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| 1 | Prevention of esophageal strictures after endoscopic submucosal dissection显示文摘Endoscopic mucosal resection(EMR) and endoscopic submucosal dissection(ESD) have recently been accepted as less invasive methods for treating patients with early esophageal cancers such as squamous cell carcinoma and dysplasia of Barrett's esophagus.However,the large defects in the esophageal mucosa often cause severe esophageal strictures,which dramatically reduce the patient's quality of life.Although preventive endoscopic balloon dilatation can reduce dysphagia and the frequency of dilatation,other approaches are necessary to prevent esophageal strictures after ESD.This review describes several strategies for preventing esophageal strictures after ESD,with a particular focus on anti-inflammatory and tissue engineering approaches.The local injection of triamcinolone acetonide and other systemic steroid therapies are frequently used to prevent esophageal strictures after ESD.Tissue engineering approaches for preventing esophageal strictures have recently been applied in basic research studies.Scaffolds with temporary stents have been applied in five cases,and this technique has been shown to be safe and is anticipated to prevent esophageal strictures.Fabricated autologous oral mucosal epithelial cell sheets to cover the defective mucosa similarly to how commercially available skin products fabricated from epidermal cells are used for skin defects or in cases of intractable ulcers.Fabricated autologous oralmucosal-epithelial cell sheets have already been shown to be safe. | Shinichiro Kobayashi Nobuo Kanai Takeshi Ohki Ryo Takagi Naoyuki Yamaguchi Hajime Isomoto Yoshiyuki Kasai Takahiro Hosoi Kazuhiko Nakao Susumu Eguchi Masakazu Yamamoto Masayuki Yamato Teruo Okano | 2014 | World Journal of Gastroenterology2014，20，41： | 12 |
| 2 | Genetic changes of p53,K-ras,and microsatellite instability in gallbladder carcinoma in high-incidence areas of Japan and Hungary显示文摘AIM: To disclose geographic differences in genetic changes involved in gallbladder carcinogenesis between two distinct high-incidence areas of Japan and Hungary.METHODS: We examined 42 cases of gallbladder carcinoma: 22 Japanese and 20 Hungarian cases. p53 mutations at exons 5 to 8 and K-ras mutations at codon 12 were tested by direct sequencing. Microsatellite instability was determined from fluorescent dye-labeled PCR amplifications of five-microsatellite markers (BAT-25, BAT-26, D2S123, D5S346, and D17S250).RESULTS: Mutations of p53 were detected in 11 of 22 Japanese cases and 6 of 18 Hungarian cases (11/22 vs 6/18, P = 0.348). Transition at CpG sites was found in none of 11 Japanese cases and 2 of 6 Hungarian cases; the difference was marginally significant (0/11 vs 2/6, P = 0.110). K-ras mutations were detected in only one of the Hungarian cases. Eight of 19 (42.1%) Japanese cases were MSI-high (presence of novel peaks in more than one of the five loci analyzed), whereas only 1 of 15 (6.7%) Hungarian cases was MSI-high (P = 0.047).CONCLUSION: It appears that the p53 mutations and MSI differ in patients with gallbladder carcinoma between two distinct high-incidence areas. Geographic variation might exist in the process of gallbladder carcinogenesis. | Masayuki Nagahashi Yoichi Ajioka Istvan Lang Zoltan Szentirmay Miklos Kasler Hiroto Nakadaira Naoyuki Yokoyama Gen Watanabe Ken Nishikura Toshifumi Wakai Yoshio Shirai Katsuyoshi Hatakeyama Masaharu Yamamoto | 2008 | World Journal of Gastroenterology2008，14，1： | 9 |
| 3 | Cell sheet technology for regeneration of esophageal mucosa显示文摘The progress of tissue-engineering technology has realized development of new therapies to treat various disorders by using cultured cells. Cell-and tissue-based therapies have been successfully applied to human patients, and several tissue-engineered products have been approved by the regulatory agencies and are commercially available. In the review article, we describe our experience of development and clinical application of cell sheet-based regenerative medicine.Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) have been shown to be useful for removal of gastrointestinal neoplasms with less invasiveness compared with open surgery, especially in esophageal surgery. However, postoperative inflammation and stenosis are major complications observed after intensive mucosal resection. Therefore, we have developed novel regenerative medicine to prevent such complications and promote wound healing of esophageal mucosa after EMR or ESD. Transplantable oral mucosal epithelial cell sheets were fabricated from patients' own oral mucosa. Immediately after EMR or ESD, fabricated autologous cell sheets were endoscopically transplanted to the ulcer sites. We performed a preclinical study with a canine model. In human clinical settings, cell culture and cell sheet fabrication were performed in clean rooms according to good manufacturing practice guidelines, and pharmaceutical drugs were used as supplements to culture medium in place of research regents used in animal study. We believe that cell-based regenerative medicine would be useful to improve quality of life of patients after EMR or ESD. | Ryo Takagi Masayuki Yamato Nobuo Kanai Daisuke Murakami Makoto Kondo Takaaki Ishii Takeshi Ohki Hideo Namiki Masakazu Yamamoto Teruo Okano | 2012 | World Journal of Gastroenterology2012，18，37： | 9 |
| 4 | Application of Rainbow Schlieren Deflectometry for Axisymmetric Supersonic Jets (Comparison of Experiments with Numerical Analysis)显示文摘This paper analyzes the correctly-expanded supersonic jet from a convergent-divergent axisymmetric nozzle by using numerical simulation of turbulent flow.And the calculated density distributions in this flow are compared with the present experimental data using rainbow schlieren deflectometry.The value of the density from the experimental data agrees well with the results calculated by this simulation.Therefore,the present method of the measurement using rainbow schlieren deflectometry is useful for the measurement of the density of the correctly-expanded supersonic jet. | Hideki Yamamoto Masayuki Irie Yoshiaki Miyazato Kazuyasu Matsuo | 2010 | Journal of Thermal Science2010，19，3： | 5 |
| 5 | 尼可地尔经皮冠状动脉介入治疗(PCI)降低心肌损伤显示文摘背景尼可地尔作为辅助治疗药物,在缺血性心脏病患者的治疗中具有良好效果。本研究旨在评估尼可地尔选择性经皮冠状动脉治疗(PCI)后对心肌的保护作用。方法我们随机地将49个接受选择性PCI治疗的病人分为尼可地尔及对照这两组。PCI治疗前,尼可地尔组先静脉推注4mg尼可地尔,介入治疗后再以6mg每小时的量静脉滴注24小时。口服尼可地尔给药组持续给药直至接下来的冠状动脉造影(CAG)。PCI治疗前及PCI治疗后0、4、24及48小时分别采集各组静脉血样,检测肌酸激酶(CK)、肌酸激酶MB亚型(CK-MB)、肌钙蛋白Ⅰ(TnI)和肌红蛋白的量。通过对比治疗前后的脑室造影来评价左心室功能及左心室壁运动。结果 PCI治疗后24小时,尼可地尔组的心肌酶水平显著低于对照组;实验组及对照组的CK分别为78.1±34.9,117.4±137.9U/l,显著性P=0.0141,CK-MB为1.57±1.90,2.67±4.50U/l,显著性P=0.0485,TnI为0.37±0.55,0.86±1.65ng/ml,显著性P=0.0101。尼可地尔组的局部左心室壁运动在后期较对照组显著增强。结论尼可地尔能抑制选择性PCI治疗后心肌酶的水平,并在后期显著增强左心室壁的运动,表明尼可地尔可提高PCI治疗时对心肌的保护,降低因血管成形术造成的心肌损伤。 | Tsuyoshi Isono Hiroshi Kamihata Yasuo Sutani Masayuki Motohiro Satoshi Yamamoto Shiori Kyoui Yoshiji Iharada Kouji Kurimoto Katsuko Hara Hakuo Takahashi Toshiji Iwasaka 陈浩 | 2016 | 首都食品与医药2016，23，20： | 3 |
| 6 | Endoscopic ultrasound-guided biliary drainage for right hepatic bile duct obstruction: novel technical tips显示文摘 | Takeshi Ogura Tatsushi Sano Saori Onda Akira Imoto Daisuke Masuda Kazuhiro Yamamoto Masayuki Kitano Toshihisa Takeuchi Takuya Inoue Kazuhide Higuchi | 2014 | Endoscopy2014，，： | 3 |
| 7 | Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia显示文摘 | Toshihiro Yamamoto Satoshi Yuki Toshiaki Watanabe Masayuki Mitsuka Ken-Ichi Saito Kyuya Kogure | 1997 | Brain Research1997，，1： | 3 |
| 8 | An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements显示文摘 | Ken Itoh Tomoki Chiba Satoru Takahashi Tetsuro Ishii Kazuhiko Igarashi Yasutake Katoh Tatsuya Oyake Norio Hayashi Kimihiko Satoh Ichiro Hatayama Masayuki Yamamoto Yo-ichi Nabeshima | 1997 | Biochemical and Biophysical Research Communications1997，，2： | 2 |
| 9 | Clinicopathology of pancreaticobiliary maljunction: relationship between alterations in background biliary epithelium and neoplastic development显示文摘 | Makoto Seki Akio Yanagisawa Eiji Ninomiya Yasuro Ninomiya Hirotoshi Ohta Akio Saiura Junji Yamamoto Toshiharu Yamaguchi Akiko Aruga Keiko Yamada Koichi Takano Rikiya Fujita Masayuki Ikeda Keiko Sasaki Yo Kato | 2005 | Journal of Hepato - Biliary - Pancreatic Surgery2005，，3： | 2 |
| 10 | Multicenter study evaluating the clinical performance of the OSNA assay for the molecular detection of lymph node metastases in gastric cancer patients显示文摘 | Koshi Kumagai Noriko Yamamoto Isao Miyashiro Yasuhiko Tomita Hitoshi Katai Ryoji Kushima Hitoshi Tsuda Yuko Kitagawa Hiroya Takeuchi Makio Mukai Masayuki Mano Hidetaka Mochizuki Yo Kato Nariaki Matsuura Takeshi Sano | 2014 | Gastric Cancer2014，，2： | 2 |
| 11 | Effect of eplerenone versus spironolactone on cortisol and hemoglobin A 1c levels in patients with chronic heart failure显示文摘 | Masayuki Yamaji Takayoshi Tsutamoto Chiho Kawahara Keizo Nishiyama Takashi Yamamoto Masanori Fujii Minoru Horie | 2010 | American Heart Journal2010，，5： | 2 |
| 12 | Transmesosigmoid Hernia: Report of a Case显示文摘 | Takamitsu Sasaki Koutaro Sakai Daisuke Fukumori Masayuki Sato Hitoshi Ohmori Fumio Yamamoto | 2002 | Surgery Today2002，，12： | 1 |
| 13 | A reduced NO x reaction model for pulverized coal combustion under fuel-rich conditions显示文摘 | Masayuki Taniguchi Kenji Yamamoto Hironobu Kobayashi Kenji Kiyama | 2001 | Fuel2001，，3： | 1 |
| 14 | Optimal band imaging system can facilitate detection of changes in depressed-type early gastric cancer显示文摘 | Hiroyuki Osawa Mitsuyo Yoshizawa Hironori Yamamoto Hiroto Kita Kiichi Satoh Hirohide Ohnishi Hidetoshi Nakano Masahiro Wada Masayuki Arashiro Mamiko Tsukui Kenichi Ido Kentaro Sugano | 2008 | Gastrointestinal Endoscopy2008，，2： | 1 |
| 15 | microRNA-504 inhibits cancer cell proliferation via targeting CDK6 inhypopharyngeal squamous cell carcinoma显示文摘 | Naoko Kikkawa Takashi Kinoshita Nijiro Nohata Toyoyuki Hanazawa Noriko Yamamoto Ichiro Fukumoto Takeshi Chiyomaru Hideki Enokida Masayuki Nakagawa Yoshitaka Okamoto Naohiko Seki | 2014 | International Journal of Oncology2014，，： | 1 |
| 16 | Transposon-independent increase of transcription by the Sleeping Beauty transposase显示文摘 | Keita Masuda Seiji Yamamoto Masayuki Endoh | 2004 | Biochem Biophys Res Commun2004，317，3： | 1 |
| 17 | Triam-cinolone-Assisted Internal Limiting Membrane Peeling DuringIdiopathic Macular Hole Surgery 显示文摘 | Naoichi Horio Masayuki Horiguch Naoki Yamamoto | 2005 | Arch Ophthalmol2005，23，： | 1 |
| 18 | Solidification cracking susceptibility of modified 9Cr1Mo steel weld metal during hot-wire laser welding with a narrow gap groove显示文摘 | Rittichai Phaoniam Kenji Shinozaki Motomichi Yamamoto Kota Kadoi Akito Nishijima Masayuki Yamamoto | 2014 | Welding in the World2014，，4： | 1 |
| 19 | Color quantization using the fast k-means algorithm显示文摘 | ideo Kasuga Hiroaki Yamamoto Masayuki Okamoto | 2000 | Systesm and Computers in Japan2000，31，8： | 1 |
| 20 | The transcription factor NRF2 protects against pulmonary fibrosis显示文摘 | HYE-YOUN CHO SEKHAR PM REDDY MASAYUKI YAMAMOTO | 2004 | The FASEB Journal2004，，10： | 1 |
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