaldo Cruz Rio de Janeiro2007，102，2： | 1 |
| 14 | Comparison of morphological and functional outcomes of mouse sciatic nerve repair with three biodegradable polymer conduits containing poly (lactic acid)显示文摘Poly(lactic acid)(PLA)-containing nerve guidance conduits(NGCs) are currently being investigated for nerve repair as an alternative to autograft, which leads to permanent functional impairment in the territory innervated by the removed nerve. Combination of polymers modifies the physical properties of the conduits, altering their nerve-guidance properties. Conduits made from PLA-only or combined with other polymers have been used successfully for nerve repair, but their efficiency has not been compared. We compared the morphological and functional outcomes of peripheral nerve repair by using NGCs made of poly(lactic acid) and combined or not with polycaprolactone(PLA/PCL) or polyvinylpyrrolidone(PLA/PVP). To assess the functional recovery, we employed a mechanical hyperalgesia analysis, sciatic functional index(SFI), and electroneuromyography. The mechanical hyperalgesia analysis showed that the PLA group improved more rapidly than the PLA/PVP and PLA/PCL groups; similarly, in the electroneuromyography assay, the PLA group exhibited higher amplitude than the PLA/PCL and PLA/PVP groups. However, the SFI improvement rates did not differ among the groups. Morphologically, the PLA group showed more vascularization, while the nerve fiber regeneration did not differ among the groups. In conclusion, the PLA-only conduits were superior to the other NGCs tested for nerve repair. | Fernanda Marques Pestana Rui C.C.Domingues Júlia Teixeira Oliveira Daniela F.P.A.Durco Camila Oliveira Goulart Henrique Rocha Mendonca Anne Caroline Rodrigues dos Santos Natália Tavares de Campos Beatriz Theodoro da Silva Cristina Cardoso Pereira Cristiano Piacsek Borges Ana Maria Blanco Martinez | 2018 | Neural Regeneration Research2018，13，10： | 1 |
| 15 | Sequential batch reactor for eucalypt kraft pulp effuent treatment with Trametes versicolor 显示文摘 | Ana MRB Xavier Ana Paula M Tavares | 2008 | Chem Technol Biotechnol2008，83，： | 1 |
| 16 | Assessment and prediction of tablet properties using transmission and backscattering Raman spectroscopy and transmission NIR spectroscopy显示文摘This study investigated whether Raman and Near Infrared(NIR) spectroscopy could predict tablet properties. Granules were produced on a continuous line by varying granulation parameters. Tableting process parameters were adjusted to obtain uniform tablet weight and thickness. Spectra were collected offline and tablet properties determined with traditional analyzing methods. Partial Least Squares(PLS) regression was used to correlate spectral information to tablet properties, but predictive models couldn’t be established. Principal component analysis(PCA) was effectively used to distinguish theophylline concentrations and hydration levels and multiple linear regression(MLR) analysis allowed insight on how granulation parameters affect granule and tablet properties. | Elisabeth Peeters Ana Filipa Tavares da Silva Maunu Toiviainen Jeroen Van Renterghem Jurgen Vercruysse Mikko Juuti Joao Almeida Lopes Thomas De Beer Chris Vervaet Jean-Paul Remon | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，4： | 1 |
| 17 | Oxygen bleaching of kraft pulp with polyoxometalates and laccase applying a novel multi-stage process显示文摘 | Jose A F Gamelas Ana P M Tavares Dmitry V Evtuguin | 2005 | Journal of Molecular Catalysis B: Enzyme2005，33，36： | 1 |
| 18 | Fertility-Sparing Surgery for Early-Stage Cervical Cancer显示文摘 | Adelaide Fernanda Ribeiro Cubal Joana Isabel Ferreira Carvalho Maria Fernanda Martins Costa Ana Paula Tavares Branco Harry J. Wanebo | 2012 | International Journal of Surgical Oncology2012，，： | 1 |
| 19 | Antibacterial activity and inhibition against Staphylococcus aureus NorA efflux pump by ferulic acid and its esterified derivatives显示文摘Objective:To evaluate the inhibitory activity of ferulic acid and four of its esterified derivatives(methyl,ethyl,propyl,and butyl)against resistance mechanisms in Staphylococcus aureus strains.Methods:Ferulic acid derivatives were obtained by esterification with methanol,ethanol,propanol,and butanol,and then characterized by hydrogen and carbon-13 nuclear magnetic resonance analysis.The minimum inhibitory concentrations(MIC)of ferulic acid and its esterified derivatives,ethidium bromide,and norfloxacin were obtained using the microdilution test,while the efflux pump inhibition test was conducted by examining reduction in the MICs of norfloxacin and ethidium bromide.Molecular docking was also carried out using the Schrodinger Suite 2015 molecular modeling software.A three-dimensional model of NorA efflux pump was generated using I-TASSER.The best scoring model was used as a receptor for ligand-receptor docking.Results:The methyl and butyl ester derivatives did not demonstrate significant antimicrobial activity.However,a significant synergic effect was evidenced when norfloxacin was combined with the ethyl and propyl esterified derivatives.The docking study demonstrated favorable energy of interaction between ferulate derivatives and NorA,and amino acid residues TYR57,TYR58,and LEU255 were present commonly in stabilizing all complexes.The PCA analysis corroborated the docking hypothesis that the lipophilic character and hydrogen bond interactions were the most relevant characteristics involved with NorA inhibitors.The pharmacokinetic parameters of ferulic acid derivatives showed good ADMET properties,demonstrating that they can be easily absorbed and have no effect or inhibit the cytochrome P450 enzyme complex,revealing their potential as drug candidates.Conclusions:This study provides strong evidence that the molecular basis for this activity is potentially due to the NorA efflux pump. | Patrícia Gonçalves Pinheiro Gilvandete Maria Pinheiro Santiago Francisco Erivaldo Freitas da Silva Ana Carolina Justino de Araújo Cícera Rejane Tavares de Oliveira Priscilla Ramos Freitas Janaína Esmeraldo Rocha JoséBezerra de Araújo Neto Maria Milene Costa da Silva Saulo Relison Tintino Irwin Rose Alencar de Menezes Henrique Douglas Melo Coutinho JoséGalberto Martins da Costa | 2021 | Asian Pacific Journal of Tropical Biomedicine2021，11，9： | 0 |
| 20 | Validation of the Portuguese version of the social isolation scale with a sample of community-dwelling older adults显示文摘Objectives The aim of this study was to analyze the psychometric properties(reliability and validity)of the Social Isolation Scale(SIS)in a sample of Portuguese community-dwelling older adults.Methods A transversal descriptive study was carried out with a convenience sample of 250 community-dwelling older adults(≥65 years).The survey comprised a sociodemographic questionnaire,SIS,Geriatric Depression Scale-4(GDS-4),6-item Lubben Social Network Scale(LSNS-6),a loneliness self-assessment question,and Satisfaction with Life Scale(SWLS).Construct validity(confirmatory factor analysis)and convergent validity were analyzed,and ISI internal reliability(composite reliability),external reliability(test-retest,intraclass correlation coefficient)and inter-rater reliability(Cohen’s kappa coefficient)were evaluated.Results Confirmatory factor analysis showed a two-factor model with an excellent index of fit.The SIS showed significant correlations with LSNS-6(rs=0.47),SWLS(rs=0.26),the loneliness self-assessment question(rs=0.35),and GDS-4(rs=−0.16).SIS composite reliability was good(0.708).The inter-class correlation coefficient varied from 0.84 to 0.98.The Cohen’s kappa coefficient ranged from 0.936 to 1.Conclusions SIS has been shown to be a valid and reliable instrument for assessing social isolation among Portuguese community-dwelling older adults.Healthcare professionals,particularly nurses working in community settings,can use SIS to assess social isolation in older adults to design,implement,and evaluate interventions. | João Tavares Ana Faria Delphine Gonçalves Diana Mendes Sofia Silva Liliana Sousa | 2023 | International Journal of Nursing Sciences2023，10，2： | 0 |
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