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| 1 | Comprehensive lifestyle intervention vs soy protein-based meal regimen in non-alcoholic steatohepatitis显示文摘BACKGROUND Non-alcoholic steatohepatitis(NASH) has become one of the leading causes of liver disease in the western world. In obese patients weight reduction is recommended. Up to now there are no specific guidelines for weight loss in order to reduce hepatic fat content.AIM To investigate the effects of a 24-wk guided lifestyle intervention program compared to a meal replacement regimen based on soy protein.METHODS Twenty-six subjects with NASH participated in a randomized single-center study. They were randomly assigned to either meal replacement group(MR-G)with soy-yogurt-honey preparation or to guided lifestyle change group(LC-G)with endurance activity and nutrition counselling. Serum alanine transaminase(ALT), aspartate transaminase(AST), lipid parameters, and adipokines were measured. Liver fat content and lipid composition were determined by magnetic resonance imaging and magnetic resonance spectroscopy. Body fat mass and lean body mass were assessed using Bod Pod? device. Pre-and post-intervention monitoring of parameters was performed. Statistical analyses were conducted with SPSS software, results were expressed as median(interquartile range).RESULTS Twenty-two subjects(MR-G, n = 11 and LC-G, n = 11) completed the study(9 women, 13 men; age 52.1(15.0) years, body mass index(BMI) 32.3(3.3) kg/m^2).In both groups a significant weight loss was achieved(MR-G:-6.4(3.6) kg, P <0.01; LC-G:-9.1(10.4) kg, P < 0.01). BMI dropped in both groups(MR-G:-2.3(1.5)kg/m^2, P = 0.003; LC-G:-3.0(3.4) kg/m^2, P = 0.006). Internal fat and hepatic lipid content were markedly reduced in both groups in comparable amount. There was a strong correlation between reduction in liver fat and decrease in ALT.Likewise, both groups showed an improvement in glycemic control and lipid profile. Changes in adipokines, particularly in adiponectin and leptin were closely related to intrahepatic lipid changes.CONCLUSION Comprehensive lifestyle intervention and meal replacement regimen have comparable effects on body and liver fat, as well as decrease in markers of hepatic inflammation among NASH patients. | Peter Deibert Adhara Lazaro Denise Schaffner Aloys Berg Daniel Koenig Wolfgang Kreisel Manfred W Baumstark Daniel Steinmann Martin Buechert Thomas Lange | 2019 | World Journal of Gastroenterology2019，25，9： | 3 |
| 2 | Hidden Markov Model-Baed Emotion Recognition 显示文摘 | Bjom Sehuller Gerhard RigoU Manfred Lang | 2003 | IEEE Signal Processing Magazine2003，10，6： | 1 |
| 3 | Simulation of micro discharges for the optimization of energy requirments for removal of NOx from exhaust gases显示文摘 | Holger Russ Manfred Neiger Tfirgen E lang | 1999 | IEEE Trans on Plasma Science1999，27，1： | 1 |
| 4 | Treatment of Crigler-Najjar type 1 disease: relevance of early liver transplantation显示文摘 | Rolf Schauer Manfred Stangl Thomas Lang Andreas Zimmermann Alexander Chouker Alexander L Gerbes Friedrich W Schildberg Horst G Rau | 2003 | Journal of Pediatric Surgery2003，，8： | 1 |
| 5 | A new treatment option for pulmonary valvar insufficiency: first experiences with implantation of a self-expanding stented valve without use of cardiopulmonary bypass <sup>☆</sup>显示文摘 | Christian Schreiber Jürgen H?rer Manfred Vogt Sohrab Fratz Markus Kunze Christoph Galm Andreas Eicken Rüdiger Lange | 2007 | European Journal of Cardio-Thoracic Surgery2007，，1： | 1 |
| 6 | Demosaicing of images obtained from single - chip imaging sensors in YUV color space显示文摘 | Jayanta Mukherjee Lang Manfred K Mitra S K | 2005 | Pattern Recognition Letters2005，26，： | 1 |
| 7 | Long-Term Results of Repair of Anomalous Origin of the Left Coronary Artery From the Pulmonary Artery显示文摘 | Rüdiger Lange Manfred Vogt Jürgen H?rer Julie Cleuziou Andrea Menzel Klaus Holper John Hess Christian Schreiber | 2007 | The Annals of Thoracic Surgery2007，，4： | 1 |
| 8 | Skincare plants of the Naxi of NW Yunnan, China显示文摘The Naxi of Northwest Yunnan,China use medicinal plants to treat skin conditions related to traditional lifestyles in extreme environments.However,modernization endangers both the medicinal plants used to treat skin conditions and traditional knowledge.Therefore,investigation and documentation of the medicinal plants used and associated traditional knowledge is necessary.In this study,we conducted an ethnobotanical survey in 12 Naxi communities in Northwest Yunnan.For this purpose,we used semistructured surveys to interview 840 informants from Naxi communities.We used informant consensus factor and use frequency as quantitative indices to evaluate the importance of medicinal plant species.A total of 161 medicinal plant species belonging to 69 families were documented.The highest informant consensus factor(ICF)values were recorded for skin nourishing(ICF?0.849),frostbite and chapped skin(ICF?0.833).These skin treatments are highly related to the environment and lifestyle of Naxi communities.The main active compounds of plants used to treat skin conditions in Naxi communities are known to have skin-treating properties.This study reveals that the skin conditions treated by the Naxi are associated with traditional medicine culture and social economic development.In addition,this study uses ethnobotanical indices to explain how skin condition treatments are linked to the natural environment of Naxi communities. | Yanqiang Zhao Zexing Yang Bayi Lang Manfred Shao Wu Meng Dayuan Xue Lu Gao Lixin Yang | 2020 | Plant Diversity2020，42，6： | 0 |
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