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| 1 | A history of high-power laser research and development in the United Kingdom显示文摘The first demonstration of laser action in ruby was made in 1960 by T.H.Maiman of Hughes Research Laboratories,USA.Many laboratories worldwide began the search for lasers using different materials,operating at different wavelengths.In the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications.This historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years. | Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone | 2021 | High Power Laser Science and Engineering2021，9，2： | 5 |
| 2 | Clinical use of bone-targeting radiopharmaceuticals with focus on alpha-emitters显示文摘Various single or multi-modality therapeutic options are available to treat pain of bone metastasis in patients with prostate cancer.Different radionuclides that emitβ-rays such as 153Samarium and 89Strontium and achieve palliation are commercially available.In contrast toβ-emitters,223Radium as a a-emitter has a short path-length.The advantage of the a-emitter is thus a highly localized biological effect that is caused by radiation induced DNA double-strand breaks and subsequent cell killing and/or limited effectiveness of cellular repair mechanisms.Due to the limited range of the a-particles the bone surface to red bone marrow dose ratio is also lower for 223Radium which is expressed in a lower myelotoxicity.The a emitter 223Radium dichloride is the first radiopharmaceutical that significantly prolongslife in castrate resistant prostate cancer patients with wide-spread bone metastatic disease.In a phaseⅢ,randomized,double-blind,placebo-controlled study 921patients with castration-resistant prostate cancer and bone metastases were randomly assigned.The analysis confirmed the 223Radium survival benefit compared to the placebo(median,14.9 mo vs 11.3 mo;P<0.001).In addition,the treatment results in pain palliation and thus,improved quality of life and a delay of skeletal related events.At the same time the toxicity profile of223Radium was favourable.Since May 2013,223Radium dichloride(Xofigo?)is approved by the US Food and Drug Administration. | Hinrich A Wieder Michael Lassmann Martin S Allen-Auerbach Johannes Czernin Ken Herrmann | 2014 | World Journal of Radiology2014，6，7： | 4 |
| 3 | PSMA配体的前列腺癌PET显像显示文摘近年来,用68Ga和18F标记PET显像剂靶向前列腺特异膜抗原(PSMA)逐渐受到重视。多项回顾性研究指出,与常规影像相比,PSMA配体前列腺癌PET/CT显像具有较高的检测效能,前列腺癌生化复发已被世界多个地区确立为PSMA配体前列腺癌PET/CT显像的临床适应证。对于高危原发前列腺癌,越来越多的证据表明该显像方式有助于探测隐匿性淋巴结和前列腺癌骨转移;对于原发和复发性前列腺癌的临床适应证,初步研究证实其对临床管理有着重要影响;另有证据表明,其对前列腺内的肿瘤定位、治疗分期和特定临床情况下的晚期病灶治疗监测将成为未来的适应证。随着有关生理性和病理性摄取模式和误区文献数量的剧增,PSMA配体PET显像报告的标准也在不断改进。文章旨在对PSMA配体PET显像的现状进行概述,包括显像程序和解释、临床适应证、诊断潜力及其对治疗计划的影响。 | 黎翔(译) 杨卫东(译) 汪静(审校) Sarah M.Schwarzenboeck Isabel Rauseher Christina Bluemel Wolfgang P.Fendler Steven P. Rowe Martin G.Pomper Ali Asfhar-Oromieh Ken Herrrnann Matthias Eiber | 2019 | 中华核医学与分子影像杂志2019，39，2： | 3 |
| 4 | Identification of Gene Expression–Based Prognostic Markers in the Hematopoietic Stem Cells of Patients With Myelodysplastic Syndromes显示文摘 | Andrea Pellagatti Axel Benner Ken I. Mills Mario Cazzola Aristoteles Giagounidis Janet Perry Luca Malcovati Matteo G. Della Porta Martin J?dersten Amit Verma Emma-Jane McDonald Sally Killick Eva Hellstr?m-Lindberg Lars Bullinger James S. Wainscoat Jacquel | 2013 | Journal of Clinical Oncology2013，，28： | 2 |
| 5 | Shape memory polymer nanocomposites显示文摘 | Ken Gall Martin L. Dunn Yiping Liu Dudley Finch Mark Lake Naseem A. Munshi | 2002 | Acta Materialia2002，，20： | 1 |
| 6 | Applications of petroleum geochemistry to ex- ploration and reservoir management显示文摘 | Ken E P Martin G F | 2002 | Organic Geochemistry2002，33，1： | 1 |
| 7 | Survival following HIV infection of a cohort followed up from seroconversion in the UK显示文摘 | Fiona M Ewings Krishnan Bhaskaran Ken McLean David Hawkins Martin Fisher Sarah Fidler Richard Gilson Demelza Nock Ray Brettle Margaret Johnson Andrew Phillips Kholoud Porter | 2008 | AIDS2008，，1： | 1 |
| 8 | Classical and Modern Receiver Architectures显示文摘 | Mirabbasl Shahriar Martin Ken | 2000 | IEEE Communi cations Magazine2000，38，11： | 1 |
| 9 | Complaints caused by aircraft operations: an assessment of annoyance by noise,level and time ofday显示文摘 | Ken Humea Martin Gregga Callum Thomasb Daniela Terranova | 2003 | Journal of Air Transport Management2003，12，9： | 1 |
| 10 | Effects of the Op-amp finite gain and bandwidth on the performance of switched-capacitor filters显示文摘 | Ken Martin Adel S Sedra | 1981 | IEEE Transactions on Circuits and Systems1981，28，8： | 1 |
| 11 | The role of wholesale brands for buyer loyalty: a transaction cost perspective显示文摘 | Peter Kenning Stephan Grzeskowiak Christian Brock Martin Ahlert | 2011 | Journal of Business & Industrial Marketing2011，，3： | 1 |
| 12 | Thermomechanics of shape memory polymers: uniaxial experiments and constitu- tive modeling显示文摘 | LIU Yiping KEN G MARTIN L D | 2006 | International Journal of Plasticity2006，22，： | 1 |
| 13 | Applications of petroleum geochemistry to exploration and reservoir management显示文摘 | Ken E Peters Martin G Fowler | 2002 | Organic Geochemistry2002，，1： | 1 |
| 14 | Applications of petroleum geochemistry to exploration and reservoir management显示文摘 | Ken E Peters Martin G Fowler | 2002 | Organic Geochemistry2002，33，1： | 1 |
| 15 | Maximizing the Population Benefit From Thrombolysis in Acute Ischemic Stroke:A Modeling study of In-Hospital Delays显示文摘 | Thomas Monks Martin PittEng D Ken Stein | | 0，，06： | 1 |
| 16 | Preparation and Optical Properties of Capped - CdSe Nanocrystals 显示文摘 | KEN - ICHI HASHIZUME MARTIN VACHA TOSHIRO TANI | 2000 | Journal of Luminescence2000，8789，： | 1 |
| 17 | Applications of petroleum geochemistry to exploration and reservoir management 显示文摘 | KEN E P MARTIN G F | 2002 | Organic Geochemistry2002，33，1： | 1 |
| 18 | Applications of petroleum geochemistry to exploration and reservoir management显示文摘 | KEN E P MARTIN G F | 2002 | Org Geochem2002，33，1： | 1 |
| 19 | Shape Memory Polymer Nanocomposites显示文摘 | Durra Martin L Liu Yiping | 2002 | Aeta Material2002，50，20： | 1 |
| 20 | Cost-Effectiveness of Sorafenib for Second-Line Treatment of Advanced Renal Cell Carcinoma显示文摘 | Martin Hoyle Colin Green Jo Thompson-Coon Zulian Liu Karen Welch Tiffany Moxham Ken Stein | 2010 | Value in Health2010，，1： | 1 |
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