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| 1 | Comprehensive lifestyle intervention vs soy protein-based meal regimen in non-alcoholic steatohepatitis显示文摘BACKGROUND Non-alcoholic steatohepatitis(NASH) has become one of the leading causes of liver disease in the western world. In obese patients weight reduction is recommended. Up to now there are no specific guidelines for weight loss in order to reduce hepatic fat content.AIM To investigate the effects of a 24-wk guided lifestyle intervention program compared to a meal replacement regimen based on soy protein.METHODS Twenty-six subjects with NASH participated in a randomized single-center study. They were randomly assigned to either meal replacement group(MR-G)with soy-yogurt-honey preparation or to guided lifestyle change group(LC-G)with endurance activity and nutrition counselling. Serum alanine transaminase(ALT), aspartate transaminase(AST), lipid parameters, and adipokines were measured. Liver fat content and lipid composition were determined by magnetic resonance imaging and magnetic resonance spectroscopy. Body fat mass and lean body mass were assessed using Bod Pod? device. Pre-and post-intervention monitoring of parameters was performed. Statistical analyses were conducted with SPSS software, results were expressed as median(interquartile range).RESULTS Twenty-two subjects(MR-G, n = 11 and LC-G, n = 11) completed the study(9 women, 13 men; age 52.1(15.0) years, body mass index(BMI) 32.3(3.3) kg/m^2).In both groups a significant weight loss was achieved(MR-G:-6.4(3.6) kg, P <0.01; LC-G:-9.1(10.4) kg, P < 0.01). BMI dropped in both groups(MR-G:-2.3(1.5)kg/m^2, P = 0.003; LC-G:-3.0(3.4) kg/m^2, P = 0.006). Internal fat and hepatic lipid content were markedly reduced in both groups in comparable amount. There was a strong correlation between reduction in liver fat and decrease in ALT.Likewise, both groups showed an improvement in glycemic control and lipid profile. Changes in adipokines, particularly in adiponectin and leptin were closely related to intrahepatic lipid changes.CONCLUSION Comprehensive lifestyle intervention and meal replacement regimen have comparable effects on body and liver fat, as well as decrease in markers of hepatic inflammation among NASH patients. | Peter Deibert Adhara Lazaro Denise Schaffner Aloys Berg Daniel Koenig Wolfgang Kreisel Manfred W Baumstark Daniel Steinmann Martin Buechert Thomas Lange | 2019 | World Journal of Gastroenterology2019，25，9： | 3 |
| 2 | From Vulnerable Plaque to Vulnerable Patient—Part III: Executive Summary of the Screening for Heart Attack Prevention and Education (SHAPE) Task Force Report显示文摘 | Morteza Naghavi Erling Falk Harvey S. Hecht Michael J. Jamieson Sanjay Kaul Daniel Berman Zahi Fayad Matthew J. Budoff John Rumberger Tasneem Z. Naqvi Leslee J. Shaw Ole Faergeman Jay Cohn Raymond Bahr Wolfgang Koenig Jasenka Demirovic Dan Arking Victoria | 2006 | The American Journal of Cardiology2006，，2： | 1 |
| 3 | A pilot study on religiousness/spirituality and ADHD显示文摘 | Dew RE Daniel SS Koenig HG | 2007 | Int J Adolesc Med Health2007，19，4： | 1 |
| 4 | Fine genetic mapping of RXopJ4 , a bacterial spot disease resistance locus from Solanum pennellii LA716显示文摘 | Molly Sharlach Douglas Dahlbeck Lily Liu Joshua Chiu José M. Jiménez-Gómez Seisuke Kimura Daniel Koenig Julin N. Maloof Neelima Sinha Gerald V. Minsavage Jeffrey B. Jones Robert E. Stall Brian J. Staskawicz | 2013 | Theoretical and Applied Genetics2013，，3： | 1 |
| 5 | Plasma cystatin C for prediction of 1-year cardiac events in Mediterranean patients with non-ST elevation acute coronary syndrome显示文摘 | Nevio Taglieri Daniel J. Fernandez-Berges Wolfgang Koenig Luciano Consuegra-Sanchez José Maria Cruz Fernandez Nicolas Roberto Robles Pedro Luis Sánchez Alfonso Castro Beiras Pedro Maria Montes Orbe Juan Carlos Kaski | 2009 | Atherosclerosis2009，，1： | 1 |
| 6 | A pilot study on religiousn-ess/spirituality and ADHD显示文摘 | Dew R E Daniel S S Koenig H G | 2007 | Int J Adolesc Med Health2007，19，4： | 1 |
| 7 | Theta*: any-angle path planning on grids 显示文摘 | DANIEL K NASH A KOENIG S | 2010 | Journal of Artificial Intelligence Research2010，39，1： | 1 |
| 8 | A dual‐targeting antibody against EGFR‐VEGF for lung and head and neck cancer treatment显示文摘 | Hongzheng Zhang Sujin Yun Thil D. Batuwangala Michael Steward Steve D. Holmes Lin Pan Mourad Tighiouart Hyung Ju C. Shin Lydia Koenig Wungki Park Daniel Rycroft Sreenivas Nannapaneni Yuxiang Wang Zhuo (Georgia) Chen Dong M. Shin | 2011 | Int J Cancer2011，，4： | 1 |
| 9 | Theta*: Any-angle Path Planning on Grids显示文摘 | Daniel K Nash A Koenig S | 2010 | Journal of Artificial Intelligence Research2010，39，1： | 1 |
| 10 | NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar–Ductal Transdifferentiation in the Pancreas显示文摘 | Nai-Ming Chen Garima Singh Alexander Koenig Geou-Yarh Liou Peter Storz Jin-San Zhang Lisanne Regul Sankari Nagarajan Benjamin Kühnemuth Steven A. Johnsen Matthias Hebrok Jens Siveke Daniel D. Billadeau Volker Ellenrieder Elisabeth Hessmann | 2015 | Gastroenterology2015，，5： | 1 |
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