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| 1 | Rho A signaling and blood pressure: The consequence of failing to “Tone it Down”显示文摘Uncontrolled high blood pressure is a major risk factor for heart attack, stroke, and kidney failure and contributes to an estimated 25% of deaths worldwide. Despite numerous treatment options, estimates project that reasonable blood pressure(BP) control is achieved in only about half of hypertensive patients. Improvements in the detection and management of hypertension will undoubtedly be accomplished through a better understanding of the complex etiology of this disease and a more comprehensive inventory of the genes and genetic variants that influence BP regulation. Recent studies(primarily in pre-clinical models) indicate that the small GTPase Rho A and its downstream target, Rho kinase, play an important role in regulating BP homeostasis. Herein, we summarize the underlying mechanisms and highlight signaling pathways and regulators that impart tight spatial-temporal control of Rho A activity. We also discuss known allelic variations in the Rho A pathway and consider how these polymorphisms may affect genetic risk for hypertension and its clinical manifestations. Finally, we summarize the current(albeit limited) clinical data on the efficacy of targeting the Rho A pathway in hypertensive patients. | Xue Bai Rachel Dee Kevin D Mangum Christopher P Mack Joan M Taylor | 2016 | World Journal of Hypertension2016，6，1： | 3 |
| 2 | Reducing Hospital Morbidity and Mortality Following Esophagectomy显示文摘 | B.Zane Atkins Ashish S. Shah Kelley A. Hutcheson Jennifer H. Mangum Theodore N. Pappas David H. Harpole Thomas A. D’Amico | 2004 | The Annals of Thoracic Surgery2004，，4： | 2 |
| 3 | A prospective, randomized, multicentered controlled trial to compare the annual glycemic and quality outcomes of patients with diabetes mellitus monitored with weekly fructosamine testing versus usual care显示文摘 | Lindsey CC Carter AW Mangum S | 2004 | Diabetes Technol Ther2004，6，3： | 1 |
| 4 | Pulmonary segmenteeto- my by thoraeotomy or thoracoscopy: reduced hospital length of stay with a minimally-invasive approach 显示文摘 | Atkins BZ Harpole DH Jr Mangum JH | 2010 | Ann Thorac Surg2010，84，4： | 1 |
| 5 | Opposing actions of Statl and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor figands in pulmonary fibroblasts显示文摘 | Ingrain JL Antac-Menezes A Mangum JB | 2006 | J Immunol2006，177，6： | 1 |
| 6 | Dickens and the Female Terrorist :The Long Shadow of Madame Defarge 显示文摘 | Mangum Teresa | 2009 | Nineteenth-Century Con- texts2009，31，2： | 1 |
| 7 | Combined small-cell and non-small-cell lung cancer显示文摘 | Mangum MD Greco FA Hainsworth JD | 1989 | J Clin Oncol1989，7，5： | 1 |
| 8 | A review of narrative peda- gogy strategies to transform traditional nursing education显示文摘 | Brown ST Kirkpatrick MK Mangum D | 2008 | J Nuts Edue2008，47，6： | 1 |
| 9 | A neural network approach to real-time condition monitoring of induction motors显示文摘 | Chow M Y Mangum P M | 1999 | IEEE Transactions on Industrial Electronics1999，38，6： | 1 |
| 10 | Effect of preexposure to ultrafine carbon black on respiratory syncytial virus infection in mice 显示文摘 | LAMBERT A L TRASTI F S MANGUM J B | 2003 | Toxicol Sci2003，72，2： | 1 |
| 11 | Long-of three laboratory rodent species to subehronic inhalation of pigmentary titanium dioxide particles 显示文摘 | Bermudez E Mangum J B term pulmonary responses Asgharian B | 2002 | Toxicotogyieal Sciences2002，70，1： | 1 |
| 12 | Proteomic profiling of facial development in chick embryos 显示文摘 | MANGUM J E FARLIE P G Hubbard M J | 2005 | Proteomics2005，5，： | 1 |
| 13 | Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles 显示文摘 | Bermudez E Mangum JB Wong BA Asgharian B Hext PM David B Everitt J | 2004 | Toxicol Sci2004，77，2： | 1 |
| 14 | Effect of pore size on adsorption of hydrocarbons in phenolic-based activated carbon fibers显示文摘 | Mangum C L Daley M A Braatz R D | 1998 | Carbon1998，36，12： | 1 |
| 15 | Pulmonary responses of mice,rats,and hamsters to subchronic inhalation of ultrafine titanium dioxide particles显示文摘 | BERMUDEZ E MANGUM J B WONG B A | 2004 | Toxicological Sciences2004，77，2： | 1 |
| 16 | A prospective, randomized, multicentered controlled triaⅠ to com-pare the annual glycemic and quality outcomes ot patients with diabetes mellitus monitored with weekly fructosamine testing versus usual care显示文摘 | Lindsey CC Carter AW Mangum S | 2004 | Diabetes Technol Ther2004，6，3： | 1 |
| 17 | A prospective, randomized, multicentered controlled trial to compare the annual glycemic and quality outcomes of patients with diabetes mellitus monitored with weekly fructosamine testing versus usual care 显示文摘 | Lindsey CC Carter AW Mangum S | 2004 | Diabetes Technol Ther2004，6，3： | 1 |
| 18 | Precut papillotomy has a low complication rate in experienced hands:a 6-year retrospective review from a specialist center显示文摘 | Chotiprasidhi P Roback Mangum G Branch Ms | 2000 | Gastrointest Endosc2000，51，4： | 1 |
| 19 | Combined small-cell and non-small-cell lung cancer显示文摘 | Mangum MD Greeo FA Hainsworth JD | 1989 | J Clin Oncol1989，7，： | 1 |
| 20 | Relationship between gap width and recurrent dental caries beneath occlusal margins of amalgam restorations显示文摘 | Hodges DJ Mangum FI Ward MT | 1995 | Community Dent Oral Epidemiol1995，23，4： | 1 |
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