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| 1 | Incidence and mortality of primary liver cancer in England and Wales: Changing patterns and ethnic variations显示文摘AIM: To explore recent trends, modes of diagnosis, ethnic distribution and the mortality to incidence ratio of primary liver cancer by subtypes in England and Wales. METHODS: We obtained incidence(1979-2008) and mortality(1968-2008) data for primary liver cancer for England and Wales and calculated age-standardised incidence and mortality rates. Trends in age-standardised mortality(ASMR) and incidence(ASIR) rates and basis of diagnosis of primary liver cancer and subcategories: hepatocellular carcinoma, intrahepatic bile duct and unspecified liver tumours, were analysed over the study period. Changes in guidelines for the diagnosis of primary liver cancer(PLC) may impact changing trends in the rates that may be obtained. We thus explored changes in the mode of diagnosis as reported to cancer registries. Furthermore, we examined the distribution of these tumours by ethnicity. Most of the statistical manipulations of these data was carried out in Microsoft excel(Seattle, Washington, United Sttaes). Additional epidemiological statistics were done in Epi Info software(Atlanta, GA, United Sttaes). To define patterns of change over time, we evaluated trends in ASMR and ASIR of PLC and intrahepatic bile duct carcinoma(IHBD) using a least squares regression line fitted to the natural logarithm of the mortality and incidence rates. We estimated the patterns of survival over subsequent 5 and 10 years using complement of mortality to incidence ratio(1-MIR). RESULTS: Age-standardised mortality rate of primary liver cancer increased in both sexes: from 2.56 and 1.29/100000 in 1968 to 5.10 and 2.63/100000 in 2008 for men and women respectively. The use of histology for diagnostic confirmation of primary liver cancer increased from 35.7% of registered cases in 1993 to plateau at about 50% during 2005 to 2008. Reliance on cytology as a basis of diagnosis has maintained a downward trend throughout the study period. Although approximately 30% of the PLC registrations had information on ethnicity, there was a relatively higher registration of the major tumour subtypes in patients whose ethnic backgrounds were from high incident regions of the world. Survival from PLC is estimated to get poorer in 10 years(2018) relative to 2008, particularly as a result of IHBD. CONCLUSION: Incidence and mortality of PLC, and particularly IHBD, have continued to rise in England and Wales. Changes in the modes of diagnosis may be contributing. | Nimzing G Ladep Shahid A Khan Mary ME Crossey Andrew V Thillainayagam Simon D Taylor-Robinson Mireille B Toledano | 2014 | World Journal of Gastroenterology2014，20，6： | 15 |
| 2 | Hepatic steatosis and fibrosis: Non-invasive assessment显示文摘Chronic liver disease is a major cause of morbidity and mortality worldwide and usually develops over many years, as a result of chronic inflammation and scarring, resulting in end-stage liver disease and its complications. The progression of disease is characterised by ongoing inflammation and consequent fibrosis, although hepatic steatosis is increasingly being recognised as an important pathological feature of disease, rather than being simply an innocent bystander. However, the current gold standard method of quantifying and staging liver disease, histological analysis by liver biopsy, has several limitations and can have associated morbidity and even mortality. Therefore, there is a clear need for safe and noninvasive assessment modalities to determine hepatic steatosis, inflammation and fibrosis. This review covers key mechanisms and the importance of fibrosis and steatosis in the progression of liver disease. We address non-invasive imaging and blood biomarker assessments that can be used as an alternative to information gained on liver biopsy. | Rustam N Karanjia Mary ME Crossey I Jane Cox Haddy KS Fye Ramou Njie Robert D Goldin Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，45： | 6 |
| 3 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 4 | Gender differences in blood pressure and heart rate in spontaneously hypertensive and Wistar-Kyoto rats显示文摘 | Maris ME Melchert RB Joseph J | 2005 | Clin Exp Pharmacol Physiol2005，32，12： | 1 |
| 5 | High-Harmonic Generation and Correlated Electron Emission from Relativistic Plasma Mirrors at 1 kHz Repetition Rate显示文摘We report evidence for the first generation of XUV spectra from relativistic surface high-harmonic generation(SHHG)on plasma mirrors at a kilohertz repetition rate,emitted simultaneously with energetic electrons.SHHG spectra and electron angular distributions are measured as a function of the experimentally controlled plasma density gradient scale length Lg for three increasingly short and intense driving pulses:24 fs and a0=1:1,8 fs and a0=1:6,and finally 4 fs and a0≈2:1,where a0 is the peak vector potential normalized by mec/e with the elementary charge e,the electron rest mass me,and the vacuum light velocity c.For all driver pulses,we observe correlated relativistic SHHG and electron emission in the range Lg∈½λ/20,λ/4,with an optimum gradient scale length of Lg≈λ/10.This universal optimal Lg-range is rationalized by deriving a direct intensity-independent link between the scale length Lg and an effective similarity parameter for relativistic laser-plasma interactions. | Stefan Haessler Marie Ouillé Jaismeen Kaur Maïmouna Bocoum Frederik Böhle Dan Levy Louis Daniault Aline Vernier Jérôme Faure Rodrigo Lopez-Martens | 2022 | Ultrafast Science2022，，3： | 1 |
| 6 | Alterations of plasma metabolite profiles related to adipose tissue distribution and cardiometabolic risk显示文摘 | Boulet Marie Miche?le Chevrier Genevie?e?ve Grenier-Larouche Thomas Pelletier Me?e?e?lissa Nadeau Me?e?e?e?lanie Scarpa Julia Prehn Cornelia Marette Andre?e?e?e?e? Adamski Jerzy Tchernof Andre?e?e?e?e?e? | 2015 | AJP: Endocrinology and Metabolism2015，，： | 1 |
| 7 | Induction of protective immunity against toxoplasmosis in mice by DNA immunization with a plasmid edcoding Toxoplasma gondii GRA4 gene显示文摘 | DESOL ME B MARIE NOELLE M BUZONI GATL D | 2000 | Vaccine2000，18，： | 1 |
| 8 | Twin pregnancy with complete hydatidiform mole and coexistent fetus显示文摘 | Jér?me Massardier Fran?ois Golfier Dorothée Journet Lucien Frappart Marcel Zalaquett Anne Marie Schott Véronique Trillet Lenoir Olivier Dupuis Touria Hajri Daniel Raudrant | 2009 | European Journal of Obstetrics and Gynecology2009，，2： | 1 |
| 9 | Cuff-leak test for the diagnosis of upper airway obstruction in adults: a system- atic review and meta-analysis 显示文摘 | Ochoa ME del Carmen Mari n M Frutos-Vivar F | 2009 | Intensive Care Med2009，35，7： | 1 |
| 10 | Challenges of liver cancer:Future emerging tools in imaging and urinary biomarkers显示文摘Chronic liver disease has become a global health problem as a result of the increasing incidence of viral hepatitis, obesity and alcohol misuse. Over the past three decades, in the United Kingdom alone, deaths from chronic liver disease have increased both in men and in women. Currently, 2.5% of deaths worldwide are attributed to liver disease and projected figures suggest a doubling in hospitalisation and associated mortality by 2020. Chronic liver diseases vary for clinical manifestations and natural history, with some individuals having relatively indolent disease and others with a rapidly progressive course. About 30% of patients affected by hepatitis C has a progressive disease and develop cirrhosis over a 20 years period from the infection, usually 5-10 years after initial medical presentation. The aim of the current therapeutic strategies is preventing the progression from hepatitis to fibrosis and subsequently, cirrhosis. Hepatic steatosis is a risk factor for chronic liver disease and is affecting about the half of patients who abuse alcohol. Moreover non-alcoholic fatty liver disease is part of the metabolic syndrome, associated with obesity, hypertension, type Ⅱ diabetes mellitus and dyslipidaemia, and a subgroup of patients develops non-alcoholic steatohepatitis and fibrosis with subsequent cirrhosis. The strengths and pitfalls of liver biopsy are discussed and a variety of new techniques to assess liver damage from transient elastography to experimental techniques, such as in vitro urinary nuclear magnetic resonance spectroscopy. Some of the techniques and tests described are already suitable for more widespread clinical application, as is the case with ultrasound-based liver diagnostics, but others, such as urinary metabonomics, requires a period of critical evaluation or development to take them from the research arena to clinical practice. | Francesca M Trovato Joshua M Tognarelli Mary ME Crossey Daniela Catalano Simon D Taylor-Robinson Guglielmo M Trovato | 2015 | World Journal of Hepatology2015，7，26： | 1 |
| 11 | Unrecognized intrahepatic cholangiocarcinoma: an analysis of 993 adult cirrhotic liver explants显示文摘 | Mélanie Vallin Nathalie Sturm Géraldine Lamblin Olivier Guillaud Marie‐No?lle Hilleret Valérie Hervieu Juliette Joubert Armand Abergel Vincent Leroy Olivier Boillot Jér?me Dumortier Jean‐Yves Scoazec | 2013 | Clin Transplant2013，，3： | 1 |
| 12 | Performance-oriented assessment of mobility problems in elderly patients 显示文摘 | Mary E Tinetti ME | 1986 | J Am Geriatr Soc1986，34，2： | 1 |
| 13 | Society for Maternal-Fetal Medicine (SMFM) Clinical Guideline #8: the fetus at risk for anemia - diagnosis and management显示文摘 | Mari G Norton ME Stone J | 2015 | Am J Obstet Gynecol2015，212，6： | 1 |
| 14 | Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation显示文摘 | Jér?me N. Feige Marie Lagouge Carles Canto Axelle Strehle Sander M. Houten Jill C. Milne Philip D. Lambert Chikage Mataki Peter J. Elliott Johan Auwerx | 2008 | Cell Metabolism2008，，5： | 1 |
| 15 | Positivity rates and performances of immunochemical faecal occult blood tests at different cut-off levels within a colorectal cancer screening programme显示文摘 | Jean Faivre Vincent Dancourt Sylvain Manfredi Bernard Denis Gérard Durand Isabelle Gendre Jeanne Marie Bidan Christine Jard Romuald Levillain Sylvie Jung Jér?me Viguier Etienne Dorval | 2012 | Digestive and Liver Disease2012，，8： | 1 |
| 16 | Esophageal Distensibility as a Measure of Disease Severity in Patients with Eosinophilic Esophagitis显示文摘 | Frédéric Nicodème Ikuo Hirano Joan Chen Kenika Robinson Zhiyue Lin Yinglian Xiao Nirmala Gonsalves Mary J. Kwasny Peter J. Kahrilas John E. Pandolfino | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 1 |
| 17 | The clinical nurse leader and the case manager: are both roles needed? 显示文摘 | Stachowial ME Mary Jo Bugel | 2013 | Advance Jounal of Nursing2013，113，1： | 1 |
| 18 | Common competencies for all healthcare managers: The healthcare leadership alliance model 显示文摘 | Mary E Stefl ME | 2008 | Journal of Healthcare Management2008，53，6： | 1 |
| 19 | Common competencies for all healthcare managers : The heahhcare leadership alliance mode 显示文摘 | Mary E Stefl ME | 2008 | Jour- nal of Heahhcare Management2008，53，6： | 1 |
| 20 | Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation显示文摘 | Jér?me N. Feige Marie Lagouge Carles Canto Axelle Strehle Sander M. Houten Jill C. Milne Philip D. Lambert Chikage Mataki Peter J. Elliott Johan Auwerx | 2008 | Cell Metabolism2008，，5： | 1 |
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