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| 1 | Percutaneous radiofrequency ablation for early hepatocellular carcinoma: Risk factors for survival显示文摘AIM: To evaluate outcomes of radiofrequency ablation(RFA) therapy for early hepatocellular carcinoma(HCC) and identify survival- and recurrence-related factors. METHODS: Consecutive patients diagnosed with early HCC by computed tomography(CT) or magnetic resonance imaging(MRI)(single nodule of ≤ 5 cm, or multi-(up to 3) nodules of ≤ 3 cm each) and who underwent RFA treatment with curative intent between January 2010 and August 2011 at the Instituto do Cancer do Estado de S o Paulo, Brazil were enrolled in the study. RFA of the liver tumors(with 1.0 cm ablative margin) was carried out under CT-fluoro scan and ultrasonic image guidance of the percutaneous ablation probes. Procedure-related complications were recorded. At 1-mo post-RFA and 3-mo intervals thereafter, CT and MRI were performed to assess outcomes of complete response(absence of enhancing tissue at the tumor site) or incomplete response(enhancing tissue remaining at the tumor site). Overall survival and diseasefree survival rates were estimated by the Kaplan-Meier method and compared by the log rank test or simple Cox regression. The effect of risk factors on survival was assessed by the Cox proportional hazard model. RESULTS: A total of 38 RFA sessions were performed during the study period on 34 patients(age in years: mean, 63 and range, 49-84). The mean follow-up time was 22 mo(range, 1-33). The study population showed predominance of male sex(76%), less severe liver disease(Child-Pugh A, n = 26; Child-Pugh B, n = 8), and single tumor(65%). The maximum tumor diameters ranged from 10 to 50 mm(median, 26 mm). The initial(immediately post-procedure) rate of RFAinduced complete tumor necrosis was 90%. The probability of achieving complete response was significantly greater in patients with a single nodule(vs patients with multi-nodules, P = 0.04). Two patients experienced major complications, including acute pulmonary edema(resolved with intervention) and intestinal perforation(led to death). The 1- and 2-year overall survival rates were 82% and 71%, respectively. Sex, tumor size, initial response, and recurrence status influenced survival, but did not reach the threshold of statistical significance. Child-Pugh class and the model for end-stage liver disease score were identified as predictors of survival by simple Cox regression, but only Child-Pugh class showed a statistically significant association to survival in multiple Cox regression analysis(HR = 15; 95%CI: 3-76 mo; P = 0.001). The 1-and 2-year cumulative disease-free survival rates were 65% and 36%, respectively. CONCLUSION: RFA is an effective therapy for local tumor control of early HCC, and patients with preserved liver function are the best candidates. | Luciana Kikuchi Marcos Menezes Aline L Chagas Claudia M Tani Regiane SSM Alencar Marcio A Diniz Venncio AF Alves Luiz Augusto Carneiro D’Albuquerque Flair José Carrilho | 2014 | World Journal of Gastroenterology2014，20，6： | 5 |
| 2 | Liver preservation prior to transplantation: Past, present, and future显示文摘Since Dr. Thomas Starzl performed the first series of successful liver transplants(LTs), important advances have been made in immunosuppression, operative techniques, and postoperative care. In 1988, Belzer's group reported the first successful LT using the University of Wisconsin preservation solution(UW).Since then, UW has replaced EuroCollins solution and allowed prolonged and safer preservation of liver, kidney, and pancreas allografts, thus contributing to the improvement of transplant outcomes. Although UW is still considered the standard of care in the United States and in several countries worldwide, a recent meta-analysis revealed similar LT outcomes among UW, Celsior solution, and the Institut Georges Lopez-1 preservation solution, which were slightly superior to those obtained with histidine-tryptophan-ketoglutarate preservation solution.Dynamic preservation has been recently developed, and liver allografts are preserved mainly through the following methods: hypothermic machine perfusion, normothermic machine perfusion, and subnormothermic machine perfusion. Their use has the potential advantage of improving clinical results in LT involving extended criteria donor allografts. Although associated with increased costs, techniques employing machine perfusion of liver allografts have been considered clinically feasible. This editorial focuses on recent advances and future perspectives in liver allograft preservation. | Marcio F Chedid Marcelo A Pinto Jose Felipe G Juchem Tomaz J M Grezzana-Filho Cleber R P Kruel | 2019 | World Journal of Gastrointestinal Surgery2019，11，3： | 4 |
| 3 | MACROPHAGE MIGRATION INHIBITORY FACTOR LEVELS CORRELATE WITH FATAL OUTCOME IN SEPSIS显示文摘 | Fernando A Bozza Rachel N Gomes André M Japiassú Marcio Soares Hugo C Castro-Faria-Neto Patrìcia T Bozza Marcelo T Bozza | 2004 | Shock2004，，4： | 1 |
| 4 | The kinetics of gibbsite dissolution in NaOH显示文摘 | JANANA A M PEREIRA MARCIO SCHWAAB ENRICO DELL'ORO | 2009 | Hydrometallurgy2009，96，12： | 1 |
| 5 | Flow Injection Analysis-Amperometric Determination of Ascorbic Acid and Uric Acid in Urine Using Arrays of Gold Microelectrode Modified by Electro Deposition of Palladium 显示文摘 | Renato C M Marcio A A Claudimir L L | 2000 | Anal Chim Acta2000，404，： | 1 |
| 6 | Domain size effects in molecular dynamics simulation of phonon transport in silicon 显示文摘 | ROGERIO F S MARCIO A R C A JANDIR M H | 2003 | Appl Phys Lett2003，89，17： | 1 |
| 7 | Formulating and optimizing a combustion pathways for oil shale and its semi-coke 显示文摘 | Marco A B Z Henrique M Marcio F M | 2012 | Combustion and Flame2012，159，10： | 1 |
| 8 | Displacement control in tunnels excavated by the NATM 3D numerical simulations显示文摘 | De Marcio M F Alvaro H M J De Andre P A | 2004 | Tunneling and Underground Space Technology2004，19，： | 1 |
| 9 | Dis- Placement Control in Tunnels Excavated by the NATM3D Numerical Simulations显示文摘 | De Marcio M F Alvaro H MJ De Andre P A | 2004 | Tunneling and Underground Space Technology2004，19，5： | 1 |
| 10 | Geochemical characterization of natural gas:a physical multivariable approach and its applications in maturity and migration estimates 显示文摘 | Prinzhofer A Marcio R M Tikae T | 2000 | AAPG Bulletin2000，84，8： | 1 |
| 11 | Displacement control intunnels excavated by the NATM : 3-D numerical simulations显示文摘 | Marcio M F Alvaro H M Andre P A | 2004 | Tunnelling and Underground Space Technology2004，19，3： | 1 |
| 12 | Prop-erties of chemically treated natural amorphous silica fibers aspolyurethane reinforcement显示文摘 | Guilherme M O Barra Marcio C Fredel Hazim A | 2006 | Polymer Composites2006，27，： | 1 |
| 13 | A review on microbial lipases production显示文摘 | TREITHEL H OLIVEIRA D MARCIO A M | 2010 | Food Bioprocess Technol2010，，3： | 1 |
| 14 | Geochemical character- ization of natural gas: A physical multivariable approach and its applications in maturity and migration estimates 显示文摘 | Prinzhofer A Marcio R M Tikae T | 2000 | AAPG Bulletin2000，84，8： | 1 |
| 15 | Efficacy of esmolol as a myocardial protective agent during continuous retrograde blood cardioplegia显示文摘 | Marcio S Alexandre M Nawwar A | 2003 | J Thorac Cardiovasc Surg2003，125，5： | 1 |
| 16 | The kinetics of gibbsite dissolution in NaOH显示文摘 | Pereira J A M Marcio S Enrico D O | 2009 | Hydrometallurgy2009，96，12： | 1 |
| 17 | Displacement control in tunnels excavated by the NATM 3D numerical simulations显示文摘 | De Marcio M F Alvaro H M J De Anere P A | 2004 | Tunneling and Underground Space Technology2004，19，： | 1 |
| 18 | Displacement control in tunnels excavated by the NATM: 3-D numerical simulations 显示文摘 | Marcio M F Alvaro H M Andre P A | 2004 | Tunnelling and Underground Space Technology2004，19，3： | 1 |
| 19 | Modeling and Simulation of Petroleum Coke Calcinations in Rotary Kilns显示文摘 | Marcio A M Leandro S O Adriana S F | 2001 | Fu-el2001，80，11： | 1 |
| 20 | Mathematical modeling and simulation of inulinase adsorption in expanded bed column 显示文摘 | Caroline C M Marcio A M Maria I R | 2009 | J Chromatogr A2009，1216，： | 1 |
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