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| 1 | Tumor infiltrating lymphocytes in triple negative breast cancer receiving neoadjuvant chemotherapy显示文摘AIM To determine influence of neoadjuvant-chemotherapy(NAC) over tumor-infiltrating-lymphocytes(TIL) intriple-negative-breast-cancer(TNBC).METHODS TILs were evaluated in 98 TNBC cases who came to Instituto Nacional de Enfermedades Neoplasicas from 2005 to 2010. Immunohistochemistry staining for CD3, CD4, CD8 and FOXP3 was performed in tissue microarrays(TMA) sections. Evaluation of H/E in full-face and immunohistochemistry in TMA sections was performed in pre and post-NAC samples. STATA software was used and P value < 0.05 was considered statistically significant. RESULTS Higher TIL evaluated in full-face sections from pre-NAC tumors was associated to pathologic-complete-response(pCR)(P = 0.0251) and outcome(P = 0.0334). TIL evaluated in TMA sections showed low level of agreement with full-face sections(ICC = 0.017-0.20) and was not associated to pCR or outcome. TIL in post-NAC samples were not associated to response or outcome. PostNAC lesions with pC R had similar TIL levels than those without pCR(P = 0.6331). NAC produced a TIL decrease in full-face sections(P < 0.0001). Percentage of TIL subpopulations was correlated with their absolute counts. Higher counts of CD3, CD4, CD8 and FOXP3 in pre-NAC samples had longer disease-free-survival(DFS). Higher counts of CD3 in pre-NAC samples had longer overallsurvival. Higher ratio of CD8/CD4 counts in pre-NAC was associated with pCR. Higher ratio of CD4/FOXP3 counts in pre-NAC was associated with longer DFS. Higher counts of CD4 in post-NAC samples were associated with pCR.CONCLUSION TIL in pre-NAC full-face sections in TNBC are correlated to longer survival. TIL in full-face differ from TMA sections, absolute count and percentage analysis of TIL subpopulation closely related. | Carlos A Castaneda Elizabeth Mittendorf Sandro Casavilca Yun Wu Miluska Castillo Patricia Arboleda Teresa Nunez Henry Guerra Carlos Barrionuevo Ketty Dolores-Cerna Carolina Belmar-Lopez Julio Abugattas Gabriela Calderon Miguel De La Cruz Manuel Cotrina Jorge Dunstan Henry L Gomez Tatiana Vidaurre | 2016 | World Journal of Clinical Oncology2016，7，5： | 6 |
| 2 | Clinicopathological predictors of long-term benefit in breast cancer treated with neoadjuvant chemotherapy显示文摘AIM To investigate the survival impact of clinicopathological factors, including pathological complete response(p CR) and tumor-infiltrating lymphocytes(s TIL) levels according to subtypes, in breast cancer(BC) patients who received neo-adjuvant chemotherapy(NAC).METHODS We evaluated 435 BC patients who presented and received NAC at the Instituto Nacional de Enfermedades Neoplasicas from 2003 to 2014. s TIL was analyzed as the proportion of tumor stroma occupied by lymphocytes, and was prospectively evaluated on hematoxylin and eosin-stained sections of the preN AC core biopsy. p CR was considered in the absence of infiltrating cancer cells in primary tumor and axillary lymph nodes. Analysis of statistical association between clinical pathological features, s TIL, p CR and survival were carried out using SPSSvs19.RESULTS Median age was 49 years(range 24-84 years) and the most frequent clinical stage was ⅢB(58.3%). Luminal A, Luminal B, HER2-enriched and(triple-negative) TN phenotype was found in 24.6%, 37.9%, 17.7% and 19.8%, respectively. p CR was observed in 11% and median percentage of s TIL was 40%(2%-95%) in the whole population. p CR was associated to Ct1-2(P = 0.045) and to high s TIL(P = 0.029) in the whole population. There was a slight trend towards significance for s TIL(P = 0.054) in Luminal A. s TIL was associated with grade Ⅲ(P < 0.001), no-Luminal A subtype(P < 0.001), RE-negative(P < 0.001), PgR-negative(P < 0.001), HER2-positive(P = 0.002) and p CR(P = 0.029) in the whole population. Longer disease-free survival was associated with grade Ⅰ-Ⅱ(P = 0.006), cN 0(P < 0.001), clinical stage Ⅱ(P = 0.004), ER-positive(P < 0.001), Pg R-positive(P < 0.001), luminal A(P < 0.001) and p CR(P = 0.002). Longer disease-free survival was associated with grade Ⅰ-Ⅱ in Luminal A(P < 0.001), N0-1 in Luminal A(P = 0.045) and TNBC(P = 0.01), clinical stage Ⅱ in Luminal A(P = 0.003) and TNBC(P = 0.038), and pC R in TNBC(P < 0.001). Longer overall survival was associated with grade Ⅰ-Ⅱ(P < 0.001), ER-positive(P < 0.001), PgR-positive(P < 0.001), Luminal A(P < 0.001), cN 0(P = 0.002) and p CR(P = 0.002) in the whole population. Overall survival was associated with clinical stage Ⅱ(P = 0.017) in Luminal A, older age(P = 0.042) in Luminal B, and pC R in TNBC(P = 0.005).CONCLUSION Predictive and prognostic values of clinicopathological features, like p CR and s TIL, differ depending on the evaluated molecular subtype. | Marco Galvez Carlos A Castaneda Joselyn Sanchez Miluska Castillo Lia Pamela Rebaza Gabriela Calderon Miguel De La Cruz Jose Manuel Cotrina Julio Abugattas Jorge Dunstan Henry Guerra Omar Mejia Henry L Gomez | 2018 | World Journal of Clinical Oncology2018，9，2： | 4 |
| 3 | Analysis and biological properties of amino acid derivates formed by Maillard reaction in foods显示文摘 | José Manuel Silván Jürgen van de Lagemaat Agustín Olano Maria Dolores del Castillo | 2006 | Journal of Pharmaceutical and Biomedical Analysis2006，，5： | 2 |
| 4 | sTWEAK is a marker of early haematoma growth and leukoaraiosis in intracerebral haemorrhage显示文摘Objective To study the association between early growth of haematoma with biomarkers of endothelial dysfunction such as leukoaraiosis(LA)and the soluble tumour necrosis factor-like weak inducer of apoptosis(sTWEAK)in patients with intracerebral haemorrhage(ICH).Methods This is a retrospective observational study of patients with nontraumatic ICH.Clinical and biochemical parameters were analysed.sTWEAK levels were measured by ELISA.LA was analysed in the hemisphere without haemorrhage to avoid interference with the acute injury.The main endpoint was the haematoma growth evaluated by the difference in volume between the second and the initial neuroimage.Poor functional outcome,defined as a modified Rankin Scale>2 at 3 months,was considered as secondary endpoint.Receiver operating characteristic curve analysis was performed to stablish the best cut-off for sTWEAK levels associated with haematoma growth.Results We included 653 patients with ICH in our analysis(71.1±11.9 years,44%women).Haematoma growth was observed in 188 patients(28.8%).sTWEAK levels≥5600 pg/mL predicted ICH growth with a sensitivity of 84%and a specificity of 87%.sTWEAK levels≥5600 pg/mL and the presence of LA were associated with haematoma growth(OR:42.46;(CI 95%22.67 to 79.52)and OR:2.73(CI 95%1.39 to 5.34),respectively).Also,the presence of LA(OR:4.31(CI 95%2.89 to 6.42))and the interaction between ICH growth and sTWEAK(OR:2.23(CI 95%1.40 to 3.55))were associated with poor functional outcome at 3 months.Conclusion sTWEAKs,together with the presence and grade of LA,are biomarkers able to predict ICH growth and poor functional outcome in patients with ICH. | Andrés da Silva-Candal Iria López-Dequidt Manuel Rodriguez-Yañez PauloÁvila-Gómez JoséManuel Pumar JoséCastillo Tomás Sobrino Francisco Campos Ramón Iglesias-Rey Pablo Hervella | 2021 | Stroke & Vascular Neurology2021，6，4： | 2 |
| 5 | In vitro glycation and antigenicity of soy proteins显示文摘 | Jürgen van de Lagemaat J. Manuel Silván F. Javier Moreno Agustín Olano M. Dolores del Castillo | 2006 | Food Research International2006，，1： | 2 |
| 6 | Health-related fitness assessment in childhood and adolescence: a European approach based on the AVENA, EYHS and HELENA studies显示文摘 | Jonatan R. Ruiz Francisco B. Ortega Angel Gutierrez Dirk Meusel Michael Sj?str?m Manuel J. Castillo | 2006 | Journal of Public Health2006，，5： | 1 |
| 7 | High serum levels of pro-brain natriuretic peptide (pro BNP) identify cardioembolic origin in undetermined stroke显示文摘 | Manuel Rodríguez-Yá?ez Tomás Sobrino Miguel Blanco Natalia Pérez de la Ossa David Brea Raquel Rodríguez-González Rogelio Leira Antonio Dávalos José Castillo | 2009 | Disease Markers2009，，4： | 1 |
| 8 | Preclinical cadaveric study of transanal robotic proctectomy with total mesorectal excision combined with laparoscopic assistance显示文摘 | M. Gomez Ruiz I. Martin Parra A. Calleja Iglesias H. Stein S. Sprinkle C. Manuel Palazuelos J. Alonso Martin C. Cagigas Fernandez J. Castillo Diego M. Gomez Fleitas | 2015 | Int J Med Robotics Comput Assist Surg2015，，2： | 1 |
| 9 | The impact of the prevention strategies on the indirect effects of CMV infection in solid organ transplant recipients显示文摘 | Antonio Roman Nicolás Manito Josep Maria Campistol Valentín Cuervas-Mons Luis Almenar Manuel Arias Fernando Casafont Domingo del Castillo María G. Crespo-Leiro Juan F. Delgado J. Ignacio Herrero Paloma Jara José M. Morales Mercedes Navarro Federico Oppenh | 2014 | Transplantation Reviews2014，，： | 1 |
| 10 | Synthesis and antiparasitic activity of 1 H -benzimidazole derivatives显示文摘 | Juan Valdez Roberto Cedillo Alicia Hernández-Campos Lilián Yépez Francisco Hernández-Luis Gabriel Navarrete-Vázquez Amparo Tapia Rafael Cortés Manuel Hernández Rafael Castillo | 2002 | Bioorganic & Medicinal Chemistry Letters2002，，16： | 1 |
| 11 | Synthesis and antiparasitic activity of 2-(Trifluoromethyl)benzimidazole derivatives显示文摘 | Gabriel Navarrete-Vázquez Roberto Cedillo Alicia Hernández-Campos Lilián Yépez Francisco Hernández-Luis Juan Valdez Raúl Morales Rafael Cortés Manuel Hernández Rafael Castillo | 2001 | Bioorganic & Medicinal Chemistry Letters2001，，2： | 1 |
| 12 | Laparoscopic Repair of Renal Artery Aneurysm: A Description of the Technique and Results in 2 Cases显示文摘 | Octavio A. Castillo Gonzalo J. Vitagliano Rafael Sanchez-Salas Hernán Chamorro Mario Fava Manuel A. Díaz | 2008 | Surgical Laparoscopy Endoscopy & Percutaneous Techniques2008，，4： | 1 |
| 13 | Age Determines the Effects of Blood Pressure Lowering During the Acute Phase of Ischemic Stroke: The TICA Study显示文摘 | Rogelio Leira Mónica Millán Exuperio Díez-Tejedor Miguel Blanco Joaquín Serena Blanca Fuentes Manuel Rodríguez-Yá?ez Mar Castellanos Aida Lago Antonio Dávalos José Castillo | 2009 | Hypertension2009，，4： | 1 |
| 14 | Visible-near Infrared Spectroscopy Sensor for Predicting Curd and Whey Composition during Cheese Processing 显示文摘 | Fagan Colette C Manuel Castillo Donal J 0 'Callaghan | 2009 | Sensing and Instrumentation for Food Quality and Safety2009，31，： | 1 |
| 15 | Neurological Deterioration in Acute Lacunar Infarctions: The Role of Excitatory and Inhibitory Neurotransmitters显示文摘 | Joaquín Serena Rogelio Leira José Castillo José Manuel Pumar Mar Castellanos Antoni Dávalos | 2001 | Stroke: Journal of the American Heart Association2001，，5： | 1 |
| 16 | Progression of ischaemic stroke and excitotoxic aminoacids显示文摘 | José Castillo Antoni Dávalos Manuel Noya | 1997 | 1997 (9045)1997，，9045： | 1 |
| 17 | Minimally Invasive Pediatric Cardiac Surgery. Atrial Septal Defect Closure Through Axillary and Submammary Approaches显示文摘 | Juan Miguel Gil-Jaurena Juan-Ignacio Zabala Lourdes Conejo Victorio Cuenca Beatriz Picazo Clara Jiménez Rafael Castillo Manuel Ferreiros Manuel de Mora Julio Gutiérrez de Loma | 2010 | 2010，，： | 1 |
| 18 | Solvent engineering: an effective tool to direct chemoselectivity in a lipase-catalyzed Michael addition显示文摘 | Jaime Priego Claudia Ortíz-Nava Manuel Carrillo-Morales Agustín López-Munguía Jaime Escalante Edmundo Castillo | 2008 | Tetrahedron2008，，2： | 1 |
| 19 | Temporal profile and clinical significance of serum neuron-specific enolase and S100 in ischemic and hemorrhagic stroke显示文摘 | David Brea Tomás Sobrino Miguel Blanco Iván Cristobo Raquel Rodríguez-González Manuel Rodríguez-Ya?ez Octavio Moldes Jesús Agulla Rogelio Leira José Castillo | 2009 | Clinical Chemistry and Laboratory Medicine2009，，12： | 1 |
| 20 | Antioxidant and emulsifying properties of alcalase-hydrolyzed potato proteins in meat emulsions with different fat concentrations显示文摘 | Gema Nieto Manuel Castillo Youling L Xiong | 2009 | Meat Science2009，83，： | 1 |
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