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| 1 | Effect of Nimesulide on proliferation and apoptosis of human hepatoma SMMC-7721 cells显示文摘AIM: Cyclooxygenase-2 (COX-2) has been suggested to beassociated with carcinogenesis. We sought to investigatethe effect of the selective COX-2 inhibitor, Nimesulide onproliferation and apoptosis of SMMC-7721 human hepatomacells.METHODS: This study was carried out on the culture ofhepatic carcinoma SMMC-7721 cell line. Variousconcentrations of Nimesulide (0、200 μmol/L、300 μmol/L、400μmol/L) were added and incubated. Cell proliferation wasdetected with MTT colorimetric assay, cell apoptosis byelectron microscopy, flow cytometry and TUNEL.RESULTS: Nimesulide could significantly inhibit SMMC-7721cells proliferation dose-dependent and in a dependentmanner compared with that of the control group. Theduration lowest inhibition rate produced by Nimesulide inSMMC-7721 cells was 19.06 %, the highest inhibition ratewas 58.49 %. After incubation with Nimesulide for 72 h, themost highest apoptosis rate and apoptosis index of SMMC-7721 cells comparing with those of the control were 21. 20 %+1.62% vs2.24% +0.26% and21.23+ 1.78 vs2.01+0.23(p<0.05).CONCLUSION: The selective COX-2 inhibitor, Nimesulide caninhibit the proliferation of SMMC-7721 cells and increaseapoptssis rate and apoptosis index of SMMC-7721 cells. Theapoptoois rate and the apoptosis index are dose-dependent.Under electron microscope SMMC-7721 cells incubated with 300μmol and 400 μmol Nimesulide show apoptotic characteristics.With the clarification of the mechanism of selective COX-2inhibitors, These COX-2 selective inhibitors can become thechoice of prevention and treatment of cancers. | Geng Tian Jie-Ping Yu He-Sheng Luo Bao-Ping Yu Hui Yue Jian-Ying Li Oiao Mei,Gastroenterology department,Renmin hospital of Wuhan university,Wuhan 430060,Hubei Province,China | 2002 | World Journal of Gastroenterology2002，8，3： | 51 |
| 2 | Dual-targeting and microenvironment-responsive micelles as a gene delivery system to improve the sensitivity of glioma to radiotherapy显示文摘Dbait is a small double-stranded DNA molecule that has been utilized as a radiosensitizer to enhance the sensitivity of glioma to radiotherapy(RT). However, there is no effective drug delivery system to effectively overcome the blood–brain barrier(BBB). The aim of this study was to develop a gene delivery system by using the BBB and glioma dual-targeting and microenvironment-responsive micelles(ch-Kn(s-s)R8-An) to deliver Dbait into glioma for RT. Angiopep-2 can target the low-density lipoprotein receptor-related protein-1(LRP1) that is overexpressed on brain capillary endothelial cells(BCECs) and glioma cells. In particular, due to upregulated matrix metalloproteinase 2(MMP-2) in the tumor microenvironment, we utilized MMP-2-responsive peptides as the enzymatically degradable linkers to conjugate angiopep-2. The results showed that ch-Kn(s-s)R8-An micelles maintained a reasonable size(80–160 nm) with a moderate distribution and a decreased mean diameter from the cross-linking as well as exhibited low critical micelle concentration(CMC) with positive surface charge, ranging from 15 to40 mV. The ch-K5(s-s)R8-An/pEGFP showed high gene transfection efficiency in vitro, improved uptake in glioma cells and good biocompatibility in vitro and in vivo. In addition, the combination of ch-K5(s-s)R8-An/Dbait with RT significantly inhibited the growth of U251 cells in vitro. Thus, ch-K5(s-s)R8-An/Dbait may prove to be a promising gene delivery system to target glioma and enhance the efficacy of RT on U251 cells. | Xiuxiu Jiao Yuan Yu Jianxia Meng Mei He Charles Jian Zhang Wenqian Geng Baoyue Ding Zhuo Wang Xueying Ding | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 13 |
| 3 | First mass measurement of short-lived nuclides at HIRFL-CSR显示文摘Recent commissioning of the HIRFL-CSR has demonstrated its ability to perform direct mass measurement for short-lived nuclides. Projectile fragments produced by the 78Kr ions at 481.88 MeV/u were separated with the new radioactive beam line in Lanzhou (RIBLL2), and injected into and stored in the experimental storage ring (CSRe). By operating the CSRe as an isochronous mass spectrometry, a typical mass resolution around 2.0×10?5 has been achieved. The masses for 63Ge, 65As and 67Se were measured for the first time. The measured masses are compared with theoretical predictions and the location of the proton drip-line for As isotopes is discussed. The implication of the 65As mass in the astrophysical rapid proton capture process has also been addressed. | XU HuShan TU XiaoLin YUAN YouJin XIA JiaWen ZANG YongDong WANG Meng MAO RuiShi HU ZhengGuo MEI Bo SHUAI Peng ZHU ZhiChao TANG ShuWen GENG Peng LIU Yong ZHAO TieCheng ZHANG XueYing YANG JianCheng MAO LiJun ZHANG YuHu ZHOU XiaoHong HUANG WenXue XIAO GuoQing ZHAO HongWei ZHAN WenLong | 2009 | Chinese Science Bulletin2009，54，24： | 11 |
| 4 | Erythrocytic or serum hydrogen sulfide association with hypertension development in untreated essential hypertension显示文摘在这研究的 hypertension.The 目的一个重要角色是与未经治疗的必要 hypertension.Methods 在病人调查红血球和浆液 H2S 的角色的背景内长的氢硫化物( H2S )戏我们与未经治疗的 prehypertension 或高血压招募了 62 个病人(年龄 22-74 年),并且 .We 估计了的 64 个正常血压的题目(年龄 18-64 年)在红血球的 3-mercaptopyruvate sulphurtransferase ( MPST )蛋白质表示并且从红血球和 se 测量了 H2S | ZHENG Mei ZENG Qiang SHI Xiao-qin ZHAO Jing TANG Chao-shu SUN Ning-ling GENG Bin | 2011 | Chinese Medical Journal2011，，22： | 8 |
| 5 | Prediction of 10-year Atherosclerotic Cardiovascular Disease Risk among Adults Aged 40-79 Years in China:a Nationally Representative Survey显示文摘Objective To establish the distribution of 10-year atherosclerotic cardiovascular disease(ASCVD) risk among Chinese adults.Methods We estimated the 10-year ASCVD risk by applying the 2013 American College of Cardiology/American Heart Association pooled cohort equations(PCEs) to the data obtained from the 2010 China Chronic Disease and Risk Factor Surveillance that involved 61,541 participants(representing 520,158,652 Chinese adults) aged 40-79 years.We also compared the ASCVD risk with the 10-year ischemic cardiovascular disease(ICVD) risk,which was calculated using the simplified scoring tables recommended by the Chinese Guidelines for Prevention of Cardiovascular Diseases(Chinese model).Results Based on the PCEs,the average 10-year ASCVD risk among adults without self-reported stroke or myocardial infraction was 12.5%.Approximately 247 million(47.4%) and 107 million(20.6%) adults had ≥ 7.5% and > 20% 10-year ASCVD risks,respectively.The 10-year ASCVD risk > 20% was higher among men,less educated individuals,smokers,drinkers,and physically inactive individuals than among their counterparts.Overall,29.0% of adults categorized using the Chinese model were overclassified with the PCEs.Conclusion Our results define the distribution of 10-year ASCVD risk among Chinese adults.The 10-year ASCVD risk predicted by the PCEs was higher than the ICVD risk predicted by the Chinese model. | ZHANG Mei JIANG Yong WANG Li Min LI Yi Chong HUANG Zheng Jing LI Jian Hong ZHOU Mai Geng ZHAO Wen Hua 无 | 2017 | Biomedical and Environmental Sciences2017，30，4： | 7 |
| 6 | The Cellular Toxicity of PM_(2.5) Emitted from Coal Combustion in Human Umbilical Vein Endothelial Cells显示文摘Objective To explore the relationship between different components of fine particulate matter(PM_(2.5))emitted from coal combustion and their cytotoxic effect in the vascular endothelial cells.Methods Coal-fired PM_(2.5) was sampled using a fixed-source dilution channel and flow sampler.The sample components were analyzed by ion chromatography and inductively coupled plasma atomic emission spectroscopy(ICP-AES).The PM_(2.5) suspension was extracted using an ultrasonic water-bath method and then human umbilical vein endothelial cells(EA.hy926)were treated with various concentrations of the PM_(2.5) suspension.Cell proliferation,oxidative DNA damage,and global DNA methylation levels were used to measure the cellular toxicity of PM_(2.5) emitted from coal combustion.Results Compared to other types of coal-fired PM_(2.5) preparations,the PM_(2.5) suspension from Yinchuan coal had the highest cytotoxicity.PM_(2.5) suspension from Datong coal had the highest toxic effect while that from Yinchuan coal had the lowest.Exposure to coal-fired PM_(2.5) from Jingxi coal resulted in lower8-hydroxy-2'-deoxyguanosine(8-OHd G)levels.At the same dose,PM_(2.5) emitted from coal combustion could produce more severe DNA impairment compared to that produced by carbon black.Cell survival rate was negatively correlated with chloride and potassium ions content.The 5-methylcytosine(5-m C)level was positively correlated with Mn and negatively correlated with Zn levels.The 8-OHd G%level was positively correlated with both Mn and Fe.Conclusion PM_(2.5) emitted from coal combustion can decrease cell viability,increase global DNA methylation,and cause oxidative DNA damage in EA.hy926 cells.Metal components may be important factors that influence cellular toxicity. | WANG Fei Fei GENG Chun Mei HAO Wei Dong ZHAO Yong Dong LI Qin WANG Hong Mei QIAN Yan | 2016 | Biomedical and Environmental Sciences2016，29，2： | 5 |
| 7 | Diffusion mechanism simulation of cloud manufacturing complex network based on cooperative game theory显示文摘Cloud manufacturing is a specific implementation form of the 'Internet + manufacturing' strategy. Why and how to develop cloud manufacturing platform(CMP), however, remains the key concern of both platform operators and users. A microscopic model is proposed to investigate advantages and diffusion forces of CMP through exploration of its diffusion process and mechanism. Specifically, a three-stage basic evolution process of CMP is innovatively proposed. Then, based on this basic process, a more complex CMP evolution model has been established in virtue of complex network theory, with five diffusion forces identified. Thereafter, simulations on CMP diffusion have been conducted. The results indicate that, CMP possesses better resource utilization,user satisfaction, and enterprise utility. Results of simulation on impacts of different diffusion forces show that both the time required for CMP to reach an equilibrium state and the final network size are affected simultaneously by the five diffusion forces. All these analyses indicate that CMP could create an open online cooperation environment and turns out to be an effective implementation of the 'Internet + manufacturing' strategy. | GENG Chao QU Shiyou XIAO Yingying WANG Mei SHI Guoqiang LIN Tingyu XUE Junjie JIA Zhengxuan | 2018 | Journal of Systems Engineering and Electronics2018，29，2： | 4 |
| 8 | Prognostic value of clinicopathological characteristics in patients with pancreatic cancer显示文摘Background:The purpose of this study was to analyze me effects of all clinical characteristics on the overall survival time,in order to provide a basis for determining the prognostic factor of patients with pancreatic cancer.Methods:A total of 103 pancreatic cancer patients were admitted to the Department of Radiotherapy and Chemotherapy of the Ruijin Hospital,Shanghai Jiaotong University School of Medicine,between January 2002 and December 2012.There were 68 men and 35 women;the median age was 62 years.Diagnoses of pancreatic cancer in all patients were confirmed by histopathology,cytology,or clinical diagnosis.The Kaplan-Meier method was performed to calculate the overall survival rate.The log-rank method was used to examine the univariate analysis.The Cox regression model was performed for multivariate analysis.Results:The median survival time was 293 days,the 1-,2-,and 3-year survival rates were 27.18%,5.83%,and 1.94%,respectively.Cox regression analysis revealed that age(P=0.015),Karnofsky performance status(PS)(P=0.002),surgical types(P<0.001),and platelet counts(P<0.001) were independent prognostic factors affecting the overall survival of patients with pancreatic cancer.Conclusions:Pancreatic cancer had a poor prognosis,the general physical condition,age,the availability of radical surgery,and platelet counts were factors influencing the overall survival of patients with pancreatic cancer. | Mei Geng Haoping Xu Ruobing Ren Qing Qu Chengfang Shangguan Junwei Wu Jinsong Jiang Hao Li Weiguo Cao | 2015 | Chinese Journal of Cancer Research2015，27，5： | 4 |
| 9 | Effects of L-arginine during ischemia-reperfusion injury in rat orthotopic liver transplantation显示文摘EfectsofLarginineduringischemiareperfusioninjuryinratorthotopiclivertransplantationDIAOTongJin1,YAOXiaoPing2,JIBing1,YANG... | DIAO Tong Jin 1, YAO Xiao Ping 2, JI Bing 1, YANG Jia Mei 2, WU Meng Chao 2 and ZHANG Shao Geng 3 1Department of General Surgery, Chinese PLA 401 Navy Hospital, Qingdao 266071, Shandong Province, China 2Eastern Hospital of Hepa | 1998 | World Journal of Gastroenterology1998，4，3： | 4 |
| 10 | Vegetable and Fruit Consumption among Chinese Adults and Associated Factors: A Nationally Representative Study of 170,847 Adults显示文摘Objective This study examined vegetable and fruit(VF) consumption rate and its associated factors among Chinese adults.Methods Nationally representative data from the 2013 China Chronic Disease Surveillance survey were used. Dietary intake data, including VF consumption during the last 12 months, were collected. All analyses were weighted to obtain nationally representative estimates. Associations between VF consumption and other factors(e.g., meal frequency and physical activity) were examined through logistic regression analysis.Results The average fruit consumption was 102.3 g/day(95% CI: 97.0‐107.6) and the average vegetable consumption was 350.6 g/day(95% CI: 339.3‐361.8). Over half(53.2%, 95% CI: 50.9‐55.4) of Chinese adults met the VF consumption of 400 g/day recommended by the World Health Organization(WHO). Rural residents had a higher prevalence of low VF consumption rate than urban residents[49.20%(95% CI: 46.2%‐52.2%) vs. 44.0%(95% CI: 41.7%‐46.3%) P < 0.01]. Old age(OR = 1.01, 95% CI:1.00‐1.01), low educational level, low income, minority ethnicity(OR = 1.41, 95% CI: 1.15‐1.74),underweight(OR = 1.17, 95% CI: 1.03‐1.33), single marital status(OR = 1.20, 95% CI: 1.08‐1.33), low health literacy, irregular breakfast(OR = 1.20, 95% CI: 1.04‐1.38) or lunch(OR = 1.58, 95% CI: 1.26‐1.99)habits, and no leisure‐time physical activity were associated with low VF consumption.Conclusion Only half of Chinese adults met the VF consumption recommended by the WHO. Low socio‐economic status, irregular diet, and poor health literacy were likely associated with low VF consumption. National efforts and programs are needed to promote VF consumption. | LI Yi Chong JIANG Bo ZHANG Mei HUANG Zheng Jing DENG Qian ZHOU Mai Geng ZHAO Zhen Ping WANG You Fa WANG Li Min | 2017 | Biomedical and Environmental Sciences2017，30，12： | 3 |
| 11 | The establishment and evaluation of near infrared universal model to determinate the effective ingredient content in pesticide rapidly显示文摘一个近红外线的通用定量分析模型被建立到确定在杀虫剂 EC (hikernalisation ) 由的有效成分内容请(部分最少的广场) 算法,模型预兆的能力被外部检查方法评估。模型在从五个不同公司,和模型决心系数 R2 和 RMSECV (生气确认的根均方差)包含一样的活跃成分的样品之中被建立分别地,是 0.9997 和 0.0223 在预言的价值和严峻的集合样品的化学价值之间的相对错误在2.71%和3.36%之间,它显示方法到确定在由确定的通用模型的杀虫剂 EC 的有效成分内容能遇见 | Yan Mei Xiong Xiang Zhong Song Chang Zhou Chen Hong Ping Lin Guo Tang Yue Huang Jia Duan Shun Geng Min | 2012 | Chinese Chemical Letters2012，23，9： | 3 |
| 12 | Research progress of rare earth composite shielding materials显示文摘With the rapid development of nuclear technology,nuclear protection has received extensive attention.As an important strategic resource,rare earth plays an important role in the field of nuclear shielding materials.In this review,the shielding principles of rare earth materials are first introduced.According to the type of matrix,the characteristics and current research status of metal-based,inorganic nonmetallic-based and polymer-based rare earth shielding materials are reviewed.Meanwhile,the future development trend of rare earth shielding materials is discussed. | Hui Jing Laiyao Geng Shaoyu Qiu Huawei Zou Mei Liang Dan Deng | 2023 | Journal of Rare Earths2023，41，1： | 3 |
| 13 | Learning hyperspectral images from RGB images via a coarse-to-fine CNN显示文摘Hyperspectral remote sensing is well-known for its extraordinary spectral distinguishability to discriminate different materials.However,the cost of hyperspectral image(HSI)acquisition is much higher compared to traditional RGB imaging.In addition,spatial and temporal resolutions are sacrificed to obtain very high spectral resolution owing to the limitations of sensor technologies.Therefore,in this paper,HSIs are reconstructed using easily acquired RGB images and a convolutional neural network(CNN).As a result,high spatial and temporal resolution RGB images can be inherited to HSIs.Specifically,a two-stage CNN,referred to as the spectral super-resolution network(SSR-Net),is designed to learn the transformation model between RGB images and HSIs from training data,including a band prediction network(BP-Net)to estimate hyperspectral bands from RGB images and a refinement network(RF-Net)to further reduce spectral distortion in the band prediction step.As a result,the learned joint features in the proposed SSR-Net can directly predict HSIs from their corresponding scenes in RGB images without prior knowledge.Experimental results obtained on several benchmark datasets demonstrate that the proposed SSR-Net outperforms several state-of-the-art methods by ensuring higher quality in HSI reconstruction,and significantly improves the performance of traditional RGB images in classification. | Shaohui MEI Yunhao GENG Junhui HOU Qian DU | 2022 | Science China(Information Sciences)2022，65，5： | 3 |
| 14 | Decomposition of mixed rare earth concentrate by NaOH roasting and kinetics of hydrochloric acid leaching process显示文摘A new clean extraction technology for the decomposition of Bayan Obo mixed rare earth concentrate by NaOH roasting is proposed.The process mainly includes NaOH roasting to decompose rare earth concentrate and HCl leaching roasted ore.The effects of roasting temperature,roasting time,NaOH addition amount on the extraction of rare earth and factors such as HCl concentration,liquid-solid ratio,leaching temperature and leaching time on the dissolution kinetics of roasted ore were studied.The experimental results show that when the roasting temperature is 550℃and the roasting time is 60 min,the mass ratio of NaOH:rare earth concentrate is 0.60:1,the concentration of HCl is 6.0 mol/L,the ratio of liquid to solid(L/S)6.0:1.0,and the leaching temperature 90℃,leaching time 45 min,stirring speed 200 r/min,and the extraction of rare earth can reach 92.5%.The relevant experimental data show that the process of HCl leaching roasted ore conforms to the shrinking core model,but the control mechanism of the che mical reaction process is different when the leaching temperature is different.When the leaching temperature is between 40 and 70℃,the chemical reaction process is controlled by the diffusion of the product through the residual layer of the inert material.The average surface activation energy of the rare earth element is E_a=9.96 kJ/mol.When the leaching temperature is 75-90℃,the chemical reaction process is controlled by the interface transfer across the product layer(product layer interface mass transfer)and diffusion.The average surface activation energy of rare earth elements is E_a=41.65 kJ/mol.The results of this study have certain significance for the green extraction of mixed rare earth ore. | Mei Li Jianfei Li Dongliang Zhang Kai Gao Huihui Wang Wei Xu Jinlong Geng Xiaoyan Zhang Xiufen Ma | 2020 | Journal of Rare Earths2020，38，9： | 2 |
| 15 | miR-34a regulates cisplatin-induce gastric cancer cell death by modulating PI3K/AKT/survivin pathway显示文摘 | Weiguo Cao Weiping Yang Rong Fan Hao Li Jinsong Jiang Mei Geng Yening Jin Yunlin Wu | 2014 | Tumor Biology2014，，2： | 2 |
| 16 | Air-Steam Etched Construction of Hierarchically Porous Metal-Organic Frameworks显示文摘The introduction of mesoporosity into the microporous metal-organic frameworks(MOFs)is expected to expand their applications.Herein,we report a green and facile method to obtain hierarchically porous MOF structures by using an air-steam etching process.By virtue of the protonation reaction between the imidazole moiety and water vapor,the protonated imidazole related linkers leave the framework,resulting in the formation of mesopores in the zeolitic imidazolate frameworks(ZIFs),as exemplified by ZIF-8.Given the mild etching process,the materials'structural integrity and crystallinity are well maintained.Accordingly,the hierarchical porous ZIF-8 exhibited enhanced performance in the dye removal as well as CO_(2) cycloaddition reaction with epichlorohydrin in comparison with microporous ZIF-8,owing to the accelerated mass transfer arising from mesoporous structures.Remarkably,the proposed steam etching approach is generally applicable,which can be readily extended to other ZIFs,such as ZIF-14,ZIF-69,and ZIF-71,thus representing a powerful strategy to construct hierarchically porous MOF materials. | Hongliang Huang Yuxiu Sun Xuemeng Jia Wenjuan Xue Chenxu Geng Xin Zhao Donghai Mei Chongli Zhong | 2021 | Chinese Journal of Chemistry2021，39，6： | 2 |
| 17 | Porous fiber paper and 3D patterned electrodes composed high-sensitivity flexible piezoresistive sensor for physiological signal monitoring显示文摘The research on flexible pressure sensors has drawn widespread attention in recent years,especially in the fields of health care and intelligent robots.In practical applications,the sensitivity of sensors directly affects the precision and integrity of weak pressure signals.Here,a pressure sensor with high sensitivity and a wide measurement range composed of porous fiber paper and 3D patterned electrodes is proposed.Multi-walled carbon nanotubes with excellent conductivity were evenly sprayed on the fiber paper to form the natural spatial conducting networks,while the copper-deposited polydimethylsiloxane films with micropyramids array were used as electrodes and flexible substrates.Increased conducting paths between electrodes and fibers can be obtained when high-density micro-pyramids fall into the porous structures of the fiber paper under external pressure,thereby promoting the pressure sensor to show an ultra-high sensitivity of 17.65 kPa^(-1)in the pressure range of 0–2 kPa,16 times that of the device without patterned electrodes.Besides,the sensor retains a high sensitivity of 2.06 kPa^(-1)in an ultra-wide measurement range of 150 kPa.Moreover,the sensor can detect various physiological signals,including pulse and voice,while attached to the human skin.This work provides a novel strategy to significantly improve the sensitivity and measurement range of flexible pressure sensors,as well as demonstrates attractive applications in physiological signal monitoring. | HOU XiaoJuan ZHONG JiXin HE Jian YANG ChangJun YU JunBin MEI LinYu MU JiLiang GENG WenPing CHOU XiuJian | 2022 | Science China(Technological Sciences)2022，65，5： | 2 |
| 18 | Teicoplanin combined with conventional vancomycin therapy for the treatment of pulmonary methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis infections显示文摘BACKGROUND Vancomycin and teicoplanin are both antibiotics that have significant antimicrobial effects on Gram-positive cocci.AIM To explore the value of teicoplanin combined with conventional(vancomycin only)anti-infective therapy for the treatment of methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis pulmonary infections.METHODS A total of 86 patients with methicillin-resistant Staphylococcus aureus or methicillin-resistant Staphylococcus epidermidis pulmonary infections,treated in our hospital between January 2018 and February 2020,were assigned to the study and control groups using a random number table method,with 43 patients in each group.The control group received conventional treatment(vancomycin),and the study group received both teicoplanin and conventional treatment.The following indicators were assessed in both groups:the time required for symptom relief,treatment effectiveness,serum levels of inflammatory factors(procalcitonin,interleukin-1β,tumor necrosis factor-α,C-reactive protein),clinical pulmonary infection scores before and after treatment,and the incidence of adverse reactions.RESULTS Patients in the study group were observed to have faster cough and expectoration resolution,white blood cell count normalization,body temperature normalization,and rales disappearance than patients in the control group(all P<0.05);the total rate of effectiveness was 93.02%in the study group,higher than the 76.74%in the control group(P<0.05).The pre-treatment serum levels of procalcitonin,interleukin-1β,tumor necrosis factor-α,and C-reactive protein as well as the clinical pulmonary infection scores were similar among the patients in both groups.However,the post-treatment serum levels of procalcitonin,interleukin-1β,tumor necrosis factor-α,and C-reactive protein as well as the clinical pulmonary infection scores were significantly lower in the study group than in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the groups.CONCLUSION Compared with conventional(vancomycin only)therapy,teicoplanin and vancomycin combination therapy for patients with pulmonary methicillinresistant Staphylococcus aureus and methicillin-resistant Staphylococcus epidermidis infections can improve patient clinical symptoms,modulate serum inflammatory factor levels,and improve treatment efficacy,without increasing the risk of adverse reactions. | Wei Wu Min Liu Jia-Jing Geng Mei Wang | 2021 | World Journal of Clinical Cases2021，9，34： | 2 |
| 19 | A cross-sectional study of sputum handling by and supervision of patients with pulmonary tuberculosis tr-eated at home in China显示文摘 | Mei L Tobe R G Geng H | 2012 | Bioscience Trends2012，6，6： | 1 |
| 20 | SIRT1 Mediates Sestrin1-Induced Improvement in Hepatic Insulin Resistance显示文摘Mitochondria are important intracellular organelles that carry out oxidative phosphorylation,synthesize ATP,and provide energy for cell activities.Mitochondrial dysfunction can affect the normal function of the entire cell and is thought to be a major risk factor in the onset and progression of some diseases associated with chronic inflammation and insulin resistance[1]. | GENG Chao XUE Yuan YANG Jia Hui GAO Ming Yue ZHAO Wei LI Chun Mei XIE Xiang Hong ZHANG Wei Hong ZHANG Hua Bing FANG Fu De YAO Hong LIU Xiao Jun | 2022 | Biomedical and Environmental Sciences2022，35，1： | 1 |
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