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| 1 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 2 | Aortic valve sclerosis and aortic atherosclerosis: different manifestations of the same disease? Insights from a population-based study 显示文摘 | Meissner I Sicks JR O'Fallon WM | 2001 | J Am Coil Cardiol2001，38，： | 1 |
| 3 | Therapeutic effects of pre-gelatinized maca (lepidium peruvianum ehacon) used as a non-hormonal alternative to HRT in perimenopausal women - clinical pilot study显示文摘 | Henry O Meissner HW Reich B | 2006 | Int J Biomed Sci2006，2，2： | 1 |
| 4 | Hormone-balancing effect of pre-gelatinized organic Maea (Lepidium peruvianum Chacon): (11) physiological and symptomatic responses of early-postmenopausal women to standardized doses of Maca in double blind, randomized, placebo-controlled, multi-centre clinical study 显示文摘 | Meissner H O Mscisz A Reich-Bilinska H | 2006 | IJBS2006，2，4： | 1 |
| 5 | Sensitivity of the Pacific white shrimp, Penaeus vannamei, to aflatoxin B1 显示文摘 | Ostrowski - Meissner H T LeaMaster B R Duerr E O | 1995 | Aquaculture1995，131，： | 1 |
| 6 | Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment显示文摘 | Wiebers D O Whisnant J P Huston J 3 rd Meissner I Brown R D Jr Piepgras D G | 2003 | Lancet2003，362，： | 1 |
| 7 | The fastest contracting muscles of nonmammalian vertebrates express only one isoform of the ryanodine receptor显示文摘 | O'Brien J Meissner G Block B A | 1993 | Biophys J1993，65，6： | 1 |
| 8 | Unruptured in- tracranial aneurysms: natural history, clinical out- come, and risks of surgical and endovascular treatment 显示文摘 | Wiebers D O Whisnant J P Huston J 34 Meissner I Brown R D Jr Piepgras D G | 2003 | Lancet2003，362，： | 1 |
| 9 | CC chemokine ligand 20 partially controls adhesion of naive B cells to activated endothelial cells under shear stress显示文摘 | Meissner A Zilles O Varona R et aI | 2003 | Blood2003，102，8： | 1 |
| 10 | Frequency of Atrial Septal Aneurysms in Patients With Cerebral Ischemic Events显示文摘 | Yoram Agmon Bijoy K. Khandheria Irene Meissner Federico Gentile Jack P. Whisnant JoRean D. Sicks W. Michael O’Fallon Jody L. Covalt David O. Wiebers James B. Seward | 1999 | Circulation1999，，： | 1 |
| 11 | Carotenoid supply in breast-fed and formula-fed neonates 显示文摘 | SOMMERBURG O MEISSNER K NELLE M | 2000 | Eur J Pediatr2000，159，： | 1 |
| 12 | Diagnostic accuracy of optical coherence tomography and intravascular ultrasound for the detection and characterization of atherosclerotic plaque composition in ex-vivo coronary specimens:a comparison with histology显示文摘 | Richer J Meissner O Babaryka G | 2006 | Coronary Artery Disease2006，17，5： | 1 |
| 13 | Markers of Plasma coagulation and fibrinolysis after acute deep ve- nous thrombosis显示文摘 | Meissner M H Zierler B K Bergelin R O | 2000 | J Vas Sur2000，32，5： | 1 |
| 14 | Determination of DNA single-strand breaks in lymphocytes of smokers and nonsmokers exposed to environmental tobacco smoke using the nick translation assay显示文摘 | Einhaus M Holz O Meissner R | 1994 | Clin Investig1994，72，11： | 1 |
| 15 | Rho kinase inhibition miti- gates sunitinib - induced rise in arterial pressure and renal vascular resistance but not increased renal sodium reabsorption 显示文摘 | Grisk O Koenen A Meissner T | 2014 | J Hy- pertens2014，32，11： | 1 |
| 16 | HLA ‐typing, clinical, and immunological characterization of youth with type 2 diabetes mellitus phenotype from the German/Austrian DPV database显示文摘 | Wendy L Awa Bernard O Boehm Silke Rosinger Peter Achenbach Anette G Ziegler Stephanie Krause Thomas Meissner Susanne Wiegand Thomas Reinehr Thomas Kapellen Beate Karges Thomas Eiermann Edith Schober Reinhard W Holl | 2013 | Pediatr Diabetes2013，，8： | 1 |
| 17 | Diagnostic accuracy of op-tical coherence tomography and intravascular ultrasound for the de-tection and characterization of atherosclerotic plaque composition in ex-vivo coronary specimens:a comparison with histology显示文摘 | Rieber J Meissner O Babaryka G | 2006 | Coro-nary Artery Disease2006，17，42： | 1 |
| 18 | HLA ‐typing, clinical, and immunological characterization of youth with type 2 diabetes mellitus phenotype from the German/Austrian DPV database显示文摘 | Wendy L Awa Bernard O Boehm Silke Rosinger Peter Achenbach Anette G Ziegler Stephanie Krause Thomas Meissner Susanne Wiegand Thomas Reinehr Thomas Kapellen Beate Karges Thomas Eiermann Edith Schober Reinhard W Holl | 2013 | Pediatr Diabetes2013，，8： | 1 |
| 19 | Subthalamic high frequency stimulation induced mtatious are differentially mediated by D1 and D2 receptors 显示文摘 | Bergnann O Winter C Meissner W et L | 2004 | Neuropharmacol2004，46，7： | 1 |
| 20 | PIasmid-encoded mercuric reductase in Mycobacterium scrofulaceum显示文摘 | Meissner P S Falkinham Ⅲ J O | 1984 | J Bacteriol1984，157，2： | 1 |
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