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| 1 | Duodenal duplication cyst causing severe pancreatitis:Imaging findings and pathological correlation显示文摘We here report a case of a 18-year-old man with a history of recurrent abdominal pain and a previous episode of severe acute pancreatitis. Abdominal ultrasonography, contrast enhanced multislice computer tomography, endoscopic retrograde cholangiopancreatography, endoscopic ultrasonography and magnetic resonance imaging demonstrated a cystic mass lesion. Only on delayed phase magnetic resonance images after GadoliniumBOPTA injection, it was possible to demonstrate the lesion's relationship with the biliary tree, differentiating the lesion from intraluminal duodenal diverticulum, and to achieve the diagnosis of duodenal duplication cyst, a recognized rare cause of acute pancreatitis. The diagnosis was confirmed by histology. | Alessandro Guarise Niccolo' Faccioli Mauro Ferrari Luigi Romano Alice Parisi Massimo Falconi | 2006 | World Journal of Gastroenterology2006，12，10： | 6 |
| 2 | Multifunctional to multistage delivery systems: The evolution of nanoparticles for biomedical applications显示文摘Nanomaterials are advancing in several directions with significant progress being achieved with respect to their synthesis, functionalization and biomedical application. In this review, we will describe several classes of prototypical nanocarriers, such as liposomes, silicon particles, and gold nanoshells, in terms of their individual function as well as their synergistic use. Active and passive targeting, photothermal ablation, and drug controlled release constitute some of the crucial functions identified to achieve a medical purpose. Current limitations in targeting, slow clearance, and systemic as well as local toxicity are addressed in reference to the recent studies that attempted to comprehend and solve these issues. The demand for a more sophisticated understanding of the impact of nanomaterials on the body and of their potential immune response underlies this discussion. Combined components are then discussed in the setting of multifunctional nanocarriers, a class of drug delivery systems we envisioned, proposed, and evolved in the last 5 years. In particular, our third generation of nanocarriers, the multistage vectors, usher in the new field of nanomedicine by combining several components onto multifunctional nanocarriers characterized by emerging properties and able to achieve synergistic effects. | MARTINEZ Jonathan O BROWN Brandon S QUATTROCCHI Nicoletta EVANGELOPOULOS Michael FERRARI Mauro TASCIOTTI Ennio | 2012 | Chinese Science Bulletin2012，57，31： | 4 |
| 3 | Restored Function of HBV-Specific T Cells After Long-term Effective Therapy With Nucleos(t)ide Analogues显示文摘 | Carolina Boni Diletta Laccabue Pietro Lampertico Tiziana Giuberti Mauro Viganò Simona Schivazappa Arianna Alfieri Marco Pesci Giovanni B. Gaeta Giuseppina Brancaccio Massimo Colombo Gabriele Missale Carlo Ferrari | 2012 | Gastroenterology2012，，4： | 3 |
| 4 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 5 | Differential Scanning Calorimetry as a Tool to Investigate the Transfer of Anticancer Drugs to Biomembrane Model显示文摘 | Maria Grazia Sarpietro Maria Lorena Accolla Christian Celia Alessandro Grattoni Francesco Castelli Massimo Fresta Mauro Ferrari Donatella Paolino | 2013 | Current Drug Targets2013，，9： | 1 |
| 6 | Characterization of micromachined silicon membranes for immunoisolation and bioseparation applications显示文摘 | Hansford Derek Ferrari Mauro | 1999 | Journal of Membrane Science1999，159，12： | 1 |
| 7 | Interstitial Stress and Fluid Pressure Within a Growing Tumor显示文摘 | Malisa Sarntinoranont Frank Rooney Mauro Ferrari | 2003 | Annals of Biomedical Engineering2003，，3： | 1 |
| 8 | Cancer nanotechnology:opportunities and challenges显示文摘 | Mauro Ferrari | 2005 | Nature2005，5，： | 1 |
| 9 | Comparing Attendance and Detection Rate of Colonoscopy With Sigmoidoscopy and FIT for Colorectal Cancer Screening显示文摘 | Nereo Segnan Carlo Senore Bruno Andreoni Alberto Azzoni Luigi Bisanti Alessandro Cardelli Guido Castiglione Cristiano Crosta Andrea Ederle Alberto Fantin Arnaldo Ferrari Mario Fracchia Franco Ferrero Stefano Gasperoni Serafino Recchia Mauro Risio Tiziana | 2007 | Gastroenterology2007，，7： | 1 |
| 10 | Effects of elevated egg corticosterone levels on behavior, growth, and immunity of yellow-legged gull ( Larus michahellis ) chicks显示文摘 | Diego Rubolini Maria Romano Giuseppe Boncoraglio Raffaella Paola Ferrari Roberta Martinelli Paolo Galeotti Mauro Fasola Nicola Saino | 2005 | Hormones and Behavior2005，，5： | 1 |
| 11 | Emergency colonoscopy显示文摘 | Francesco Paolo Rossini M.D. Arnaldo Ferrari M.D. Mauro Spandre M.D. Mariella Cavallero M.D. Carlo Gemme M.D. Carlo Loverci M.D. Alberto Bertone M.D. Marco Pinna Pintor M.D | 1989 | World Journal of Surgery1989，，2： | 1 |
| 12 | Model of Wetland Carbon Sequestration in the Venetian Lagoon, Italy显示文摘 | Mauro Doimi Angelo Ferrari Daniele DalMolin Italo Gardan | 2013 | Journal of Environmental Science and Engineering(B)2013，2，11： | 1 |
| 13 | A formal framework of synthesis and verification of logic programs显示文摘 | Alessandro Avellone Mauro Ferrari Camillo Fiorentini | 1999 | IBM Journal of Research and Derelopment1999，32，1： | 1 |
| 14 | SJWD14081900000560显示文摘 | Dong Soon Choi Elvin Blanco Yoo‐Shin Kim Angel A. Rodriguez Hong Zhao Tim Hui‐Ming Huang Chun‐Liang Chen Guangxu Jin Melissa D. Landis Lacey A. Burey Wei Qian Sergio M. Granados Bhuvanesh Dave Helen H. Wong Mauro Ferrari Stephen T. C. Wong Jenny C. Chang | 2014 | Stem Cells2014，，9： | 1 |
| 15 | Gadolinium metallofullerenol nanoparticles inhibit cancer metastasis through matrix metalloproteinase inhibition: imprisoning instead of poisoning cancer cells显示文摘 | Huan Meng Gengmei Xing Elvin Blanco Yan Song Lina Zhao Baoyun Sun Xiaoda Li Paul C. Wang Alexandru Korotcov Wei Li Xing-Jie Liang Chunying Chen Hui Yuan Feng Zhao Zhen Chen Tong Sun Zhifang Chai Mauro Ferrari Yuliang Zhao | 2012 | Nanomedicine: Nanotechnology, Biology, and Medicine2012，，2： | 1 |
| 16 | Cancer Nanotechnology:Opportunities and Challenges显示文摘 | Mauro Ferrari | 2005 | Nature Publishing Group2005，5，： | 1 |
| 17 | Nanotexture optimization by oxygen plasma of mesoporous silica thin film for enrichment of low molecular weight peptides captured from human serum显示文摘The optimization of mesoporous silica thin films by nanotexturing using oxygen plasma versus thermal oxidation was investigated.Calcination in oxygen plasma provides superior control over pore formation with regard to the pore surface and higher fidelity to the structure of the polymer template.The resulting porous film offers an ideal substrate for the selective partitioning of peptides from complex mixtures.The improved chemico-physical characteristics of porous thin films(pore size distribution,nanostructure,surface properties and pore connectivity) were systematically characterized with XRD,Ellipsometry,FTIR,TEM and N2 adsorption/desorption isotherm.The enrichment of low molecular weight proteins captured from human serum on mesoporous silica thin films fabricated by both methodologies was investigated by comparison of their MALDI-TOF MS profiles.This novel on-chip fractionation technology offers advantages in recovering the low molecular weight peptides from human serum,which has been recognized as an informative resource for early diagnosis of cancer and other diseases. | Louis BROUSSEAU Ali BOUAMRANI Mauro FERRARI | 2010 | Science China Chemistry2010，53，11： | 0 |
| 18 | Real-world treatment patterns and disease control over one year in patients with inflammatory bowel disease in Brazil显示文摘BACKGROUND Crohn’s disease(CD)and ulcerative colitis(UC)are inflammatory bowel diseases(IBDs)with a remission-relapsing presentation and symptomatic exacerbations that have detrimental impacts on patient quality of life and are associated with a high cost burden,especially in patients with moderate-to-severe disease.The Real-world Data of Moderate-to-Severe Inflammatory Bowel Disease in Brazil(RISE BR)study was a noninterventional study designed to evaluate disease control,treatment patterns,disease burden and health-related quality of life in patients with moderate-to-severe active IBD.We report findings from the prospective follow-up phase of the RISE BR study in patients with active UC or CD.AIM To describe the 12-mo disease evolution and treatment patterns among patients with active moderate-to-severe IBD in Brazil.METHODS This was a prospective,noninterventional study of adult patients with active Crohn’s disease(CD:Harvey-Bradshaw Index≥8,CD Activity Index≥220),inadequate CD control(i.e.,calprotectin>200μg/g or colonoscopy previous results),or active ulcerative colitis(UC:Partial Mayo score≥5).Enrollment occurred in 14 centers from October 2016 to February 2017.The proportion of active IBD patients after 9-12 mo of follow-up,Kaplan-Meier estimates of the time to mild or no activity and a summary of treatment initiation,discontinuation and dose changes were examined.RESULTS The study included 118 CD and 36 UC patients,with mean±SD ages of 43.3±12.6 and 44.9±16.5 years,respectively.The most frequent drug classes at index were biologics for CD(62.7%)and 5-aminosalicylate derivates for UC patients(91.7%).During follow-up,65.3%of CD and 86.1%of UC patients initiated a new treatment at least once.Discontinuations/dose changes occurred in 68.1%of CD patients[median 2.0(IQR:2-5)]and 94.3%of UC patients[median 4.0(IQR:3-7)].On average,CD and UC patients had 4.4±2.6 and 5.0±3.3 outpatient visits,respectively.The median time to first mild or no activity was 319(IQR:239-358)d for CD and 320(IQR:288-358)d for UC patients.At 9-12 mo,22.0%of CD and 20.0%of UC patients had active disease.CONCLUSION Although a marked proportion of active IBD patients achieved disease control within one year,the considerable time to achieve this outcome represents an unmet medical need of the current standard of care in a Brazilian real-world setting. | Ligia Yukie Sassaki Sender J Miszputen Roberto Luiz Kaiser Junior Wilson R Catapani Mauro Bafutto António S Scotton Cyrla Zaltman Julio Pinheiro Baima Hagata S Ramos Mikaell Alexandre Gouvea Faria Carolina D Gonçalves Isabella Miranda Guimaraes Cristina Flores Heda M B S Amarante Rodrigo Bremer Nones JoséMiguel Luz Parente Murilo Moura Lima Júlio Maria Chebli Maria de Lourdes Abreu Ferrari Julia F Campos Maria G P Sanna Odery Ramos Rogério Serafim Parra Jose J R da Rocha Omar Feres Marley R Feitosa Rosana Fusaro Caratin Juliana Tosta Senra Genoile Oliveira Santana | 2021 | World Journal of Gastroenterology2021，27，23： | 0 |
| 19 | Real-world disease activity and sociodemographic,clinical and treatment characteristics of moderate-to-severe inflammatory bowel disease in Brazil显示文摘BACKGROUND Understanding the treatment landscape of inflammatory bowel diseases(IBD)is essential for improving disease management and patient outcomes.Brazil is the largest Latin American country,and it presents socioeconomic and health care differences across its geographical regions.This country has the highest increase in IBD incidence and prevalence in Latin America,but information about the clinical and treatment characteristics of IBD is scarce.AIM To describe the sociodemographic,clinical,and treatment characteristics of IBD outpatients in Brazil overall and in the Southeast,South and Northeast/Midwest regions.METHODS Multicenter,cross-sectional study with a 3-year retrospective chart review component.Patients with moderate-to-severe Crohn’s disease(CD)or ulcerative colitis(UC)were consecutively enrolled between October 2016 and February 2017.Active CD at enrollment was defined as a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or a calprotectin level>200μg/g or an active result based on colonoscopy suggestive of inadequate control during the previous year;active UC was defined as a partial Mayo score≥5.Descriptive statistics were used to analyze all variables.RESULTS In a total of 407 included patients,CD was more frequent than UC,both overall(264 CD/143 UC patients)and by region(CD:UC ratios of 2.1 in the Southeast,1.6 in the South and 1.2 in the Northeast/Midwest).The majority of patients were female(54.2%of CD;56.6%of UC),and the mean ages were 45.9±13.8 years(CD)and 42.9±13.0 years(UC).The median disease duration was 10.0(range:0.5-45)years for both IBD types.At enrollment,44.7%[95%confidence interval(CI):38.7-50.7]of CD patients and 25.2%(95%CI:18.1-32.3)of UC patients presented with active disease.More than 95%of IBD patients were receiving treatment at enrollment;CD patients were commonly treated with biologics(71.6%)and immunosuppressors(67.4%),and UC patients were commonly treated with mesalazine[5-Aminosalicylic acid(5-ASA)]derivates(69.9%)and immunosuppressors(44.1%).More than 50%of the CD patients had ileocolonic disease,and 41.7%presented with stricturing disease.One-quarter of CD patients had undergone CD-related surgery in the past 3 years,and this proportion was lower in the Northeast/Midwest region(2.9%).CONCLUSION In Brazil,there are regional variations in IBD management.CD outweighs UC in both frequency and disease activity.However,one-quarter of UC patients have active disease,and most are receiving 5-ASA treatment. | Cyrla Zaltman Rogério Serafim Parra Ligia Yukie Sassaki Genoile Oliveira Santana Maria de Lourdes Abreu Ferrari Sender J Miszputen Heda M B S Amarante Roberto Luiz Kaiser Junior Cristina Flores Wilson R Catapani JoséMiguel Luz Parente Mauro Bafutto Odery Ramos Carolina D Gonçalves Isabella Miranda Guimaraes Jose J R da Rocha Marley R Feitosa Omar Feres Rogerio Saad-Hossne Francisco Guilherme Cancela Penna Pedro Ferrari Sales Cunha Tarcia NF Gomes Rodrigo Bremer Nones Mikaell Alexandre Gouvea Faria Mírian Perpétua Palha Dias Parente António S Scotton Rosana Fusaro Caratin Juliana Senra Júlio Maria Chebli | 2021 | World Journal of Gastroenterology2021，27，2： | 0 |
| 20 | Characterization of Wave Dispersion in Viscoelastic Cellular Assemblies by Doublet Mechanics显示文摘 | 金燕芳 熊春阳 方竞 FERRARI Mauro | 2009 | Chinese Physics Letters2009，26，8： | 0 |
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