|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease显示文摘BackgroundKlotho 蛋白质(α - 并且 β) 是基于膜的传播调整细胞新陈代谢的蛋白质,以及成纤维细胞生长因素(FGF ) 的 lifespan modulating 活动。最近的数据证明了更高的血浆传播 Klotho 层次减少心血管的风险,建议 Klotho 有在心血管的疾病的一个保护的角色。然而,尽管到目前为止它在各种各样的机关被识别了,它是未知的是否,并且高心血管的风险是否能影响 Klotho 的心脏的表示 cardiomyocytes 快车 Klotho 和 FGF , FGF 和另外的 molecules.MethodsWe 与心血管的疾病和 10 匹配年龄的控制使遭到,估计的10年的低风险经历的一名估计的10年的高动脉粥样硬化患者选择了 20 个病人为除冠的动脉以外的原因的心脏的外科绕过。在心肌的活体检视,我们由免疫组织化学评估了 Klotho 和 FGF 是否在 cardiomyocytes 被表示,并且更高心血管的风险是否影响涉及 endoplasmic 蜂窝胃应力的另外的分子的表示,氧化应力,发炎并且 fibrosis.ResultsOnly ,有更高心血管的风险的病人的 cardiomyocytes 显示出 Klotho 的更低的表示,但是 FGF 的更高的表情。而且,更高心血管的风险与增加的表示被联系氧化并且网状的应力,发炎和 fibrosis.ConclusionsThis 学习的 endoplasmic 第一次证明 Klotho 蛋白质在人的 cardiomyocytes 被表示, Klotho 的那心脏的表情在更高心血管的风险病人是下面调整的,当压力相关的分子的表示显著地被增加时。 | Giovanni Corsetti Evasio Pasini Tiziano M Scarabelli Claudia Romano Pratik R Agrawal Carol Chen-Scarabelli Richard Knight Louis Saravolatz Jagat Narula Mario Ferrari-Vivaldi Vincenzo Flati Deodato Assanelli Francesco S Dioguardi | 2016 | Journal of Geriatric Cardiology2016，13，8： | 7 |
| 2 | Hepatitis C virus-related B cell subtypes in non Hodgkin's lymphoma显示文摘AIM:To evaluate if indolent B cell-non Hodgkin's lymphoma(B-NHL) and diffuse large B-cell lymphoma(DLBCL) in hepatitis C virus(HCV) positive patients could have different biological and clinical characteristics requiring different management strategies.METHODS:A group of 24 HCV related B-NHL patients(11 indolent,13 DLBCL) in whom the biological and clinical characteristics were described and confronted.Patients with DLBCL were managed with the standard of care of treatment.Patients with indolent HCV-related B-NHL were managed with antiviral treatment pegylated interferon plus ribavirin and their course observed.The outcomes of the different approaches were compared.RESULTS:Patients with DLBCL had a shorter duration of HCV infection and a higher prevalence of HCV genotype 1 compared to patients with indolent B-NHL in which HCV genotype 2 was the more frequent genotype.Five of the 9 patients with indolent HCV-relatedB-NHL treated with only antiviral therapy,achieved a complete response of their onco-haematological disease(55%).Seven of the 13 DLBCL patients treated with immunochemotheraphy obtained a complete response(54%).CONCLUSION:HCV genotypes and duration of HCV infection differed between B-NHL subtypes.Indolent lymphomas can be managed with antiviral treatment,while DLBCL is not affected by the HCV infection. | Adriano M Pellicelli Massimo Marignani Valerio Zoli Mario Romano Aldo Morrone Lorenzo Nosotti Giuseppe Barbaro Antonio Picardi Umberto Vespasiani Gentilucci Daniele Remotti Cecilia D'Ambrosio Caterina Furlan Fabrizio Mecenate Ettore Mazzoni Ignazio Majolino Roberto Villani Arnaldo Andreoli Giorgio Barbarini | 2011 | World Journal of Hepatology2011，3，11： | 4 |
| 3 | Efficacy of a therapeutic strategy for eradication of Helicobacter pylori infection显示文摘AIM: To determine the efficacy of our therapeutic strategy for Helicobacter pylori (H. pylori) eradication and to identify predictive factors for successful eradication. METHODS: From April 2006 to June 2010, we retrospectively assessed 2428 consecutive patients (1025 men, 1403 women; mean age 55 years, age range 18-92 years) with gastric histology positive for H. pylori infection referred to our unit for 13-C urea breath test(UBT), after first-line therapy with proton pump inhibitor (PPI) b.i.d. + amoxicillin 1 g b.i.d. + clarithromycin 500 mg b.i.d. for 7 d. Patients who were still positive to UBT were recommended a second-line therapy (PPI b.i.d. + amoxicillin 1 g b.i.d. + tinidazole 500 mg b.i.d. for 14 d). Third choice treatment was empirical with PPI b.i.d. + amoxicillin 1 g b.i.d. + levofloxacin 250 mg b.i.d. for 14 d. RESULTS: Out of 614 patients, still H. pylori-positive after first-line therapy, only 326 and 19 patients respectively rechecked their H. pylori status by UBT after the suggested second and third-line regimens. 'Per protocol' eradication rates for first, second and thirdline therapy were 74.7% (95% CI: 72.7%-76.4%), 85.3% (95% CI: 81.1%-89.1%) and 89.5% (95% CI: 74.9%-103%) respectively. The overall percentage of patients with H. pylori eradicated after two treatments was 97.8% (95% CI: 97.1%-98.4%), vs 99.9% (95% CI: 99.8%-100%) after three treatments. The study found that eradication therapy was most effective in patients with ulcer disease (P < 0.05, P = 0.028), especially in those with duodenal ulcer. Smoking habits did not significantly affect the eradication rate. CONCLUSION: First-line therapy with amoxicillin and clarithromycin produces an H. pylori eradication rate comparable or superior to other studies and secondline treatment can still be triple therapy with amoxicillin and tinidazole. | Giuliana Sereni Francesco Azzolini Lorenzo Camellini Debora Formisano Francesco Decembrino Veronica Iori Cristiana Tioli Maurizio Cavina Francesco Di Mario Giuliano Bedogni Romano Sassatelli | 2012 | World Journal of Gastroenterology2012，18，33： | 4 |
| 4 | Quality of bowel preparation in patients with inflammatory bowel disease undergoing colonoscopy:What factors to consider?显示文摘An adequate bowel preparation in patients with inflammatory bowel disease(IBD)is a prerequisite for successful colonoscopy for screening,diagnosis,and surveillance.Several bowel preparation formulations are available,both high-and low-volume based on polyethylene glycol.Generally,low-volume formulations are also based on several compounds such as magnesium citrate preparations with sodium picosulphate,oral sulphate solution,and oral sodium phosphatebased solutions.Targeted studies on the quality of bowel preparation prior to colonoscopy in the IBD population are still required,with current evidence from existing studies being inconclusive.New frontiers are also moving towards the use of alternatives to anterograde ones,using preparations based on retrograde colonic lavage. | Antonietta Gerarda Gravina Raffaele Pellegrino Mario Romeo Giovanna Palladino Marina Cipullo Giorgia Iadanza Simone Olivieri Giuseppe Zagaria Nicola De Gennaro Antonio Santonastaso Marco Romano Alessandro Federico | 2023 | World Journal of Gastrointestinal Endoscopy2023，15，3： | 2 |
| 5 | Results, Outcome Predictors, and Complications after Stapled Transanal Rectal Resection for Obstructed Defecation显示文摘 | Giuseppe Gagliardi M.D. Mario Pescatori M.D. F.R.C.S. E.B.S.Q. Donato F. Altomare M.D. Gian Andrea Binda M.D. Corrado Bottini M.D. Giuseppe Dodi M.D. Vincenzino Filingeri M.D. Giovanni Milito M.D. Marcella Rinaldi M.D. Giovanni Romano M.D. Liana Spazzaf | 2008 | Diseases of the Colon & Rectum2008，，2： | 2 |
| 6 | Anomalous origin of the coronary arteries in children: diagnostic role of three-dimensional coronary MR angiography显示文摘 | Alberto Clemente Mario Del Borrello Pietro Greco Paolo Mannella Franco Di Gregorio Silvia Romano Aldo Morra | 2010 | Clinical Imaging2010，，： | 1 |
| 7 | Is flexible bronchoscopy necessary to confirm the position of double-lumen tubes before thoracic surgery? ☆显示文摘 | Mario de Bellis Rosanna Accardo Massimo Di Maio Carmine Lamanna Giovanni Battista Rossi Maria Caterina Pace Vincenzo Romano Gaetano Rocco | 2011 | European Journal of Cardio-Thoracic Surgery2011，，4： | 1 |
| 8 | Vitrectomy With or Without Preoperative Intravitreal Bevacizumab for Proliferative Diabetic Retinopathy: A Meta-Analysis of Randomized Controlled Trials显示文摘 | Zhi-Hua Zhang Hai-Yun Liu Sergio E. Hernandez-Da Mota Mario R. Romano Khalil G. Falavarjani Hamid Ahmadieh Xun Xu Kun Liu | 2013 | American Journal of Ophthalmology2013，，1： | 1 |
| 9 | Prognostic Value of Pathologic Complete Response After Neoadjuvant Therapy in Locally Advanced Rectal Cancer: Long-Term Analysis of 566 ypCR Patients显示文摘 | Carlo Capirci Vincenzo Valentini Luca Cionini Antonino De Paoli Claus Rodel Robert Glynne-Jones Claudio Coco Mario Romano Giovanna Mantello Silvia Palazzi Falchetti Osti Mattia Maria Luisa Friso Domenico Genovesi Cristiana Vidali Maria Antonietta Gambacor | 2008 | International Journal of Radiation Oncology Biology Physics2008，，1： | 1 |
| 10 | Psychopharmacological Treatment and Psychological Interventions in Irritable Bowel Syndrome显示文摘 | Emanuele Sinagra Claudia Romano Mario Cottone Giovanni Barbara | 2012 | Gastroenterology Research and Practice2012，，： | 1 |
| 11 | Results, Outcome Predictors, and Complications after Stapled Transanal Rectal Resection for Obstructed Defecation显示文摘 | Giuseppe Gagliardi M.D. Mario Pescatori M.D. F.R.C.S. E.B.S.Q. Donato F. Altomare M.D. Gian Andrea Binda M.D. Corrado Bottini M.D. Giuseppe Dodi M.D. Vincenzino Filingeri M.D. Giovanni Milito M.D. Marcella Rinaldi M.D. Giovanni Romano M.D. Liana Spazzaf | 2008 | Diseases of the Colon & Rectum2008，，2： | 1 |
| 12 | Prevalence rates of gallstone disease in Italy显示文摘 | Paola Loria Michele A. Dilengite Mara Bozzoli Francesca Carubbi Roberto Messora Romano Sassatelli Marco Bertolotti Auro Tampieri Pier Luigi Tartoni Mariateresa Cassinadri Mario Delia Ciana Maurizio Contemori Nicola Save Bruno Sordi ulio Alimenti brizio Fa | 1994 | European Journal of Epidemiology1994，，2： | 1 |
| 13 | miR-221&222 Regulate TRAIL Resistance and Enhance Tumorigenicity through PTEN and TIMP3 Downregulation显示文摘 | Michela Garofalo Gianpiero Di Leva Giulia Romano Gerard Nuovo Sung-Suk Suh Apollinaire Ngankeu Cristian Taccioli Flavia Pichiorri Hansjuerg Alder Paola Secchiero Pierluigi Gasparini Arianna Gonelli Stefan Costinean Mario Acunzo Gerolama Condorelli Carlo M | 2009 | Cancer Cell2009，，6： | 1 |
| 14 | Heavy Silicone Oil and Intraocular Inflammation显示文摘 | Francesco Morescalchi Ciro Costagliola Sarah Duse Elena Gambicorti Barbara Parolini Barbara Arcidiacono Mario R. Romano Francesco Semeraro Kenneth Li | 2014 | BioMed Research International2014，，： | 1 |
| 15 | Vitreous Substitutes: The Present and the Future显示文摘 | Simone Donati Simona Maria Caprani Giulia Airaghi Riccardo Vinciguerra Luigi Bartalena Francesco Testa Cesare Mariotti Giovanni Porta Francesca Simonelli Claudio Azzolini Mario R. Romano | 2014 | BioMed Research International2014，，： | 1 |
| 16 | miR-221&222 Regulate TRAIL Resistance and Enhance Tumorigenicity through PTEN and TIMP3 Downregulation显示文摘 | Michela Garofalo Gianpiero Di Leva Giulia Romano Gerard Nuovo Sung-Suk Suh Apollinaire Ngankeu Cristian Taccioli Flavia Pichiorri Hansjuerg Alder Paola Secchiero Pierluigi Gasparini Arianna Gonelli Stefan Costinean Mario Acunzo Gerolama Condorelli Carlo M | 2009 | Cancer Cell2009，，6： | 1 |
| 17 | Antepartum cardiotocography: A study of fetal reactivity in frequency domain显示文摘 | Maria Romano Marcello Bracale Mario Cesarelli Marta Campanile Paolo Bifulco Marianna De Falco Mario Sansone Andrea Di Lieto | 2005 | Computers in Biology and Medicine2005，，6： | 1 |
| 18 | Mechanism of Inflammation in Age-Related Macular Degeneration: An Up-to-Date on Genetic Landmarks显示文摘 | Francesco Parmeggiani Francesco S. Sorrentino Mario R. Romano Ciro Costagliola Francesco Semeraro Carlo Incorvaia Sergio D’Angelo Paolo Perri Katia De Nadai Elia Bonomo Roversi Paola Franceschelli Adolfo Sebastiani Michele Rubini John Christoforidis | 2013 | Mediators of Inflammation2013，，： | 1 |
| 19 | White matter hyperintensities and self-reported depression in a sample of patients with chronic headache显示文摘 | Gianluca Serafini Maurizio Pompili Marco Innamorati Andrea Negro Martina Fiorillo Dorian A. Lamis Denise Erbuto Francesco Marsibilio Andrea Romano Mario Amore Lidia D’Alonzo Alessandro Bozzao Paolo Girardi Paolo Martelletti | 2012 | The Journal of Headache and Pain2012，，8： | 1 |
| 20 | Irinotecan in combination with thalidomide in patients with advanced solid tumors: a clinical study with pharmacodynamic and pharmacokinetic evaluation显示文摘 | Giacomo Allegrini Antonello Paolo Elisa Cerri Samanta Cupini Federica Amatori Gianluca Masi Romano Danesi Lorenzo Marcucci Guido Bocci Mario Tacca Alfredo Falcone | 2006 | Cancer Chemotherapy and Pharmacology2006，，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员