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| 1 | Gastric endoscopic submucosal dissection:From animal model to patient显示文摘AIM:To assess whether the use of porcine models is useful for learning endoscopic submucosal dissection(ESD),thus contributing to its subsequent application in human patients.METHODS:This study/learning process was carried out in 3 phases:PhaseⅠ:Ex vivo animal;PhaseⅡ:In vivo animal;PhaseⅢ:Humans.One endoscopist performed 30 gastric ESDs in porcine models,and later 5gastric ESDs in 5 patients.The ESD was done following the method practiced at the National Cancer Center in Tokyo,Japan.Technical aspects,size,time and speed of ESD,as well as complications were registered.In patients,their clinical,endoscopic and histologic evolution was additionally added.RESULTS:Thirty en bloc ESDs were carried out in animal models.The mean±SD size of the pieces was of28.4±1.2 mm,and the time of ESD was 41.7±2.4min.The time of ESD in the first 15 procedures was 43.0±3.0 min whereas in the next 15 procedures,the time was 40.3±3.9 min,P=0.588.The speed in the first 15ESDs was 1.25±0.11 cm2/min vs 2.12±0.36 cm2/min in the remaining 15,P=0.028.There were no complications.In patients,5 lesions were resected en bloc.The size of the pieces was 25.2±5.1 mm and the time was85.0±25.6 min.Endoscopic and histological controls did not show evidence of residual neoplastic tissue.CONCLUSION:A sequential ESD training program of a unique endoscopist,based on the practice in porcine models,contributed to learning ESD for its subsequent application in humans,yielding good results in efficacy and safety. | Nicolás González Adolfo Parra-Blanco Miguel Villa-Gómez Alejandra Gamba Andrés Taullard Anaulina Silveira Alberto Sanguinetti Carolina Olano Henry Cohen | 2013 | World Journal of Gastroenterology2013，19，45： | 6 |
| 2 | Analysis and biological properties of amino acid derivates formed by Maillard reaction in foods显示文摘 | José Manuel Silván Jürgen van de Lagemaat Agustín Olano Maria Dolores del Castillo | 2006 | Journal of Pharmaceutical and Biomedical Analysis2006，，5： | 2 |
| 3 | In vitro glycation and antigenicity of soy proteins显示文摘 | Jürgen van de Lagemaat J. Manuel Silván F. Javier Moreno Agustín Olano M. Dolores del Castillo | 2006 | Food Research International2006，，1： | 2 |
| 4 | Modulation of invariant natural killer T cell cytokine responses by indoleamine 2, 3-d ioxygenase 显示文摘 | M olano A I11arionov PA B esra GS | 2008 | Imm un olLett2008，117，1： | 1 |
| 5 | Isomerization of lactose catalyzed by alkaline-substituted sepiolites显示文摘 | FUENTES M A J(A)REZ M RAFAEL D VILLAMIEL M OLANO A | | 0，，03： | 1 |
| 6 | in vitro fermentability of dextran,oligodextran and maltodextrin by human gut bacteria显示文摘 | OLANO M E MOUNTZOURIS K C GIBSON G R | 2000 | British Journal of Nutrition2000，83，3： | 1 |
| 7 | Seed bank spatial pattern in a temperate secondary forest显示文摘 | OLANO J M CABALLERO I LASKURAIN N A | 2002 | Journal of Vegetation Science2002，13，： | 1 |
| 8 | Quantitative determination of carbohydrates in orange juice by gas chromatography显示文摘 | M. Villamiel Isabel Martínez-Castro Agustín Olano N. Corzo | 1998 | Zeitschrift für Lebensmitteluntersuchung und - forschung A1998，，1： | 1 |
| 9 | Small-bowel endoscopy 显示文摘 | Monkemuller K Olano C Fry LC | 2009 | Endoscopy2009，41，10： | 1 |
| 10 | Regenerative role of seed banks following an intense soil disturbance显示文摘 | LUZURIAGA A L ESCUDERO A OLANO J M | 2005 | Acta Oecologica2005，27，1： | 1 |
| 11 | Factors affecting the rennet clotting properties of ewe's milk 显示文摘 | Balcones E Olano A Catvo M M | 1996 | Journal of Agricultural and Food Chemistry1996，44，8： | 1 |
| 12 | High-pressure effects on Maillard reaction between Glucose and Lysine显示文摘 | Moreno F J Molina Elena Olano Agustian | 2003 | Journal of Agriculture and Food Chemistry2003，51，2： | 1 |
| 13 | The effects of high pressure on whey protein denaturation and cheese-making properties of raw milk显示文摘 | Lopez Fandino R Carrascosa A V Olano A | 1996 | Journal of Dairy Science1996，79，6： | 1 |
| 14 | Evaluation of basophil activation in mastocytosis with Hymenoptera venom anaphylaxis显示文摘 | Gonzalezde Olano D Alvarez Twose I Morgado JM | | 0，，3： | 1 |
| 15 | Pectins and pectic oligosaccharides inhibit Escherichia coli O157:H7 Shiga toxin as directed towards the human colonic cell line HT29显示文摘 | OLANO M RIMBACH G H | | 0，，： | 1 |
| 16 | Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering显示文摘 | Olano C Lombo F Mendez C | 2008 | Metab Eng2008，10，5： | 1 |
| 17 | Prognostic value of lactate clearance in the first 6 hours of intensive medicine course显示文摘 | Cardinal PA Olano E Acosta C | 2009 | Med Intenciva2009，33，4： | 1 |
| 18 | Quantitative tracheid anatomy reveals a complex environmental control of wood structure in continental Mediterranean climate显示文摘 | Olano J M Eugenio M Gareia-Cervig6n A I | 2012 | International Journal of Plant Science2012，173，2： | 1 |
| 19 | Comparison of the in vitro bifidogenic properties of pectins and pectic-oligosaccharides显示文摘 | Olano ME Gibson GR Rastell RA | 2002 | J Appl Microbiol2002，93，3： | 1 |
| 20 | Kinetics and thermostability of NADP-isocitrate dehydrogenase from Cephalosporium acremonium 显示文摘 | Olano J Arriaga D Busto F | 1995 | Appl Environm Microblol1995，61，6： | 1 |
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