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| 1 | Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling:Influence of smoking显示文摘瞄准:为了调查一个模糊逻辑模型是否能预言肤色,表面的癌症(CRC ) 风险由在世袭 non-polyposis 肤色吸表面的癌症(HNPCC ) 病人产生了。方法:从 Creighton 大学世袭癌症研究所登记的 340 个 HNPCC 失配修理(MMR ) 变化搬运人为当模特儿被选择。年龄依赖者曲线被产生阐明开发 CRC 的概率上的在基因变化(hMLH1 或 hMSH2 ) 之间的联合效果,性,和吸烟地位。结果:在男 hMSH2 变化搬运人的吸烟显著地增加的 CRC 风险(P <
0.05 ) 。hMLH1 变化为男性相对 hMSH2 变化搬运人扩充了 CRC 风险(P <
0.05 ) 。男性们非为 hMLH1 比女性有 CRC 的显著地更高的风险吸烟者(P <
0.05 ) , hMLH1 吸烟者(P <
0.1 ) 并且 hMSH2 吸烟者(P <
0.1 ) 。以在在男性的 hMSH2 的一种剂量依赖者方式的吸烟支持的 CRC (P <
0.05 ) 。有 hMSH2 变化的女性和与 hMLH1 组一起的两性仅仅在广泛的吸烟历史以后表明了吸烟效果(P <
0.05 ) 。结论:由在 HNPCC 病人吸烟的 CRC 提升依赖于基因变化,性和年龄。这些数据证明模糊建模可以启用临床的风险分数的明确的表达,从而允许 CRC 预防策略的 individualization。 | Rhonda M Brand David D Jones Henry T Lynch Randall E Brand Patrice Watson Ramesh Ashwathnayaran Hemant K Roy | 2006 | World Journal of Gastroenterology2006，12，28： | 5 |
| 2 | Rare-earth diffusion in zircon 显示文摘 | Cherniak D J Hanchar J M Watson E B | 1997 | Chemical Geology1997，134，4： | 1 |
| 3 | Maturity indices for composted dairy and pig manures显示文摘 | P Wang C M Changa M E Watson | 2004 | Soil Biology and Biochemistry2004，36，： | 1 |
| 4 | Rare-earth diffusion in zircon 显示文摘 | Cherniak D J I-lanchar J M Watson E B | 1997 | Chem Geol1997，134，： | 1 |
| 5 | Short-and long-term hospital and community exercise programmes for patients with chronic obstructive pulmonary disease显示文摘 | Elliott M Watson C Wilkinson E | 2004 | Respirology2004，9，3： | 1 |
| 6 | Transitlon-metal formation: Ti, V, Fe, and Ni aluminides显示文摘 | Watson R E Weinert M | 1998 | Physical Review B1998，58，10： | 1 |
| 7 | Estimation of three-phase flow functions in porous media显示文摘 | Mejia G M Watson A T Nordtvedt J E | 1996 | AIChE J1996，43，： | 1 |
| 8 | The efficacy of computer- assisted instruction versus face-to-face instruction in academic libraries: A systematic review 显示文摘 | Zhang Li Watson E M Banfield L | 2007 | Journal of Academic Librarianship2007，33，4： | 1 |
| 9 | lnteraction of DNAbinding proteins with a milk protein gene promoter in vitro: identification of a mammary gland-specific factor 显示文摘 | Watson C J Gordon K E Robertson M | 1991 | Nucleotide Acids Res1991，19，23： | 1 |
| 10 | Silage and milk production: studies with diets containing white clover si lage显示文摘 | Castle M E Reid D Watson J N | 1983 | Grass and Forage Science1983，38，3： | 1 |
| 11 | Review of volatile organic compound source apportionment by chemical mass balance显示文摘 | WATSON J G CHOW J C FUJITA E M | 2001 | Atmospheric Environment2001，35，： | 1 |
| 12 | Adaptive experimental design for construction of response surface approximations 显示文摘 | Perez V M Renaud J E Watson L W | 2002 | AIAA Journal2002，40，12： | 1 |
| 13 | Maturity indices for composted dairy and pig manures 显示文摘 | P Wang C M Changa M E Watson | 2004 | Soil Biology and Biochemistry2004，36，： | 1 |
| 14 | Mutation in invH, but not stn, reduces Salmonella induced enteritis in cattle显示文摘 | WATSON P R GALYOV E E PAULIN S M | 1998 | Infect Immun1998，66，14： | 1 |
| 15 | Randomized trial of tacrolimus versus cyclosporin microemulsion in renal transplantation显示文摘 | Trompeter R Filler G Webb NJ Watson AR Milford DV Tyden G Grenda R Janda J Hughes D Ehrich JH Klare B Zacchello G Bjorn Brekke I McGraw M Perner F Ghio L Balzar E Friman S Gusmano R Stolpe J | 2002 | Pediatr Nephrol2002，17，3： | 1 |
| 16 | Mouse macrophage paraoxonase 2 (PON2)activity is increased whereas cellular PON3 activity is decreased under oxidative stress显示文摘 | ROSENBLAT M DRAGANOV D I WATSON C E | 2003 | Arterioscler Thromb Vasc Biol2003，23，： | 1 |
| 17 | The United Kingdom public health re- sponse to an imported laboratory confirmed case of a no- vel coronavirus in September 2012显示文摘 | Pebody R G Chand M A Thomas H L Green H K Boddington N L Carvalho C Brown C S Anderson S R Rooney C Crawley-Boevey E Irwin D J Aarons E Tong C Newsholme W Price N Langrish C Tucker D Zhao H Phin N Crofts J Bermingham A Gil- gunn-Jones E Brown K E Evans B Catchpole M Watson J M | 2012 | Euro Surveill2012，17，20： | 1 |
| 18 | Vascular endothelial growth factor is a marker of tumor invasion and metastasis in squamous cell carcinoma of the head and neck 显示文摘 | Sauter E R Nesbit M Watson J C | 1999 | Clin Cancer Res1999，5，4： | 1 |
| 19 | The DNA sequence of equine herpesvirus-1 显示文摘 | Telford E A R Watson M S McBride K | 1992 | Virology1992，189，： | 1 |
| 20 | Zircon saturation revisited:Temperature and composition effects in a variety of crustal magma types显示文摘 | Watson E B Harrison T M | 1983 | Earth and Planetary Science Letters1983，64，： | 1 |
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