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| 1 | Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling:Influence of smoking显示文摘瞄准:为了调查一个模糊逻辑模型是否能预言肤色,表面的癌症(CRC ) 风险由在世袭 non-polyposis 肤色吸表面的癌症(HNPCC ) 病人产生了。方法:从 Creighton 大学世袭癌症研究所登记的 340 个 HNPCC 失配修理(MMR ) 变化搬运人为当模特儿被选择。年龄依赖者曲线被产生阐明开发 CRC 的概率上的在基因变化(hMLH1 或 hMSH2 ) 之间的联合效果,性,和吸烟地位。结果:在男 hMSH2 变化搬运人的吸烟显著地增加的 CRC 风险(P <
0.05 ) 。hMLH1 变化为男性相对 hMSH2 变化搬运人扩充了 CRC 风险(P <
0.05 ) 。男性们非为 hMLH1 比女性有 CRC 的显著地更高的风险吸烟者(P <
0.05 ) , hMLH1 吸烟者(P <
0.1 ) 并且 hMSH2 吸烟者(P <
0.1 ) 。以在在男性的 hMSH2 的一种剂量依赖者方式的吸烟支持的 CRC (P <
0.05 ) 。有 hMSH2 变化的女性和与 hMLH1 组一起的两性仅仅在广泛的吸烟历史以后表明了吸烟效果(P <
0.05 ) 。结论:由在 HNPCC 病人吸烟的 CRC 提升依赖于基因变化,性和年龄。这些数据证明模糊建模可以启用临床的风险分数的明确的表达,从而允许 CRC 预防策略的 individualization。 | Rhonda M Brand David D Jones Henry T Lynch Randall E Brand Patrice Watson Ramesh Ashwathnayaran Hemant K Roy | 2006 | World Journal of Gastroenterology2006，12，28： | 5 |
| 2 | New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC显示文摘 | Hans F.A. Vasen Patrice Watson Jukka–Pekka Mecklin Henry T. Lynch | 1999 | Gastroenterology1999，，6： | 3 |
| 3 | Is analysis of lower esophageal sphincter vector volumes of value in diagnosing gastroesophageal reflux disease?显示文摘AIM: With successful surgical treatment of gastroesophagealreflux disease (GERD), there is interest in understandingthe anti-reflux barrier and its mechanisms of failure. To date,the potential use of vector volumes to predict the DeMeesterscore has not been adequately explored.METHODS: 627 patients in the referral database receivedesophageal manometry and ambulatory 24-hour pHmonitoring. Study data included LES resting pressure (LESP),overall LES length (OL) and abdominal length (AL), totalvector volume (TW) and intrabdominal vector volume (IVV).RESULTS: In cases where LESP, TVV or IVV were all belownormal, there was an 81.4 % probability of a positiveDeMeester score. In cases where all three were normal,there was an 86.9 % probability that the DeMeester scorewould be negative. Receiver-operating characteristics (ROC)for LESP, TW and IW were nearly identical and indicatedno useful cut-off values. Logistic regression demonstratedthat LESP and IVV had the strongest association with apositive DeMeester score; however, the regression formulawas only 76.L % accurate.CONCLUSION: While the indices based on TVV, IW andLESP are more sensitive and specific, respectively, than anysingle measurement, the measurement of vector volumesdoes not add significantly to the diagnosis of GERD. | Robert E.Marsh Christopher L.Perdue Ziad T.Awad Patrice Watson Mohamed Selima Richard E.Davis Charles J.Filipi | 2003 | World Journal of Gastroenterology2003，9，1： | 3 |
| 4 | The Tumor Spectrum in the Lynch Syndrome显示文摘 | Patrice Watson Bronson Riley | 2005 | Familial Cancer2005，，3： | 1 |
| 5 | Cumulative incidence of colorectal and extracolonic cancers in mlh1 and msh2 mutation carriers of hereditary nonpolyposis colorectal cancer显示文摘 | Kevin M. Lin M.D. M. Shashidharan M.D. Alan G. Thorson M.D. Charles A. Ternent M.D. Garnet J. Blatchford M.D. Mark A. Christensen M.D. Patrice Watson Ph.D. Stephen J. Lemon M.D. M.PH. Barbara Franklin B.S.N. Beth Karr B.S.N. Jane Lynch B.S.N. Henry T. Ly | 1998 | Journal of Gastrointestinal Surgery1998，，1： | 1 |
| 6 | New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC显示文摘 | Hans F.A. Vasen Patrice Watson Jukka–Pekka Mecklin Henry T. Lynch | 1999 | Gastroenterology1999，，6： | 1 |
| 7 | Intra-abdominal carcinomatosis after prophylactic oophorectomy in women of hereditary breast ovarian cancer syndrome kindreds associated with BRCA1 and BRCA2 mutations显示文摘 | Murray Joseph Casey Carrie Synder Chhanda Bewtra Steven A. Narod Patrice Watson Henry T. Lynch | 2005 | Gynecologic Oncology2005，，2： | 1 |
| 8 | 盛大的逃亡显示文摘糟糕的日子,寻求一种方法,哦寻找大逃亡乘上他的车。 | Patric Watson 金茨 | 2013 | 疯狂英语(阅读版)2013，，7： | 0 |
| 9 | 津巴布韦:马纳潭国家公园独木舟探险记显示文摘提到津巴布韦,除了雄壮的维多利亚瀑布和严重的通货膨胀(前段时间该国曾发行面值为100万亿的世界最大面额的钞票)外,你还知道哪些呢?事实上,津巴布韦的旅游项目多种多样,是绝佳的户外探险目的地。在这里,你能观赏到上千种其他地方看不到的野生动物,体验独木舟以及漂流的刺激,攀登寒冷的高峰……本期“环球风情”将带大家前往位于津巴布韦北部的马纳潭国家公园,体验原始的非洲风情。 | Patrice Watson Twilight | 2009 | 疯狂英语(初中天地)2009，，11： | 0 |
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