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| 1 | Percutaneous radiofrequency ablation for early hepatocellular carcinoma: Risk factors for survival显示文摘AIM: To evaluate outcomes of radiofrequency ablation(RFA) therapy for early hepatocellular carcinoma(HCC) and identify survival- and recurrence-related factors. METHODS: Consecutive patients diagnosed with early HCC by computed tomography(CT) or magnetic resonance imaging(MRI)(single nodule of ≤ 5 cm, or multi-(up to 3) nodules of ≤ 3 cm each) and who underwent RFA treatment with curative intent between January 2010 and August 2011 at the Instituto do Cancer do Estado de S o Paulo, Brazil were enrolled in the study. RFA of the liver tumors(with 1.0 cm ablative margin) was carried out under CT-fluoro scan and ultrasonic image guidance of the percutaneous ablation probes. Procedure-related complications were recorded. At 1-mo post-RFA and 3-mo intervals thereafter, CT and MRI were performed to assess outcomes of complete response(absence of enhancing tissue at the tumor site) or incomplete response(enhancing tissue remaining at the tumor site). Overall survival and diseasefree survival rates were estimated by the Kaplan-Meier method and compared by the log rank test or simple Cox regression. The effect of risk factors on survival was assessed by the Cox proportional hazard model. RESULTS: A total of 38 RFA sessions were performed during the study period on 34 patients(age in years: mean, 63 and range, 49-84). The mean follow-up time was 22 mo(range, 1-33). The study population showed predominance of male sex(76%), less severe liver disease(Child-Pugh A, n = 26; Child-Pugh B, n = 8), and single tumor(65%). The maximum tumor diameters ranged from 10 to 50 mm(median, 26 mm). The initial(immediately post-procedure) rate of RFAinduced complete tumor necrosis was 90%. The probability of achieving complete response was significantly greater in patients with a single nodule(vs patients with multi-nodules, P = 0.04). Two patients experienced major complications, including acute pulmonary edema(resolved with intervention) and intestinal perforation(led to death). The 1- and 2-year overall survival rates were 82% and 71%, respectively. Sex, tumor size, initial response, and recurrence status influenced survival, but did not reach the threshold of statistical significance. Child-Pugh class and the model for end-stage liver disease score were identified as predictors of survival by simple Cox regression, but only Child-Pugh class showed a statistically significant association to survival in multiple Cox regression analysis(HR = 15; 95%CI: 3-76 mo; P = 0.001). The 1-and 2-year cumulative disease-free survival rates were 65% and 36%, respectively. CONCLUSION: RFA is an effective therapy for local tumor control of early HCC, and patients with preserved liver function are the best candidates. | Luciana Kikuchi Marcos Menezes Aline L Chagas Claudia M Tani Regiane SSM Alencar Marcio A Diniz Venncio AF Alves Luiz Augusto Carneiro D’Albuquerque Flair José Carrilho | 2014 | World Journal of Gastroenterology2014，20，6： | 5 |
| 2 | Eco-efficien- cy management program (EEMP) a model for road fleet operation 显示文摘 | Marcio D' Agosto Suzana Kahn Ribeiro | 2004 | Transportation Research Part D: Transport and Environment2004，，6： | 1 |
| 3 | Electrically, chemically, and photonically powered torsional and tensile actuation of hybrid carbon nanotube yam muscles显示文摘 | Marcio D L Li Na Monica Jung de Andrade | 2012 | Science2012，338，6116： | 1 |
| 4 | Transition from progressive buckling to global bending of circular shells under axial impact-Part Ⅰ: Experimental and numerical observations显示文摘 | Karagiozova D Marcio A | 2004 | International Journal of Solids and Structures2004，41，： | 1 |
| 5 | Effect of pre-strain on the fatigue life of 7050-T7451 aluminium ally显示文摘 | S A Kassim A D Marcio N T Dilermando etal | 2007 | Materials Science and Engineering A2007，，464： | 1 |
| 6 | Eco efficiency management program(EEMP)a model for road fleet operation显示文摘 | MARCIO D A SUZANA K R | 2004 | Trans- portation Research Part D: Transport and Environment2004，9，6： | 1 |
| 7 | Production of inulinase by solid-state fermentation:effect of process parameters on production and preliminary characterization of enzyme preparations显示文摘 | MARCIO M GUSTAVO C MARCO D L | 2007 | Bioprocess and Biosystems Engineering2007，30，5： | 1 |
| 8 | A review on microbial lipases production显示文摘 | TREITHEL H OLIVEIRA D MARCIO A M | 2010 | Food Bioprocess Technol2010，，3： | 1 |
| 9 | Eco-efficiency management Program(EEMP):A model for road fleet operation:Transportation research part D显示文摘 | Marcio D' Agosto Suzana Kahn Ribeiro | 2004 | Transport and Environment2004，9，6： | 1 |
| 10 | Eco-efficiency manage-ment program(EEMP)a model for road fleet operation显示文摘 | Marcio D’Agosto Suzana Kahn Ribeiro | 2004 | Transportation Research Part D:Transport and Environment2004，9，6： | 1 |
| 11 | The kinetics of gibbsite dissolution in NaOH显示文摘 | Pereira J A M Marcio S Enrico D O | 2009 | Hydrometallurgy2009，96，12： | 1 |
| 12 | Eco-efficiency manage- ment program (EEMP) a model for road fleet operation显示文摘 | Marcio D' Agosto Suzana Kahn Ribeiro | 2004 | Transportation Research Part D: Transport and Environment2004，9，6： | 1 |
| 13 | Biscrolling Nanotube Sheets and Functional Guests into Yarns 显示文摘 | Lima Marcio D Fang Shaoli Lepro Xavier | 2011 | Science2011，331，6013： | 1 |
| 14 | Phenol degradation by ad- vanced electrochemical oxidation process Electro - Fenton using a carbon felt cathode 显示文摘 | Marcio P Nihal O Marcia D ct al | 2008 | Apply Catalysis B: Environment2008，83，12： | 1 |
| 15 | Electri- cally, Chemically, and Photonically Powered Torsional and Ten- sile Actuation of Hybrid Carbon Nanotube Yam Muscles显示文摘 | Lima Marcio D Li Na Andrade MSnica Jung de | 2012 | Sci- ence2012，338，6109： | 1 |
| 16 | Eco - efficiency Management Pro- gram(EEMP) a Model for Road Fleet Opertian显示文摘 | Marcio D' Agosto Suzana Kahn Ribeiro | 2004 | Transportation Research Part D : Transport and Environment2004，9，6： | 1 |
| 17 | A Review on Microbial Lipases Production 显示文摘 | Treichel H Oliveira D Marcio A | 2010 | Food Bioprocess Tech2010，3，2： | 1 |
| 18 | A review on microbial lipases production显示文摘 | TREITHEL H OLIVEIRA D MARCIO A M | 2010 | Food Bioprocess Technol2010，3，： | 1 |
| 19 | Phenol degradation by advanced electrochemical oxidation process electro-Fenton using a carbon felt cathode显示文摘 | Marcio P Nihal O Marcia D | 2008 | Applied Catalysis2008，83，3： | 1 |
| 20 | A Review on Microbial Lipases Production显示文摘 | Helen Treichel Débora Oliveira Marcio A. Mazutti Marco Luccio J. Vladimir Oliveira | 2010 | Food and Bioprocess Technology2010，，2： | 1 |
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