|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Predictive value of Ki67 and p53 in locally advanced rectal cancer:Correlation with thymidylate synthase and histopathological tumor regression after neoadjuvant 5-FU-based chemoradiotherapy显示文摘AIM: To investigate the predictive value of Ki67 and p53 and their correlation with thymidylate synthase (TS) gene expression in a rectal cancer patient cohort treated according to a standardized recommended neoadjuvant treatment regimen.METHODS: Formalin fixed, paraffin embedded pre-therapeutical tumor biopsies (n = 22) and post-therapeutical resection specimens (n = 40) from patients with rectal adenocarcinoma (clinical UICC stage Ⅱ/Ⅲ) receiving standardized neoadjuvant 5-fluorouracil (5-FU) based chemoradiotherapy were studied for Ki67 and p53 expression by immunohistochemistry and correlated with TS mRNA expression by quantitative TaqMan real-time PCR after laser microdissection. The results were compared with histopathological tumor regression according to a standardized semiquantitative score grading system.RESULTS: Responders (patients with high tumor regression) showed a significantly lower Ki67 expression than non-responders in the pre-therapeutical tumor biopsies (81.2% vs 16.7%; P < 0.05) as well as in the post-therapeutical resection specimens (75.8% vs 14.3%; P < 0.01). High TS mRNA expression was significantly correlated with a high Ki67 index and low TS mRNA expression was significantly correlated with a low Ki67 index in the pre-therapeutical tumor biopsies (corr. coef. = 0.46; P < 0.01) as well as in the post-therapeutical resection specimens (corr. coef. = 0.40; P < 0.05). No significant association was found between p53 and TS mRNA expression or tumor regression.CONCLUSION: Ki67 has, like TS, predictive value in rectal cancer patients after neoadjuvant 5-FU based chemoradiotherapy. The close correlation between Ki67 and TS indicates that TS is involved in active cell cycle processes. | Christiane Jakob Torsten Liersch Wolfdietrich Meyer Heinz Becker Gustavo B Baretton Daniela E Aust | 2008 | World Journal of Gastroenterology2008，14，7： | 29 |
| 2 | 未来欧洲沼气:畜禽粪便、秸秆和牧草促进欧洲沼气生产可持续发展的潜力显示文摘沼气将在实现欧盟未来能源政策的目标方面扮演重要角色。但由于越来越多的农业用地种植能源作物,一些讨论开始质疑沼气原料的可持续性。该研究的目的是选择可持续性的农业废弃物,预测并绘制出2030年欧盟28国的生物质和沼气能源潜力的地图。选取的农业废弃物包括畜禽粪便、谷物生产的副产品秸秆、轮作和永久草地和草甸中的牧草。有资料显示这些废弃物在沼气生产中混合消化时能提高产沼气量。到2030年,欧盟28国上述生物质产沼气的潜力在1. 2×103到2. 3×103PJ·y-1之间,取决于生物质的可用性。研究结果显示欧盟28个成员国都有替代玉米的可持续性原料,能够确保欧洲沼气持续不断地发展。 | A K P Meyer E A Ehimen J B Holm-Nielsen 程静思 | 2018 | 中国沼气2018，36，5： | 6 |
| 3 | Mammary gland growth and vascularity at parturition and during lactation in primiparous ewes fed differing levels of selenium and nutritional plane during gestation显示文摘Background: Objectives were to examine the effects of selenium(Se) supply and maternal nutritional plane during gestation on mammary gland growth, cellular proliferation, and vascularity at parturition and d 20 of lactation. Rambouillet primiparous ewes(n = 84) were allocated to treatments in a 2 x 3 factorial. Factors were dietary Se(adequate Se [ASe, 11.5 μg/kg BW] or high Se [HSe, 77.0 μg/kg BW]) and nutritional plane(60% [RES], 100% [CON], or 140% [EXC]). At parturition, lambs were removed and 42 ewes(7/treatment) were necropsied. Remaining ewes were fed a common diet meeting requirements for lactation and mechanically milked twice daily until necropsy on d 20. At both necropsy periods, mammary glands were dissected and tissues harvested. Samples were analyzed for RNA, DNA, and protein content, cell proliferation, and vascularity. Where interactions were present(P ≤ 0.05), least squares means from the highest-order interaction are presented. Results: Final body weight of ewes was least(P ≤ 0.002) in RES, intermediate for CON, and greatest for EXC, regardless of stage of the ewe at necropsy(parturition or d 20 of lactation). In ewes necropsied at parturition, mammary glands were heavier(P = 0.02) in EXC compared to RES, with CON intermediate. Concentration of RNA(mg/g) was decreased(P = 0.01) in EXC compared to CON at parturition. There was a tendency(P = 0.07) for a Se by nutrition interaction in percentage of cells proliferating where ASe-EXC ewes had greater(P ≤ 0.02) number of proliferating cells then all other treatments. Mammary vascular area tended(P = 0.08) to be affected by a Se by nutrition interaction where ASe-CON had less(P = 0.007) vascular area than HSe-CON ewes. In ewes necropsied at d 20 of lactation, the number of alveoli per area was decreased(P ≤ 0.05) in RES compared to CON and EXC-fed ewes. Conclusions: Results of this study indicate that proper maternal nutritional plane during gestation is important for mammary gland development, even out to d 20 of lactation. | Tammi L Neville Allison M Meyer Arshi Reyaz Pawel B Borowicz Dale A Redmer Lawrence P Reynolds Joel S Caton Kimberly A Vonnahme | 2013 | Journal of Animal Science and Biotechnology2013，4，4： | 3 |
| 4 | Persistent hantavirus infections:characteristics and mechanisms显示文摘 | Meyer B J Schmaljohn C S | 2000 | Trends Microbiol2000，8，2： | 2 |
| 5 | An introduction to wavelet analysis in oceanography and meteorology: with application to the dispersion of Yannai waves显示文摘 | Meyers S D Kelly B G O'Brien J J | 1993 | Mon Wea Rev1993，121，10： | 2 |
| 6 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 7 | Hepatitis C and renal disease: an update 1 1 Summary of a workshop held October 21 to 22, 2002, in the Lister Hill Auditorium, The National Institutes of Health, Bethesda, MD.显示文摘 | Catherine M Meyers Leonard B Seeff Catherine O Stehman-Breen Jay H Hoofnagle | 2003 | American Journal of Kidney Diseases2003，，4： | 2 |
| 8 | De novo expression of intercellular adhesion molecule 1 ( ICAM-1 CD54) in pancreas cancer显示文摘 | Schwaeble W Kerlin M Meyer Zum Büschenfelde KH | | 0，，： | 2 |
| 9 | A Comparative Study of Prussian - Blue - modified Graphite Paste Electrodes and Solid Graphite Electrodes with Mechanically Immobilized Prussian Blue 显示文摘 | Zakharchuk N F Meyer B Hennig H | 1995 | Journal of Electroanalytical Chemistry1995，398，12： | 1 |
| 10 | Knickpoint migration due to baselevel lowering显示文摘 | Begin Meyer Z B F Schumm S A | 1980 | J of the Waterway Port and Ocean Division ASCE1980，106，： | 1 |
| 11 | Environmental jolts and industry revolutions: Organizational responses to discontinuous change显示文摘 | Meyer A D Brook G Goes J B | 1990 | Strategic Management Journal1990，11，： | 1 |
| 12 | N-teminal pro -B-type natriuretic peptide is an independent predictor of outcome in an unselected cohort of critically ill patients 显示文摘 | Meyer B Huelsmann M Wexberg P | 2007 | Crit Care Med2007，35，： | 1 |
| 13 | Distinct functional role of hepatitis C virus core protein on NF-KB regulation is linked to genomic variation显示文摘 | Ray R B Meyer K Steele R | 2002 | Virus Rearch2002，87，： | 1 |
| 14 | Interleukin-12 requires initial CD80-mediated T-cell activation to support immune responses toward human breast and ovarian carcinoma显示文摘 | Guckel B Meyer GC Rudy W | 1999 | Cancer Gene Ther1999，6，： | 1 |
| 15 | Crustal thickening in Gansu-Qinghai, lithospheric mantle subduction, and oblique,strike-slip controlled growth of the Tibet plateau 显示文摘 | Meyer B Tapponnier P Bourjot L | 1998 | Geophysical Journal International1998，135，： | 1 |
| 16 | A global perspective on the use,sales,exposure pathways,occurrence,fate and effects of veterinary antibiotics (Vas) in the environment显示文摘 | Sarmah A K Meyer M T Boxall A B A | 2006 | Chemosphere2006，，65： | 1 |
| 17 | The course of geriatric depression with' reversible dementia':a controlled study显示文摘 | ALEXOPOULOS G MEYERS B S YOUNG R C | 1993 | Am J Psychiatry1993，150，11： | 1 |
| 18 | Resistance gene candidates identified by PCR with degenerate oligonucleotide primers map to clusters of resistance genes in lettuce显示文摘 | SHEN K A MEYERS B C ISLAMFAIDI | 1998 | MPMI1998，11，： | 1 |
| 19 | Balloon-assisted coil embolization of intracranial aneurysms显示文摘 | MEYER F B | 2006 | J Neurosurg2006，105，39： | 1 |
| 20 | System Atic Concurrent Object-oriented Programming显示文摘 | Meyer B | 1993 | Communications of the ACM1993，36，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员