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| 1 | Type 2 diabetes mellitus in children and adolescents显示文摘Type 2 diabetes mellitus is emerging as a new clinical problem within pediatric practice.Recent reports indicate an increasing prevalence of type 2 diabetes mellitus in children and adolescents around the world in all ethnicities,even if the prevalence of obesity is not increasing any more.The majority of young people diagnosed with type 2 diabetes mellitus was found in specific ethnic subgroups such as African-American,Hispanic,Asian/Pacific Islanders and American Indians.Clinicians should be aware of the frequent mild or asymptomatic manifestation of type 2 diabetes mellitus in childhood.Therefore,a screening seems meaningful especially in high risk groups such as children and adolescents with obesity,relatives with type 2 diabetes mellitus,and clinical features of insulin resistance(hypertension,dyslipidemia,polycystic ovarian syndrome,or acanthosis nigricans).Treatment of choice is lifestyle intervention followed by pharmacological treatment(e.g.,metformin).New drugs such as dipeptidyl peptidase inhibitors or glucagon like peptide 1 mimetics are in the pipeline for treatment of youth with type2 diabetes mellitus.However,recent reports indicate a high dropout of the medical care system of adolescents with type 2 diabetes mellitus suggesting that management of children and adolescents with type2 diabetes mellitus requires some remodeling of current healthcare practices. | Thomas Reinehr | 2013 | World Journal of Diabetes2013，4，6： | 21 |
| 2 | Apoptotic retinal ganglion cell loss is accompanied by complement and cytokine response in theβB1-CTGF primary open-angle glaucoma mouse model显示文摘Glaucoma is a multifactorial disease and occurs in many different species.In humans,glaucoma is accounted one of the leading causes for blindness worldwide.Due to glaucoma's complexity,it is still unclear what pathomechanisms may be involved in its development in humans as well as in other species,such as canines.Diagnosis of glaucoma can be delayed because patients often do not notice a visual field loss until approximately30%of retinal ganglion cells(RGCs)are lost(Kerrigan-Baumrind et al.,2000).Although the exact undergoing pathomechanisms of glaucoma disease are not fully understood yet,an increased intraocular pressure(IOP)is related to RGCdeath and is considered the main risk factor. | Ana Maria Mueller-Buehl Sabrina Reinehr | 2023 | Neural Regeneration Research2023，18，2： | 2 |
| 3 | Diabetes mellitus type?2 in childhood and adolescence in Germany and parts of Austria显示文摘 | Edith Schober Reinhard W. Holl Matthias Grabert Angelika Thon Birgit Rami Thomas Kapellen Ora Seewi Thomas Reinehr | 2005 | European Journal of Pediatrics2005，，11： | 2 |
| 4 | Leptin concentrations are a predictor of overweight reduction in a lifestyle intervention 显示文摘 | Reinehr T Kleber M de Sousa G | 2009 | Int J Pediatr Obes2009，4，4： | 1 |
| 5 | Sorafenib ac- tivates CD95 and promotes autophagy and cell death via Src family kinases in gastrointestinal tumor cells显示文摘 | Park MA Reinehr R Haussinger D | 2010 | Mol Cancer Ther2010，9，8： | 1 |
| 6 | Fetuin-A and Its Relation to Metabolic Syndrome and Fatty Liver Disease in Obese Children Before and After Weight Loss显示文摘 | Reinehr T Roth CL | 2008 | J Clin Endocrinol Metab2008，93，11： | 1 |
| 7 | The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells显示文摘 | Keitel V Reinehr R Gatsios P | 2007 | Hepatology2007，45，3： | 1 |
| 8 | Cardiovaseular risk in 26 008 EuroPean overweight children as established by a multieenter database显示文摘 | Allemand D WiegandS Reinehr T | 2008 | Obesity(Silve Spring)2008，16，7： | 1 |
| 9 | The G -protein cou- pled bile salt receptor TGR5 is expressed in liver sinusoidal en- dothelial cells显示文摘 | KEITEL V REINEHR R GATSIOS P | 2007 | Hepatology2007，45，3： | 1 |
| 10 | Activation of rat hepatic stellate cells in culture is associated with increased sensitivity to endothelin 1 显示文摘 | Reinehr RM Kubitz R Peters-Regehr T | 1998 | Hepatology1998，28，6： | 1 |
| 11 | Does steroid treatment of ab- dominal pain prevent renal involvement in Henoeh-Seha nlein purpura? 显示文摘 | Reinehr T Btirk G Andler W | 2000 | J Pediatr Gastroenterol Nutr2000，31，3： | 1 |
| 12 | Vitamin D status and parathyroid hormone in obese children before and after weight loss显示文摘 | Reinehr T de Sousa G Alexy U | 2007 | Eur J Endoerinol2007，157，2： | 1 |
| 13 | Releas of osmolytes from perfused rat liver on perivascular nerve stimulation:alpha-adrenergic control of osmolyte efflux from parenchymal and nonparenchymal liver cells显示文摘 | Vom-Dahl S Bode JG Reinehr RM | 1999 | Hepatology1999，29，： | 1 |
| 14 | Effects of angiotensin Ⅱ on rat pancreatic stellate cells显示文摘 | Reinehr R Zoller S Klonowski-Stumpe H | 2004 | Pancreas2004，28，2： | 1 |
| 15 | Effect oflifestyle intervention on features of polycystic ovarian syndrome,metabolic syndrome,and intima-media thickness in obeseadolescent girls显示文摘 | Lass A Kleber M Winkel K Wunsch R Reinehr T | 2011 | J Clin Endocrinol MeTab2011，96，11： | 1 |
| 16 | Vitamin D status and parathyroid hormone in obese children before and after weight loss显示文摘 | Reinehr T de Sousa G Alexy U | 2007 | Eur J Endocrinol2007，157，2： | 1 |
| 17 | Effects of angiotensin Ⅱ on rat pancreatic stellate cells显示文摘 | Reinehr R Zoller S Klonowski-Stumpe H | 2004 | Pancreas2004，28，： | 1 |
| 18 | Adrogens before and after weight loss in obese children显示文摘 | | 2005 | Clinical The Journal of Endocrinology and Metabolism2005，90，10： | 1 |
| 19 | Cardiovascular risk in 26,008 European overweight children as established by a multicenter database 显示文摘 | I'Allemand D Wiegand S Reinehr T | 2008 | Obesity ( Silver Spring )2008，16，： | 1 |
| 20 | Obesity and thyoid function显示文摘 | Reinehr T | 2010 | Mol Cell Endocrinol2010，316，2： | 1 |
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