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| 1 | Bmi-1:At the crossroads of physiological and pathological biology显示文摘Bmi-1 is a member of the Polycomb repressor complex 1 that mediates gene silencing by regulating chromatin structure and is indispensable for self-renewal of both normal and cancer stem cells.Despite three decades of research that have elucidated the transcriptional regulation,post-translational modifications and functions of Bmi-1 in regulating the DNA damage response,cellular bioenergetics,and pathologies,the entire potential of a protein with such varied functions remains to be realized.This review attempts to synthesize the current knowledge on Bmi-1 with an emphasis on its role in both normal physiology and cancer.Additionally,since cancer stem cells are emerging as a new paradigm for therapy resistance,the role of Bmi-1 in this perspective is also highlighted.The wide spectrum of malignancies that implicate Bmi-1 as a signature for stemness and oncogenesis also make it a suitable candidate for therapy.Nonetheless,new approaches are vitally needed to further characterize physiological roles of Bmi-1 with the long-term goal of using Bmi-1 as a prognostic marker and a therapeutic target. | Resham Bhattacharya Soumyajit Banerjee Mustafi Mark Street Anindya Dey Shailendra Kumar Dhar Dwivedi | 2015 | Genes & Diseases2015,2,3: | 15 |
| 2 | Outcomes of Early- and Late-Identified Children at 3 Years of Age: Findings From a Prospective Population-Based Study显示文摘 | Teresa Y. C. Ching Harvey Dillon Vivienne Marnane Sanna Hou Julia Day Mark Seeto Kathryn Crowe Laura Street Jessica Thomson Patricia Van Buynder Vicky Zhang Angela Wong Lauren Burns Christopher Flynn Linda Cupples Robert S. C. Cowan Greg Leigh Jessica Sja | 2013 | Ear and Hearing2013,,5: | 2 |
| 3 | New amorphous-silicon image sensor for X-ray diagnostic medical imaging applications显示文摘 | Weisfield Richard L Harmey Mark A Street Robert A | 1998 | Proc of SPIE1998,3336,7: | 1 |
| 4 | New amorphous-silicon image sensor for X-ray diagnostic medical imaging applications显示文摘 | Richard L Weisfield Mark A Hartney Robert A Street | 1998 | Proc of PIE1998,3336,: | 1 |
| 5 | New amorphous-silicon image sensor for X-ray diagnostic medical imaging applications 显示文摘 | Richard L WEISFIELD Mark A HARTNEY Robert A STREET | 1998 | SPIE1998,3336,: | 1 |
| 6 | MaaS:出行服务的颠覆者显示文摘在过去的许多年中,MaaS概念已经以各种形式提及,但它在不同城市和交通运输方式中的实现状况却不尽相同。中国的大型科技公司已经开始创新,使他们的商业模式更符合MaaS的原则。但是,由于互联出行市场的分散性,还未能够开发出一个端到端、多出行模式的单一应用。 | Mark Streeting 陈玮 Emma Edgar Justin Koh | 2017 | 中国战略新兴产业2017,0,23: | 1 |
| 7 | New amorphous-silicon image sensor for X-ray diagnostic medical imaging applications显示文摘 | Richard L Weisfield Mark A Hartney Robert A Street | 1998 | Proc of SPIE1998,3336,: | 1 |
| 8 | 减少城市道路拥堵,自动驾驶汽车能解决问题吗?显示文摘随着市场上互联自动驾驶汽车(CAV)的大量出现及共享经济在城市交通中的持续增长,当今社会正处于全球社会和经济变革的边缘。自动驾驶汽车技术的潜在能力是多少?消费者将如何使用自动驾驶汽车?针对这些疑问,来自L.E.K.艾意凯咨询的专家们给出了解答。 | Simon Barrett Mark Streeting Ashish Khanna | 2020 | 汽车与配件2020,0,6: | 0 |
| 9 | Advanced Magnetic Metrology Instrumentation显示文摘The extraordinary progress in magnetic peripheral storage systems has been fueled by the advancements in heads (MR, GMR, spin valves) and in very high coercivity, low requirethickness product (M_rt) media. These advancements are imposing new performance requirements on the magnetometers (VSM_s) used to characterize these materials. At the same time, they have introduced a new paradigm for in-process (nondestructive, robotic) magnetic metrology tools to assure the stringent product uniformity requirements. In this paper, we discuss the recent advancements in magnetometry for characterizing state-of-the-art media and heads, as well as other magnetic materials. | Dennis Speliotis and Mark Willingham (Digital Measurement Systems Division of ADE Technologies, Inc. 77 Rowe Street, Newton, Massachusetts 02466, U.S.A.) | 2000 | Journal of Materials Science & Technology2000,16,2: | 0 |
| 10 | 出行即平台(MaaP):创新的跳板显示文摘外部变化催生产业内部的变革,许多新兴的跨行业趋势由此诞生,出行和交通运输方式的变革就是其中之一。基于交通运输成本结构的变化,L.E.K.提出了'出行即平台'(Mobility as a Platform,MaaP)框架,旨在让企业将出行方式与自身业务运营相结合,优化客户体验、提升客户忠诚度、创新运营模式、推动业绩增长。本文详细介绍了'出行即平台'(MaaP)框架的建立基础,以及如何通过该框架帮助企业发展,把握变革新机遇。 | Ashish Khanna Mark Streeting 滕勇 | 2019 | 汽车与配件2019,0,18: | 0 |