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| 1 | Integrated single-cell RNA sequencing analysis reveals distinct cellular and transcriptional modules associated with survival in lung cancer显示文摘Lung adenocarcinoma(LUAD)and squamous carcinoma(LUSC)are two major subtypes of non-small cell lung cancer with distinct pathologic features and treatment paradigms.The heterogeneity can be attributed to genetic,transcriptional,and epigenetic parameters.Here,we established a multi-omics atlas,integrating 52 single-cell RNA sequencing and 2342 public bulk RNA sequencing.We investigated their differences in genetic amplification,cellular compositions,and expression modules.We revealed that LUAD and LUSC contained amplifications occurring selectively in subclusters of AT2 and basal cells,and had distinct cellular composition modules associated with poor survival of lung cancer.Malignant and stage-specific gene analyses further uncovered critical transcription factors and genes in tumor progression.Moreover,we identified subclusters with proliferating and differentiating properties in AT2 and basal cells.Overexpression assays of ten genes,including sub-cluster markers AQP5 and KPNA2,further indicated their functional roles,providing potential targets for early diagnosis and treatment in lung cancer. | Li Zhang Yiming Zhang Chengdi Wang Ying Yang Yinyun Ni Zhoufeng Wang Tingting Song Menglin Yao Zhiqiang Liu Ningning Chao Yongfeng Yang Jun Shao Zhidan Li Ran Zhou Li Chen Dan Zhang Yuancun Zhao Wei Liu Yupeng Li Ping He Jing-wen Lin Yuan Wang Kang Zhang Lu Chen Weimin Li | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 2 |
| 2 | 10-and 40 Gb/s forward errorcorrection devices for optical communications显示文摘 | Song Leilei Yu Menglin | 2002 | IEEEJournal of Solid-State Circuits2002，37，11： | 1 |
| 3 | Porous hollow palladium nanoplafform for imaging-guided trimodal chemo-, photothermal-, and radiotherapy显示文摘 | Menglin Song Nian Liu Le He Gang Liu Daishun Ling Xinhui Su Xiaolian Sun | 2018 | Nano Research2018，11，5： | 1 |
| 4 | Radioiodinated tyrosine based carbon dots with efficient renal clearance for single photon emission computed tomography of tumor显示文摘Nan oparticles with effective tumor accumulation and efficient renal clearance have attracted significant interests for clinical applications.Weprepared 2.5 nm tyrosine based carbon dots(TCDs)with phenolic hydroxyl groups on the surface for directly 125I labeling.The 125I labeledpolyethylene glycol(PEG)functionalized TCDs(125I-TCDPEGs)showed excellent radiochemical stability both in vitro and in vivo.Due to theenhanced permeability and retentio n effect,these 125I-TCDPEGs demonstrated a tumor accumulatio n around 4%-5%of the injected doseper gram(ID/g)for U87MG,4T1,HepG2 and MCF7 tumor-bearing mice at 1 h post-injection.Meanwhile,the 125I-TCDPEGs also could befast renally excreted,with less than 0.6%ID/g left in the liver and spleen within 24 h.These radioactive carb on dots not only can be used forcellular fluorescence imaging due to their intrinsic optical property,but are also effective single photon emission computed tomography(SPECT)imaging agents for tumor.Together with their excellent biocompatibility and stability,we anticipate these 125I-TCDPEGs of great potential for earlytumor diagnosis in clinic.Whafs more,our TCDPEGs are also proved to be feasible carriers for other iodine isotopes such as 127I and 131I fordifferent biomedical application. | Nian Liu Yiyue Shi Jingru Guo Hai Li Qiang Wang Menglin Song Zhiyuan Shi Le He Xinhui Su Jin Xie Xiaolian Sun | 2019 | Nano Research2019，12，12： | 1 |
| 5 | Artificial optical microfingerprints for advanced anticounterfeiting显示文摘Artificial optical microfingerprints,known as physically unclonable functions(PUFs)offer a groundbreaking approach for anti-counterfeiting.However,these PUFs artificial optical microfingerprints suffer from a limited number of challenge-response pairs,making them vulnerable to machine learning(ML)attacks when additional error-correcting units are introduced.This study presents a pioneering demonstration of artificial optical microfingerprints that combine the advantages of PUFs,a large encoding capacity algorithm,and reliable deep learning authentication against ML attacks.Our approach utilizes the triple-mode PUFs,incorporating bright-field,multicolor fluorescence wrinkles,and the topography of surface enhanced Raman scattering in the mechanical and optical layers.Notably,the quaternary encoding of these PUFs artificial microfingerprints allows for an encoding capacity of 6.43×10^(24082) and achieves 100%deep learning recognition accuracy.Furthermore,the PUFs artificial optical microfingerprints exhibit high resilience against ML attacks,facilitated by generative adversarial networks(GAN)(with mean prediction accuracy of~85.0%).The results of this study highlight the potential of utilizing up to three PUFs in conjunction with a GAN training system,paving the way for achieving encoded information that remains resilient to ML attacks. | Xueke Pang Qiang Zhang Jingyang Wang Xin Jiang Menglin Wu Mingyue Cui Zhixia Feng Wenxin Xu Bin Song Yao He | 2024 | Nano Research2024，17，5： | 0 |
| 6 | Integrative Identification by Hi‑C Revealed Distinct Advanced Structural Variations in Lung Adenocarcinoma Tissue显示文摘Advanced three-dimensional structure variations of chromatin in large genome fragments,such as conversion of A/B compartment,topologically associated domains(TADs)and chromatin loops are related closely to occurrence of malignant tumors.However,the structural characteristics of lung cancer still remain uncovered.In this study,we used high-throughput chromosome(Hi-C)conformation capture technology to detect the advanced structural variations in chromatin of two nonsmoking lung adenocarcinoma(LUAD)tumor and paired normal tissues.The results indicate that significant chromatin variations are detected in tumor tissues compared with normal tissues.At compartment scale,the main conversion type of compartment is A→B in tumor tissues,which are concentrated mainly on chromosome 3(Chr3)(33.6%).A total of 216 tumor-specific TADs are identified in tumor tissues,which are distributed mainly in Chr1(19),Chr2(15)and Chr3(17).Forty-one distinct enhancer-promoter loops are observed in tumor tissue,which are associated closely to tumor-related pathways including mitogen-activated protein kinase(MAPK),Phosphatidylinositol-3-kinase-Protein kinase B(PI3K-AKT),Ras,Wnt and Ras1.The most important observation in this study is that we identify five important genes(SYT16,NCEH1,NXPE3,MB21D2,and DZIP1L),which are detected in both A→B compartment,TADs and chromatin loops in tumor samples,and four of these genes(NCEH1,NXPE3,MB21D2,and DZIP1L)locate on q arm of Chr3.Further gene expression and invasion experiment analysis show that NCEH1,MB21D2 and SYT16 are involved in the tumor development.Thus,we provide a comprehensive overview of advanced structures in LUAD for the first time and provide a basis for further research on the genetic variation of this tumor. | Tingting Song Menglin Yao Ying Yang Zhiqiang Liu Li Zhang Weimin Li | 2023 | Phenomics2023，3，4： | 0 |
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