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| 1 | Factors correlating with acoustic radiation force impulse elastography in chronic hepatitis C显示文摘AIM: To investigate the factors other than fibrosis stage correlating with acoustic radiation force impulse(ARFI) elastograpy in chronic hepatitis C. METHODS: ARFI elastograpy was performed in 108 consecutive patients with chronic hepatitis C who underwent a liver biopsy. The proportion of fibrosis area in the biopsy specimens was measured by computerassisted morphometric image analysis. RESULTS: ARFI correlated significantly with fibrosis stage(β = 0.1865, P < 0.0001) and hyaluronic acid levels(β = 0.0008, P = 0.0039) in all patients by multiple regression analysis. Fibrosis area correlated significantly with ARFI by Spearman's rank correlation test but not by multiple regression analysis. ARFI correlated significantly with body mass index(BMI)(β =-0.0334, P = 0.0001) in F 0 or F 1, with γ-glutamyltranspeptidase levels(β = 0.0048, P = 0.0012) in F 2, and with fibrosis stage(β = 0.2921, P = 0.0044) and hyaluronic acid levels(β = 0.0012, P = 0.0025) in F 3 or F 4. The ARFI cutoff value was 1.28 m/s for F ≥ 2, 1.44 m/s for F ≥ 3, and 1.73 m/s for F 4. CONCLUSION: ARFI correlated with fibrosis stage and hyaluronic acid but not with inflammation. ARFI was affected by BMI, γ-glutamyltranspeptidase, and hyaluronic acid in each fibrosis stage. | Toru Nishikawa Senju Hashimoto Naoto Kawabe Masao Harata Yoshifumi Nitta Michihito Murao Takuji Nakano Yuko Mizuno Hiroaki Shimazaki Toshiki Kan Kazunori Nakaoka Yuka Takagawa Masashi Ohki Naohiro Ichino Keisuke Osakabe Kentaro Yoshioka | 2014 | World Journal of Gastroenterology2014，20，5： | 7 |
| 2 | A new index for non-invasive assessment of liver fibrosis显示文摘AIM:To construct and evaluate a new non-invasive fibrosis index for assessment of the stage of liver f ibrosis. METHODS:A new f ibrosis index (Fibro-Stiffness index) was developed in 165 of 285 patients with chronic hepatitis C, and was validated in the other 120 patients where liver biopsy was performed. Its usefulness was compared with liver stiffness (LS) measured by FibroScan, the aminotransferase-to-platelet ratio index, the Forns index and the FibroIndex. RESULTS: The Fibro-Stiffness index consists of LS,platelet count and prothrombin time. The values of the Fibro-Stiffness index differed signif icantly between neighboring f ibrosis stages except F0-F1. The area under the receiver operating characteristics curves of the Fibro-Stiffness index for prediction of F≥2 (0.90), F≥ 3 (0.90) and F= 4(0.92) in the estimation group and those for F≥ 3 (0.93) and F =4 (0.97) in the validation group were the highest among the 5 methods examined. The accuracy of the Fibro-Stiffness index had highest values for F≥2, F≥3 and F=4 in both the estimation and validation groups. The diagnostic performance for F= 4 was improved by a combination of the Fibro-Stiffness index with serum hyaluronic acid level. CONCLUSION: The Fibro-Stiffness index was constructed and validated. It showed superior diagnostic performance to other indices for F ≥ 2,3 and 4. | Naohiro Ichino Keisuke Osakabe Toru Nishikawa Hiroko Sugiyama Miho Kato Shiho Kitahara Senju Hashimoto Naoto Kawabe Masao Harata Yoshifumi Nitta Michihito Murao Takuji Nakano Yuko Arima Hiroaki Shimazaki Koji Suzuki Kentaro Yoshioka | 2010 | World Journal of Gastroenterology2010，16，38： | 7 |
| 3 | Clostridium difficile-associated diarrhea after living donor liver transplantation显示文摘瞄准:估计发生并且在成年人在生活施主肝移植(LDLT ) 以后为梭状芽胞杆菌顽固伙伴的腹泻(CDAD ) 分析风险因素。方法:micobiological 数据和在东京大学医院经历了 LDLT 的 242 个成年接受者的医药记录回顾地被分析。为手术后的 CDAD 的独立风险因素被识别。结果:手术后的 CDAD 发生在 11 (5%) 病人。CDAD 的中部的发作是手术后的 d 19 (范围, 5-54 ) 。在里面多,变量分析,男性(机会比率, 4.56 ) 并且浆液肌酸酐(>= 1.5 mg/dL,机会比率, 16.0 ) 独立地预言的手术后的 CDAD。结论:CDAD 应该在 LDLT 以后与手术后的腹泻在病人的鉴别诊断被考虑。 | Masao Hashimoto Yasuhiko Sugawara Sumihito Tamura Junichi Kaneko Yuichi Matsui Junichi Togashi Masatoshi Makuuchi | 2007 | World Journal of Gastroenterology2007，13，14： | 2 |
| 4 | Anomalous Vertebral Artery at the Extraosseous and Intraosseous Regions of the Craniovertebral Junction: Analysis by Three-Dimensional Computed Tomography Angiography显示文摘 | Masashi Yamazaki Masao Koda Masa-aki Aramomi Mitsuhiro Hashimoto Yutaka Masaki Akihiko Okawa | 2005 | Spine2005，，21： | 1 |
| 5 | A comparison of a new limited cone beam computed tomography machine for dental use with a multidetector row helical CT machine显示文摘 | Koji Hashimoto Yoshinori Arai Kazuo Iwai Masao Araki Shoji Kawashima Masaaki Terakado | 2003 | Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology2003，，： | 1 |
| 6 | The loss of HBeAg without precore mutation results in lower HBV DNA levels and ALT levels in chronic hepatitis B virus infection显示文摘 | Naoto Kawabe Senju Hashimoto Masao Harata Yoshifumi Nitta Michihito Murao Takuji Nakano Hiroaki Shimazaki Yuko Arima Naruomi Komura Kyoko Kobayashi Kentaro Yoshioka | 2009 | Journal of Gastroenterology2009，，7： | 1 |
| 7 | Transplantation of Bone Marrow Stromal Cell-Derived Schwann Cells Promotes Axonal Regeneration and Functional Recovery after Complete Transection of Adult Rat Spinal Cord显示文摘 | Takahito Kamada Masao Koda Mari Dezawa Katsunori Yoshinaga Masayuki Hashimoto Shuhei Koshizuka Yutaka Nishio Hideshige Moriya Masashi Yamazaki | 2005 | JNEN: Journal of Neuropathology & Experimental Neurology2005，，1： | 1 |
| 8 | The loss of HBeAg without precore mutation results in lower HBV DNA levels and ALT levels in chronic hepatitis?B virus infection显示文摘 | Naoto Kawabe Senju Hashimoto Masao Harata Yoshifumi Nitta Michihito Murao Takuji Nakano Hiroaki Shimazaki Yuko Arima Naruomi Komura Kyoko Kobayashi Kentaro Yoshioka | 2009 | Journal of Gastroenterology2009，，7： | 1 |
| 9 | Differential Expression of Human Spasmolytic Polypeptide (Trefoil Factor Family-2) in Pancreatic Carcinomas, Ampullary Carcinomas, and Mucin-Producing Tumors of the Pancreas显示文摘 | Gakuji Ohshio Hirofumi Suwa Yoshiya Kawaguchi Masayuki Imamura Yoshio Yamaoka Hirohiko Yamabe Masao Matsumoto Hideyuki Yoshioka Yosuke Hashimoto Hiroshi Takeda | 2000 | Digestive Diseases and Sciences2000，，4： | 1 |
| 10 | A phase I/II study of gemcitabine-concurrent proton radiotherapy for locally advanced pancreatic cancer without distant metastasis显示文摘 | Kazuki Terashima Yusuke Demizu Naoki Hashimoto Dongcun Jin Masayuki Mima Osamu Fujii Yasue Niwa Kento Takatori Naoto Kitajima Sachiyo Sirakawa Ku Yonson Yoshio Hishikawa Mitsuyuki Abe Ryohei Sasaki Kazuro Sugimura Masao Murakami | 2012 | Radiotherapy and Oncology2012，，1： | 1 |
| 11 | Molecular simulations in the virtual material laboratory显示文摘 | Akira Suzuki Masao Kamiko Roichi Yamamoto Yuji Tateizumi Minoru Hashimoto | 1999 | Computational Materials Science1999，14，： | 1 |
| 12 | Successful outcomes of a novel endoscopic treatment for GI tumors: endoscopic submucosal dissection with a mixture of high-molecular-weight hyaluronic acid, glycerin, and sugar显示文摘 | Mitsuhiro Fujishiro Naohisa Yahagi Masanori Nakamura Naomi Kakushima Shinya Kodashima Satoshi Ono Katsuya Kobayashi Takuhei Hashimoto Nobutake Yamamichi Ayako Tateishi Yasuhito Shimizu Masashi Oka Keiji Ogura Takao Kawabe Masao Ichinose Masao Omata | 2006 | Gastrointestinal Endoscopy2006，，2： | 1 |
| 13 | AlN and AlGaN growth using low-pressure metalorganic chemical vapor deposition显示文摘 | Fumihiko Nakamura Shigeki Hashimoto Masaki Hara Synji Imanaga Masao Ikeda Hiroji Kawai | 1998 | Journal of Crystal Growth1998，，： | 1 |
| 14 | A Molecular Basis for the Control of Preimmune Escape Variants by HIV-Specific CD8 + T Cells显示文摘 | Kristin Ladell Masao Hashimoto Maria Candela Iglesias Pascal G. Wilmann James E. McLaren Stéphanie Gras Takayuki Chikata Nozomi Kuse Solène Fastenackels Emma Gostick John S. Bridgeman Vanessa Venturi Za?na A?t Arkoub Henri Agut David J. van Bockel Jorge R | | Immunity0，，： | 1 |
| 15 | Anomalous Vertebral Artery at the Extraosseous and Intraosseous Regions of the Craniovertebral Junction: Analysis by Three-Dimensional Computed Tomography Angiography显示文摘 | Masashi Yamazaki Masao Koda Masa-aki Aramomi Mitsuhiro Hashimoto Yutaka Masaki Akihiko Okawa | 2005 | Spine2005，，21： | 1 |
| 16 | C5 palsy following anterior decompression and spinal fusion for cervical degenerative diseases显示文摘 | Mitsuhiro Hashimoto Macondo Mochizuki Atsuomi Aiba Akihiko Okawa Koichi Hayashi Tsuyoshi Sakuma Hiroshi Takahashi Masao Koda Kazuhisa Takahashi Masashi Yamazaki | 2010 | European Spine Journal2010，，10： | 1 |
| 17 | 全球环境保护对策的探讨显示文摘1.第三次高潮的到来从1987~1988年无论是日本国内还是国外,环境问题及其对策都有很大变化。从日本环境问题的历史看,第一次高潮始于地方上出现严重的公害问题;第二次高潮是在1970年左右举国上下出现对环境认识上和解决措施上的巨大变化;第三次高潮是八十年代后期掀起全球性的环境保护高潮。另外,为对付国际经济摩擦和日元增值等问题而制定的产业结构调整对策,给日本的产业结构和布局也带来很大变化。产业结构渊整对策的制定使环境问题发生很大变化。尖端技术企业在内地建厂、企业向国外扩散、合并公司的扩大等出现了与传统的产业公害完全不同的环境问题;由于进口产品的竞争和市场的开放,给农业带来很大压力。 | Masao Hashimoto 齐祥云 | 1990 | 世界环境1990，0，1： | 0 |
| 18 | STUDIES ON THE CONSTITUENTS OF THE ROOTS OF SCUTELLARIA PLANIPES显示文摘STUDIESONTHECONSTITUENTSOFTHEROOTSOFSCUTELLARIAPLANIPES￥YousYuZHaNG;XianLI;YunZhenGOU(ShenrengPharmaceuticalUniversity,Shenan... | Yous Yu ZHaNG Xian LI Yun Zhen GOU (Shenreng Pharmaceutical University,Shenang 110015 Yoshthiro HARIGAYA, Maraguki ONDA School of Pharmaceutical Sciences, Kitasato Univsity,Tokyo 108. Japan KadBunorl HASHIMOTO, Yuklnobu IK EYA. Minoru OKADA, Masao MARU | 1994 | Chinese Chemical Letters1994，5，10： | 0 |
| 19 | Non-Hodgkin lymphoma as a cause of obstructive jaundice with simultaneous extrahepatic portal vein obstruction:A case report显示文摘Non-Hodgkin lymphoma is a rare cause of biliary ob-struction. To the best of our knowledge, non-Hodgkin lymphoma in the peripancreatic region causing obstruc-tive jaundice with simultaneous portal vein (PV) inva-sion has not yet been reported. We present a 50-year-old patient with obstructive jaundice whose extrahepatic portal vein was obstructed by the invasion of a peripan-creatic non-Hodgkin lymphoma. The patient denied any other symptoms such as recurrent fever, night sweat and loss of body weight. Computed tomography (CT) revealed a 10 cm mass in the retroperitoneal space behind the head of the pancreas causing obstruction of the distal bile duct and the PV. A pylorus-preserving pancreaticoduodenectomy combined with a PV resection was performed. The PV was reconstructed using an au-tologous right internal jugular vein graft. The resected specimen showed endoluminal invasion of both the bile duct and the PV. Histological examination showed the mass consisting of diffuse sheets of large malignant lymphoid cells. These cells were positive for CD20 and CD79a, partially positive for CD10, and negative for CD3, CD4, CD5, CD8 and CD30. The pathologic diagno-sis was diffuse large B-cell type non-Hodgkin lymphoma and the patient was transferred to the Department of Hematology and Oncology for chemotherapy. He re-ceived four cycles of combined chemotherapy including cyclophosphamide, doxorubicin, vincristine and pred-nisone plus rituximab, and three cycles of intrathecal chemoprophylaxis including methotorexate, cytosine arbinoside and prednisone. The patient is alive with noevidence of the disease for 7 mo after operation and will receive additional courses of chemotherapy. | Masao Hashimoto Nobutaka Umekita Kazumasa Noda | 2008 | World Journal of Gastroenterology2008，14，25： | 0 |
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