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| 1 | 急性缺血性卒中患者早期处理指南:美国心脏协会/美国卒中协会对医疗专业人员的指南(续前)显示文摘7静脉溶栓
7.1静脉rtPA
急性卒中的静脉溶栓治疗现已得到普遍接受。美国FDA于1996年批准静脉应用rtPA,部分基于NINDSrtPA卒中试验结果。 | Edward C. Jauch Jeffrey L. Saver Harold P. Adams Askiel Bruno J.J. (Buddy) Connors Bart M. Demaerschalk Pooja Khatri Paul W. McMullan Adnan I. Qureshi Kenneth Rosenfield Phillip A. Scott Debbie R. Summers David Z. Wang Max Wintermark Howard Yonas 李海峰(译) 岳耀先(译) 王琦(译) 张贤军(译) 丁晓君(译) | 2013 | 国际脑血管病杂志2013，21，8： | 975 |
| 2 | The Global Stratotype Section and Point (GSSP) for the boundary between the Capitanian and Wuchiapingian Stage (Permian)显示文摘 | Yugan Jin Shuzhong Shen Charles M. Henderson Xiangdong Wang Wei Wang Yue Wang Changqun Cao Qinghua Shang | 2006 | Episodes2006，29，4： | 39 |
| 3 | Cosmogenic ^(10)Be dating of Guxiang and Baiyu Glaciations显示文摘Guxiang and Baiyu Glaciations are two previously recognized local glaciations of the Tibetan Plateau. They have been widely used as the reference standard for classifying Late Quaternary glaciations on the Tibetan Plateau and its surrounding mountains. However, the numerical chronologies of both glaciations have been lacking. In this study, cosmogenic 10Be dating was undertaken to define the timing of these two glaciations. The surface boulders deposited by the glaciers of the Guxiang and Baiyu Glaciations have exposure ages of 112.9±16.7―136.5±15.8 ka BP and 11.1±1.9―18.5±2.2 ka BP, respectively. It is likely that the Guxiang and Baiyu Glaciations correspond to marine isotope stages 6 and 2, respectively. | ZHOU ShangZhe XU LiuBing PATRICK M. Colgan DAVID M. Mickelson WANG XiaoLi WANG Jie ZHONG Wei | 2007 | Chinese Science Bulletin2007，52，10： | 28 |
| 4 | Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion显示文摘 | Zhenrui Li Pengxu Qian Wanqing Shao Hailing Shi Xi C. He Madelaine Gogol Zulin Yu Yongfu Wang Meijie Qi Yunfei Zhu John M. Perry Kai Zhang Fang Tao Kun Zhou Deqing Hu Yingli Han Chongbei Zhao Richard Alexander Hanzhang Xu Shiyuan Chen Allison Peak Kathyrn Hall Michael Peterson Anoja Perera Jeffrey S. Haug Tari Parmely Hua Li Bin Shen Julia Zeitlinger Chuan He Linheng Li | 2018 | Cell Research2018，28，9： | 18 |
| 5 | 急性缺血性卒中患者早期处理指南:美国心脏协会/美国卒中协会对医疗专业人员的指南显示文摘背景和目的作者提供了关于成年急性缺血性卒中患者评估和治疗方面的现有证据和处理推荐的一份概述。目标读者为涉及急性缺血性卒中患者发病48h内诊治的院前诊疗人员、医生、综合医疗保健人员和医院管理者。该指南将取代先前的2007年版指南及其2009年更新版。方法著述委员会成员由美国卒中协会卒中委员会的科学声明监督委员会指定,代表各个领域的医疗专家。在形成共识的整个过程中,严格遵循美国心脏协会的利益冲突原则。委员会成员被分配给与其专业领域相关的内容,对卒中文献进行回顾,重点为前一版指南发表之后的文献,然后按照美国心脏协会卒中委员会的证据强度分级方案起草推荐意见。结果本指南的目的是减少卒中相关的残疾和死亡。本指南支持卒中医疗体系的全局性概念以及从患者识别、急救医疗服务激活、转送和分诊到急诊室和卒中单元内最初数小时诊治的卒中诊治细节。本指南讨论了早期卒中评估和一般治疗、缺血性卒中治疗、特殊干预措施,如再灌注策略以及脑复苏的一般生理学干预原则。结论由于许多推荐意见基于有限的证据,还迫切需要对急性缺血性卒中的治疗做进一步的研究。 | Edward C. Jauch Jeffrey L. Saver Harold P. Adams Askiel Bruno J.J. (Buddy) Connors Bart M. Demaerschalk Pooja Khatri Paul W. McMullan Jr, Adnan I. Qureshi Kenneth Rosenfield Phillip A. Scott Debbie R. Summers David Z. Wang Max Wintermark Howard Yonas 李海峰(译) 岳耀先(译) 王琦(译) 张贤军(译) 丁晓君(译) | 2013 | 国际脑血管病杂志2013，21，7： | 17 |
| 6 | TiZr-base Bulk Metallic Glass with over 50 mm in Diameter显示文摘Low-cost TiZr-base bulk metallic glasses(BMGs)(Ti36.1Zr33.2Ni5.8Be24.9)100-xCux(x=5,7 and 9) with a maximum size of over 50 mm in diameter were developed by optimizing the alloy composition.The idea is initiated by selecting a particular microstructure comprising primary β-Ti dendrite and amorphous phase.Afterwards,based on this composition of amorphous phase,a class of TiZr-base bulk metallic glasses was designed step by step to reach the optimum composition range.The glass transition temperature(Tg),initial crystallization temperature(Tx) and width of supercooled region(△T) of(Ti36.1Zr33.2Ni5.8Be24.9)91Cu9 BMG are 611,655 and 44 K,respectively.The(Ti36.1Zr33.2Ni5.8Be24.9)91Cu9 BMG exhibits low density of 5.541 g·cm-3 and high compressive fracture strength of 1800 MPa,which promises the potential application as structural materials. | M. Q. Tang H.F. Zhang Z. W. Zhu H.M. Fu A.M. Wang H. Li Z.Q. Hu | 2010 | Journal of Materials Science & Technology2010，26，6： | 17 |
| 7 | Vegetation Change Prediction with Geo-Information Techniques in the Three Gorges Area of China显示文摘A computerized parametric methodology was applied to monitor, map, and estimate vegetation change in combination with '3S' (RS-remote sensing, GIS-geographic information systems, and GPS-global positioning system) technology and change detection techniques at a 1:50000 mapping scale in the Letianxi Watershed of western Hubei Province, China. Satellite images (Landsat TM 1997 and Landsat ETM 2002) and thematic maps were used to provide comprehensive views of surface conditions such as vegetation cover and land use change. With ER Mapper and ERDAS software, the normalized difference vegetation index (NDVI) was computed and then classified into six vegetation density classes. ARC/INFO and ArcView software were used along with field observation data by GPS for analysis. Results obtained using spatial analysis methods showed that NDVI was a valuable first cut indicator for vegetation and land use systems. A regression analysis revealed that NDVI explained 94.5% of the variations for vegetation cover in the largest vegetation area, indicating that the relationship between vegetation and NDVI was not a simple linear process. Vegetation cover increased in four of areas. This meant 60.9% of land area had very slight to slight vegetation change, while 39.1% had moderate to severe vegetation change. Thus, the study area, in general, was exposed to a high risk of vegetation cover change. | M. T. JABBAR SHI Zhi-Hua WANG Tian-Wei CAI Chong-Fa | 2006 | Pedosphere2006，16，4： | 16 |
| 8 | Interactions of IL-12A and IL-12B Polymorphisms on the Risk of Cervical Cancer in Chinese Women显示文摘 | Chen, X. J. Han, S. P. Wang, S. N. Zhou, X. Y. Zhang, M. F. Dong, J. Shi, X. Y. Qian, N. F. Wang, X. R. Wei, Q. Y. Shen, H. B. Hu, Z.B. | 2009 | 南京医科大学学报(自然科学版)2009，29，3： | 16 |
| 9 | Genome of Wild Mandarin and Domestication History of Mandarin显示文摘官员(柠檬 reticulata ) 是世界范围的最重要的柠檬庄稼之一。它的驯服被相信发生在华南,它是四几千年的官员耕作的中心之一。我们在 Nanling 区域附近收集了官员的自然野人口并且在附近栽培了 landraces。我们发现柠檬性的酸水平戏剧性地在栽培官员被减少。理解 ? 官员驯服的基因基础,我们 de novo 装配了野官员的一个草稿染色体并且分析了一套 104 个柠檬染色体。我们发现 Mangshan 官员是一种原始类型并且二个独立驯服事件发生了,分别地导致在北方和南方 Nanling 山的二组栽培官员(MD1 和 MD2 ) 。二个瓶颈和有效人口尺寸的二扩大为栽培官员的 MD1 组被识别。然而,在 MD2 组织 ? 在人口尺寸有长、连续的减少。MD1 和 MD2 官员从栽培 pummelo 种类显示出种间的基因渗入的不同模式。我们在官员的驯服期间在选择下面可能在基因在柠檬酸盐内容的规定包含了的 aconitate hydratase (ACO ) 识别了高分叉的一个区域,它是。这研究为现存野官员人口的地理起源提供具体基因证据并且使驯服和官员的进化历史清楚些。 | Lun Wang Fa He Yue Huang Jiaxian He Shuizhi Yang Jiwu Zeng Chongling Deng Xiaolin Jiang Yiwen Fang Shaohua Wen Rangwei Xu Huiwen Yu Xiaoming Yang Guangyan Zhong Chuanwu Chen Xiang Yan Changfu Zhou Hongyan Zhang Zongzhou Xie Robert M. Larkin Xiuxin Deng Qiang Xu | 2018 | Molecular Plant2018，11，8： | 14 |
| 10 | Paleoproterozoic volcanic rocks in the southern margin of the North China Craton, central China:Implications for the Columbia supercontinent显示文摘The volcanic rocks of the Xiong’er Group are situated in the southern margin of the North China Craton(NCC).Research on the Xiong er Group is important to understand the tectonic evolution of the NCC and the Columbia supercontinent during the Paleoproterozoic.In this study,to constrain the age of the Xiong’er volcanic rocks and identify its tectonic environment,we report zircon LA-ICP-MS data with Hf isotope,whole-rock major and trace element compositions and Sr-Nd-Pb-Hf isotopes of the volcanic rocks of the Xiong’er Group.The Xiong’er volcanic rocks mainly consist of basaltic andesite,andesite.dacite and rhyolite,with minor basalt.Our new sets of data combined with those from previous studies indicate that Xiong’er volcanism should have lasted from 1827 Ma to 1746 Ma as the major phase of the volcanism.These volcanics have extremely low MgO.Cr and Ni contents,are enriched in LREEs and LILEs but depleted in HFSEs(Nb,Ta,and Ti),similar to arc-related volcanic rocks.They are characterized by negative zirconεHft values of-17.4 to 8.8,whole-rock initial 87Sr/86Sr values of 0.7023 to 0.7177 andεNd(t)values of-10.9 to 6.4.and Pb isotopes(206Pb/204Pb=14.366-16.431,207Pb/204Pb=15.106-15.371,208Pb/204Pb=32.455-37.422).The available elemental and Sr-Nd-Pb-Hf isotope data suggest that the Xiong’er volcanic rocks were sourced from a mantle contaminated by continental crust.The volcanic rocks of the Xiong’er Group might have been generated by high-degree partial melting of a lithospheric mantle that was originally modified by oceanic subduction in the Archean.Thus,we suggest that the subduction-modified lithospheric mantle occurred in an extensional setting during the breakup of the Columbia supercontinent in the Late Paleoproterozoic,rather than in an arc setting. | Changming Wang Xinyu He Emmanuel John M. Carranza Chengmin Cui | 2019 | Geoscience Frontiers2019，10，4： | 14 |
| 11 | The Effect of Sparger Geometry on Gas Bubble Flow Behaviors Using Electrical Resistance Tomography显示文摘By electrical resistance tomography (ERT) the cross sectional profiles of gas hold-up in a φ56mm bubble column are obtained with four designs of gas sparger. The effect of sparger geometry on the bubble distribution is re-vealed by applying a sensitivity conjugated gradients reconstruction method (SCG). Experimental results show that over-all hold-up obtained by ERT is generally in good agreement with those measured with the pressure transducer and the ERT system produces informative evidence that the radial profiles of hold-up is very similar to the sparger design in the lower section of bubble column. Meanwhile, the rise velocity of bubble swarm and the Sauter mean bubble size are evaluated using ERT based on dynamic gas disengagement theory. The experimental results are in good agreement with correlations and conventional estimation obtained using pressure transmitter methods. | 靳海波 M. Wang R. A. Williams | 2006 | Chinese Journal of Chemical Engineering2006，14，1： | 13 |
| 12 | Optimization of N18 Zirconium Alloy for Fuel Cladding of Water Reactors显示文摘In order to optimize the microstructure and composition of N18 zirconium alloy(Zr-1Sn-0.35Nb-0.35Fe-0.1Cr,in mass fraction,%),which was developed in China in 1990s,the effect of microstructure and composition variation on the corrosion resistance of the N18 alloy has been investigated.The autoclave corrosion tests were carried out in super heated steam at 400 ℃/10.3 MPa,in deionized water or lithiated water with 0.01 mol/L LiOH at 360 ℃/18.6 MPa.The exposure time lasted for 300-550 days according to the test temperature.The results show that the microstructure with a fine and uniform distribution of second phase particles(SPPs),and the decrease of Sn content from 1%(in mass fraction,the same as follows) to 0.8% are of benefit to improving the corrosion resistance;It is detrimental to the corrosion resistance if no Cr addition.The addition of Nb content with upper limit(0.35%) is beneficial to improving the corrosion resistance.The addition of Cu less than 0.1% shows no remarkable influence upon the corrosion resistance for N18 alloy.Comparing the corrosion resistance of the optimized N18 with other commercial zirconium alloys,such as Zircaloy-4,ZIRLO,E635 and E110,the former shows superior corrosion resistance in all autoclave testing conditions mentioned above.Although the data of the corrosion resistance as fuel cladding for high burn-up has not been obtained yet,it is believed that the optimized N18 alloy is promising for the candidate of fuel cladding materials as high burn-up fuel assemblies.Based on the theory that the microstructural evolution of oxide layer during corrosion process will affect the corrosion resistance of zirconium alloys,the improvement of corrosion resistance of the N18 alloy by obtaining the microstructure with nano-size and uniform distribution of SPPs,and by decreasing the content of Sn and maintaining the content of Cr is discussed. | B.X. Zhou M. Y. Yao Z.K. Li X.M. Wang J. Zhoua C.S. Long Q. Liu B.F. Luan | 2012 | Journal of Materials Science & Technology2012，28，7： | 13 |
| 13 | The Measurement of ^(41)Ca and Its Application for Cell Messenger显示文摘Ca is an important element in human body. Many diseases relate with Ca in organizations and cells.41Ca (T1/2=1.04×105 a, pure electron capture with emission or Auger electrons and X-rays) is an idealtracer to understand of the mechanism of the disease. The measurement of 41Ca with AMS has been usedfor study of long-term bone resorption, bone resorption in a human, Ca uptake and deposition in heardtissue and skeletal Ca metabolism. Ca2+ in cytoplasm of human cell as a cell messenger plays an | S. JIANG, M. HE, K. DONG, D. YUE, S. WU, G.XU, J.QIN, Q.YOU, Y.ZHENG, Y.GUAN, Q. LIANG, X. ZHAO, Q. WANG S. LIU(Department of Nuclear Physics, C1AE, Beijing 102413, China Department of biology, Beijing Normal University, Beijing 100875, China Department of Physics, Guangxi University, Nanning 530004, China College of Public Health, Beijing University, Beijing 100083, China College of Applied Arts and Science, Beijing Union University, Beijing 100083, China) | 2002 | Annual Report of China Institute of Atomic Energy2002，，0： | 12 |
| 14 | Abnormal function of the posterior cingulate cortex in heroin addicted users during resting-state and drug-cue stimulation task显示文摘 | LI Qiang YANG Wei-chuan WANG Ya-rong HUANG Yu-fang LI Wei ZHU Jia ZHANG Yi ZHAO Li-yan QIN Wei YUAN Kai Karen M. von Deneen WANG Wei TIAN Jie | 2013 | Chinese Medical Journal2013，，4： | 12 |
| 15 | Iron-doped nickel disulfide nanoarray: A highly efficient and stable electrocatalyst for water splitting显示文摘特别地为阳极的氧进化反应(OER ) ,发展中的有效切开水的 electrocatalysts 是在精力变换技术的重要挑战。在这研究,我们经由它的 nickel-iron-layered 的 sulfidation 在 Ti 网孔(Fe 0.1-NiS2 NA/Ti ) 上报导做铁的镍二硫化物 nanoarray 的发展两倍氢氧化物先锋(NiFe-LDH NA/Ti ) 。作为三维的 OER 阳极, Fe 0.1-NiS2 NA/Ti 在 1.0 M KOH 展出显著活动和稳定性,与完成 100 mAlecular 解吸附作用的 231 mV 的低过电位的要求。温度的功能在 36 和 44 点显示出解吸附作用山峰的试验性地测量的微分工作功能? | Na Yang Chun Tang Kunyang Wang Gu Du Abdullah M. Asiri Xuping Sun | 2016 | Nano Research2016，9，11： | 11 |
| 16 | Antibiotic Resistance Genes in the Human-Impacted Environment:A One Health Perspective显示文摘Antibiotic resistance and its environmental component are gaining more attention as part of combating the growing healthcare crisis. The One Health framework, promulgated by many global health agencies, recognizes that antimicrobial resistance is a truly inter-domain problem in which human health, animal agriculture, and the environment are the core and interrelated components.This prospectus presents the status and issues relevant to the environmental component of antibiotic resistance, namely, the needs for advancing surveillance methodology: the environmental reservoirs and sources of resistance, namely, urban wastewater treatment plants, aquaculture production systems, soil receiving manure and biosolid, and the atmosphere which includes longer range dispersal.Recently, much work has been done describing antibiotic resistance genes in various environments;now quantitative, mechanistic,and hypothesis-driven studies are needed to identify practices that reduce real risks and maintain the effectiveness of our current antibiotics as long as possible. Advanced deployable detection methods for antibiotic resistance in diverse environmental samples are needed in order to provide the surveillance information to identify risks and define barriers that can reduce risks. Also needed are practices that reduce antibiotic use and thereby reduce selection for resistance, as well as practices that limit the dispersal of or destroy antibiotic-resistant bacteria or their resistance genes that are feasible for these varied environmental domains. | James M. TIEDJE WANG Fang Celia M. MANAIA Marko VIRTA SHENG Hongjie MA Liping ZHANG Tong Edward TOPP | 2019 | Pedosphere2019，29，3： | 11 |
| 17 | Recently duplicated sesterterpene(C25) gene clusters in Arabidopsis thaliana modulate root microbiota显示文摘Land plants co-speciate with a diversity of continually expanding plant specialized metabolites(PSMs) and root microbial communities(microbiota).Homeostatic interactions between plants and root microbiota are essential for plant survival in natural environments.A growing appreciation of microbiota for plant health is fuelling rapid advances in genetic mechanisms of controlling microbiota by host plants.PSMs have long been proposed to mediate plant and single microbe interactions.However,the effects of PSMs,especially those evolutionarily new PSMs,on root microbiota at community level remain to be elucidated.Here,we discovered sesterterpenes in Arabidopsis thaliana,produced by recently duplicated prenyltransferase-terpene synthase(PT-TPS) gene clusters,with neo-functionalization.A single-residue substitution played a critical role in the acquisition of sesterterpene synthase(sesterTPS) activity in Brassicaceae plants.Moreover,we found that the absence of two root-specific sesterterpenoids,with similar chemical structure,significantly affected root microbiota assembly in similar patterns.Our results not only demonstrate the sensitivity of plant microbiota to PSMs but also establish a complete framework of host plants to control root microbiota composition through evolutionarily dynamic PSMs. | Qingwen Chen Ting Jiang Yong-Xin Liu Haili Liu Tao Zhao Zhixi Liu Xiangchao Gan Asis Hallab Xuemei Wang Juan He Yihua Ma Fengxia Zhang Tao Jin M. Eric Schranz Yong Wang Yang Bai Guodong Wang | 2019 | Science China(Life Sciences)2019，62，7： | 11 |
| 18 | Efficient Silencing of Endogenous MicroRNAs Using Artificial MicroRNAs in Arabidopsis thaliana显示文摘我们这里报导内长的 microRNAs (miRNAs ) 的表示能是高效地在用人工的 miRNA (amiRNA ) 的 Arabidopsis thaliana (Arabidopsis ) 的 silenced 技术。我们证明设计指向成熟 miRNA 的 amiRNA 对所有 miRNA 家庭成员指导 silencing,而设计指向一个 miRNA 先锋抄本的茎环区域的 amiRNA 对指向的仅仅单个家庭成员指导 silencing。而且,我们的结果显示指向成熟 miRNA 和茎环顺序的 amiRNAs 通过 miRNA 先锋抄本的劈开指导 RNA silencing,它大概在 miRNA 生物的续生说的起始的阶段期间发生在一个植物房间的原子核。这建议小 RNA (sRNA ) 指导了 RNA 在植物的劈开不仅在细胞质,而且在原子核发生。许多植物 miRNA 基因家庭经由定序和生物信息的分析被识别了,,但是,迄今为止,仅仅这些的小 tranche 机能上地由于有效前面或反向的基因工具的缺乏被描绘了。我们的调查结果因此在植物为 miRNA 功能的分析提供一个新、强大的颠倒基因的工具。 | Andrew L. Eamens Claire Agius Nell A. Smith Peter M. Waterhouse Ming-Bo Wang | 2011 | Molecular Plant2011，4，1： | 10 |
| 19 | Vagal Nerve Stimulation May Be a Potentially Beneficial Treatment for Acute Myocardial Ischemia显示文摘 | J. Xiong F. S. Xue Y. J. Yuan Q. Wang S. Li J. H. Liu X. Liao Y. M. Zhang | 2010 | 麻醉与监护论坛2010，17，5： | 10 |
| 20 | 7~Be: A Geochemical Tracer for Seasonal Erosion of Surface Soil in Watershed of Lake Hongfeng, Guizhou, China显示文摘7Be penetrative depth in undisturbed surface soil is within 4mm.^7Be activity shows exponential decrease with soil depth,which is expressed as a diffusion process.7Be penetrative depth in undisturbed surface soil is apparently deeper in the fall (0.22-0.37g cm^-1) than in the spring (0.11-0.28g cm^-2) at the same site;Whereas,^7Be apparent activity at the top of surface soil is higher in the spring (0.3-2.2Bq g^-1)than in the fall (0.2-0.5Bqg^-1) at the same site,The 7Be inventory(189-544Bq m^-2)changes with both locations and seasons.Although the ^7Be flux to the earth's surface increases with amount of precipitation,its maximum inventory in the soil profiles decreases to 30%-40% after the rainy period.Calculated by the diffusion equation,the erosion and accumulation rates of soil particles are agreeable with the observation in situ,Which shows that the rates in fall are 1.5 times those in spring.The eroded soil particles almost all have been removed on the tablelands rathel than transported into the drainage system.This indicates that the soil erosion process in the karst region is only partial transportation within a short distance. | BAI ZHANGUO WAN GUOJIANG WANG CHANGSHENG WAN XI HUANGRONGGUI P.H. SANTSCHIZ and M. BASKARANZ(1￣State Key Lab. Of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences,Guiyang 550002 (China))(2￣Department Of Marine Scien | 1996 | Pedosphere1996，6，1： | 10 |
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