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| 1 | Intraoperative cell salvage with autologous transfusion in liver transplantation显示文摘Liver transplant(LT) is the primary treatment for patients with end-stage liver disease. About 25000 LTs are performed annually in the world. The potential for intraoperative bleeding is quite variable. However, massive bleeding is common and requires blood transfusion. Allogeneic blood transfusion has an immunosuppressive effect and an impact on recipient survival, in addition to the risk of transmission of viral infections and transfusion errors, among others.Techniques to prevent excessive bleeding or to use autologous blood have been proposed to minimize the negative effects of allogeneic blood transfusion.Intraoperative reinfusion of autologous blood is possible through previous selfdonation or blood collected during the operation. However, LT does not normally allow autologous transfusion by prior self-donation. Hence, using autologous blood collected intraoperatively is the most feasible option. The use of intraoperative blood salvage autotransfusion(IBSA) minimizes the perioperative use of allogeneic blood, preventing negative transfusion effects without negatively impacting other clinical outcomes. The use of IBSA in patients with cancer is still a matter of debate due to the theoretical risk of reinfusion of tumor cells. However, studies have demonstrated the safety of IBSA in several surgical procedures, including LT for hepatocellular carcinoma. Considering the literature available to date, we can state that IBSA should be routinely used in LT, both in patients with cancer and in patients with benign diseases. | Marcelo A Pinto Marcio F Chedid Leo Sekine Andre P Schmidt Rodrigo P Capra Carolina Prediger Jo?o E Prediger Tomaz JM Grezzana-Filho Cleber RP Kruel | 2019 | World Journal of Gastrointestinal Surgery2019，11，1： | 16 |
| 2 | Liver preservation prior to transplantation: Past, present, and future显示文摘Since Dr. Thomas Starzl performed the first series of successful liver transplants(LTs), important advances have been made in immunosuppression, operative techniques, and postoperative care. In 1988, Belzer's group reported the first successful LT using the University of Wisconsin preservation solution(UW).Since then, UW has replaced EuroCollins solution and allowed prolonged and safer preservation of liver, kidney, and pancreas allografts, thus contributing to the improvement of transplant outcomes. Although UW is still considered the standard of care in the United States and in several countries worldwide, a recent meta-analysis revealed similar LT outcomes among UW, Celsior solution, and the Institut Georges Lopez-1 preservation solution, which were slightly superior to those obtained with histidine-tryptophan-ketoglutarate preservation solution.Dynamic preservation has been recently developed, and liver allografts are preserved mainly through the following methods: hypothermic machine perfusion, normothermic machine perfusion, and subnormothermic machine perfusion. Their use has the potential advantage of improving clinical results in LT involving extended criteria donor allografts. Although associated with increased costs, techniques employing machine perfusion of liver allografts have been considered clinically feasible. This editorial focuses on recent advances and future perspectives in liver allograft preservation. | Marcio F Chedid Marcelo A Pinto Jose Felipe G Juchem Tomaz J M Grezzana-Filho Cleber R P Kruel | 2019 | World Journal of Gastrointestinal Surgery2019，11，3： | 4 |
| 3 | Sodium glucose co-transporter 2 inhibition reduces succinate levels in diabetic mice显示文摘BACKGROUND Type 1 diabetes(T1D) is associated with major chronic microvascular complications which contribute significantly to diabetes associated morbidity.The protein primarily responsible for glucose reabsorption in the kidney is sodium glucose co-transporter 2(SGLT2). Presently, SGLT2 inhibitors are widely used in diabetic patients to improve blood glucose levels and prevent cardiovascular and renal complications. Given the broad therapeutic application of SGLT2 inhibitors, we hypothesised that SGLT2 inhibition may exert its protective effects via alterations of the gut microbiome and tested this in a type 1 diabetic mouse model of diabetic retinopathy.AIM To determine whether the treatment with two independent SGLT2 inhibitors affects gut health in a type 1 diabetic mouse model.METHODS The SGLT2 inhibitors empagliflozin or dapagliflozin(25 mg/kg/d) or vehicle dimethylsulfoxide(DMSO) were administered to C57 BL/6 J, Akita, Kimba and Akimba mice at 10 wk of age for 8 wk via their drinking water. Serum samples were collected and the concentration of succinate and the short chain fatty acid(SCFA) butyric acid was measured using gas chromatography-mass spectrometry. Enzyme-linked immunosorbent assay(ELISA) was performed to determine the concentration of insulin and leptin. Furthermore, the norepinephrine content in kidney tissue was determined using ELISA. Pancreatic tissue was collected and stained with haematoxylin and eosin and analysed using brightfield microscopy.RESULTS Due to the presence of the Akita allele, both Akita and Akimba mice showed a reduction in insulin production compared to C57 BL/6 J and Kimba mice.Furthermore, Akita mice also showed the presence of apoptotic bodies within the pancreatic islets. The acinar cells of Akita and Akimba mice showed swelling which is indicative of acute injury or pancreatitis. After 8 wk of SGLT2 inhibition with dapagliflozin, the intermediate metabolite of gut metabolism known as succinate was significantly reduced in Akimba mice when compared to DMSO treated mice. In addition, empagliflozin resulted in suppression of succinate levels in Akimba mice. The beneficial SCFA known as butyric acid was significantly increased in Akita mice after treatment with dapagliflozin when compared to vehicle treated mice. The norepinephrine content in the kidney was significantly reduced with both dapagliflozin and empagliflozin therapy in Akita mice and was significantly reduced in Akimba mice treated with empagliflozin.In non-diabetic C57 BL/6 J and Kimba mice, serum leptin levels were significantly reduced after dapagliflozin therapy.CONCLUSION The inhibition of SGLT2 reduces the intermediate metabolite succinate, increases SCFA butyric acid levels and reduces norepinephrine content in mouse models of T1 D. Collectively, these improvements may represent an important mechanism underlying the potential benefits of SGLT2 inhibition in T1 D and its complications. | Lakshini Y Herat Natalie C Ward Aaron L Magno Elizabeth P Rakoczy Marcio G Kiuchi Markus P Schlaich Vance B Matthews | 2020 | World Journal of Gastroenterology2020，26，23： | 3 |
| 4 | The successive projections algorithm for spectral variable selection in classification problems 显示文摘 | Marcio J C P Roberto K H G Mario C U A | 2005 | Chemometrics and Intelligent Laboratory Systems2005，78，： | 1 |
| 5 | Lithosphere-asthenosphere interaction and the origin of cretaceous tholelltic magmatism in northeastern Brazil- Sr-Nd-Pb isotopic evidence显示文摘 | MARIA H B M H MARCIO M P DIOGENES C O | 2006 | Lithos2006，86，1： | 1 |
| 6 | Combined zero-valent iron and fenton processes for the treatment of Brazilian TNT industry wastewater显示文摘 | MARCIO B R FLáVIO T S TERESA C B P | 2009 | Journal of Hazardous Materials2009，165，： | 1 |
| 7 | Thermal characteristics analysis of an IGBT using a fiber bragg grating显示文摘 | BAZZO J P TIAGO L MARCIO V | 2012 | Optics and La- sers in Engineering2012，50，2： | 1 |
| 8 | Longterm follow-up of patients with giant cell tumer of the sacrum treated with selective arterial embolizaion显示文摘 | Lin Patrick P Guzel Volkan B Moura Marcio F | 2002 | Cancer2002，95，： | 1 |
| 9 | Noise-to-Harmonics ratio as an acoustic measure of voice disorders in boys显示文摘 | GERALDO P J ONIVALDO C MARCIO A | 2002 | J Voice2002，16，： | 1 |
| 10 | Displacement control in tunnels excavated by the NATM 3D numerical simulations显示文摘 | De Marcio M F Alvaro H M J De Andre P A | 2004 | Tunneling and Underground Space Technology2004，19，： | 1 |
| 11 | Dis- Placement Control in Tunnels Excavated by the NATM3D Numerical Simulations显示文摘 | De Marcio M F Alvaro H MJ De Andre P A | 2004 | Tunneling and Underground Space Technology2004，19，5： | 1 |
| 12 | Thermal characteristics analysis of an IGBT using a fiber brag grating 显示文摘 | BAZZO J P TIAGO L MARCIO V | 2012 | Opt Lasers Eng2012，50，2： | 1 |
| 13 | Displacement control intunnels excavated by the NATM : 3-D numerical simulations显示文摘 | Marcio M F Alvaro H M Andre P A | 2004 | Tunnelling and Underground Space Technology2004，19，3： | 1 |
| 14 | Predicting the Brazilian stock market through neural networks and adaptive exponential smoot- hing methods 显示文摘 | E L de Faria Marcelo P Albuquerque J L Gonzalez J T P Cav- alcante Marcio P Albuquerque | 2009 | Expert Systems with Applications2009，36，12： | 1 |
| 15 | Thermal characteristics analysis of an IGBT using a fiber bragg grating 显示文摘 | BAZZO J P TIAGO L MARCIO V | 2012 | Optics and Lasers in Engineering2012，50，2： | 1 |
| 16 | Reduction of interference signal of ascorbate and urate in poly(pyrrole)-based ammonia sensors in aquerous solutions显示文摘 | Marcio Vidotti Luiz H Dall Antonia Cintra E P | 2004 | Electrochim Acta2004，49，： | 1 |
| 17 | Thermal Characteristics Analysis of an IGBT Using a Fiber Bragg Grating显示文摘 | Bazzo J P Tiago L Marcio V | 2012 | Optics and Lasers in Engineering2012，50，： | 1 |
| 18 | Pattern recognition of weld defects in preprocessed TOFD signals using linear classifiers double glow surface alloying process显示文摘 | ELINEUDO P ROMEU R MARCIO H | 2004 | Journal of Nondestructive Evaluation2004，23，4： | 1 |
| 19 | Constrained smoothing B-splines for the term structure of interest rates显示文摘 | Marcio P L Marcelo M | 2010 | Insurance: Mathematics and Economics2010，46，2： | 1 |
| 20 | Cost-effectiveness of fondaparinux in patients with acute coronary syndrome without ST-segment elevation显示文摘 | Camila P Marcio M Alexandre O | 2012 | Arq Bras Cardiol2012，99，1： | 1 |
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