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| 1 | Alectinib: a novel second generation anaplastic lymphoma kinase(ALK) inhibitor for overcoming clinically-acquired resistance显示文摘The development of inhibitors for the tyrosine anaplastic lymphoma kinase(ALK) has advanced rapidly, driven by biology and medicinal chemistry. The first generation ALK inhibitor crizotinib was granted US FDA approval with only four years of preclinical and clinical testing. Although this drug offers significant clinical benefit to the ALK-positive patients, resistance has been developed through a variety of mechanisms. In addition to ceritinib, alectinib is another second-generation ALK inhibitor launched in 2014 in Japan. This drug has a unique chemical structure bearing a 5H-benzo[b]carbazol-11(6H)-one structural scaffold with an IC_(50) value of 1.9 nmol/L, and is highly potent against ALK bearing the gatekeeper mutation L1196 M with an IC_(50) of 1.56 nmol/L. In the clinic, alectinib is highly efficacious in treatment of ALK-positive non-small cell lung cancer(NSCLC), and retains potency to combat crizotinib-resistant ALK mutations L1196 M, F1174 L, R1275 Q and C1156 Y. | Zilan Song Meining Wang Ao Zhang | 2015 | Acta Pharmaceutica Sinica B2015，5，1： | 10 |
| 2 | Layer-by-layer assembled carbon nanotubes for selective determination of dopamine in the presence of ascorbic acid显示文摘 | ZHANG MEINING GONG KUANPING ZHANG HONGWU | 2005 | Biosensors and Bioelectronics2005，20，： | 1 |
| 3 | Layer-by-layer assembled carbon nanotubes for selective determination of dopamine in the presenceof ascorbic acid 显示文摘 | Meining Zhang Kuanping Gong Hongwu Zhang et al | 2005 | Biosensors and Bioelectronics2005，20，： | 1 |
| 4 | Gibberellin inhibitors improve embryogenic tissue initiation in conifers显示文摘 | Gerald S. Pullman J. Mein S. Johnson Y. Zhang | | 0，2005，： | 1 |
| 5 | Sustainability indices as a tool for urban managers, evidience from four mediumsized Chinese cities 显示文摘 | Meine Pieter van Dijk Zhang Mingshun | 2005 | Environmental Impact Assessment Review2005，25，： | 1 |
| 6 | Sustainability indices as a tool for urban managers,evidience from four medium-sized Chinese cities显示文摘 | Zhang Mingshun | 2005 | Environmental Impact Assessment Review2005，25，： | 1 |
| 7 | Flaps and grafts reconstructior显示文摘 | I Zhang AY Meine JG | 2011 | Dermatol Clin2011，29，2： | 1 |
| 8 | Bioelectrochemically Functional Nanohybrids through Co-Assembling of Proteins and Surfactants onto Carbon Nanotubes: Facilitated Electron Transfer of Assembled Proteins with Enhanced Faradic Response 显示文摘 | Yiming Yan Wei Zheng Meining Zhang | 2005 | Langmuir2005，21，： | 1 |
| 9 | Surfactant functionalization of carbon nanotubes(CNTs)for layer-by-layer assembling of CNT multi-layer films and fabrication of gold nanoparticle/CNT nanohybrid显示文摘 | Zhang Meining Su Lei Mao Lanqum | 2006 | Carbon2006，44，2： | 1 |
| 10 | Single-atom electrocatalysis: a new approach to in vivo electrochemical biosensing显示文摘Modulation of interfacial electron transfer has been proven to pave a new approach to in vivo electrochemical monitoring of brain chemistry;however,designing and establishing highly efficient electrocatalytic scheme towards neurochemicals remain a longstanding challenge.Here,we find that recently established single-atom catalyst(SAC)can be used for catalyzing the electrochemical process of physiologically relevant chemicals and thus offers a new avenue to in vivo electrochemical biosensing.To prove this new concept,we used Co single-atom catalyst(Co-SAC),in which the atomic active sites are dispersed in ordered porous N-doping carbon matrix at atomic level,as an example of SACs for analyzing glucose as the physiologically relevant model chemicals.We found that Co-SAC catalyzes the electrochemical oxidation of hydrogen peroxide(H2O2)at a low potential of ca.+0.05 V(vs.Ag/AgCl).This property was further used for developing an oxidase-based glucose biosensor that was used subsequently as a selective detector of an online electrochemical system(OECS)for continuous monitoring of microdialysate glucose in rat brain.The OECS with Co-SAC-based glucose biosensor as the online detector was well responsive to glucose without interference from other electroactive species in brain microdialysate.This study essentially offers a new approach to in vivo electrochemical analysis with SACs as electrocatalysts to modulate interfacial electron transfer. | Hanfeng Hou Junjie Mao Yunhu Han Fei Wu Meining Zhang Dingsheng Wang Lanqun Mao Yadong Li | 2019 | Science China Chemistry2019，62，12： | 1 |
| 11 | Sustainability Indices as a Tool for Urban Managers, Evidence from Four Medium-sized Chinese Cities显示文摘 | Meine Pieter van Dijka Zhang Mingshun | 2005 | Environmental Impact Assessment Review2005，，25： | 1 |
| 12 | A structrurebased modal of the reaction catalyed by lumazine synthase form Aquifex aeolicus 显示文摘 | ZHANG XF MEINING W CUSHMAN M | 2003 | J Mol Biol2003，328，1： | 1 |
| 13 | Surfactant functionlization of carbon nanotubes (CNTs) for layer - by - layer assembling of CNT multi - layer films and fabrication of gold nanoparticle/CNT nanohybrid显示文摘 | Zhang Meining Su Lei Mao Lanqun | 2006 | Carbon2006，44，： | 1 |
| 14 | Sustainability indices as a tool for urban managers, evidence from four medium-sized Chinese cities显示文摘 | Meine Pieter van Dijk Zhang Mingshun | 2004 | Environmental Impact Assessment Review2004，，6： | 1 |
| 15 | 降低Pin1对大肠癌SW620细胞的增殖和凋亡能力的影响(英文)显示文摘Objective:The aim of our study was to investigate the effects of Pin1 reduction on SW620 cell proliferation and apoptosis in human colorectal carcinoma.Methods:We constructed a plasmid of RNA interfering(shRNA) for Pin1 gene(pGenesl-1-Pin1),then the plasmid was transfected into colorectal carcinoma SW620 cells line by liposome mediation.The protein expression of Pin1 was tested by Western blotting.The proliferation rate was analyzed by MTT and the apoptotic rate of cells was tested by flow cytometry.In order to explain further the effect of Pin1 in SW620 cells,the protein level of Bcl-2 was analyzed by Western blotting.Results:pGenesil-1-Pin1 plasmid was successfully constructed and confirmed by sequencing.The protein relative levels of Pin1 were 0.06 ± 0.04 for the P-shRNA/SW620 cells,and 0.32 ± 0.09 for the P-Con/SW620 cells.The cell growth rate of SW620 cells was slower while the apoptotic rate was increased after transfection with pGenesil-Pin1 plasmid,and the apoptotic rate was 12.38% ± 1.55% for the P-shRNA/SW620 group.At the same time,we found that the protein expression of Bcl-2 was also reduced.The results were 0.13 ± 0.04 for the P-shRNA/SW620 cells,and 0.36 ± 0.08 for the P-Con/SW620 cells.Conclusion:Inhibited Pin1 expression may suppress the cell proliferation and promote apoptosis of colorectal carcinoma cells in vitro. | Yan Zhu Liyuan Qin Meining Li Dong Zhang Yuehong Zhang Niuliang Cheng | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，2： | 0 |
| 16 | Nkx2.1 downregulation is involved in brain abnormality induced by excess retinoic acid显示文摘Abnormal development of central nervous system(CNS)caused by neural tube defects is not only a major con tributor in the prevale nee of stillbirths and n eonatal deaths but also causes lifelong physical disability in surviving infants.Due to insufficient known investigated causes,CNS developmental abnormality has brought sever burden on health around the world.From previous results of high throughput transcriptome sequencing,we selected transcription factor Nkx2.1 as a candidate to investigate its role on brain abnormalities induced by excessive retinoic acid.The result of in situ hybridization showed that Nkx2.1 was mainly expressed in mouse brain.After the Nkx2.1 gene was sileneed,retarded proliteration and accelerated apoptosis were found in mouse Neuro-2a(N2a)cells.Furthermore,our results indicated that the main components of sonic hedgehog(Shh)signaling pathway were affected in Nkx2.7-silenced cells,implying that Nkx2.1 plays an important role in the development of mouse brain by regulating Shh signaling pathway. | Sansan Jia Li Zhang Kaili Zhang Lei Wang Ajab Khan Juan Zhang Yuqing Sun Yufei Wang Meiyan Song Yi Lyu Meining Li Xin Lu Bo Niu Zhizhen Liu Jun Xie | 2020 | Acta Biochimica et Biophysica Sinica2020，52，6： | 0 |
| 17 | 抑制Pin1通过NF-κB途经抑制大肠癌HCT116细胞的端粒酶(英文)显示文摘Objective: The aim of our study was to investigate the effect of Pin1 on the telomerase activity in human colorectal carcinoma HCT116 cells. Methods: Firstly, we transfected plasmid pGenesil-1-Pin1 (p-shRNA) using liposome (Lipofectamine 2000) into colorectal cancer HCT-116 cells to down-regulate the expression of Pin1. To detect the apoptotic rate of HCT116 cells was by cytometry (FCM). The expression of Pin1 and hTERT at RNA levels in human colorectal cancer HCT116 cells were determined by RT-PCR. To evaluate the activity of telomerase was by TRAP-silver staining. The subcellular localization and accumulative level of p-NF-κB/p65 protein at the nuclear was detected by Immunofluorescence and Western blotting. The DNA-binding activity of NF-κB/p65 was detected by electrophoretic mobility shift assay (EMSA). Results: Using liposome into colorectal cancer HCT-116 cells, and down-regulate the expression of Pin1 (0.392 ± 0.072-fold; P = 0.001), and the apoptotic rate was increased (11.40% ± 1.54%; P < 0.05). Compared with transfected p-CON cell group, in transfected p-shRNA cell group, the transcription of hTERT was lower (0.171 ± 0.060-fold; P = 0.001) by quantitative real-time RT-PCR, and the results of TRAP-silver staining analysis suggested that the telomerase activity was significantly declined (0.384 ± 0.015-fold; P < 0.05). Furthermore, it was demonstrated by Immunofluorescence that p-NF-κB/p65 had a nuclear localization, and the level of p-NF-κB/p65 protein at the nuclear was reduced with silencing the expression of Pin1 by Western blotting. Using EMSA, it was suggested that NF-κB/p65 was able to bind to hTERT promoter, and the direct interaction was declined with silencing the expression of Pin1. Conclusion: Taken together, silencing Pin1 may suppress activity of telomerase and the expression of hTERT by inhibiting NF-κB/p65 activity and reducing the combination of NF-κB/p65 and hTERT gene promoter. | Jianwen Sun Lijun Fan Meining Li Yuehong Zhang Niuliang Cheng | 2013 | The Chinese-German Journal of Clinical Oncology2013，12，4： | 0 |
| 18 | Synthesis Study toward Mayamycin显示文摘自然产品 mayamycin 是在在 benz 的 C5 位置展示一个 C-glycoside 连接的 angucycline 班上的第一个例子[一] 有显著生物活动的 anthracenone 核心。我们成功地综合了二 retrosynthetic 碎片,但是发现最后的 C-glycosylation 没发生。或者, A-ring 浸透了 aglycon 被准备,但是建议 C-glycosylation 仍然没继续。最后,简化底层被使用,随后的 C-glycosylation 顺利通过了,给 mayamycin 的二戒指的更少类似物。 | Kui Wu Meining Wang Qizheng Yao Ao Zhang | 2013 | Chinese Journal of Chemistry2013，31，1： | 0 |
| 19 | 降低Pin1可以抑制大肠癌细胞SW620的侵袭转移能力(英文)显示文摘Objective:The aim of our study was to investigate the effect of Pin1 on the expression of MMP-2 and MMP-9 in human colorectal carcinoma SW620 cells. Methods: We constructed a eukaryotic expression vector of RNA interfering (shRNA) for Pin1 gene (pGenesil-1-Pin1), and then observed its expression in SW620 cells by Western blotting. The cells motility were tested by wound healing assay and Boyden chamber assay. The protein levels and activity of MMP-2 and MMP-9 were tested by Western blotting and Gelatin zymography in SW620 cells after transfected with pGenesil-1-PIN1. Results: pGenesil-1-PIN1 was successfully constructed, which was confirmed by sequencing. Silencing the Pin1 by RNAi significantly decreased the cells motility from 96.4±3.9 per field (×10 objective) to 52.7±4.4 per field (P<0.05, Student's t-test) for SW620 cells transfected with pGenesil-1-PIN1 (SW620/p-shRNA) in Boyden chamber assay, and reduced the MMP-2 and MMP-9 expressions and activity in SW620 cells. The protein relative levels of MMP-2 were 0.32±0.04 for SW620/p-shRNA, and 0.76±0.03 for SW620/p-Con; MMP-9 were 0.41±0.09 for SW620/p-shRNA, and 0.94±0.07 for SW620/p-Con (p<0.05). Conclusion: Inhibited Pin1 expression may contribute to the suppression of the invasive and metastatic capacity of colon cancer cells in vitro. | Liyuan Qin Hua Hao Meining Li Dong Zhang Jianlin Zhang Niuliang Cheng | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，4： | 0 |
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