|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mogroside V inhibits LPS-induced COX-2 expression/ROS production and overexpression of HO-1 by blocking phosphorylation of AKT1 in RAW264.7 cells显示文摘Momordica grosvenori is a valuable edible plant with medicinal purposes, and it is widely used in medicated diets and traditional Chinese medicine in Asia. Mogroside V (MV), the main bioactive component from M. grosvenori, is comm only used as a natural sweetener. M. grosvenori extracts have been reported to exert potent anti-inflammatory property, however the underlying molecular mechanism still remains unknown. In the present study, the biological effect of MV in inflammation was investigated in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. The ELISA and western blot analysis results showed that MV significantly inhibited LPS-induced prostaglandin E2 (PGE2) production and cyclooxygenase-2 (COX-2) expression. MV markedly decreased the phosphorylation of IxB-a, increased IkB-oc, and reduced nuclear p-65 and C/EBP6. Furthermore, MV attenuated LPS-induced phosphorylation of MAPKs and AKT1, and only the phosphorylation status of AKT1 was found to be consistent with the expression trend of COX-2. Moreover, MV reduced ROS level and restored overexpressed HO-1 and AP-1 to basal level, which can be markedly reversed by AKT1 inhibitor LY294002. These results revealed that AKT1 plays a key role in LPS-induced COX-2 expression, and acts as a mediator to keep the redox balance in LPS-stimulated RAW264.7 cells. MV exerts anti-inflammatory property by blocking AKT1-mediated NF-kB and C/EBP6 activation, ROS generation and AP-1/ HO-1 expression. Therefore, the present study indicated that MV has a significant chemopreventive effect on the inflammatory lesions and suggested that AKT1 is a potential specific target of MV for relieving inflammation. | Yong Li Luyan Zou Tao Li Dengni Lai Yanyang Wu Si Qin | 2019 | Acta Biochimica et Biophysica Sinica2019，51，4： | 14 |
| 2 | PslG, a self-produced glycosyl hydrolase, triggers biofilm disassembly by disrupting exopolysaccharide matrix显示文摘Biofilms 是在细胞外的矩阵嵌入的微生物的联系表面的社区。Exopolysaccharide 是在维持 biofilm 建筑学并且保护居民 biofilm 细菌免受抗菌剂和主人免疫者攻击的伤害的细胞外的矩阵的一个批评部件。然而,指向矩阵 exopolysaccharides 的自我生产的因素,仍然糟糕被理解。这里,我们显示出那 PslG,在 Pseudomonas aeruginosa 涉及关键 biofilm 矩阵 exopolysaccharide Psl 的合成的蛋白质,阻止 biofilm 形成并且拆卸存在在外长地供应的在 nanomolar 集中的分钟以内的 biofilms。PslG 的水晶结构显示 endoglycosidase 的典型特征。PslG 主要破坏 Psl 矩阵从 biofilms 驱散细菌。PslG 处理显著地提高 biofilm 敏感到抗菌素和巨噬细胞房间,导致在一只老鼠的改进 biofilm 清理植入感染模型。而且, PslG 对大量 Pseudomonas 种类显示出 biofilm 抑制和拆卸活动,显示它在与 biofilm 相关的复杂并发症作斗争的大潜力。 | Shan Yu Tiantian Su Huijun Wu Shiheng Liu Di Wang Tianhu Zhao Zengjun Jin Wenbin Du Mei-Jun Zhu Song Lin Chua Liang Yang Deyu Zhu Lichuan Gu Luyan Z Ma | 2015 | Cell Research2015，25，12： | 13 |
| 3 | A polyoxometalate-functionalized two-dimensional titanium carbide composite MXene for effective cancer theranostics显示文摘作为一个新家庭二维(2D ) nanomaterials,因为高效, MXenes 最近包括精力在万用的应用吸引了许多注意存储和电气化学,而是他们到 biomedicine 的特定的申请很少被报导了特别为 theranostic nanomedicine,即,并发的诊断成像和治疗。这研究第一次显示出表面设计和 2D Ti 3 由 GdW 10-based polyoxometalates (POM ) 的集成的 C 2 MXene nanosheets。这些多功能的 GdW 10@Ti3 C 2 合成 nanosheets 向过高热的治疗提供磁性的回声(先生) 或计算断层摄影术(CT ) 向肿瘤房间或异种皮移植的成像指导。没有进一步的出现,一个肿瘤有效地在观察时期期间被根除。是综合的到 Ti 310 nanoclusters > C 2 nanosheets 被表明基于他们的唯一的作文为提高对比的 CT 和先生成像用作一个对比代理人,因此为诊断成像的指导显示出潜力并且为肿瘤过高热 nanotherapy 监视。在 GdW 10@Ti3 C 2 合成 nanosheets 被表明保证他们的随后的翻译进医疗。这研究为由表面工程和 multifunctionalization 拓宽 MXenes 的生物医学的应用提供新奇策略,它被期望在 nanotheranostics 支持 MXenes 的生物医学的应用的进一步的探索。 | Luyan Zong Huixia Wu Han Lin Yu Chen | 2018 | Nano Research2018，11，8： | 9 |
| 4 | Quantitative trait locus mapping with background control in genetic populations of clonal F_1 and double cross显示文摘In this study, we considered five categories of molecular markers in clonal F_1 and double cross populations,based on the number of distinguishable alleles and the number of distinguishable genotypes at the marker locus. Using the completed linkage maps, incomplete and missing markers were imputed as fully informative markers in order to simplify the linkage mapping approaches of quantitative trait genes. Under the condition of fully informative markers, we demonstrated that dominance effect between the female and male parents in clonal F_1 and double cross populations can cause the interactions between markers. We then developed an inclusive linear model that includes marker variables and marker interactions so as to completely control additive effects of the female and male parents, as well as the dominance effect between the female and male parents. The linear model was finally used for background control in inclusive composite interval mapping(ICIM) of quantitative trait locus(QTL). The ef ficiency of ICIM was demonstrated by extensive simulations and by comparisons with simple interval mapping, multiple-QTL models and composite interval mapping. Finally, ICIM was applied in one actual double cross population to identify QTL on days to silking in maize. | Luyan Zhang Huihui Li Junqiang Ding Jianyu Wu Jiankang Wang | 2015 | Journal of Integrative Plant Biology2015，57，12： | 4 |
| 5 | Degradable Hybrid CuS Nanoparticles for Imaging-Guided Synergistic Cancer Therapy via Low-Power NIR-II Light Excitation显示文摘Near-infrared(NIR)-II light-excitable photonic agents capable of generating tumor hyperthermia and cytotoxic free radicals are promising for synergistic phototherapy of tumors.However,the lack of NIR-II excitable agents makes it challenging to achieve combinational tumor phototherapy.Here,the authors have reported on a tumor-targeting and degradable hybrid copper sulfide(CuS)nanoparticle(AIBA@CuS-FA)via loading a hydrophilic Azo initiator(AIBA)into an amphiphilic lipid-encapsulating CuS nanoparticle.AIBA@CuS-FA shows high photothermal conversion efficiency(PCE≈47.5%)at 1064 nm,enabling heat production to trigger tumor hyperthermia and thermal decomposition of AIBA into cytotoxic free alkyl radicals upon irradiation with a 1064-nm laser under low-power density(0.5 W/cm2).Moreover,alkyl radicals can drive degradation of AIBA@CuS-FA and embedded CuS nanodisks,releasing Cu^(2+)ions that can catalyze a Fenton-like reaction for hydroxyl radical(•OH)production to promote tumor therapy.Findings demonstrate promise for combinational photothermal therapy(PTT),oxygen-independent alkyl radical therapy,and chemodynamic therapy(CDT)of tumors. | Yidan Sun Hua Shi Xiaoyang Cheng Luyan Wu Yuqi Wang Zhengyang Zhou Jian He Hong-Yuan Chen Deju Ye | 2021 | CCS Chemistry2021，3，5： | 2 |
| 6 | Determination of mannitoland threesugars in Ligustrum lucidum Ait by capillary electropho-resis with electrochemical detection显示文摘 | CHEN Gang ZHANG Luyan WU Xingliang | 2005 | Analytica Chimica Acta2005，530，1： | 1 |
| 7 | Facile Synthesis of Multi-Branched Gold Nanostructures through a TBAB-Assisted Route in Aqueous Solution and Their SERS Property显示文摘由把 tetrabutyl 铵溴化物(TBAB ) 用作一个盖住的代理人的多分叉的金 nanostructures 的灵巧的合成被描述。反应在温和温度在一个一步舞过程被执行。有在长度从 70 ~ 130 nm 的超过六个锋利的分支的金 nanostructures 在高产量被综合。TBAB 的相对弱吸附能力导致不完全地盖住的金表面, nanoparticles 的生长在揭开的金表面上发生,这被建议,因此短的分支因而出现。然后断然在金表面上控告了 TBAB 层阻止分支与刺激分支生长的对方一起聚集。准备分叉的金 nanoparticles 表演散布的有效提高表面的拉曼(重量的单位) 性质。低温度(4mas 可能从充实的披风被导出我(EM-I ) 结束成员。在锆石 U-Pb 同位素标明日期上基于 LA-ICPMS,在 Dhi Samir 采矿区域的煌斑岩有 602 precipi 的年龄吗?? | Wang, Luyan Wu, Xinzhou Pei, Meishan Wu, Zhiyan Li, Xiaonan Tao, Xutang | 2011 | Chinese Journal of Chemistry2011，29，1： | 1 |
| 8 | An activatable ratiometric near-infrared fluorescent probe for hydrogen sulfide imaging in vivo显示文摘Ratiometric fluorescent probes hold great promise for in vivo imaging;however,stimuli-activatable ratiometric probes with fluorescence emissions in near-infrared(NIR)region are still very few.Herein,we report a hydrogen sulfide(H_2S)-activatable ratiometric NIR fluorescent probe(1-SPN)by integrating a H_2S-responsive NIR fluorescent probe 1 into a H_2S-inert poly[2,6-(4,4-bis-(2-ethylhexyl)-4 H-cyclopenta[2,1-b;3,4-b′]dithiophene)-alt-4,7(2,1,3-benzothiadiazole)](PCPDTBT)-based NIR semiconducting polymer nanoparticle(SPN).1-SPN shows'always on'PCPDTBT fluorescence at 830 nm and weak probe 1 fluorescence at 725 nm under excitation at 680 nm.The ratio of NIR fluorescence intensities between 725 and 830 nm(I_(725)/I_(830))is small.Upon interaction with H_2S,the fluorescence at 725 nm is rapidly switched on,resulting in a large enhancement of I_(725)/I_(830),which is allowed for sensitive visualization and quantification of H_2S concentrations in living cells.Taking advantage of enhanced tissue penetration depth of NIR fluorescence,1-SPN is also applied for real-time ratiometric fluorescence imaging of hepatic and tumor H_2S in living mice.This study demonstrates that activatable ratiometric NIR fluorescent probes hold great potential for in vivo imaging. | Luyan Wu Wenhui Zeng Liandong Feng Yuxuan Hu Yidan Sun Yingxiao Yan Hong-Yuan Chen Deju Ye | 2020 | Science China Chemistry2020，63，5： | 0 |
| 9 | External control of qubit-photon interaction and multi-qubit reset in a dissipative quantum network显示文摘A quantum network is a promising quantum many-body system because of its tailored geometry and controllable interaction. Here,we propose an external control scheme for the qubit-photon interaction and multiqubit reset in a dissipative quantum network,which comprises superconducting circuit chains with microwave drives and filter-filter couplings. The traditional multiqubit reset of the quantum network requires physically disconnected qubits to prevent their entanglement. However, we use an original effect of dissipation, i.e., consuming the entanglement generated by qubits’ interaction, to achieve an external control of the multiqubit reset in an always-connected superconducting circuit. The reset time is independent of the number of qubits in the quantum network. Our proposal can tolerate considerable fluctuations in the system parameters and can be applicable to higherdimensional quantum networks. | Xian-Peng Zhang Li-Tuo Shen Yuan Zhang Luyan Sun Huaizhi Wu Zhen-Biao Yang Zhang-Qi Yin | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，5： | 0 |
| 10 | Research on error accumulation control of three-dimensional adjustment with offset constraint显示文摘Background Currently,laser tracker is the primary instrument used to carry out three-dimensional position measurement in accelerator alignment.Theoretically,three-dimensional measuring data processed by three-dimensional adjustment are more rigorous,however,error accumulation is found in practice.Purpose In order to control error accumulation and further improve the measurement accuracy of accelerator alignment,this research introduces the laser alignment system into the activity of measurement and data processing.Methods A measurement scheme combining laser tracker and laser alignment system is proposed.To construct the constraint condition,the offset values from the measuring points to the laser straight-line datum were used.To carry out the three-dimensional adjustment with offset constraint,the laser tracker observations were used.Results A three-dimensional adjustment function model of laser tracker observations is given.The construction method of the constraint equation is researched,and the calculation formulas of the three-dimensional adjustment with offset constraint are derived.A 200 m linac tunnel control network is designed,using simulation measurement method,the measuring data of laser tracker and the offset values from the measuring points to the laser straight-line datum were generated.The simulated data are calculated by the method given in this paper and the result is analyzed.Conclusion Simulation result shows introducing the laser alignment system into laser tracker measurement and applying the three-dimensional adjustment with offset constraint can effectively suppress the error accumulation caused by long distance move station measurement. | Wang Xiaolong Kang Ling Dong Lan Li Bo Men Lingling Luo Tao Wang Tong Liang Jing He Zhenqiang Ke Zhiyong Ma Na Lu Shang Han Yuanying Yan Luping Zhang Luyan Liu Xiaoyang Yan Haoyue Li Chunhua Wu Lei | 2022 | Radiation Detection Technology and Methods2022，6，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员